Journal of Life Science

Korean Society of Life Science (한국생명과학회)
권호 표지

The Effect of Ethanol on 5-Hydrosytryptamine Receptor-Mediated Ion Current in Cultured NCB-20 Neuroblastoma Cells

  • Woo, Hyo-Geyng (College of Dentistry and Research Institute for oral Biotechnoloty, Pusan National University, Pusan 602-739) ;
  • Chung, In-Kyo (College of Medicine and Research Institute for oral Biotechnoloty, Pusan National University, Pusan 602-739) ;
  • Cho, Goon-Jae (College of Medicine and Research Institute for oral Biotechnoloty, Pusan National University, Pusan 602-739) ;
  • Chung, Yong-Za (College of Pharmacy Kyungsung University, Pusan 608-736) ;
  • Il Yun (Corresponding author, College of Dentistry and Research Institute for oral Biotechnoloty, Pusan National University, Pusan 602-739)
  • Published : 1999.10.01

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Abstract

The effects of ethanol on 5-hydrosytryptamine(5-HT3) receptor-mediated ion current were evaluated in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. Ethanol(25-100mM) potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner.

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