• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.995-1000
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• 2000

In this paper. a mechanistic model is first constructed to predict three-dimensional cutting forces, and the uncut chip th thickness is calculated by following the movements of the position of the center of a cutter, which varies with the nominal feed, cutter deflection and runout. For general implementation to a real machining, this paper presents the method that determines constant cutting force coefficients, irrespective of the cutting conditions or cutter rotation angles. In addition, this study presents the approach which estimates runout-related parameters. the runout offset and its location angle, using only one measurement of cutting forces. For more accurate cutting force predictions, the size effect has to be considered in the cutting force model. In this paper, two approximate methods are suggested since the strict approach is practically impossible due to a measurement problem. The size effect is individually considered for narrow and wide cuts.

• Geomechanics and Engineering
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• v.17 no.4
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• pp.405-411
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• 2019

A significant influence of the particle size distribution on the resilient behaviour of granular aggregates was usually observed in laboratory tests. However, the mechanisms underlying this phenomenon were rarely reached. In this study, a mechanistic model considering particle breakage is proposed. It is found to be the combined effects of the coefficient of uniformity and the size range between maximum and minimum particle sizes that influences the resilient modulus of granular aggregates. The resilient modulus is found to undergo reduction with evolution of particle breakage by shifting the initial particle size distribution to a broader one.

• Journal of the Korean Chemical Society
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• v.65 no.2
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• pp.113-120
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• 2021

New phenylthiophenechalcones,1-(biphenyl-4-yl)-3-(5-phenylthiophen-2-yl)prop-2-en-1-one (3a) and 3-(5-phenylthiophen-2-yl)-1-(4-(piperidin-1-yl) phenyl) prop-2-en-1-one (3b) were synthesized, next, their treatment with thiosemicarbazide in ethanol afforded their pyrazoline derivatives (4a) and (4b), respectively. The molecular structures of the synthesized compounds were confirmed via elemental analysis, FT-IR, 1H, 13C NMR and mass spectroscopy. The geometrical elucidation of four suggested conformers has been studied for these compounds. DFT calculations have been performed to study the stability and the structural parameters of the predicted conformers and revealed that orientation of the biphenyl and the phenylthiophene moieties affect the stability of the estimated conformers of the synthesized chalcones and pyrazoline. Moreover, two reaction mechanisms have been proposed to illustrate the reaction products and the DFT calculations have been used to confirm the reaction mechanism of the pyrazoline compounds.

• Journal of the Society of Disaster Information
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• v.9 no.1
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• pp.1-10
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• 2013

The main objective of this research is to develop the Mechanistic-Empirical (M-E) guidelines for evaluating the capacity of existing highways to sustain route overweight truck traffic over a specified performance period due to a growing concern on the impact of increasing overweight truck loads on highways. In this study, a two-stage framework was developed for this purpose. Level I procedure involves the use of pavement evaluation charts to identify the best possible route from among the alternatives considered and to determine what additional tests and analyses are needed as a screening tool. Level II involves the application of the Overweight Truck Route Analysis (OTRA) program to evaluate the structural adequacy of an existing route to carry routine overweight truck traffic over the specified performance period along with estimating asphalt concrete overlay thickness, if necessary.

• Animal Bioscience
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• v.35 no.9
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• pp.1444-1453
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• 2022

Objective: Acetate plays an important role in host lipid metabolism. However, the network of acetate-regulated lipid metabolism remains unclear. Previous studies show that mitogen-activated protein kinases (MAPKs) and mechanistic target of rapamycin (mTOR) play a crucial role in lipid metabolism. We hypothesize that acetate could affect MAPKs and/or mTOR signaling and then regulate lipid metabolism. The present study investigated whether any cross talk occurs among MAPKs, mTOR and acetate in regulating lipid metabolism. Methods: The ceramide C6 (an extracellular signaling-regulated kinases 1 and 2 [ERK1/2] activator) and MHY1485 (a mTOR activator) were used to treat rabbit adipose-derived stem cells (ADSCs) with or without acetate, respectively. Results: It indicated that acetate (9 mM) treatment for 48 h decreased the lipid deposition in rabbit ADSCs. Acetate treatment decreased significantly phosphorylated protein levels of ERK1/2 and mTOR but significantly increased mRNA level of hormone-sensitive lipase (HSL). Acetate treatment did not significantly alter the phosphorylated protein level of p38 MAPK and c-Jun aminoterminal kinase (JNK). Activation of ERK1/2 and mTOR by respective addition in media with ceramide C6 and MHY1485 significantly attenuated decreased lipid deposition and increased HSL expression caused by acetate. Conclusion: Our results suggest that ERK1/2 and mTOR signaling pathways are associated with acetate regulated HSL gene expression and lipid deposition.

• Bulletin of the Korean Chemical Society
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• v.29 no.12
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• pp.2477-2481
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• 2008

• International Journal of Highway Engineering
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• v.2 no.3
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• pp.155-165
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• 2000

Periodical evaluations of the airfield pavement are necessary to provide the ability for the existing pavement to support the increasing volume of air traffic. Also, the evaluation of the existing Pavement condition is necessary for the decision of the maintenance strategy. For this reason, airport pavements in Korea have been evaluated every five years currently. It was known, however, that the current pavement evaluation methodology was not logical and practical. The purpose of this study is to compare the current pavement evaluation method with design chart to the mechanistic approach used in other advanced countries. As a result of this study the mechanistic approach is found to be more logical than the current method.

• International Journal of Highway Engineering
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• v.11 no.1
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• pp.165-175
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• 2009

With the current move towards adopting mechanistic-empirical concepts in the design of pavement structures, state-of-the-art mechanistic analysis methodologies are needed to determine accurate pavement responses, such as stress, strain, and deformation. Previous laboratory studies of pavement foundation geomaterials, i.e., unbound granular materials used in base/subbase layers and fine-grained soils of a prepared subgrade, have shown that the resilient responses followed by nonlinear, stress-dependent behavior under repeated wheel loading. This nonlinear behavior is commonly characterized by stress-dependent resilient modulus material models that need to be incorporated into finite element (FE) based mechanistic pavement analysis methods to predict more realistically predict pavement responses for a mechanistic pavement analysis. Developed user material subroutine using aforementioned resilient model with nonlinear solution technique and convergence scheme with proven performance were successfully employed in general-purpose FE program, ABAQUS. This numerical analysis was investigated in predicted critical responses and domain selection with specific mesh generation was implemented to evaluate better prediction of pavement responses. Results obtained from both axisymmetric and three-dimensional (3D) nonlinear FE analyses were compared and remarkable findings were described for nonlinear FE analysis. The UMAT subroutine performance was also validated with the instrumented full scale pavement test section study results from the Federal Aviation Administration's National Airport Pavement Test Facility (FAA's NAPTF).

• Journal of Biosystems Engineering
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• v.37 no.4
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• pp.258-264
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• 2012

Purpose: This review aims at introducing 3 modeling approaches classified into 3 categories based on the purpose (estimation or prediction), structure (linear or non-linear) and phase (steady-state or dynamic-state); 1) statistical approaches, 2) kinetic modeling and 3) mechanistic modeling. We hope that this review can be a useful guide in the model-based approach of calcium metabolism as well as illustrates an application of engineering tools in studying biosystems. Background: The meaning of biosystems has been expanded, including agricultural/food system as well as biological systems like genes, cells and metabolisms. This expansion has required a useful tool for assessing the biosystems and modeling has arisen as a method that satisfies the current inquiry. To suit for the flow of the era, examining the system which is a little bit far from the traditional biosystems may be interesting issue, which can enlarge our insights and provide new ideas for prospective biosystem-researches. Herein, calcium metabolic models reviewed as an example of application of modeling approaches into the biosystems. Review: Calcium is an essential nutrient widely involved in animal and human metabolism including bone mineralization and signaling pathways. For this reason, the calcium metabolic system has been studied in various research fields of academia and industries. To study calcium metabolism, model-based system analyses have been utilized according to the purpose, subject characteristics, metabolic sites of interest, and experimental design. Either individual metabolic pathways or a whole homeostasis has been modeled in a number of studies.

• Molecular & Cellular Toxicology
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• v.3 no.4
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• pp.231-237
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• 2007

Exposure to DNA-damaging agents can elicit a variety of stress-related responses that may alter the expression of genes associated with numerous biological pathways. We used 19 k whole human genome chip to detect gene expression profiles and potential signature genes in human normal hepatocytes (THLE-3) by treatment of five direct acting mutagens, furylfuramide (AF-2), N-nitroso-N-methylurea (MNU), methylmethanesulfonate (MMS), 4-nitroquinoline-N-oxide (4-NQO) and 2-nitrofluorene (2NF) of the $IC_{20}$ concentration for 3 h. Fifty one up-regulated common genes and 45 down-regulated common genes above 1.5-fold by five direct-acting mutagens were identified by clustering analysis. Many of these changed genes have some association with apoptosis, control of cell cycle, regulation of transcription and signal transduction. Genes related to these functions, as TP73L, E2F5, MST016, SOX5, MAFB, LIF, SII3, TFIIS, EMR1, CYTL1, CX3CR1 and RHOH are up-regulated. Down-regulated genes are ALOX15B, xs155, IFITM1, BATF, VAV2, CD79A, DCDC2, TNFSF8 and KOX8. We suggest that gene expression profiling on mutagens by toxicogenomic analysis affords promising opportunities to reveal potential new mechanistic markers of genotoxicity.