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http://dx.doi.org/10.7314/APJCP.2014.15.5.2379

Anthocyanins: Targeting of Signaling Networks in Cancer Cells  

Sehitoglu, Muserref Hilal (Department of Medical Biochemistry, Canakkale Onsekiz Mart University)
Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College)
Qureshi, Muhammad Zahid (Biochemistry Lab, Department of Chemistry)
Butt, Ghazala (Phycology Lab, Department of Botany, GC University)
Aras, Aliye (Department of Biology, Faculty of Science, Istanbul University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.5, 2014 , pp. 2379-2381 More about this Journal
Abstract
It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to l imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.
Keywords
Apoptosis; anthocyanins; signaling; cancer;
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