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Inhibitory Effect of Scutellaria baicalensis Root Extract on Chemical Mediator Release and Immune Response  

Choi, Se-Young (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Choi, Dong-Kug (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Park, Pyo-Jam (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Choi, Wahn-Soo (College of Medicine, Konkuk University)
Kim, Jong-Dai (School of Bioscience & Biotechnology, Kangwon National University)
Shin, Heung-Mook (Department of Physiology, College of Oriental Medicine, Dongguk University)
Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.15, no.2, 2007 , pp. 132-137 More about this Journal
Abstract
Inhibitory effect of Scutellaria baicalensis ethanol extracts (SR) on chemical mediator release and immunoglobulin (Ig) production from Sprague-Dawley rats originated cells as type I allergic reaction was examined. SR showed concentration-dependent inhibition on basal and concanavalin A (ConA)-stimulated Ig production. In the mesenteric lymph node lymphocytes, the inhibitory effect of SR on the IgE production in the presence of Con A was stronger than these on IgA and IgG production. Moreover, tumor necrosis factor-alpha $(TNF-{\alpha})$ production-inhibiting effect of SR in the presence ConA was observed. However, SR did not affect the production of $interferon-{\gamma}$. SR also inhibited histamine release from the peritoneal exudate cells stimulated with a calcium ionophore A23187. In the case of leukotriene B4, SR markedly inhibited it at the concentration of 100 mg/ml. From these results, ethanol extracts obtained from Scutellaria baicalensis may have an anti-allergic effect on the intestinal system of rats.
Keywords
Scutellaria baicalensis ethanol extract (SR); chemical mediators; Ig production; $TNF-{\alpha}$; allergy;
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