• Advances in Traditional Medicine
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• 제1권2호
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• pp.21-28
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• 2000

We compared the effect between CAS and WAS(root, stem) on mast cell-mediated allergic reaction. CAS, WAS-root and WAS-stem, significantly inhibited compound 48/80-induced systemic allergic reaction(1g/kg) and histamine release from RPMC(1mg/ml). CAS, WAS-root and WAS-stem also inhibited passive cutaneous anaphylactic reaction. In addition, IgE-induced $TNF-{\alpha}$ secretion from RBL-2H3 was inhibited by pretreatment of CAS, WAS-root or WAS-stem$(0.01{\mu}g/ml)$. Taken together, inhibitory effect on mast cell-mediated allergic reactions of WAS-root is greater than those of WAS-stem but less than those of CAS.

• 한국생활과학회지
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• 제23권4호
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• pp.633-652
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• 2014

The purpose of this study was to investigate the effect of personality traits of the middle aged on quality of life while mediated by self-concepts such as self-efficacy and self-derogation, as well as while moderated by subjective socio-economic variables such as economic status, social activities and employment. To verify the conceptual causality model and moderating effects of contextual variables, we analysed 353 cases out of purposively collected 400 cases from a medium sized city. As results, first, conscientiousness of personality traits positively affected quality of life of the middle aged while mediated by self-concepts. Second, neuroticism of personality traits negatively affected quality of life while mediated by self-concepts. Third, agreeableness of personality traits did not eventually affect quality of life, although affected negatively on self-efficacy and positively on self-derogation. Fourth, socio-economic variables such as economic status, social activities and employment moderated various paths in the model, which indicated dynamics of internal variables were affected by contextual variables.

• International Journal of Oncology
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• 제54권2호
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• pp.665-672
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• 2019

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a dynamic cytokine that initiates the apoptosis of cancer cells, but exhibits little or no toxicity in normal cells. Luteolin is a flavonoid compound frequently used in the treatment of cancer. In the current study, we demonstrate that treatment with luteolin and TRAIL exerts a synergistic effect and the mechanisms on TRAIL-resistant Huh7 cells. The results demonstrated that luteolin induced an autophagic flux in human liver cancer cells. The attenuation of the autophagic flux by applying the specific inhibitor of autophagy, chloroquine, significantly suppressed DR5 expression. Treatment with genetically modified autophagy-related 5 siRNA abrogated the luteolin-mediated sensitizing effect of TRAIL. Furthermore, pre-treatment with the c-Jun N-terminal kinase (JNK) inhibitor, SP600125, significantly attenuated the luteolin-induced upregulation of DR5 expression, thereby suggesting that JNK activation promotes DR5 expression. Our findings also revealed that Akt phosphorylation was required for TRAIL sensitization. On the whole, the findings of this study indicated that luteolin effectively enhanced TRAIL-initiated apoptosis, and that these effects were likely to be mediated by autophagy and JNK-mediated DR5 expression.

• Biomolecules & Therapeutics
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• 제18권4호
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• pp.402-410
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• 2010

Although the overproduction of prostaglandin $E_2$ ($PGE_2$) in intestinal epithelial cells has been considered to be highly correlated with the colorectal carcinogenesis, the precise mechanism of action remains poorly elucidated. Accumulating evidence suggests that the PGE receptor (EP)-mediated signal transduction pathway might play an important role in this process. In the present study, we investigated the mechanism of action underlying $PGE_2$-mediated cell proliferation and the effect of resveratrol on the proliferation of human colon cancer cells in terms of the modulating $PGE_2$-mediated signaling pathway. $PGE_2$ stimulated the proliferation of several human colon cancer cells and activated growth-stimulatory signal transduction, including Akt and ERK. $PGE_2$ also increased the phosphorylation of GSK-$3{\beta}$, the translocation of ${\beta}$-catenin into the nucleus, and the expressions of c-myc and cyclin D1. Resveratrol, a cancer chemopreventive phytochemical, however, inhibited $PGE_2$-induced growth stimulation and also suppressed $PGE_2$-mediated signal transduction, as well as ${\beta}$-catenin/T cell factor-mediated transcription in human colon cancer cells. These findings present an additional mechanism through which resveratrol affects the regulation of human colon cancer cell growth.

• 한국콘텐츠학회논문지
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• 제12권10호
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• pp.280-290
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• 2012

본 연구는 노인들의 연령집단별 신체 심리 사회 건강성, 가족지지, 자아통합감의 관련성을 파악하고, 건강성과 자아통합감의 관계에서 가족지지의 매개효과를 분석하고자, B광역시의 65세 이상노인을 대상으로 설문조사를 실시하였다. 그 결과 첫째, 신체 심리 사회 건강성, 가족지지, 자아통합감은 '전기노인' 집단이 모두 높았고 '초고령'으로 갈수록 낮아졌다. 둘째, 전기, 후기 연령집단은 사회건강성과 심리건강성이 자아통합감에, 또 85세 이상 초고령집단은 심리건강성과 신체건강성이 자아통합감에 유의미한 영향을 미쳤다. 셋째, 모든 연령집단에서 건강성과 자아통합감 영향경로에 가족지지 매개효과가 있었다. 따라서, 노인연령 집단에 따른 가족지지의 다양한 개입과 자아통합감 향상을 위한 건강증진시스템에서 연령범주별 차별화된 서비스제공과 사회원조전략이 필요하다.

• 한국가족복지학
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• 제58호
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• pp.123-150
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• 2017

본 연구의 목적은 저임금 여성근로자가 경험하는 직무스트레스가 직장-가정갈등을 매개로 우울에 미치는 영향에서 탄력성의 매개된 조절효과를 검증하는 데 있다. 본 연구의 분석대상은월 임금 200만원 이하의 여성근로자 총 190명이다. 분석결과, 직무스트레스는 직장-가정갈등을매개로 우울에 영향을 미치는 것으로 나타났으며, 탄력성의 완전 매개된 조절효과가 검증되었다. 이러한 결과를 바탕으로 저임금 여성근로자의 직무스트레스와 우울과 같은 정신건강문제에대한 개입방안, 직장-가정갈등의 예방을 위한 가족친화제도 강화, 실효성 있는 직장-가정양립정책 추진, 탄력성 증진을 위한 기업복지 프로그램의 필요성 등을 제언하였다.

• International journal of advanced smart convergence
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• 제10권2호
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• pp.31-36
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• 2021

This study aims to provide basic data on establishing online learning by identifying the effects of self-efficacy as a medium on factors affecting self-control according to self-determination motivation through contactless online learning due to Covid-19. The research method used SPSS 25 and Sobel test to examine the causal relationship between the spokesmen and 196 middle and high school students in W-city, Gangwon-do. Self-determination motivation has had a significant effect on self-efficacy and self-control, and self-efficacy has been shown to have a significant effect on self-control. Also, Self-efficacy had a partial mediating effect on self-determination motivation affecting self-control. Based on this, fundamental and continuous development of online education programs to promote self-control of online learners is required, and efforts should be made to support learners' capabilities through psychological counseling.

• 한방안이비인후피부과학회지
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• 제15권1호
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• pp.1-30
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• 2002

This experimental study was done to research effects of a number of extract on the anti-allergic effect. The results were obtained as follows: 1. In effect of herb-extract on compound $\frac{48}{80}$-mediated histamine release from Evans blue skin assay, Isatis Japonica Miquel, Dictamnus dasycarpus Turcz, Spirodela polyrhiza, Cimicifuga heracleifolia, Bupleurum chinense, Magnolia liliflora, Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(MtOH), Trichosanthes kirilowii, Phellodendron amurense Rupr, Schizonepeta tenuifolia Var, Betula platyphylla show considerable visible anti-allergic effect. In the result of quantification of histamine induced compound $\frac{48}{80}$, Spirodela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively. 2. In effect of Herb-Extract on compound $\frac{48}{80}$-mediated histamine release from RPMC, Spirodcla polyrhiza, Cimicifuga heracleifolia inhibit histamine release effectively. 3. In effect of Herb-Extract on anti-DNP IgE-mediated histamine release from Evansblue skin assay. Spirodela polyrhiza, Cimicifuga heracleifolia(0.1mg/ml). Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(0.1mg/ml), Trichosanthes kirilowii(0.1mg/ml) show considerable visible anti-allergic effect. In the result of quantification of histamine induced anti-DNP IgE, Spiradela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively 4. In the result of genetic manifestative inhibition about the human mast cell-1(HMC-1), Cimicifuga heracleifolia has considerable effect in IL-4 in IL-5, and Tussilage farfara L. has in IL-4. According to the above results, it is suggested that several Herb-Extract have anti-allergic effect.

• Journal of Ginseng Research
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• 제32권1호
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• pp.1-7
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• 2008

Ginseng saponin has been shown to inhibit the development of dependence on morphine, cocaine, methamphetamine, but the antinarcotics effects of ginseng on nalbuphine remains still largely unknown. Ginseng administration attenuated the naloxone-induced jumping behavior on nalbuphine dependent mice. The development of morphine dependence was mediated through ${\mu}-opioid$ receptor, however, development of nalbuphine dependence was mediated through ${\kappa}-opioid$ receptor. However, it was found that the efficacy of analgesic antagonism of GTS was mediated through the serotonergic mechanism, not mediated through the opioid receptor. In addition, ginseng administration modulated cellular signal transduction in the brain. The increased NMDA receptor subunit (NR1, pNR1), phosphate extracellular signal regulated protein kinase (pERK), phosphate cAMP response element binding protein (pCREB) expression by nalbuphine was decreased by the administration of ginseng powder in cortex, hippocampus, striatum of rat brain. These results suggest that ginseng could be one of the targets of antinarcotic therapies to reduce the development of tolerance and dependence on nalbuphine as well as morphine.

• Journal of Life Science
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• 제9권2호
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• pp.82-85
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• 1999

The effects of ethanol on 5-hydrosytryptamine(5-HT3) receptor-mediated ion current were evaluated in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. Ethanol(25-100mM) potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner.