• Molecules and Cells
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• 제42권4호
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• pp.285-291
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• 2019

Eukaryotic cells use conserved quality control mechanisms to repair or degrade defective proteins, which are synthesized at a high rate during proteotoxic stress. Quality control mechanisms include molecular chaperones, the ubiquitin-proteasome system, and autophagic machinery. Recent research reveals that during autophagy, membrane-bound organelles are selectively sequestered and degraded. Selective autophagy is also critical for the clearance of excess or damaged protein complexes (e.g., proteasomes and ribosomes) and membrane-less compartments (e.g., protein aggregates and ribonucleoprotein granules). As sessile organisms, plants rely on quality control mechanisms for their adaptation to fluctuating environments. In this mini-review, we highlight recent work elucidating the roles of selective autophagy in the quality control of proteins and RNA in plant cells. Emphasis will be placed on selective degradation of membrane-less compartments and protein complexes in the cytoplasm. We also propose possible mechanisms by which defective proteins are selectively recognized by autophagic machinery.

• Journal of Microbiology and Biotechnology
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• 제31권1호
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• pp.1-7
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• 2021

Bacterial biofilm is a community of bacteria that are embedded and structured in a self-secreted extracellular matrix. An important clinical-related characteristic of bacterial biofilms is that they are much more resistant to antimicrobial agents than the planktonic cells (up to 1,000 times), which is one of the main causes of antibiotic resistance in clinics. Therefore, infections caused by biofilms are notoriously difficult to eradicate, such as lung infection caused by Pseudomonas aeruginosa in cystic fibrosis patients. Understanding the resistance mechanisms of biofilms will provide direct insights into how we overcome such resistance. In this review, we summarize the characteristics of biofilms and chronic infections associated with bacterial biofilms. We examine the current understanding and research progress on the major mechanisms of antibiotic resistance in biofilms, including quorum sensing. We also discuss the potential strategies that may overcome biofilm-related antibiotic resistance, focusing on targeting biofilm EPSs, blocking quorum sensing signaling, and using recombinant phages.

• International Journal of Computer Science & Network Security
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• 제22권4호
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• pp.33-38
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• 2022

The main purpose of the study is to determine the key aspects of the mechanisms of state management of the exchange of information about cyberattacks, cyber incidents, and information security incidents. The methodology includes a set of theoretical methods. Modern government, on the one hand, must take into account the emergence of such a new weapon as cyber, which can break various information systems, can be used in hybrid wars, influence political events, pose a threat to the national security of any state. As a result of the study, key elements of the mechanisms of state management of the exchange of information about cyberattacks, cyber incidents, and information security incidents were identified.

• 한국정밀공학회지
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• 제13권10호
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• pp.56-61
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• 1996

In this study a method for a robust design of mechanisms is proposed. The method used in the experimental analysis and quality engineering is applied for mechanisms design. A mathematical model for a mechanism is estimated by the response surface analysis and the estimated model is used in minimization of the variance. Using this result, robust design can be carried out. The method can be applied for general mechansims. Furthermore because the method can be used in the design stage using the computer model, improved quality and lower cost of the product is achieved even in the design stage.

• 한국전기전자재료학회논문지
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• 제37권1호
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• pp.11-25
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• 2024

Lithium-ion batteries (LIBs) have attracted great attention as the common power source in energy storage fields of large-scale applications such as electrical vehicles (EVs), industries, power plants, and grid-scale energy storage systems (ESSs). Insertion, alloying, and conversion reactions are the main electrochemical energy storage mechanisms in LIBs, which determine their electrochemical properties and performances. The electrochemical reaction mechanisms are determined by several factors including crystal structure, components, and composition of electrode materials. This article reviews a new strategy to compensate for the intrinsic shortcomings of each reaction mechanism by introducing the material systems to form a single compound with different types of reaction mechanisms and to allow the simultaneous hybrid electrochemical reaction of two different mechanisms in a single solid solution phase.

• Biomolecules & Therapeutics
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• 제32권1호
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• pp.1-12
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• 2024

Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in particular, are frequently unpredictable. However, the wide spectrum of skin manifestations poses a formidable diagnostic challenge. Comprehending the pathomechanisms underlying ADRs is essential for accurate diagnosis and effective management. The skin, being an active immune organ, plays a pivotal role in ADRs, although the precise cutaneous immunological mechanisms remain elusive. Fortunately, clinical manifestations of skin-related ADRs, irrespective of their severity, are frequently rooted in immunological processes. A comprehensive grasp of ADR morphology can aid in diagnosis. With the continuous development of new pharmaceuticals, it is noteworthy that certain drugs including immune checkpoint inhibitors have gained notoriety for their association with ADRs. This paper offers an overview of immunological mechanisms involved in cutaneous ADRs with a focus on clinical features and frequently implicated drugs.

• International journal of advanced smart convergence
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• 제13권2호
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• pp.110-118
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• 2024

This study examines factors influencing nonusers' resistance to the adoption of the metaverse, focusing on propagation mechanisms. It elucidates the role of innovation resistance within the metaverse adoption process. We applied the Innovation Resistance Model in the context of the metaverse and considers three major groups of factors influencing resistance to the metaverse: innovation characteristics (perceived usefulness, compatibility, perceived risk, and complexity), consumer characteristics (personal innovativeness), and propagation mechanisms (mass media, online media, and personal communication). An online survey of college students who do not use the metaverse revealed that perceived usefulness, compatibility, personal innovativeness, and online media were negative predictors of resistance to the metaverse. Conversely, perceived risk, mass media, and personal communication were positive predictors of resistance to the metaverse. Furthermore, innovation resistance was found to play a mediating role in the metaverse adoption process. Drawing upon the findings, we suggested marketing strategies to decrease resistance to the metaverse.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 C
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• pp.1337-1339
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• 1999

This paper presents transmission pricing mechanisms based on postage stamp rule. Two pricing mechanisms with three different calculation methods are suggested, followed by case studies in KEPCO system.

• 로봇학회논문지
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• 제7권4호
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• pp.292-298
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• 2012

It is a real-time system that the system correctness depends not only on the correctness of the logical result of the computation but also on the result delivery time. Real-time Operating System (RTOS) is a software that manages the time of a microprocessor to ensure that the most important code runs first so that it is a good building block to design the real-time system. The real-time performance is achieved by using real-time mechanisms through data communication and synchronization of inter-task communication (ITC) between tasks. Therefore, test on the response time of real-time mechanisms is a good measure to predict the performance of real-time systems. This paper aims to analysis the response characteristics of real-time mechanisms in kernel space for real-time embedded Linux: RTAI and Xenomai. The performance evaluations of real-time mechanism depending on the changes of task periods are conducted. Test metrics are jitter of periodic tasks and response time of real-time mechanisms including semaphore, real-time FIFO, Mailbox and Message queue. The periodicity of tasks is relatively consistent for Xenomai but RTAI reveals smaller jitter as an average result. As for real-time mechanisms, semaphore and message transfer mechanism of Xenomai has a superior response to estimate deterministic real-time task execution. But real-time FIFO in RTAI shows faster response. The results are promising to estimate deterministic real-time task execution in implementing real-time systems using real-time embedded Linux.

• 한국가스학회지
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• 제10권1호
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• pp.32-37
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• 2006

원유정제 플랜트 주요 요소는 운전조건, 사용재료, 내부유체 등에 따라 다양한 열화 손상기구에 노출되므로, 그에 따른 적절한 검사기법 및 진단 방법을 적용하여야 한다. 따라서 원유정제 플랜트 요소에 발생하는 다양한 손상기구에 대한 대처 방안을 제시할 수 있는 정보를 제공할 수 있는 표준화된 데이터베이스를 확보하는 것이 필요하다. 이에 본 연구에서는 API기준에서 제시하는 손상 기구를 모두 포함하는 손상정보 시스템을 개발하였으며, 이를 기본으로 하여 향후 정보시스템을 확장할 수 있도록 시스템을 구성하였다. 시스템 내의 손상 정보 범위는 API기준 내의 컨텐츠를 반영할 수 있도록 하였으며, 미국 및 일본에서 사용하는 손상기구 검색표 방식을 도입하여 요소의 가동온도, 내부유체, 응력상태 등의 운전조건과 재질에 따른 손상기구를 파악할 수 있도록 하였다. 이 시스템은 기존의 RBI프로그램과 연동하여 사용할 수 있다.