• Journal of Korean Medicine Rehabilitation
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• v.29 no.4
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• pp.101-108
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• 2019

Objectives The purpose of this study is to evaluate the safety of Gunghatang tablet in healthy male volunteers. Methods Single center pharmacokinetics study was carried out in healthy male volunteers. Through the laboratory test, vital sign and adverse event data, safety evaluation was conducted. Total 15 of 16 subjects who met the inclusion criteria were enrolled and three subjects were allocated to waiting group. 12 subjects were allocated by serial number according to registration order. Subjects took the maximum daily dose of the tablet on the second day of hospitalization. For the evaluation of safety, blood samples were collected and vital sign were checked 4 times (screening, before administration, after administration and follow up period) during the trial. All adverse events were recorded and summarized as frequency and percentage. All continuous data were summarized as mean and standard deviation. For comparison of variables between before administration and after administration, data were analyzed by paired T-test or Wilcoxon signed rank test (p<0.05). Results As a result of all data related to vital sign and laboratory test in both group, there were no significant differences associated with the clinical trial drug between pre and post administration. And there was no adverse event associated with the clinical trial drug. Conclusions Gunghatang tablet were found to be safe for healthy male volunteers.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.791-799
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• 2019

We evaluated the physical properties that occur to dose enhancement and changes from secondary particle production resulting from the interaction between enhancement material. Geant4 was used to perform a Monte Carlo simulation, and the medical internal radiation dose (MIRD) head phantom were employed. X-rays of 4, 6, 10, 15, 18, and 25 MV were used. Aurum (Au) and gadolinium (Gd) were applied within the tumor volume at 10, 20, and 30 mg/g, and an experiment using soft tissue exclusively was concomitantly performed for comparison. Also, particle fluence and initial kinetic energy of secondary particle of interaction were measured to calculate equivalent doses using the radiation weight factor. The properties of physical interaction by the radiation enhancement material showed the great increased in photoelectric effect as compared to the compton scattering and pair production, occurred with the highest, in aurum and gadolinium it is shown in common. The photonuclear effect frequency increased as the energy increased, thereby increasing secondary particle production, including alpha particles, protons, and neutrons. During dose enhancement using aurum, a maximum 424.25-fold increase in the equivalent dose due to neutrons was observed. This study was Monte Carlo simulation corresponds to the physical process of energy transmission in dose enhancement. Its results may be used as a basis for future in vivo and in vitro experiments aiming to improve effects of dose enhancement.

• Journal of the Korea Society of Computer and Information
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• v.19 no.11
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• pp.9-15
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• 2014

In this paper, We propose a block reallocation algorithm for reducing network traffic in Hadoop cluster. The scheduler of Hadoop cluster receives a job from users. And the job is divided into multiple tasks assigned to nodes. At this time, the scheduler allocates the task to the node that satisfied data locality. If a task is assigned to the node that does not have the data(block) to be processed, the task is processed after the data transmission from another node. There is difference of workload among nodes because blocks in cluster have different access frequency. Therefore, the proposed algorithm relocates blocks according to the task allocation pattern of Hadoop scheduler. Eventually, workload of nodes are leveled, and the case of the task processing in a node that does not have the block to be processing is reduced. Thus, the network traffic of the cluster is also reduced. We evaluate the proposed block reallocation algorithm by a simulation. The simulation result shows maximum 23.3% reduction of network consumption than default delay scheduling for jobs processing.

• Food Engineering Progress
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• v.15 no.4
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• pp.398-403
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• 2011

A dielectric barrier discharge plasma (DBDP) treatment system was fabricated and the optimum operating conditions for the plasma generation were determined in order to explore the potential of cold plasma as a non-thermal proessing technology. The microbial inactivation performance of the system was also evaluated against Staphyloocus aureus. The system consisted of power supply, transformer, electrode assembly and sample treatment plate. The input power was 220 V single phase AC and amplified to 10.0-50.0 kV on a transformer. A pulsed sine wave of frequency 10.0-50.0 kHz was introduced to the electrode embedded in ceramic as a dielectric barrier material in order to generate plasma at atmospheric pressure. Higher currents and consequently greater power were required for the plasma generation as the frequencies increased. A homogeneous and stable plasma was generated at currents of 1.0-2.0, and frequencies of 32.0-35.3 kHz. The optimum electrode-gaps for the plasma generation were 1.85 mm without loaded samples. More power was consumed as the electrode-gaps increased. The practically optimum electrode- gap was, however, 2.65 mm when samples were treated on slide-glasses for microbial inactivation. The maximum temperature increase after 10 min treatment was less than 20$^{\circ}C$, indicating no microbial inactivation effect by heat and thereby insuring a non-thermal method. The DBDP inactivation effect against Staphyloocus aureus increased linearly with treatment time up to 5 min, but plateaued afterward. More than 5 log reduction was achieved by 10 min treatment at 1.25 A.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.142-149
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• 2019

In this study, the past erosion history and current status in the CHUNG-UI beach of Eulwang-dong, Jung-gu, Incheon-Si, South Korea were investigated and analyzed the wave with wave-induced current to investigate the causes of coastal erosion. As a result, the significant wave height ($H_{1/3}$) was in the range of 0.07~1.57 m and the mean value was 0.21 m. The maximum wave height ($H_{max}$) was in the range of 0.02-4.76m and the mean value was 0.27m. The vertical wave height and cycles were estimated through numerical model experiments of wave transformation. The 50-year frequency design wave height ranged from 0.82m to 3.75m. As a result of the experiment of wave-induced current, wave-induced current in the CHUNG-UI beach was decreased after the installation of the Detached breakwater and the Jetty. On the other hand, when the crest elevation was increased up to 5 m, there was no significant change, but when the crest elevation was increased to 8m, strong wave-induced current occurred around the submerged breakwaters due to lowered depth of water. In addition, the main erosion of the CHUNG-UI beach is due to the intensive invasion of the wave characteristics coming from the outer sea into the white sandy beach. The deformation of the wave centered on the front of the sandy beach caused additional longshore currents flowing parallel to the sandy beach and rip currents in the transverse direction, thus confirming that the longshore sediment was moved out of the front and out of the sea. The results of this study can be used as preliminary data for the recovery of the sand and the selection of efficient erosion prevention facilities.

• 재활복지
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• v.22 no.1
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• pp.169-194
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• 2018

The aim of this study is to examine changes in swallowing function and quality of life with therapeutic singing-based music therapy for patients with dysphagia. The music therapy program was based on the previous study (Kim, 2010), and designed to improve breathing, phonation, and swallowing functions focusing on laryngeal elevation. Three patients with dysphagia participated in this study and each participant received a total of 11 or 12 individual music therapy sessions and each session was conducted for 30 minutes. In this study, three kinds of measurements were used. First, the measures of maximum phonation time (MPT), fundamental frequency, average intensity, jitter, shimmer, noise to harmonics ratio (NHR) by Praat test, second, laryngeal-diadochokinesis (L-DDK) to investigate laryngeal elevation, and last, the Swallowing-Quality of Life (SWAL-QOL) was measured. These cases have shown improved breathing, phonation, swallowing function, and the scores of SWAL-QOL in all of the patients. It suggests that this music therapy intervention was effective on laryngeal elevation, and the music intervention with therapeutic singing can be effectively implemented in further research for patients with dysphagia.

• Tribology and Lubricants
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• v.35 no.1
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• pp.44-51
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• 2019

The paper presents the rotordynamic performance measurements and model predictions of a fuel cell electric vehicle (FCEV) air compressor supported on gas foil bearings (GFBs). The rotor has an impeller on one end and a thrust runner on the other end. The front (impeller side) and rear (thrust side) gas foil journal bearings (GFJBs) are located between the impeller and thrust runner to support the radial loads, and a pair of gas foil thrust bearings are located on both sides of the thrust runner to support the axial loads. The test GFJBs have a partial arc shim foil installed between the top foil and bump strip layers to enhance hydrodynamic pressure generation. During the rotordynamic performance tests, two sets of orthogonally installed eddy-current displacement sensors measure the rotor radial motions at the rotor impeller and thrust ends. A series of speed-up and coast-down tests to 100k rpm demonstrates the dominant synchronous (1X) rotor responses to imbalance masses without noticeable subsynchronous motions, which indicates a rotordynamically stable rotor-GFB system. Finite element analysis of the rotor determines the rotor free-free (bending) natural modes and frequencies well beyond the maximum rotating frequency. The predicted damped natural frequencies and damping ratios of the rotor-GFB system reveal rotordynamic stability over the speeds of interest. The imbalance response predictions show that the predicted critical speeds and rotor amplitudes strongly agree with the test measurements, thus validating the developed rotordynamic model.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.6
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• pp.347-352
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• 2018

This study proposes seismic response analysis technique of a two-mass rack system which sustains heavy loads with frictional behavioral characteristics. In order to deal with the nonlinear frictional characteristics of the mass on the rack system, the equations of motion of the system has been derived and the appropriate numerical simulation technique has been developed. In order to examine the seismic performance of the proposed system, we consider two parameters that are expected to have great influence on the seismic performance of the system. One is the ratio of the two masses of the load and the rack structure, and the other is the friction coefficient between rack and loaded mass. A number of numerical simulations of the seismic response of structures with various natural frequencies for both parameters have been performed in order to investigate the seismic safety of the rack structures. From the simulated results. it is observed that the maximum displacement of the rack system tends to decrease drastically as the natural frequency of the structure increases regardless of the two parameters of mass ratio and friction coefficient. The proposed study provides important reference data to guarantee the seismic safety of the rack system by considering nonlinear frictional behavior of the loaded mass.

• Fire Science and Engineering
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• v.32 no.6
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• pp.34-39
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• 2018

In this paper, the architecture of a safe stove with an automatic fire suppression function using a sound wave fire extinguisher has been proposed and developed for the first time. A microcontroller connected to a fire sensor detects and suppresses a fire by driving a fire extinguisher. The sound wave fire extinguisher is composed of a speaker and collimator, and is driven by a driver module including an audio amplifier. The attenuation of the sound wave is reduced by preventing the sound diffusion with an enclosure surrounding a stove. The frequency of the sound wave is set to 50 Hz, and the sound pressure of 93 dBA is measured at the distance of 0.5 m. It takes maximum 8 and 15 seconds to suppress the flame from 7-cc and 14-cc flammable liquid, respectively, which corresponds to 24% and 42% of the natural extinguishing time. Since the proposed safe stove is non-toxic and leaves no residues over the conventional ones, it would combine with various home appliances to suppress early-stage fires and prevent fire expansion.

• Journal of IKEEE
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• v.22 no.4
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• pp.1006-1011
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• 2018

This paper proposes a three level buck converter utilizing multi-bit flying capacitor voltage control. The conventional three-level buck converter can not control the flying capacitor voltage, so that the operation is unstable or the circuit for controlling the flying capacitor voltage can not be applied to the PWM mode. Also when the load current is increased, an error occurs in the inductor voltage. The proposed structure can control the flying capacitor voltage in PWM mode by using differential difference amplifier and common mode feedback circuit. In addition, this paper proposes a 3bit flying capacitor voltage control circuit to optimize the operation of the three level buck converter depending on the load current, and a triangular wave generation circuit using the schmitt trigger circuit. The proposed 3-level buck converter is designed in $0.18{\mu}m$ CMOS process and has an input voltage range of 2.7V~3.6V and an output voltage range of 0.7V~2.4V. The operating frequency is 2MHz, the load current range is 30mA to 500mA, and the output voltage ripple is measured up to 32.5mV. The measurement results show a maximum power conversion efficiency of 85% at a load current of 130 mA.