• Journal of Digital Convergence
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• v.17 no.2
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• pp.423-431
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• 2019

The purpose of this study is to examine the mediating effect of social support in relations between alcoholics' depression and suicidal ideation. The subjects were diagnosed with alcohol dependence by the DSM-IV, and are currently hospitalized at the hospitals in Busan, Ulsan, etc. for alcohol treatment. After explaining the purpose of this study to the participants, the questionnaires were distributed to those who agreed to the research and survey was self-written. Through this process, 217 questionnaires were analyzed. The Survey was done from October 1 to November 1, 2017. To examine the mediating effect of social support, 3steps' mediated regression analysis and Sobel test were done. The result of mediated regression analysis show halfly mediated effect of social support on alcoholics' suicidal ideation. According to these findings, intervention strategies that focus on increasing the social support on alcoholics are suggested.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.383-396
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• 2021

This study attempts to verify the effect of e-CRM on reuse intetnion of e-learning and to determine whether the presense mediates the relationship between e-CRM and reuse intetnion of e-learning through empirical analysis. The results of the study are as follows. First, The effect of e-CRM(e-marketing, e-service, e-communication) on the intention of reuse for e-learning services was significant. Second, it was found that the effect of e-CRM(e-marketing, e-service) on reuse intention of e-learning was significantly mediated by the teaching presence. Third, it was found that the effect of e-CRM(e-marketing, e-service, e-communication) on reuse intention of e-learning was significantly mediated by the cognitive presence. Finally, it was found that the effect of e-CRM(e-marketing) on reuse intention of e-learning was significantly mediated by the social presence.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.803-812
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• 2022

This study tried to examine the effect of multicultural adolescents' bicultural acceptance attitude on their life satisfaction and the serial multiple mediating effect of social competence and self-esteem in the relationship between them. To this purpose, we analyzed adolescents data from the first year(2019) of the 'Multicultural Adolescent Panel Study'(2nd group). As a result of the study, first, bicultural acceptance attitude had a significant positive effect on life satisfaction. Second, social competence mediated the effect of bicultural acceptance attitude on life satisfaction. Third, self-esteem mediated the effect of bicultural acceptance attitude on life satisfaction. Fourth, social competence and self-esteem were successively multi-mediated bicultural acceptance attitude on life satisfaction. Based on the results of this study, the implications of the results of this study were discussed along with measures to support the healthy growth and development of multicultural adolescents.

• Environmental Mutagens and Carcinogens
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• v.25 no.2
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• pp.51-59
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• 2005

Overexpression of HSP25 delayed cell growth, increased the level of $p21^{waf}$, reduced the levels of cyclin D1, cylcin A and cdc2, and induced radioresistance in L929 cells. We demonstrated that extracellular regulated kinase (ERK) and MAP kinase/ERK kinase (MEK) expressions as well as their activation (phospho-forms) were inhibited by hsp25 overexpression. To confirm the relationship between ERK1/2 and hsp25-mediated radioresistance, ERK1 or ERK2 cDNA was transiently transfected into the hsp25 overexpressed cells and their radioresistance was examined. HSP25-mediated radioresistance was abolished by overexpression of ERK2, but not by overexpression of ERK1. Alteration of cell cycle distribution and cell cycle related protein expressions (cyclin D, cyclin A and cdc2) by hsp25 overexpression were also recovered by ERK2 cDNA transfection. Increase in Bc1-2 protein by hsp25 gene transfection was also reduced by subsequent ERK2 cDNA-transfection. In addition, HSP25 overexpression reduced reactive oxygen species (ROS) and increased expression of manganese superoxide dismutase (MnSOD) gene. Increased activation of NF-kB (IkB degradation) was also found in hsp25-overexpressed cells. Moreover, transfection of hsp25 antisense gene abrogated all the HSP25-mediated phenomena. To further elucidate the exact relationship between MnSOD induction and NF-kB activation, dominant negative $I-kB\alpha(I-kB\alpha-DN)$ construction was transfected to HSP25 overexpressed cells. $I-kB\alpha-DN$ inhibited HSP25 mediated MnSOD gene expression. In addition, HSP25 mediated radioresistance was blocked by $I-kB\alpha-DN$ transfection. Blockage of MnSOD with antisense oligonucleotides in HSP25 overexpressed cells, prevented apoptosis and returned the ERK1/2 activation to the control level. From the above results, we suggest for the first time that reduced oxidative damage by HSP25 was due to MnSOD-mediated down regulation of ERK1/2.

• BMB Reports
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• v.42 no.2
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• pp.96-100
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• 2009

Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, with inhibition exceeding 84%. Moreover, the treatment produced nucleosomal DNA fragmentation and the percentage of sub-diploid cells increased in a concentration-dependent manner; both are hallmarks of apoptosis. The apoptotic effect of ar-turmerone was associated with the induction of Bax and p53 proteins, rather than Bcl-2 and p21. Activation of mitochondrial cytochrome c and caspase-3 demonstrated that the activation of caspases accompanied the apoptotic effect of ar-turmerone, which mediated cell death. These results suggest that the apoptotic effect of ar-turmerone on U937 cells may involve caspase-3 activation through the induction of Bax and p53, rather than Bcl-2 and p21.

• Journal of Ginseng Research
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• v.27 no.3
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• pp.115-119
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• 2003

There has been continuing interest in the development of synthetic and natural compounds that modify the immune response particularly for the treatment of AIDS and cancer. During the past fifty years, numerous scientific studies have been published on ginseng. Modem human studies have investigated preventive effect of ginseng on several kinds of cancer, its long term immunological effect on HIV patients, its effect on cell mediated immune functions in healthy volunteers. Similarly non clinical studies on animal model system have studied the chemopreventive action of ginseng on cancer and immunological properties of ginseng. The precise mechanism of action of ginseng, however, not clearly understood. Considering its wide-ranging therapeutic effects, this study is being undertaken to elucidate the general mode of action of ginseng, especially to test our hypothesis that its biological action may be mediated by the immune system.

• 한국유가공학회:학술대회논문집
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• 2005.10a
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• pp.1-9
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• 2005

The ubiquitous presence of lactoferrin (LF) receptor in human as reported by the research group of Prof, Bo Lonnerdal, Univ. California, encouraged us to search for the unknown physiological roles of LF. Under the collaboration with Prof. Etsumori Harada, Tottori Univ., and his research group, we have found two novel biological activities of LF as the control of the lipid metabolism and the effect on the central nervous system. Relating to the lipid metabolism, LF could, in animal experiments, reduce triglyceride and total cholesterol both in blood and liver. LF increased plasma HDL-C and lowered LDL-C. In the central nervous system, LF showed anti-nociceptive activity mediated by ${\mu}$-opioid receptor in the rat spinal cord. LF enhanced analgesic action of morphine synergistically via nitric oxide synthesis. LF showed opioid-mediated suppressive effect on distress induced by maternal separation in rat pups.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.637-637
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• 2013

We develop single-crystal poly(3,4-ethylenedioxythiopene nanowires using liquid-bridge-mediated nanotransfer printing via vapor phase polymerization. This direct printing method can simultaneously enable the synthesis, alignment and patterning of the nanowires from molecular ink solutions. Twoor three-dimensional complex structures of various single-crystal organic nanowires were directly fabricated over a large area using many types of molecular inks. This method is capable of generating several optoelectronic devices. LB-nTM is based on the direct transfer of various materials from a mold to a substrate via a liquid bridge between them. To demonstrate its usefulness, we used LB-nTM to fabricate nanowire field-effect transistors and arrays of 6,13-bis (triisopropyl- silylethynyl) pentacene (TIPS-PEN) nanowire field-effect transistors.

• Journal of Pharmaceutical Investigation
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• v.41 no.3
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• pp.143-146
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• 2011

Scutellariae Radix is widely used in the traditional herbal medicine for the treatment of fever, cough, dysentery, hepatitis and hypertension in Korea, China and Japan. In this study, we investigated the effects of 70% ethanolic extract of Scutellariae Radix (SRE) on CYP450-mediated drug metabolism in the in vitro systems using human liver microsomes and hepatocytes. The microsomal incubation assay showed that SRE inhibited the drug metabolism reactions catalyzed by CYP1A2, CYP2C8 and CYP2C9 in a dose-dependent manner. In particular, SRE was shown to strongly inhibit the metabolic activity of CYP1A2 with an $IC_{50}$ value of 4.6 ${\mu}g/mL$. When SRE was evaluated for its effect on the induction of CYP450 enzyme activities in cryopreserved human hepatocytes, SRE did not exhibit any effect.

• Bulletin of the Korean Chemical Society
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• v.28 no.11
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• pp.2051-2055
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• 2007

The solvent effect on sulfur ylide mediated epoxidation reaction was studied systematically. While higher trans/cis ratio of the epoxide was obtained in the more polar solvent, protic solvent produced the lower trans/ cis ratio than any aprotic solvent.