• Title/Summary/Keyword: Mediator effect

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Inhibitory Effect of Scutellaria baicalensis Root Extract on Chemical Mediator Release and Immune Response

  • Choi, Se-Young;Choi, Dong-Kug;Park, Pyo-Jam;Choi, Wahn-Soo;Kim, Jong-Dai;Shin, Heung-Mook;Lim, Beong-Ou
    • Korean Journal of Medicinal Crop Science
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    • v.15 no.2
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    • pp.132-137
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    • 2007
  • Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha $(TNF-{\alpha})$ production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of $interferon-{\gamma}$. SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.

Model Investigation of Subjectivity - Relatedness's Mediating Effect between College Engineering Students' Happiness and Depression (이공계 분야 대학생의 우울과 행복감 간 주체성-관계성의 매개모형 검증)

  • Kim, Hyun-Soo;Yoo, Steven Chul-Hui;Yoo, Sunmie
    • The Journal of Korean Institute for Practical Engineering Education
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    • v.4 no.1
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    • pp.108-118
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    • 2012
  • The purpose of this research was to verify a model that shows how subjectivity-relatedness can be a mediator in helping depressed college engineering students to feel happiness. The research subjects were seventy eight college students. Their age was between twenty oneto thirty years old. Assessment tools used were Depressive Experiences Questionnaire, Me Consciousness - We Consciousness Scale and Happiness Scale. The research had three questions. Question 1. Does subjectivity - relatedness have a mediating effect on depression and happiness? Question 2. Does subjectivity have a mediating effect on depression and happiness? Question 3. Does relatedness have a mediating effect on depression and happiness? The results indicate that subjectivity-relatedness as well as subjectivity and relatedness individually have a mediating effect on depression and happiness.

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Effects of Group Home Adolescents' Depression on School Resilience : Focus on Mediator Effects of Self-Esteem (공동생활가정 청소년의 우울감이 학교 적응유연성에 미치는 영향: 자아존중감의 매개효과를 중심으로)

  • Park, Eun-Mie
    • The Journal of the Korea Contents Association
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    • v.15 no.5
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    • pp.327-339
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    • 2015
  • The purpose of this study was to examine the effects of group home adolescents' depression on school resilience with focusing on mediator effect of self-esteem. Data were collected from nationwide 64 group homes by mailing questionnaire survey between August 19th to September 13th, 2013. One hundred seventy two adolescents were responded. The major findings were as follows: First, group home adolescents' depression had negative effect on school resilience. Second, their depression had also negative effect on self-esteem. Finally, self-esteem proved to have a mediating effect on the effect of depression on school resilience overall. Based on the results, the implications for social work practice and policy were suggested.

The Mediator Effect of Social Capital in Relationship between Entrepreneurship and Social Enterprise Performance (기업가정신과 사회적 기업 성과의 관계에 미치는 사회적 자본의 매개효과)

  • Lee, Jun-Hee
    • The Journal of the Korea Contents Association
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    • v.16 no.5
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    • pp.46-57
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    • 2016
  • The purpose of this study was to identify the elements of virtuous cycle to lay a foundation for the coevolution of corporations and communities based on the entrepreneurship and social capital of social enterprises. The study first set out to add the pursuit of social goals to the components of entrepreneurship, namely innovation, progressive spirit, and risk sensitivity and categorized social capital into structural, cognitive, and relational capital. The study set six hypotheses and performed correlation and regression analysis to empirically analyze mediator effect of social capital in relationship between entrepreneurship and social enterprise performance. The findings were summarized as follows: First, relational capital had full mediated effect between entrepreneurship and economic performance of social enterprise. Second, relational capital had full mediated effect between entrepreneurship and social performance of social enterprise.

Causality between Spouse Attitude and Relapse of the Psychiatrically Disordered (정신장애인의 배우자 태도와 재발의 인과적 관계에 관한 탐색)

  • Shin, Sun-In
    • Korean Journal of Social Welfare
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    • v.60 no.3
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    • pp.59-82
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    • 2008
  • This study investigated the effect of spouse attitude of psychiatric patients on relapse. The research was based on the concept that spouses' attitudes toward mental illness influences relapse, mediated by marital relationship and social adaptation. Data were collected from 102 of the psychiatrically disordered who were married, and analyzed through Structural Equation Modelling to validate causal paths and mediator effects of the variables. The marital relationship was shown to act as a mediator between spouse attitude and social adaptation, while social adaptation showed a complete mediation effect between marital relationship and relapse. Thus, spouse attitude towards mental illness was shown to have a statistically meaningful effect on relapse indirectly and through sequential mediation effect of marital relationship and social adaptation. This study proposes the facilitation of counseling and training programs to improve the marital relationships of psychiatric patients. The emphasis is on the educational program for the spouses to improve their knowledge of mental illness.

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The Effect of Public Service Motivation on Job Satisfaction and Perceived Job Performance: Focusing on the Mediation Effect of Person-Organization Fit (공공봉사동기가 직무만족 및 인지된 직무성과에 미치는 영향: 구성원-조직 적합성의 매개효과를 중심으로)

  • Lee, Kangmun;Roh, Tae-Woo
    • Journal of Digital Convergence
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    • v.15 no.9
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    • pp.155-165
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    • 2017
  • The purpose of this study is to identify the direct effects of PSM on job satisfaction (JS) and perceived job performance (PJP) in public institutions and to identify indirect effects of the mediator. In particular, we define the person-organization fit (POF) used as the mediator as the fitness of the personnel system and identify the influence of POF in the relationship between PSM, JS, and PJP. The questionnaires used in this study were conducted for the members of Changwon Public Health Center and empirical analysis using structural equation modeling was conducted and the following results were obtained. First, PSM in the integrated public service organization has a positive effect on JS and PJP. Second, PSM shows that JS and PJP of organization members are improved through mediating effect of POF. It can be concluded that PSM can improve JS and PJP through institutional fit between members and organizations.

A Study on the influence of journalist's Role-Cognition and Role-Orientation Upon Real Reportage attitude -Focus in editors of National Newspaper (사실적 보도태도에 미치는 기자의 역할인식과 역할지향의 영향력 연구 - 중앙일간지 편집기자를 중심으로)

  • Kang, Hyun Jig
    • Journal of Digital Convergence
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    • v.12 no.9
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    • pp.101-109
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    • 2014
  • The purpose of this study was to analyze the impact of mediator effect related to role-orientation of traditional newspaper editors in terms of role-cognition and role-orientation in aspects of real reportage attitude by classifying the newspaper editor's role-cognition with social stability, reform, check, on the other hand, role-orientation with reporter's intention, intention of actual fact, and reader's intention. The results were as follows: In terms of reporter's intention the research showed the fact that reporter's intentions was influenced by the role cognition of social stability and at the same time, it also made to reduce the attitude of real reportage. Compared with intention of actual fact and reader's intention, the intention of actual fact could be only influenced by the social stability, but it could not give any effectiveness to the attitude of real reportage, furthermore, the research showed the fact that reader's intention aroused some mediator effects which newspaper editor's role cognition gave rise to the attitude of real reportage much more strongly.

Mediator and Moderator Effects of Academic Resilience in Relation with Academic Burnout and School Adaptation in Gifted Youth (영재 청소년의 학업소진이 학교적응에 미치는 영향에서 학업탄력성의 매개 및 조절 효과)

  • Kim, Hong Hee;Han, Ki Soon
    • Journal of Gifted/Talented Education
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    • v.25 no.3
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    • pp.421-437
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    • 2015
  • In this study, research was held on verifying mediator effects of academic resilience of gifted youth in relation between academic burnout and school adaptation. To accomplish this, academic burnout, school adaptation, and academic resilience for gifted youth were measured from the participants of 444 gifted youth who had participated in Gifted Education Center and Gifted Class. The results were analyzed by SPSS/WIN 21.0 and AMOS 21.0. A summary of the results of this study is as follows. First, it was revealed that academic resilience for gifted youth plays a role of full mediation in relation between academic burnout and school adaptation. Second, it was revealed that academic burnout and school adaptation had moderator effects in influence of academic resilience for gifted youth. Especially, school adaptation and academic burnout were observed to be negatively correlated with low group of academic resilience. Based on the results of the study, several implications and limitations were proposed for the role of academic resilience in gifted youth.

Relation of Anger and Anger Expressions in Adolescents: Focusing on the Mediating Effect of Problem Solving Ability (청소년 분노와 분노표현유형 관계분석 연구: 문제해결능력의 매개효과를 중심으로)

  • Lee, Young Lim;Lee, Jee-Sook
    • Journal of Digital Convergence
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    • v.18 no.3
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    • pp.363-376
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    • 2020
  • Recent studies have investigated anger or anger-related problems in adolescents from various perspectives. However, understanding of anger expression types or the role of mediating variables in relation to anger and anger expressions have been disregarded. The purpose of this research was to understand the relationships between adolescents' anger, problem solving ability, and three types of anger expressions (anger-in, anger-out, anger-control) and to focus on the mediator function of problem-solving ability. Participants comprised 596 adolescents (283 males and 313 females). Anger was significantly related to all three types of anger expressions. Adolescents who showed high anger levels tended to indicate high anger-in and anger-out expressions but low anger-control expression, while controlling for age and gender. The findings also provided evidence for the mediator role of problem-solving ability on the relationship between anger and anger-control expression. From the results of this study suggestions and limitations were also discussed.

The Effect of Socially Prescribed Perfectionism of University Student to Depression: Focusing on the Mediating Effects of Intolerance of Uncertainty and Rumination, Reflective Response Style (대학생의 사회부과적 완벽주의가 우울에 미치는 영향: 불확실성에 대한 인내력 부족과 반추적, 반성적 반응양식의 매개효과)

  • Choi, Jaegwang;Song, Wonyoung
    • Korean Journal of School Psychology
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    • v.17 no.2
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    • pp.199-222
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    • 2020
  • This study was conducted to verify the effects of socially prescribed perfectionism on depression as mediated by intolerance of uncertainty and either ruminating or reflective response styles, on as will as to find ways to effectively address depression as it presents in university students. For this purpose, 283 university students at the central region were assesed using data collected from the following surveys: the Center for Epidemiological Studies-Depression Scale(CES-D), the Multidimensional Perfectionism Scale(HMPS), the Intolerance of Uncertainty Scale(IUS), and the Response to Depressed Mood Questionnaire(RDQ) and that were used to collect data. The results of this study are as follows. First, there was a positive correlation between the Intolerance of uncertainty and the rumination response style to the uncertainty of socially prescribed perfectionism, but not correlation the reflective response mode. Second, with respect to the relationship between socially prescribed perfectionism and depression, intolerance of uncertainty was set as the primary mediator variable and the rumination response style were set as the secondary mediator variables. The results shown to have a significant mediating effects. However this mediating effect was not significant when, in order to verify the mediating effect, we set the secondary mediator variable as the reflective response style. These results suggest that to prevent depression that manifests as socially prescribed perfectionism, it may be effective to intervene with a focus on the intolerance of uncertainty and the rumination response style. Finally, the implications and limitations of the study are discussed based on the results.