• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8047-8050
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• 2014

Cancer is a multifaceted and genomically complex disease and research over decades has gradually and sequentially shown that essential biological mechanisms including cell cycle arrest and apoptosis are deregulated. The benefits of essential oils from different plants have started to gain appreciation as evidenced by data obtained from cancer cell lines and xenografted mice. Encouraging results obtained from preclinical studies have attracted considerable attention and various phytochemicals have entered into clinical trials.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2010년도 춘계학술발표논문집 2부
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• pp.1227-1229
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• 2010

This paper explains what DTI (Diffusion Tensor Imaging) is and what it does. We will talk about the DTI functions and what type of image it can show, and what areas are using DTI. The tractography and other applications that DTI is being used. In this paper, we explain that DTI is not only useful in medicine but also in botany. We propose to use DTI to study structure and functions of plants.

• 한국의사학회지
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• 제16권1호
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• pp.3-16
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• 2003

In researches done previously, the characteristics of the Hyangyak medicine in the early period of Chosun shown in "HyangyakBoncho(鄕藥本草)" in Vol. 76-85 of "Hyangyakjipseongbang(鄕藥集成方)" and "Sanghan section(傷寒門)" in Vol. 5-8 of "Hyangyakjipseongbang(鄕藥集成方)" was investigated. "Cough section(咳嗽門)" in "Various Diseases volume" of "Dongeuibogam(東醫寶鑑 雜病篇)" Vol. 5 and "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" Vol 24-25 which is a paragraph related to "Sanghan section(傷寒門)" was compared. The variety of the Hyangyak, processing methods and forms of the Hyangyak were shown by comparing each oriental medical botany(本草) used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Subsequently, the difference between each structure and medical theory was speculated. The facts revealed in this research is as follows. First, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" uses only the Hyangyak, and no foreign medicines were used for treating cough(咳嗽) in "Dongeuibogam(東醫寶鑑)". Second, in [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)", medicines related to diet and medicines taken raw were widely used, and various forms of medicine such as extracts, plasters, and gruels were used. Third, like other medical books in earlier periods, [Various Coughs section(諸咳門)] of "Hyangyakjipseongbang(鄕藥集成方)" describes the medical theory with conciseness, and keeps the structure of symptom classification focused on treatment and prescription. Fourth, as [Hyangyakboncho(鄕藥本草)] extensively uses the knowledge of oriental medical botany(本草) from two of Four Masters of GeumWon(金 元); JangWonSo(張元素) and LeeDongWon(李東垣), "Various Coughs section(諸咳門)" of "Hyangyakjipseongbang(鄕藥集成方)" quotes the books of JuDanGae but does not adopt the theory and prescriptions of 'replenishing yin and downbearing fire (滋陰降火)'. To find a more descriptive picture of the Hyangyak medicine for the treatment of 'cough(咳嗽)', a comparatitive study between the books written in the same period -"Euibangyuchui(醫方類聚)" and books compilated in China should be done, and there should be more profound researches done on individual medicines and prescriptions.

• Journal of Microbiology and Biotechnology
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• 제30권8호
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• pp.1156-1168
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• 2020

Drought stress is threatening the growth and productivity of many economical crops. Therefore, it is necessary to establish innovative and efficient approaches for improving crop growth and productivity. Here we investigated the potentials of the cell-free extract of Actinobacteria (Ac) isolated from a semi-arid habitat (Al-Jouf region, Saudi Arabia) to recover the reduction in maize growth and improve the physiological stress tolerance induced by drought. Three Ac isolates were screened for production of secondary metabolites, antioxidant and antimicrobial activities. The isolate Ac3 revealed the highest levels of flavonoids, antioxidant and antimicrobial activities in addition to having abilities to produce siderophores and phytohormones. Based on seed germination experiment, the selected bioactive fraction of Ac3 cell-free extract (F2.7, containing mainly isoquercetin), increased the growth and photosynthesis rate under drought stress. Moreover, F2.7 application significantly alleviated drought stress-induced increases in H₂O₂, lipid peroxidation (MDA) and protein oxidation (protein carbonyls). It also increased total antioxidant power and molecular antioxidant levels (total ascorbate, glutathione and tocopherols). F2.7 improved the primary metabolism of stressed maize plants; for example, it increased in several individuals of soluble carbohydrates, organic acids, amino acids, and fatty acids. Interestingly, to reduce stress impact, F2.7 accumulated some compatible solutes including total soluble sugars, sucrose and proline. Hence, this comprehensive assessment recommends the potentials of actinobacterial cell-free extract as an alternative ecofriendly approach to improve crop growth and quality under water deficit conditions.

• Advances in Traditional Medicine
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• 제8권2호
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• pp.192-195
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• 2008

The effect of aqueous and alcoholic extract of roots of Berberis aristata was studied on the spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m) complex of cattle filarial parasite Setaria cervi and on the survival of microfilariae. Only aqueous extract could inhibit the spontaneous movements of S. cervi, characterized by initial stimulation followed by reversible paralysis. The concentration required to produce similar effect on n.m complex was less as compared to the w.w. The lethal concentration 50 and lethal concentration 90 for aqueous extract were 48 ng/ml and 65 ng/ml.

• Journal of Microbiology and Biotechnology
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• 제31권5호
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• pp.696-704
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• 2021

Levan is an industrially important, functional biopolymer with considerable applications in the food and pharmaceutical fields owing to its safety and biocompatibility. Here, levan-type exopolysaccharide produced by Pantoea agglomerans ZMR7 was purified by cold ethanol precipitation and characterized using TLC, FTIR, ¹H, and ¹³C NMR spectroscopy. The maximum production of levan (28.4 g/l) was achieved when sucrose and ammonium chloride were used as carbon and nitrogen sources, respectively, at 35℃ and an initial pH of 8.0. Some biomedical applications of levan like antitumor, antiparasitic, and antioxidant activities were investigated in vitro. The results revealed the ability of levan at different concentrations to decrease the viability of rhabdomyosarcoma and breast cancer cells compared with untreated cancer cells. Levan appeared also to have high antiparasitic activity against the promastigote of Leishmania tropica. Furthermore, levan had strong DPPH radical scavenging (antioxidant) activity. These findings suggest that levan produced by P. agglomerans ZMR7 can serve as a natural biopolymer candidate for the pharmaceutical and medical fields.

• 대한약침학회지
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• 제23권3호
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• pp.91-123
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• 2020

The application of antique medical instructions, practices, skills and knowledge has been considered as the most affordable treatment in many developing countries. The use of these preparations and prescriptions over generations has made a useful and valuable guide for drug discovery in modern medicine. Medical herbs have been of a high importance for this purpose. The genus Dorema, of Apiaceae family (Umbelliferae) has a wide use in ethnobotany and traditional medicine around the world. It has been used as a treatment for CNS disease, convulsion, upper respiratory tract problems, gastrointestinal disorder and high blood sugar. Furthermore, phytochemical investigations have reported Dorema species to contain a wide range of constituents including terpenes, coumarins and phenolic compounds. The current review summarizes comprehensive information regarding botany, phytochemistry and pharmacological aspects of Dorema spp.

• BMB Reports
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• 제54권7호
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• pp.374-379
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• 2021

Tetranectin (TN), an adipogenic serum protein, enhances adipocyte differentiation, however, its functional mechanism has yet to be elucidated. In the present study, we investigated the adipogenic function of TN by using medium containing TN-depleted fetal bovine serum (TN-del-FBS) and recombinant mouse TN (mTN). The adipocyte differentiation of 3T3-L1 cells was significantly enhanced by mTN supplementation essentially at differentiation induction, which indicated a potential role of the protein in the early differentiation phase. The adipogenic effect of mTN was more significant with insulin in the differentiation induction cocktail, implicating their close functional relationship. mTN enhanced not only the proliferation of growing cells, but also mitotic clonal expansion (MCE) that is a prerequisite for adipocyte differentiation in the early phase. Consistently, mTN increased the phosphorylation of ERK in the early phase of adipocyte differentiation. Results of this study demonstrate that the adipogenic function of mTN is mediated by enhancing MCE via ERK signaling.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2379-2381
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• 2014

It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to l imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.

• Genomics & Informatics
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• 제20권1호
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• pp.3.1-3.10
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• 2022

The recent development of whole-genome sequencing technologies paved the way for understanding the genomes of microorganisms. Every whole-genome sequencing (WGS) project requires a considerable cost and a massive effort to address the questions at hand. The final step of WGS is data analysis. The analysis of whole-genome sequence is dependent on highly sophisticated bioinformatics tools that the research personal have to buy. However, many laboratories and research institutions do not have the bioinformatics capabilities to analyze the genomic data and therefore, are unable to take maximum advantage of whole-genome sequencing. In this aspect, this study provides a guide for research personals on a set of bioinformatics tools available online that can be used to analyze whole-genome sequence data of bacterial genomes. The web interfaces described here have many advantages and, in most cases exempting the need for costly analysis tools and intensive computing resources.