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http://dx.doi.org/10.14348/molcells.2019.0011

Protein and RNA Quality Control by Autophagy in Plant Cells  

Yoon, Seok Ho (Department of Biological Sciences, Pusan National University)
Chung, Taijoon (Department of Biological Sciences, Pusan National University)
Publication Information
Molecules and Cells / v.42, no.4, 2019 , pp. 285-291 More about this Journal
Abstract
Eukaryotic cells use conserved quality control mechanisms to repair or degrade defective proteins, which are synthesized at a high rate during proteotoxic stress. Quality control mechanisms include molecular chaperones, the ubiquitin-proteasome system, and autophagic machinery. Recent research reveals that during autophagy, membrane-bound organelles are selectively sequestered and degraded. Selective autophagy is also critical for the clearance of excess or damaged protein complexes (e.g., proteasomes and ribosomes) and membrane-less compartments (e.g., protein aggregates and ribonucleoprotein granules). As sessile organisms, plants rely on quality control mechanisms for their adaptation to fluctuating environments. In this mini-review, we highlight recent work elucidating the roles of selective autophagy in the quality control of proteins and RNA in plant cells. Emphasis will be placed on selective degradation of membrane-less compartments and protein complexes in the cytoplasm. We also propose possible mechanisms by which defective proteins are selectively recognized by autophagic machinery.
Keywords
aggrephagy; autophagy receptor; granulophagy; NBR1; proteaphagy; ribophagy; ubiquitylation;
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