• The Korean Journal of Pain
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• v.35 no.1
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• pp.33-42
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• 2022

Background: Cupressus arizonica Greene is a coniferous tree with great importance in fragrance and pharmaceutical industries. Essential oils from C. arizonica (EC) have shown potential antioxidant, and anti-microbial activities. This study aimed at investigating the anti-nociceptive and anti-inflammatory effects/mechanisms of EC. Methods: The EC was evaluated for anti-nociceptive and anti-inflammatory activities on male Wistar rats using a formalin test and carrageenan-induced paw edema, respectively. Also, we pre-treated some of the animals with naloxone and flumazenil in the formalin test to find out the possible contributions of opioid and benzodiazepine receptors to EC anti-nociceptive effects. Finally, gas chromatography/mass spectrometry (GC/MS) analysis was used to identify the EC's constituents. Results: EC in intraperitoneal doses of 0.5 and 1 g/kg significantly decrease the nociceptive responses in both early and late phases of the formalin test. From a mechanistic point of view, flumazenil administration 20 minutes before the most effective dose of EC (1 g/kg) showed a meaningful reduction in the associated anti-nociceptive responses during the early and late phases of the formalin test. Naloxone also reduced the anti-nociceptive role of EC in the late phase. Furthermore, EC at the doses of 1, 0.5, and 0.25 g/kg significantly reduced paw edema from 0.5 hours after carrageenan injection to 4 hours. GC/MS analysis showed that isolated EC is a monoterpene-rich oil with the major presence of α-pinene (71.92%), myrcene (6.37%), δ-3-carene (4.68%), β-pinene (3.71%), and limonene (3.34%). Conclusions: EC showed potent anti-nociceptive and anti-inflammatory activities with the relative involvement of opioid and benzodiazepine receptors.

• Nutrition Research and Practice
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• v.7 no.5
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• pp.359-365
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• 2013

Anthocyanin from purple sweet potato (PSP) extracted by microwave baking (MB) and acidified electrolyzed water (AEW) exhibited antioxidant activity. After further purification by macroporous AB-8 resin, the color value of PSP anthocyanin (PSPA) reached 30.15 with a total flavonoid concentration of 932.5 mg/g. The purified extracts had more potent antioxidant activities than the crude extracts. After continuously administering the PSP extracts to 12-mo-old mice for 1 mo, the anti-aging index of the experimental group was not significantly different from that of 5-mo-old mice. To a certain degree, PSPA was also effective for controlling plasma glucose levels in male Streptozocin (STZ)-treated diabetic mice. In addition, the extracts inhibited Sarcoma S180 cell growth in ICR mice. Mice consuming the PSP extracts formed significantly fewer and smaller sarcomas than mice consuming the control diets. The highest inhibition rate was 69.03%. These results suggest that anthocyanin extracts from PSP not only exert strong antioxidant effects in vitro, but also had anti-aging, anti-hyperglycemic, and anti-tumor activities.

• Journal of Korean Medical classics
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• v.27 no.4
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• pp.39-53
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• 2014

Objectives : Hajae's Diary(荷齋日記) is a personal diary written by Gyu-Sik Ji(池圭植) between 1891 and 1911. He had a strong interest in medicine and maintained the belief that diseases could be cured by medicine. He recorded in significant detail the subject individuals, symptoms, name of prescription, price, the date of exchange and place of purchase in his diary. Methods : His study classifies the era during which Western medicine was introduced to the general public and became popularized in the late Chosun dynasty period based on articles related to medicine in Hajae's Diary. Results : It could be identified that, as of the Gabo Reform(甲午更張) in 1894, Western medicine was introduced into the traditional medicine life and, starting from the Eulsa Treaty(乙巳條約) of 1905, Western medicine became popularized. Conclusions : During the "traditional medicine period", traditional medicine was used for all medicinal activities. However, during the "Western medicine introduction period", Western medicine was used for only specific diseases. In the period during which Western medicine became popular, traditional medicine continued to be used. However, Western medicine was widely used for various diseases.

• Natural Product Sciences
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• v.2 no.1
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• pp.29-36
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• 1996

This study was to evaluate the antitumor and immunopotentiation effects of Manda Enzyme (ME). Oral administration of ME (0.2ml/mouse) to tumor bearing mice significantly prolonged survival rate compared to the control group with the prolongation ratio of 40%. The inhibition ratios for the first and the second experiments were 51.8% and 26.4%, respectively. Only the spleen index was significantly increased in the MEF-treated group, but not in the control group. Gamma globulin level of the MEF-treated group was elevated when mice were injected with sarcoma-180 cells on the left groin. Activities of natural killer (NK) and lymphokineactivated killer (LAK) cells were observed by $^{51}Cr-release$ method. Activities of NK cell against YAC-1 cells were significantly increased in the MEF treated group. And LAK cell activities against P815 cells were also significantly increased in the experimental group. These observations, therefore, suggest that ME may have an anticancer effect and immunopotentiating effect in vivo.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2297-2304
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• 2013

A series of novel benzimidazole derivatives bearing a heterocyclic ring as oxadiazole (21-32), thiadiazole (33-34), triazole (35-36) were synthesized and evaluated for their activities against Coxsackie virus B3 and B6 in Vero cells. Compounds 21-26, 31-36 with moieties of 2'-pyridyl, 3'-pyridyl and 4'-pyridyl at the 2-position and oxadiazoles, thiadiazole, or triazole substituent at the 4- or 5-position generally displayed activities against CVB3 and CVB6. Especially compound 24 ($IC_{50}=1.08{\mu}g/mL$, SI = 61.7 against CVB3) was the promising candidate as lead compound for anti-enteroviral drug. It was observed in the incorporation of heterocyclic rings in benzimidazole at the 5-position could enhance their biological activities.

• Korean Journal of Pharmacognosy
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• v.13 no.1
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• pp.33-38
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• 1982

In order to investigate the pharmacological action of the combined preparation of crude drugs, 'Saengkankunbi-Tang' were studied. These studies were conducted in an attempt to investigate the effect of 'Saengkankunbi-Tang' on activities of the liver enzyme, protein contents and the excretory action of bile juice in the serum of $CCl_4-intoxicated$ rabbits. The results of this investigate were summarized as follows; GOT, GPT activities and total cholesterol contents in the serum of rabbits induced by $CCl_4$ were shown to the remarkable decrease with the passage of the time in the oral administration of the sample. Albumin contents in the serum of rabbits induce by $CCl_4$ were noted to the significant increase with the passage of the time. Serum total protein contents were noted to the significant increase only the 4th and 6th day. BSP accumulation contents in the serum of rabbits induced by $CCl_4$ showed the remarkable decrease with the passage of the time.

• Journal of Internet Computing and Services
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• v.22 no.6
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• pp.59-69
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• 2021

Malfunctions and failures linked to medical devices may result in significant damage for human being. Thus, in order to ensure that safety of medical device is achieved, it should be established and applied the international standard. It is required to integrate and customize activities at standards, owing to reference relationship between standards, especially, activities based safety analysis is too expensive. This paper proposes a integration process that integrate activities of development lifecycle and safety process. Additionally, we derived a guidance based on STPA for integration process. As a result, we can be performed systematically from early stage of the development and increased effectiveness of integration process by the guidance.

• Quality Improvement in Health Care
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• v.5 no.2
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• pp.296-310
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• 1998

Background : Performance evaluation of medical care providers has become more important than before in Korea. Especially in university hospitals, job contents of medical staffs are so complicated that evaluation is not easily performed. In addition, in order that the feedback of evaluation be successful, acceptance of staffs to be evaluated is essential. This study is aimed at the development of items for evaluation and weighting of each item in one university hospital, and clustering departments by different weight given by medical staffs. Methods : Through resource group meeting. performance items were listed up by categories of education, research, medical services, and other activities in and out of the hospital. For each item, all the medical staffs were asked how important they thought, compared with publishing one original article. By factor analysis, the items in each category were grouped into a few subgroups. In turn, cluster analysis was done for the purpose of grouping departments by priority the medical staffs gave. Results and Conclusion : Among five major categories, medical staffs regard education, research, and medical services more important than other activities in and out of the hospital. Five categories consisted of two or three components. Departments in hospital were grouped into three. However, characteristics of each group was not clearly delineated. This result suggests that more comprehensive tool should be developed and applied in the process of performance evaluation in university hospitals.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.20 no.3
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• pp.220-229
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• 2013

Purpose: The purpose of the study was to investigate activities-specific balance confidence and risk of fallings among rehabilitation patients with impaired of mobility, and to identify the influence of activities-specific balance confidence on their risk of fallings. Method: Data for 132 rehabilitation patients were collected between October June 20 and August 20, 2012 at nine hospitals in a metropolitan city. Data were analyzed using t-test, ANOVA, Pearson correlation coefficient and stepwise multiple regression with SPSS/WIN 20.0. Result: The mean score for rehabilitation patients' activities-specific balance confidence was 40.18 out of a possible range of 0-100 and the mean score for risk of fallings among rehabilitation patients was 31.10 within a possible range of 0-125. Significant factors affecting the risk of fallings among the rehabilitation patients were 'activity level', 'dementia', 'body mass index', 'anxiety', and 'presence of a caregiver', which together explained 34.7% of the variance. The most significantly factor influencing rehabilitation patients' risk of fallings was activities-specific balance confidence which explained 23.5% of the variance. Conclusion: The study results indicate that activities-specific balance confidence as well as physical factors should be considered for interventions to decrease risk of fallings in rehabilitation patients with impaired mobility.

• Journal of Korean Academy of Nursing Administration
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• v.19 no.4
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• pp.449-461
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• 2013

Purpose: The purpose of this study was to explore the relationship between cost and revenue for inpatient nursing activities in general wards. Methods: Data were collected from 12 medical-surgical wards in one general hospital from January 1 to December 31, 2010. The nursing activities were categorized into 2 groups according to nursing service payment type in terms of the Korea health insurance system. Descriptive statistics were used to identify nursing activities and nursing activity costs. Results: Of 140 nursing activities identified as performed in general wards, payment for 69 items was included in nursing management fees. The percentage of each cost for the nursing units was 90% for labor, 4% for materials, and 6% for operating expenses. The cost for medical support nursing service accounted for 38% of costs and nursing management fees, 62%. The average profit and loss was -237,257,000 won. The cost recovery rate for nursing service was only 44%. Conclusion: The results indicate a need to measure the economic value of nursing activities performed in general wards and use it as a basis for establishing an adequate reimbursement system for nursing service.