• Journal of Advanced Information Technology and Convergence
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• v.9 no.1
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• pp.103-113
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• 2019

Motivation: Polymerized actin-based cytoskeletal structures are crucial in shape, dynamics, and resilience of a cell. For example, dynamical actin-containing ruffles are located at leading edges of cells and have a significant impact on cell motility. Other filamentous actin (F-actin) bundles, called stress fibers, are essential in cell attachment and detachment. For this reason, their mechanistic understanding provides crucial information to solve practical problems related to cell interactions with materials in tissue engineering. Detecting and counting actin-based structures in a cellular ensemble is a fundamental first step. In this research, we suggest a new method to characterize F-actin wrapping fibers from confocal fluorescence image stacks. As fluorescently labeled F-actin often envelope the fibers, we first propose to segment these fibers by diminishing an energy based on maximum flow and minimum cut algorithm. The actual actin is detected through the use of bilateral filtering followed by a thresholding step. Later, concave actin bundles are detected through a graph-based procedure that actually determines if the considered actin filament is enclosing the fiber.

• Journal of Ginseng Research
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• v.39 no.3
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• pp.206-212
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• 2015

Background: Ginseng total saponin (GTS) contains various ginsenosides. These ginsenosides are widely used for treating cardiovascular diseases in Asian communities. The aim of this study was to study the effects of GTS on cardiac injury after global ischemia and reperfusion (I/R) in isolated guinea pig hearts. Methods: Animals were subjected to normothermic ischemia for 60 minutes, followed by 120 minutes of reperfusion. GTS significantly increased aortic flow, coronary flow, and cardiac output. Moreover, GTS significantly increased left ventricular systolic pressure and the maximal rate of contraction ($+dP/dt_{max}$) and relaxation ($-dP/dt_{max}$). In addition, GTS has been shown to ameliorate electrocardiographic changes such as the QRS complex, QT interval, and RR interval. Results: GTS significantly suppressed the biochemical parameters (i.e., lactate dehydrogenase, creatine kinase-MB fraction, and cardiac troponin I levels) and normalized the oxidative stress markers (i.e., malondialdehyde, glutathione, and nitrite). In addition, GTS also markedly inhibits the expression of interleukin-$1{\beta}$ (IL-$1{\beta}$), IL-6, and nuclear factor-${\kappa}B$, and improves the expression of IL-10 in cardiac tissue. Conclusion: These data indicate that GTS mitigates myocardial damage by modulating the biochemical and oxidative stress related to cardiac I/R injury.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.283-289
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• 2013

This study was designed to evaluate the protective effect of Korean red ginseng (KRG) against ischemia/reperfusion (I/R) injury in isolated guinea pig heart. KRG has been shown to possess various ginsenosides, which are the major components of Panax ginseng. These components are known naturally occurring compounds with beneficial effects and free radical scavenging activity. The heart was induced to ischemia for 60 min, followed by 120 min reperfusion. The hearts were randomly allocated into five groups (n=8 for each group): normal control (N/C), KRG control, I/R control, 250 mg/kg KRG group and 500 mg/kg KRG group. KRG significantly increased hemodynamics parameters such as aortic flow, coronary flow and cardiac output. Moreover, KRG significantly increased left ventricular systolic pressure (LVSP), the maximal rate of contraction (+dP/$dt_{max}$) and maximal rate of relaxation (-dP/$dt_{max}$). Also, treatment of KRG ameliorated electrocardiographic index such as the QRS, QT and RR intervals. Moreover, KRG significantly suppressed the lactate dehydrogenase, creatine kinase-MB fraction and cardiac troponin I and ameliorated the oxidative stress markers such as malondialdehyde and glutathione. KRG was standardized through ultra performance liquid chromatograph analysis for its major ginsenosides. Taken together, KRG has been shown to prevent cardiac injury by normalizing the biochemical and oxidative stress.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.3
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• pp.147-152
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• 2020

The baseball elimination problem(BEP) is eliminates teams that finishes the season in the early stage without play the remaining games because of the team never most wins even though all wins of remaining games. This problem solved by max-flow/min-cut theorem. But the max-flow/min-cut method has a shortcoming of iterative constructs the network for all of team and decides the min-cut for each network. This paper suggests ascending sort in wins game plus remaining games for each team, then the candidate eliminating team set K with lower 1/2 rank and most easy, simple, and fast computes the existence or not of subset R that a team elimination decision. As a result of various experimental data, this algorithm can be find all of elimination teams for whole data with fast and correct.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.3
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• pp.1294-1298
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• 2014

Comparative analysis study of the flow characteristics and the experiment was done to try to present the orientation of the solenoid structure to be produced in the future. The comparative analysis of the analysis and experimental values was performed using the experiments and ANSYS CFD. 3D modeling of the structure are designed by the CATIA V5R18, meshing process of the flow section was used by ICEM CFD program. Flow rate was indicated by using the experimental values appear in $0-10{\ell}/min$, the result of the flow analysis, was $0.18{\ell}/min$ Max. It was possible to suggest a solenoid structure more efficient through comparative analysis of experimental values and flow analysis.

• Journal of The Korean Society of Integrative Medicine
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• v.2 no.3
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• pp.65-73
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• 2014

Purpose: The purpose of this study was to identify the effect of a kinesio tape on inspiratory muscle training(IMT) to improve muscle strength, endurance and pulmonary function. Methods: Healthy 20 males were divided into IMT group (control group) and IMT with tape group (experimental group). The same IMT program was applied to both groups using the Respifit S for four weeks, three times a week, a total 12 times. To exprimental group, kinesio tape was applied on the inspiratory agonist diaphragm and the accessory inspiratory muscle scalene, sternocleidomastoid, pectoralis minor. The inspiratory pulmonary muscle strength was measured by the maximal inspiratory pressure (PI max) and minute volume (MV) using the Respifit S and the pulmonary function were measured peak expiratory flow (PEF), forced vital capacity (FVC), forced expiratory volume in 1sec (FEV1), FEV1/FVC using the Spirometer and compared before and after. Results: Results showed that the PI max in the two groups increased significantly and experimental group increased more effectively than that of control group. However, only MV showed a significant increase in experimental group but was not significantly different between the two groups. PEF and FEV1/FVC are significantly increased in both groups, but they did not make much difference between two groups, and the FVC for the two groups did not increase significantly. FEV1 increased significantly only with control group, but did not make a difference with experimental group. Conclusion: These result show that the PI max value for experimental group increased significantly than that of control group. Therefore kinesio tape maximizes inspiratory muscle exercise effect on muscle strength improvement. However, because of the short experimental period and difficulty in subject control, increase values of the others did not show a significant difference. In other words, kinesio tape did not show maximizing the inspiratory muscle exercise effect to improve endurance and pulmonary function.

• YAKHAK HOEJI
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• v.41 no.6
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• pp.829-836
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• 1997

Studies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt ($[\pm}dP/dt_{max}$), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/$d_{max}$and -dP/$dt_{min}$ by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and $[\pm}dP/dt_{max}$, but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.

• YAKHAK HOEJI
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• v.36 no.3
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• pp.259-268
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• 1992

A procedure for the determination of KR-30075 and its metabolites in plasma and urine by high performance liquid chromatography is described. For the study of pharmacokinetic properties of KR-30075, a new PDE III inhibitor, the plasma concentration and urinary excretion after an oral administration of KR-30075 (4 mg/kg) in the male rat (Sprague Dawley) were determined by high performance liquid chromatography. The best extraction efficiency of KR-30075 and KR-30072 is obtained with ethyl ether adjusted to pH 4.0. Retention times of both KR-30072 and KR-30075 were within 5 min and resolution was complete at the flow rate of 1.0 ml/min. The sensitivity and specificity of this HPLC assay appears to be satisfactory for the pharmacokinetic study of KR-30075 and its metabolites. One-compartment open model with first-order absorption was applied to evaluate the pharmacokinetic parameters of KR-30075 according to Minimum AIC Estimation. $T_{max}$ was 1 hr, $C_{max}$ was $0.789{\pm}0.31\;{\mu}g/ml$ and elimination half $T_{1/2}$ was 6.31 min after oral administration of 4 mg/kg KR-30075 to male rats.

• Journal of the Korean Society of Clothing and Textiles
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• v.40 no.2
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• pp.305-314
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• 2016

This paper investigated the applicable possibility of PTT and wool staple fibers to the air vortex system as high quality yarns for a high emotional and comfort garment. It was found that the tactile hand of vortex yarn knitted fabrics was harsher than ring and compact yarns knitted fabrics. It was observed that formability and sewability of air vortex yarn knitted fabrics seemed worse than ring and compact yarns due to low tensile and compressional resilience and high bending and shear hysteresis of air vortex yarn knitted fabrics. It revealed that wicking and drying rates of air vortex yarn knitted fabric were better than ring and compact yarns; in addition, the heat keepability of vortex yarn knitted fabric was higher than ring and compact yarns due to low thermal conductivity and max heat flow rate ($Q_{max}$). Any difference of thermal shrinkage between air vortex and ring yarn knitted fabrics was not shown, but pilling characteristic of air vortex yarn knitted fabric was superior. However, it was shown that wicking, drying, thermal property and pilling characteristics of air vortex yarn knitted fabric were superior due to air vortex yarn structure with parallel fibers in the core part and periodical and fasciated twists in the sheath part of the yarns.

• Progress in Superconductivity
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• v.13 no.3
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• pp.169-177
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• 2012

Distribution of the local properties in GdBCO and YBCO coated conductors was investigated using Low-temperature Scanning Laser and Hall Probe Microscopy (LTSLHPM). We prepared GdBCO and YBCO coated conductors to study the spatial distribution of the current density in a single bridge. Inhomogeneity of the ${T_c}^{max}$ in the bridge was analyzed from experimental results of Scanning Laser Microscopy (SLM) near the superconducting transition. The local transport and screening current in the bridge were also investigated using Scanning Hall Probe Microscopy (SHPM). A series of line scans of SLM of the GdBCO and YBCO sample showed that lines with more inhomogeneous distributions of ${\delta}V$ had more inhomogeneous distributions of ${T_c}^{max}$. The defect of the superconducting layer of the GdBCO sample caused by damage to the substrate affected the current flow. And we could analyze the redistribution of the current density using SLM and SHPM.