• The Journal of the Korea Contents Association
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• v.16 no.12
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• pp.761-771
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• 2016

This study is significant for its proposed health care quality improvement methods to study the relationship between the medical service quality and customer loyalty in the regional hub public hospital. The subjects were selected 604 people who visited the regional hub public hospital to customers from June 9 to June 30, 2014 as the final survey. The analysis was conducted hierarchical regression analysis to identify factors affecting the reliability factor analysis and customer loyalty. In conclusion showed that accessibility factors affecting customer loyalty, awareness hospital, the perceived value of cost-effectiveness, human services on a significant impact. The regional hub public hospitals by focusing efforts I have a continuity of customer care through constant management in order to provide quality health care, increase the frequency of use and loyalty are needed.

• Journal of Biomedical Engineering Research
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• v.43 no.6
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• pp.399-408
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• 2022

Because arrhythmia occurs irregularly, it should be examined for at least 24 hours for accurate diagnosis. For this reason, this paper developed firmware software for arrhythmia detection and prevented consumption of temporal and human resources and enabled continuous management and early diagnosis. Prior to the experiment, the interval between the R peaks of the QRS Complex was calculated using the Pan-Tompkins algorithm. The developed firmware software designed and implemented an algorithm to detect arrhythmia such as tachycardia, bradycardia, ventricular tachycardia, persistent tachycardia, and non-persistent tachycardia, and a data transmission format to monitor the collected data based on BLE. As a result of the experiment, arrhythmia was found in real time according to the change in BPM as designed in this paper. And the data quality for BLE communication was verified by comparing the sensor's serial communication value with the Android application reception value. In the future, wearable devices for real-time arrhythmia detection will be lightweight and developed firmware software will be applied.

• Journal of Hospice and Palliative Care
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• v.23 no.4
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• pp.212-227
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• 2020

Purpose: This study presents the process of designing workbooks for advance care planning appropriate for the Korean cultural setting and describes actual case studies. Methods: This study focused on single inductive case studies of the utilization of an advance care planning workbook and recruited individual participants. Results: The workbook for adolescents contained six sessions and the workbook for children contained seven sessions. The workbook sessions led to four major discoveries: 1) considering the Korean cultural context, discussions on life and death must be held indirectly; 2) the role of the counselor as a supporter is crucial for the workbook to be effective; 3) the workbook must be accessible regardless of the seriousness of the illness; and 4) patients must be able to make their own choice between the workbook versions for children and adolescents. Six facilitating factors improved engagement: 1) the role of the counselor as a supporter; 2) building trust with the patient; 3) affirming freedom of expression on topics the patient wished to avoid talking about; 4) having discussions on what private information to keep secret and to whom the information can be disclosed; 5) discovering and regularly discussing relevant topics; and 6) regular communication and information-sharing with the patient's medical service providers. Conclusion: It is necessary to build on actual case studies regarding workbooks for children and adolescents in order to expand the usage of these workbooks to all relevant medical institutions in Korea.

• Parasites, Hosts and Diseases
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• v.58 no.5
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• pp.513-525
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• 2020

Clonorchis sinensis is a food-borne trematode that infects more than 15 million people. The liver fluke causes clonorchiasis and chronical cholangitis, and promotes cholangiocarcinoma. The underlying molecular pathogenesis occurring in the bile duct by the infection is little known. In this study, transcriptome profile in the bile ducts infected with C. sinensis were analyzed using microarray methods. Differentially expressed genes (DEGs) were 1,563 and 1,457 at 2 and 4 weeks after infection. Majority of the DEGs were temporally dysregulated at 2 weeks, but 519 DEGs showed monotonically changing expression patterns that formed seven distinct expression profiles. Protein-protein interaction (PPI) analysis of the DEG products revealed 5 sub-networks and 10 key hub proteins while weighted co-expression network analysis (WGCNA)-derived gene-gene interaction exhibited 16 co-expression modules and 13 key hub genes. The DEGs were significantly enriched in 16 Kyoto Encyclopedia of Genes and Genomes pathways, which were related to original systems, cellular process, environmental information processing, and human diseases. This study uncovered a global picture of gene expression profiles in the bile ducts infected with C. sinensis, and provided a set of potent predictive biomarkers for early diagnosis of clonorchiasis.

• Journal of Convergence for Information Technology
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• v.12 no.2
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• pp.184-191
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• 2022

This study aims to provide basic information necessary to find an efficient management plan for patients using auto insurance. The analysis was conducted on the five-year auto insurance medical expenses review data registered in the health care bigdata Hub from 2016 to 2020. As a result of the analysis, the number one composition ratio of auto insurance inpatient treatment expenses was treatment and surgery fees for Certified tertiary hospitals, hospitalization fees for general hospitals, hospitals and clinics, and treatment and surgery fees for oriental medical institutions and dental hospitals. outpatient treatment expenses was doctor's fee for medical institution, treatment and surgery fees for oriental medical institutions and dental hospitals. The ratio of medication, anesthesia, and special equipment significantly affected the cost of inpatient. And the ratio of physical therapy significantly affected the cost of outpatient.

• International Commerce and Information Review
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• v.12 no.4
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• pp.345-362
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• 2010

It is necessary to develop new competitive products under the world economic downturn. The medical tourism industry a good example and it has grown rapidly for last couple of years. This paper aims to investigate socio-demographic proxies of inbound medical tourists in Korea. In particular, the medical tourist behaviors are modeled by considering the factors such as acquisition process of medical tourism information, service level of medical tourism industry and the choice attributes. The results of this study are summarized that: 1) Moot inbound medical tourists are over 40-years old with professional occupation accompanied with families; 2) The information resources are mainly acquired from travel agents and WOM(Word of Mouth) such as friends and relatives; 3) Current problems are lack of various promotion channels and the competitiveness of medical coots; 4) The inbound medical tourists are not homogeneous but vary in different segments. The study suggests that various marketing strategies should be implemented for target market segments to promote Korea as a medical tourism hub.

• International Commerce and Information Review
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• v.10 no.4
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• pp.579-595
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• 2008

Medical tourism is a contemporary phenomenon which has its roots in both tourism and health care industry. This market has grown significantly' for the last 10 years. The purpose of this study is to suggest strategies to develop medical tourism in Korea by studying cases of the medical tourism developed countries such as Singapore, Malaysia, India, Thailand as well as analysis medical tourists who has visited to H university hospital. In total of 254 medical tourists were analysed and the results of the study are followed: Korean government need to appease medical law to be able to attract more medical tourists; medical industry and tourism industry need to develop Korean specialized medical tourism package, Middle-Eastern markets, where the oil money exists, should be developed.

• Journal of the Korean Institute of Rural Architecture
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• v.22 no.4
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• pp.35-42
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• 2020

This study evaluated the importance between the major indicators of living SOC in small and medium cities. AHP layer analysis was performed on a group of experts and their importance and priorities were evaluated. The results of the assessment are as follows: First, the village(walking) living zone was considered relatively more important than the local hub(vehicle) living zone. Second, the importance of health care in the local hub(vehicle) living area was assessed to be the most important in the comprehensive evaluation. Third, medical care, care, education and convenience in the village(walking) living area were ranked second, third, fourth and fifth, respectively. Fourth, the relative importance of physical education, learning, physical education, learning, relaxation, culture and village(walking) living areas in the local hub(vehicle) living areas were valued low. It is necessary to seek living SOC policies and directions in consideration of the special nature of urban social structure in small and medium-sized cities in Korea.

• Genomics & Informatics
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• v.20 no.3
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• pp.27.1-27.13
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• 2022

Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck malignancy, with frequent cervical lymph-node metastasis, leading to a poor prognosis in OSCC patients. The present study aimed to identify potential markers, including microRNAs (miRNAs) and genes, significantly involved in the etiology of early-stage OSCC. Additionally, the main OSCC's dysregulated Gene Ontology annotations and significant signaling pathways were identified. The dataset GSE45238 underwent multivariate statistical analysis in order to distinguish primary OSCC tissues from healthy oral epithelium. Differentially expressed miRNAs (DEMs) with the criteria of p-value < 0.001 and |Log2 fold change| > 1.585 were identified in the two groups, and subsequently, validated targets of DEMs were identified. A protein interaction map was constructed, hub genes were identified, significant modules within the network were illustrated, and significant pathways and biological processes associated with the clusters were demonstrated. Using the GEPI2 database, the hub genes' predictive function was assessed. Compared to the healthy controls, main OSCC had a total of 23 DEMs. In patients with head and neck squamous cell carcinoma (HNSCC), upregulation of CALM1, CYCS, THBS1, MYC, GATA6, and SPRED3 was strongly associated with a poor prognosis. In HNSCC patients, overexpression of PIK3R3, GIGYF1, and BCL2L11 was substantially correlated with a good prognosis. Besides, "proteoglycans in cancer" was the most significant pathway enriched in the primary OSCC. The present study results revealed more possible mechanisms mediating primary OSCC and may be useful in the prognosis of the patients with early-stage OSCC.

• Journal of Microbiology and Biotechnology
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• v.32 no.10
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• pp.1262-1274
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• 2022

Cholangiocarcinoma (CCA) is a complex and refractor type of cancer with global prevalence. Several barriers remain in CCA diagnosis, treatment, and prognosis. Therefore, exploring more biomarkers and therapeutic drugs for CCA management is necessary. CCA gene expression data was downloaded from the TCGA and GEO databases. KEGG enrichment, GO analysis, and protein-protein interaction network were used for hub gene identification. miRNA were predicted using Targetscan and validated according to several GEO databases. The relative RNA and miRNA expression levels and prognostic information were obtained from the GEPIA. The candidate drug was screened using pharmacophore-based virtual screening and validated by molecular modeling and through several in vitro studies. 301 differentially expressed genes (DEGs) were screened out. Complement and coagulation cascades-related genes (including AHSG, F2, TTR, and KNG1), and cell cycle-related genes (including CDK1, CCNB1, and KIAA0101) were considered as the hub genes in CCA progression. AHSG, F2, TTR, and KNG1 were found to be significantly decreased and the eight predicted miRNA targeting AHSG, F2, and TTR were increased in CCA patients. CDK1, CCNB1, and KIAA0101 were found to be significantly abundant in CCA patients. In addition, Molport-003-703-800, which is a compound that is derived from pharmacophores-based virtual screening, could directly bind to CDK1 and exhibited anti-tumor activity in cholangiocarcinoma cells. AHSG, F2, TTR, and KNG1 could be novel biomarkers for CCA. Molport-003-703-800 targets CDK1 and work as potential cell cycle inhibitors, thereby having potential for consideration for new chemotherapeutics for CCA.