• Advances in Traditional Medicine
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• v.1 no.2
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• pp.21-28
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• 2000

We compared the effect between CAS and WAS(root, stem) on mast cell-mediated allergic reaction. CAS, WAS-root and WAS-stem, significantly inhibited compound 48/80-induced systemic allergic reaction(1g/kg) and histamine release from RPMC(1mg/ml). CAS, WAS-root and WAS-stem also inhibited passive cutaneous anaphylactic reaction. In addition, IgE-induced $TNF-{\alpha}$ secretion from RBL-2H3 was inhibited by pretreatment of CAS, WAS-root or WAS-stem$(0.01{\mu}g/ml)$. Taken together, inhibitory effect on mast cell-mediated allergic reactions of WAS-root is greater than those of WAS-stem but less than those of CAS.

• Korean Journal of Human Ecology
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• v.23 no.4
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• pp.633-652
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• 2014

The purpose of this study was to investigate the effect of personality traits of the middle aged on quality of life while mediated by self-concepts such as self-efficacy and self-derogation, as well as while moderated by subjective socio-economic variables such as economic status, social activities and employment. To verify the conceptual causality model and moderating effects of contextual variables, we analysed 353 cases out of purposively collected 400 cases from a medium sized city. As results, first, conscientiousness of personality traits positively affected quality of life of the middle aged while mediated by self-concepts. Second, neuroticism of personality traits negatively affected quality of life while mediated by self-concepts. Third, agreeableness of personality traits did not eventually affect quality of life, although affected negatively on self-efficacy and positively on self-derogation. Fourth, socio-economic variables such as economic status, social activities and employment moderated various paths in the model, which indicated dynamics of internal variables were affected by contextual variables.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.402-410
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• 2010

Although the overproduction of prostaglandin $E_2$ ($PGE_2$) in intestinal epithelial cells has been considered to be highly correlated with the colorectal carcinogenesis, the precise mechanism of action remains poorly elucidated. Accumulating evidence suggests that the PGE receptor (EP)-mediated signal transduction pathway might play an important role in this process. In the present study, we investigated the mechanism of action underlying $PGE_2$-mediated cell proliferation and the effect of resveratrol on the proliferation of human colon cancer cells in terms of the modulating $PGE_2$-mediated signaling pathway. $PGE_2$ stimulated the proliferation of several human colon cancer cells and activated growth-stimulatory signal transduction, including Akt and ERK. $PGE_2$ also increased the phosphorylation of GSK-$3{\beta}$, the translocation of ${\beta}$-catenin into the nucleus, and the expressions of c-myc and cyclin D1. Resveratrol, a cancer chemopreventive phytochemical, however, inhibited $PGE_2$-induced growth stimulation and also suppressed $PGE_2$-mediated signal transduction, as well as ${\beta}$-catenin/T cell factor-mediated transcription in human colon cancer cells. These findings present an additional mechanism through which resveratrol affects the regulation of human colon cancer cell growth.

• The Journal of the Korea Contents Association
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• v.12 no.10
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• pp.280-290
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• 2012

The purpose of this study is to understand the relation among health condition of physicalness, psychology and society, family support, and self-integration in age group of old people and to analysis if there are any mediated effect of family support in relationship between health condition and self-integration. For that, the survey was conducted people aged 65 or older living in B city. First, the levels of heath condition of physicalness, psychology and society, and self-integration in 'old people aged between 65 and 74' were high, the level was getting lower in the oldest aged. Second, for the aged groups between 65 and 74, and aged group between 75 and 84, health condition of society and psychology influenced meaningfully with a factor of self-integration, and for the people aged 85 or older, health condition of society and psychology influenced meaningfully. Third, all aged groups had the mediated effect of family support through self-integration in heath condition. Therefore, health promotion for the elderly age group according to a variety of family support intervention and self-integrated sense of improvement in the system by age category providing differentiated services and social assistance strategy is necessary.

• Korean Journal of Family Social Work
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• no.58
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• pp.123-150
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• 2017

The purpose of this study is to examine the mediated moderating effect of resilience in the relationships among job stress, work-family conflict, and depression of female low-wage workers. For this purpose, a total of 190 female workers with monthly wage of less than two million won were analyzed. The results showed that the mediated effect of work-family conflict in the relationships between job stress and depression, and the mediated moderating effect of resilience. Thus, policy makers and practitioners should develop mental health program alleviating job stress and depression among female low-wage workers, enhance family-friendly policy and program necessary for work family balance, furthermore, develop occupational welfare program to promote resilience.

• International journal of advanced smart convergence
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• v.10 no.2
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• pp.31-36
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• 2021

This study aims to provide basic data on establishing online learning by identifying the effects of self-efficacy as a medium on factors affecting self-control according to self-determination motivation through contactless online learning due to Covid-19. The research method used SPSS 25 and Sobel test to examine the causal relationship between the spokesmen and 196 middle and high school students in W-city, Gangwon-do. Self-determination motivation has had a significant effect on self-efficacy and self-control, and self-efficacy has been shown to have a significant effect on self-control. Also, Self-efficacy had a partial mediating effect on self-determination motivation affecting self-control. Based on this, fundamental and continuous development of online education programs to promote self-control of online learners is required, and efforts should be made to support learners' capabilities through psychological counseling.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.1
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• pp.1-30
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• 2002

This experimental study was done to research effects of a number of extract on the anti-allergic effect. The results were obtained as follows: 1. In effect of herb-extract on compound $\frac{48}{80}$-mediated histamine release from Evans blue skin assay, Isatis Japonica Miquel, Dictamnus dasycarpus Turcz, Spirodela polyrhiza, Cimicifuga heracleifolia, Bupleurum chinense, Magnolia liliflora, Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(MtOH), Trichosanthes kirilowii, Phellodendron amurense Rupr, Schizonepeta tenuifolia Var, Betula platyphylla show considerable visible anti-allergic effect. In the result of quantification of histamine induced compound $\frac{48}{80}$, Spirodela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively. 2. In effect of Herb-Extract on compound $\frac{48}{80}$-mediated histamine release from RPMC, Spirodcla polyrhiza, Cimicifuga heracleifolia inhibit histamine release effectively. 3. In effect of Herb-Extract on anti-DNP IgE-mediated histamine release from Evansblue skin assay. Spirodela polyrhiza, Cimicifuga heracleifolia(0.1mg/ml). Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(0.1mg/ml), Trichosanthes kirilowii(0.1mg/ml) show considerable visible anti-allergic effect. In the result of quantification of histamine induced anti-DNP IgE, Spiradela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively 4. In the result of genetic manifestative inhibition about the human mast cell-1(HMC-1), Cimicifuga heracleifolia has considerable effect in IL-4 in IL-5, and Tussilage farfara L. has in IL-4. According to the above results, it is suggested that several Herb-Extract have anti-allergic effect.

• Journal of Ginseng Research
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• v.32 no.1
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• pp.1-7
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• 2008

Ginseng saponin has been shown to inhibit the development of dependence on morphine, cocaine, methamphetamine, but the antinarcotics effects of ginseng on nalbuphine remains still largely unknown. Ginseng administration attenuated the naloxone-induced jumping behavior on nalbuphine dependent mice. The development of morphine dependence was mediated through ${\mu}-opioid$ receptor, however, development of nalbuphine dependence was mediated through ${\kappa}-opioid$ receptor. However, it was found that the efficacy of analgesic antagonism of GTS was mediated through the serotonergic mechanism, not mediated through the opioid receptor. In addition, ginseng administration modulated cellular signal transduction in the brain. The increased NMDA receptor subunit (NR1, pNR1), phosphate extracellular signal regulated protein kinase (pERK), phosphate cAMP response element binding protein (pCREB) expression by nalbuphine was decreased by the administration of ginseng powder in cortex, hippocampus, striatum of rat brain. These results suggest that ginseng could be one of the targets of antinarcotic therapies to reduce the development of tolerance and dependence on nalbuphine as well as morphine.

• Journal of Life Science
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• v.9 no.2
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• pp.82-85
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• 1999

The effects of ethanol on 5-hydrosytryptamine(5-HT3) receptor-mediated ion current were evaluated in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. Ethanol(25-100mM) potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner.

• Advances in Traditional Medicine
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• v.1 no.1
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• pp.82-88
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• 2000

We investigated the effect of aqueous extract of Cichorium intybus (CIAE) on mast cell-mediated immediate type allergic reactions. CIAE dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice. Especially, CIAE inhibited compound 48/80-induced anaphylactic reaction 100% with the dose of 1000 mg/kg. CIAE 1000 mg/kg also significantly inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. When mice were pretreated with CIAE at a concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were reduced in a dose-dependent manner. CIAE (1 to 1000 g/ml) dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. These results indicate that CIAE inhibits mast cell-mediated immediate-type allergic reactions.