• Molecules and Cells
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• 제38권7호
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• pp.604-609
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• 2015

The active metabolite of vitamin D such as $1{\alpha}$,25-dihydroxyvitamin ($D_3(1{\alpha},25(OH)_2D_3)$ is a well-known key regulatory factor in bone metabolism. However, little is known about the potential of vitamin D as an odontogenic inducer in human dental pulp cells (HDPCs) in vitro. The purpose of this study was to evaluate the effect of vitamin $D_3$ metabolite, $1{\alpha},25(OH)_2D_3$, on odontoblastic differentiation in HDPCs. HDPCs extracted from maxillary supernumerary incisors and third molars were directly cultured with $1{\alpha},25(OH)_2D_3$ in the absence of differentiation-inducing factors. Treatment of HDPCs with $1{\alpha},25(OH)_2D_3$ at a concentration of 10 nM or 100 nM significantly upregulated the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein1 (DMP1), the odontogenesis-related genes. Also, $1{\alpha},25(OH)_2D_3$ enhanced the alkaline phosphatase (ALP) activity and mineralization in HDPCs. In addition, $1{\alpha},25(OH)_2D_3$ induced activation of extracellular signal-regulated kinases (ERKs), whereas the ERK inhibitor U0126 ameliorated the upregulation of DSPP and DMP1 and reduced the mineralization enhanced by $1{\alpha},25(OH)_2D_3$. These results demonstrated that $1{\alpha},25(OH)_2D_3$ promoted odontoblastic differentiation of HDPCs via modulating ERK activation.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1982년도 제16차 학술대회연제순서 및 초록
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• pp.15.2-15
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• 1982

비강 및 부비동의 점막에서 발생하는 양성상피종양인 반전성 유두종은 비교적 드물며 1854년 Ward에 의해 처음으로 기술된 이래 여러 학자들에 의해 본증이 논의되어 왔으나 한국에서는 그 보고례가 매우 드물었다. 병리조직학적으로 양성인 이 종양은 비강이나 골 및 주위조직의 파괴성 병변이 빈번하고 수술 후 재발이 잘되고 드물게 악성으로 변하는 성질을 나타내므로 임상적으로 악성으로 알려져 왔다. 일단 반전성 유두종으로 확진되게 되면 가능한 한 광범위한 절제가 필요하며 술 후에도 계속적이 추적조사가 필요하다고 하겠다. 최근 저자들은 비폐색, 종류감을 주소로하여 내원한 48세된 남자환자에서 우측비강, 상악동에서 발생하여 국소적으로 악성화 변화를 일으킨 반전성 유두종 1례를 비내 및 Caldwell＿LUC식 방법으로 절제후 Bleomycin 정맥주사, 5＿FU 국소분무요법 및 방사선요법($Co^{60}$)을 병용하여 좋은 결과를 얻었기에 이를 문헌적 고찰과 함께 보고하는 바이다.

• 대한소아치과학회지
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• 제35권2호
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• pp.376-381
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• 2008

성장기 아동의 치열은 대부분 혼합 치열로, 이 시기에는 유치 탈락 또는 계승치 미맹출로 인해 치열에 빈 공간이 많아지고, 계승치가 맹출되었다 하더라도 고정성 장치를 부착시키고 강한 호선을 적용시키기는 매우 어렵다. 이런 치료 진행의 문제점을 해결하기 위해 horseshoe 장치가 유용하게 사용될 수 있다. 이 장치는 치열에 빈 공간이 있는지의 여부에 관계없이 장치 제작이 가능하며, 치열 상태와 무관하게 전 치열을 하나로 묶어준다. 그리고 구강내에 이미 맹출된 치아의 모든 치면을 피개하므로 치아의 정출과 회전이 발생하지 않으면서 악간 고무줄의 힘에 의해 치조골의 골개조가 상악과 하악 치궁에서 서로 반대 방향으로 유도된다. 경희대학교 치대병원 소아치과에 내원한 환아에서, Horseshoe Appliance를 이용하여 III급 부정교합에서 양호한 결과를 얻었기에 보고하는 바이다.

• 구강회복응용과학지
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• 제25권4호
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• pp.431-436
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• 2009

심한 치조골 흡수를 동반한 III급 악골 관계 환자의 총의치 제작의 경우 안정적이고 지속적인 교합을 제공하는 치료계획을 세워야 한다. 불리한 치관 대 치근 비와 임상적 동요도가 관찰되는 하악 잔존치를 고정하여 사용함으로써 환자의 불편감을 줄이고 시간적, 경제적으로 효율적인 치료를 제공할 수 있다. 본 증례에서는 상악 편악 무치악 환자의 기능적인 하악 운동과 조화로운 총의치 균형 교합을 이루기 위해 T-Scan System을 이용하였다.

• 대한치과교정학회지
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• 제23권2호
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• pp.165-177
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• 1993

Upper canine is important because it protects and maintains the stability of the dental arch and also, joins the anterior with the posterior teeth. The incidence of impaction of upper canine is the second most frequent next to the third molar because it takes a long period of time to develop, and has a complicated path of eruption, and erupts lately. After the age of 10, clinical and radioglaphic examination can be used in revealing the possibility of impaction and efforts should be put to reduce the side effects. To prevent impaction, selective extraction of primary canine at the age of 8 to 9 could be considered and prolonged retention of primary canine in oral cavity should be avoided at this time. Once the impaction is iden, the first stage of the treatment is to lcocalize the lesion by radiographic examination and According to the severity, orthodontic traction or autotransplantation should be considered and comprehensive diagnosis and treatment plan of malocclusion should be established. Generally, labial impaction is due to arch length discrepancy and palatal impaction is due to malposition or morphologic pathosis of lateral incisors rather than arch length discrepancy. In surgical procedure, peridontal problems should be considered and the minimum amount of bone and soft tissue should be reduced and direct bonding method of many attachment methods should be recommended. Especially in traction of labially impacted canine, it should be guided to erupt through the keratinized zone and proper forced magnitude should be applied. The importance of periodontal condition should always be in mind following the patient education to mintain the good oral hygiene at each stage of treatment. Properly managed impacted canine can provide function and esthetic by proper diagnosis and treatment if extraction of canine is not indicated.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.546-552
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• 2013

Background The zygoma is a major portion of the midfacial contour. When deformity occurs in this area, a reduction should be conducted to correct it. If a sagittal fracture at the temporal root of the zygomatic arch occurs, this also requires reduction, but it is difficult to approach due to its anatomical location, and the possibility of fixation is also limited. Thus, the authors attempted the reduction of sagittal fracture by two- or three-point fixation and the Gillies approach without direct manipulation. The preoperative and postoperative results of the patients were evaluated. Follow-up was performed to establish a treatment guideline. Methods A retrospective study was done with 40 patients who had sagittal fractures at the temporal root of the zygomatic arch from March 2009 to June 2012. Only two- or three-point fixation was performed for the accompanying zygomatic-orbital-maxillary fracture. The Gillies approach was used for complex fractures of the zygomatic arch, while the temporal root of the zygomatic arch was only observed without reduction. Preoperative and postoperative computed tomography and X-ray scans were performed to examine the results. Results The result of the paired t-test on preoperative and postoperative bone gap differences, the depression level, and the degree of temporal protrusion showed a marked decrease in the mean difference at a 95% confidence interval. The results were acceptable. Conclusions In the treatment of sagittal fractures at the temporal root of the zygomatic arch, it is acceptable to use indirect reduction and non-fixation methods. This leads to a satisfactory aesthetic and functional outcome.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권2호
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• pp.116-120
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• 2012

The buccal fat pad is specialized fat tissue located anterior to the masseter muscle and deep to the buccinator muscle. Possessing a central body and four processes it provides separation allowing gliding motion between muscles, protects the neurovascular bundles from injuries, and maintains facial convexity. Because of its many advantageous functions, the use of the buccal fat pad during oral and maxillofacial procedures is promoted for the reconstruction of defects secondary to tumor resection, and those defects resulting from oroantral fistula caused by dento-alveolar surgery or trauma. We used the pedicled buccal fat pad in the reconstruction of intraoral defects such as oroantral fistula, maxillary posterior bone loss, or defects resulting from tumor resection. Epithelization of the fat tissue began 1 week after the surgery and demonstrated stable healing without complications over a long-term period. Thus, we highly recommend the use of this procedure.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권3호
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• pp.170-175
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• 2009

Purpose : The purpose of this study is to evaluate 7-year survival rate of implants placed without bone graft in posterior maxilla and compare the survival rate by the age and gender of patient, length and diameter of implant, region of implant placement, bicortical engagement of fixture, and connection of prosthesis. Material and methods : 78 patients (170 implants) who visited our institution from 2002 to 2007 and were followed up with panoramic view and medical records. Kaplan-Meier survival analysis and Log Rank (Mantel-Cox) test were used. Results and conclusions : A 7-year cumulative survival rate for implants placed in posterior maxilla without sinus graft was 95.3%. The survival rate in men was 91.8%, significantly lower than 98.8% in woman.(p<0.05). However, the survival rate by the length of the implants did not show any significant differences.(p>0.05), while the wide platform implant resulted in 85% survival rate which was statistically lower than 98.5% in regular platform. The posterior maxillary implants engaged bicortically showed 97.6% of 7-year Survival rate, comparing 88.6% in not engaged implants. The survival rate of the single implant was 91.2%, while 98.5% in splinted prosthesis. Therefore, the bicortical engagement of the fixtures and splinted prosthesis may be recommended to get a long-term survival rate in posterior maxilla.

• 구강회복응용과학지
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• 제30권2호
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• pp.176-183
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• 2014

심하게 흡수된 치조제는 기능적인 하중을 견디기 어렵고 구강 조직의 유해 변화와 더불어 환자의 의치 적응을 어렵게 한다. 환자의 불편감을 해소하고 의치의 안정성과 유지력을 증가시키기 위해 임플란트를 이용한 피개의치가 치료 방법으로 선택될 수 있다. 로케이터 부착장치는 사용상의 편리성이 높으며 다양한 유지력을 갖는 남자부를 보유함으로써 임상에서 볼 형태 부착장치대용으로 많이 사용되고 있다. 본 증례는 77세 여자환자로서 낮은 수직고경과 심한 치조제 흡수를 보이는 상하악 무치악 상태였다. 이에 하악에 4개의 임플란트를 식립하고, 상악은 총의치, 하악은 로케이터 부착장치를 이용한 임플란트 피개의치로 수복하여 기능 및 심미적으로 만족할 만한 결과를 얻었기에 이를 보고하고자 한다.

• 대한치과교정학회지
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• 제34권2호
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• pp.153-163
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• 2004

II급 부정교합 치료 후 일어나는 재발에 영향을 미치는 요소를 알아보기 위하여 치료 후 결과가 안정하게 유지된 군과 재발이 일어난 군으로 구분하여 골격 및 치성요소를 비교하였다. 치료 전과 치료 후 측모 두부방사선사진을 이용하여 t-test와 상관분석을 시행한 결과 다음과 같은 결론을 얻었다. 1. 안정군과 재발군 간에 치료 전 골격 및 치성 관계는 대체로 차이가 없었다. 2. 안정군에서 하악골의 전방성장이 더 많이 일어났다. 3. 안정군에서의 하악 전치는 더 직립되었으며 상악전치는 설측 경사가 적은 경향을 보였다. 4. 재발군에서 교합평면이 전하방으로 경사되는 경향을 보였다.