• Nuclear Engineering and Technology
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• 제53권9호
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• pp.3058-3067
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• 2021

Sodium zinc borate glasses doped with dysprosium and modified with different concentrations of barium oxide (0-50 mol %) were fabricated using the melting quenching technique. The structural properties of the prepared glass systems were characterized using XRD and FTIR methods. The absorption spectra of the prepared glasses were measured to determine their energy gap and their related optical properties. The density of the glasses and other physical parameters were also reported. Additionally, with the help of Photon Shielding and Dosimetry (PSD) software, we investigated the radiation shielding parameters of the prepared glass systems at different energy values. It was found that an increase in the density of the glasses by increasing the concentration of BaO significantly improved the gamma ray shielding ability of the samples. For practical results, a compatible irradiation set up was designed to check the shielding capability of the obtained glasses using a gamma ray source at 662 keV. The experimentally obtained results strongly agreed with the data obtained by PDS software at the same energy. These results demonstrated that the investigated glass system is a good candidate for several radiation shielding applications when comparing it with other commercial shielding glasses and concretes.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.495-504
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• 2021

Three-dimensional printing (3DP) applications possess substantial versatility within surgical applications, such as complex reconstructive surgeries and for the use of surgical resection guides. The capability of constructing an implant from a series of radiographic images to provide personalized anatomical fit is what makes 3D printed implants most appealing to surgeons. Our objective is to describe the process of integration of 3DP implants into the operating room for spinal surgery, summarize the outcomes of using 3DP implants in spinal surgery, and discuss the limitations and safety concerns during pre-operative consideration. 3DP allows for customized, light weight, and geometrically complex functional implants in spinal surgery in cases of decompression, tumor, and fusion. However, there are limitations such as the cost of the technology which is prohibitive to many hospitals. The novelty of this approach implies that the quantity of longitudinal studies is limited and our understanding of how the human body responds long term to these implants is still unclear. Although it has given surgeons the ability to improve outcomes, surgical strategies, and patient recovery, there is a need for prospective studies to follow the safety and efficacy of the usage of 3D printed implants in spine surgery.

• Journal of Veterinary Science
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• 제24권6호
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• pp.75.1-75.8
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• 2023

Background: In veterinary medicine, previous studies regarding the diagnostic performance of shear wave elastography (SWE) in chronic kidney disease (CKD) are not consistent with each other. Moreover, there has been no study evaluating the relationship between symmetric dimethylarginine (SDMA) concentration and renal shear wave velocity (SWV) using two-dimensional SWE (2D SWE) in dogs with CKD. Objectives: This study aimed to evaluate the diagnostic capability of 2D SWE in dogs with CKD and to assess the relationship between renal SWV and SDMA concentration. Methods: Dogs with healthy kidneys and dogs with CKD underwent 2D SWE and SDMA assay. Renal stiffness was estimated as renal SWV in m/s. Results: SDMA concentration had a weak positive correlation with the left (r = 0.338, p = 0.022) and right renal SWV (r = 0.337, p = 0.044). Renal SWV was not significantly different between healthy kidney and CKD groups in the left (p = 0.085) and right (p = 0.171) kidneys. Conclusions: 2D SWE may could not distinguish between dogs with healthy kidney and dogs with early stage of CKD, but it would be useful for assessing the serial change of renal function in dogs.

• 혜화의학회지
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• 제14권2호
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• pp.93-105
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• 2005

Objective : We investigated the actual condition of oriental medical office in a public health center. Methods : We classified patients who visited an oriental medical office iin a public pealth center of Dalseong-gun, Daegu Metropolitan City during recent 3 years by KCPJMAIN(data processing system), according to location, age, time(month, year), sex, disease, insurance, etc. Results : As a local category, the residents in Hyeunpung-Myeon higher than 80% of the patients who visited the public health center. The patients aged over 60 occupied 80% of the patients. The frequency of the treatment was more than 10 in those patients aged over 60. The number of the patients was the highest in May when there was a change for the past 36months, whereafter the number has sustained decline for 3-5 months and repeated decreasing. As a gender category, the female inpatients were 10732(82%). This statistics shows that these musculoskeletal system disease occupied large part in them. As a heath insurance category, the patients who were insured by health care were 12454(96.30%). Conclusion : It should need to enable the rural residents who have difficulty benefitting from medical service to reach the service by making their access to the oriental medical office in public health center easier. Most of all, the support from both government and municipality should be urged to accomplish it. plus, it should be included not only boosting doctors' reliance but also improving the capability and services of doctors in public heath center. In conclusion, the treatment service in public health center should be diversified beyond musculoskeletal system disease and the identity transform of public health center should be needed to appeal to young generation.

• 융합보안논문지
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• 제16권7호
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• pp.41-49
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• 2016

오늘날 정보통신기술이 발달함에 따라 전산화된 의료정보의 유출 및 보호 문제가 사회적 이슈가 되었다. 더불어 정부에서도 의료기관의 정보보호를 위해 제도적 개선을 진행하고 있다. 그러나 의료기관의 정보보호 역량을 제고하기 위한 노력들은 자칫 의료기관 종사자들에게 스트레스를 증가시키고, 나아가 의료기관의 본질인 의료서비스의 질 하락을 야기할 수 있다. 따라서 의료기관이 관리하는 정보의 보호를 강화함에 있어서 의료기관 종사자들의 보안에 따른 스트레스 정도 및 그 선행요인들에 대해 연구할 필요성이 있다. 기존 연구를 분석하여 보안스트레스와 보안스트레스에 영향을 미치는 요인을 선정하였다. 이를 통해 업무 과중, 프라이버시 침해 그리고 업무 불확실성이라는 변수를 도출하였다. 본 연구는 국내 병원 종사자들 123명의 데이터를 수집, SPSS 21.0을 사용하여 검증하였다. 본 연구의 결과로 업무 과중, 프라이버시 침해, 그리고 업무 불확실성의 일부는 보안 스트레스에 정(+)의 영향을 미치는 요인으로 나타났다.

• Parasites, Hosts and Diseases
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• 제49권2호
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• pp.177-180
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• 2011

Entamoeba histolytica is an enteric tissue-invading protozoan parasite that can cause amebic colitis and liver abscess in humans. E. histolytica has the capability to kill colon epithelial cells in vitro; however, information regarding the role of calpain in colon cell death induced by ameba is limited. In this study, we investigated whether calpains are involved in the E. histolytica-induced cell death of HT-29 colonic epithelial cells. When HT-29 cells were co-incubated with E. histolytica, the propidium iodide stained dead cells markedly increased compared to that in HT-29 cells incubated with medium alone. This pro-death effect induced by ameba was effectively blocked by pretreatment of HT-29 cells with the calpain inhibitor, calpeptin. Moreover, knockdown of m- and ${\mu}$-calpain by siRNA significantly reduced E. histolytica-induced HT-29 cell death. These results suggest that m- and ${\mu}$-calpain may be involved in colon epithelial cell death induced by E. histolytica.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6069-6075
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• 2013

Background: At present, the diagnosis of colorectal cancer (CRC) requires a colorectal biopsy which is an invasive procedure. We undertook this pilot study to develop an alternative method and potential new biomarkers for diagnosis, and validated a set of well-integrated tools called ClinProt to investigate the serum peptidome in CRC patients. Methods: Fasting blood samples from 67 patients diagnosed with CRC by histological diagnosis, 55 patients diagnosed with colorectal adenoma by biopsy, and 65 healthy volunteers were collected. Division was into a model construction group and an external validation group randomly. The present work focused on serum proteomic analysis of model construction group by ClinProt Kit combined with mass spectrometry. This approach allowed construction of a peptide pattern able to differentiate the studied populations. An external validation group was used to verify the diagnostic capability of the peptidome pattern blindly. An immunoassay method was used to determine serum CEA of CRC and controls. Results: The results showed 59 differential peptide peaks in CRC, colorectal adenoma and health volunteers. A genetic algorithm was used to set up the classification models. Four of the identified peaks at m/z 797, 810, 4078 and 5343 were used to construct peptidome patterns, achieving an accuracy of 100% (> CEA, P<0.05). Furthermore, the peptidome patterns could differentiate the validation group with high accuracy close to 100%. Conclusions: Our results showed that proteomic analysis of serum with MALDI-TOF MS is a fast and reproducible approach, which may provide a novel approach to screening for CRC.

• Journal of Preventive Medicine and Public Health
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• 제34권1호
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• pp.55-60
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• 2001

Objectives : The SERVQUAL scale is based on gap theory, which suggests the difference between consumers' expectations and the quality of the medical service actually received. However, problems in the implementation of the SERVQUAL scale have been identified by several researchers. Some researchers have proposed a simple performance-based measure (SERVPERF) or au exportation-controlled performance-based measure(Non-Diff) as alternatives to the SERVQUAL scale. On the basis of the theoretical concerns discussed, we examined the capability of each of the three scales(SERVQUAL, Non-Diff, SERVPERF) to explain variations in consumer satisfaction. Methods : Data was gathered from a self-administered questionnaire in a 430 bed hospital. Questionnaires evaluating medical services were distributed to 180 ambulatory patients. A total of 167 usable questionnaires were gathered. The questionnaire was composed of 10 expectation, performance and expectation-controlled performance items. In addition, overall satisfaction and purchase intention were measured. Results : Compared with the SERVQUAL scale, the Non-Diff and SERVPERF scales better explained the observed variations in consumer satisfaction(SERVOQUAL, $R^2=0.29;\;Non-Diff,\;R^2=0.51;\;SERVPERF,\;R^2=0.48$) and purchase intention(SERVQUAL, $R^2=0.22;\;Non-Diff,\;R^2=0.33;\;SERVPERF,\;R^2=0.34$). Conclusion : The maier conclusion from our study is that the Non-Diff and SERVPERF scales are more efficient in assessing consumer satisfaction than the SERVQUAL scale. Therefore we suggest that consumer satisfaction he measured by the Non-Diff or SEVPERF scales.

• Journal of Korean Neurosurgical Society
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• 제55권3호
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• pp.131-135
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• 2014

Objective : With the growing interests of bacteria as a targeting vector for cancer treatment, diverse genetically engineered Salmonella has been reported to be capable of targeting primary or metastatic tumor regions after intravenous injection into mouse tumor models. The purpose of this study was to investigate the capability of the genetically engineered Salmonella typhimurium (S. typhimurium) to access the glioma xenograft, which was monitored in mouse brain tumor models using optical bioluminescence imaging technique. Methods : U87 malignant glioma cells (U87-MG) stably transfected with firefly luciferase (Fluc) were implanted into BALB/cAnN nude mice by stereotactic injection into the striatum. After tumor formation, attenuated S. typhimurium expressing bacterial luciferase (Lux) was injected into the tail vein. Bioluminescence signals from transfected cells or bacteria were monitored using a cooled charge-coupled device camera to identify the tumor location or to trace the bacterial migration. Immunofluorescence staining was also performed in frozen sections of mouse glioma xenograft. Results : The injected S. typhimurium exclusively localized in the glioma xenograft region of U87-MG-bearing mouse. Immunofluorescence staining also demonstrated the accumulation of S. typhimurium in the brain tumors. Conclusion : The present study demonstrated that S. typhimurium can target glioma xenograft, and may provide a potentially therapeutic probe for glioma.

• 한국의료윤리학회지
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• 제21권4호
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• pp.301-315
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• 2018

여성은 신체적 특징과 더불어 사회적으로 부과된 '모성'에 의해 임신과 출산, 그리고 양육의 과정에서 책임자로 위임되어 왔다. 특히 임신, 출산과 더불어 낙태 또한 자신의 몸에서 직접 체험하며, 그것으로 인해 삶에 가장 영향을 받는 대상도 여성이다. 그러나 정작 여성은 자신의 몸에 대한 자기결정권을 제대로 갖지 못하고 있다. 이른바 '생명옹호론 대 선택옹호론(pro-life vs. pro-choice)'의 낙태담론 구도 속에서 여성의 자기결정권이란 애초에 '생명존중'에 비해 하위의 것으로 치부되어 왔다. 더욱이 최근 우리사회에서 저출산 위기론이 대두되면서 낙태 처벌이 강화되고 여성의 자율적 결정이나 권리 행사는 더욱 억압되는 상황으로 치닫고 있다. 그런데 일련의 이러한 과정에서 비장애여성과 장애여성 사이에 이중 잣대의 부당함마저 존재한다. 즉 여성들 사이에서 몸의 차등화가 이루어지고 있다. 본 연구는 낙태에서 여성, 특히 장애여성의 자기결정권 문제를 센의 역량 접근 관점에서 고찰한다. 낙태는 개인적이면서도 동시에 사회적인 문제로서 단순히 낙태 허용 여부만이 아니라 임신과 출산, 양육 등과 함께 총체적인 관점에서 조망되어야 하기 때문이다. 결론적으로 낙태에서 장애여성의 자기결정권에 관한 역량 접근은 다음과 같은 윤리적 함의를 기대할 수 있다. 첫째, 장애여성이 처한 다양한 상황적 변수들을 자기결정권 개념 안에 함께 구성하도록 요청한다. 둘째, 장애여성의 실질적 자기결정권의 행사를 위해 개인과 공동체의 연대적 관계를 지향한다. 셋째, 포괄적인 장애여성의 권리로서 '재생산 권리'의 담론으로 확장시킨다.