약학회지 (YAKHAK HOEJI)
- 제36권3호
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- Pages.259-268
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- 1992
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
포스포디에스테라제 III의 저해물인 KR-30075의 흰쥐에서의 약물속도론
Pharmacokinetics of KR-30075, A Potent Phosphodiesterase III Inhibitor in Rats
- Lee, Kwang-Pyo (College of Parmacy, Chung Ang University) ;
- Kim, Hyo-Jin (College of Pharmacy, Dong Duck Women's University) ;
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Kwon, Kwang-Il
(College of Pharmacy, Chung Nam University) ;
- Cho, Song-Ja (Department of Pharmacy, Korea University Hospital)
- 발행 : 1992.06.29
초록
A procedure for the determination of KR-30075 and its metabolites in plasma and urine by high performance liquid chromatography is described. For the study of pharmacokinetic properties of KR-30075, a new PDE III inhibitor, the plasma concentration and urinary excretion after an oral administration of KR-30075 (4 mg/kg) in the male rat (Sprague Dawley) were determined by high performance liquid chromatography. The best extraction efficiency of KR-30075 and KR-30072 is obtained with ethyl ether adjusted to pH 4.0. Retention times of both KR-30072 and KR-30075 were within 5 min and resolution was complete at the flow rate of 1.0 ml/min. The sensitivity and specificity of this HPLC assay appears to be satisfactory for the pharmacokinetic study of KR-30075 and its metabolites. One-compartment open model with first-order absorption was applied to evaluate the pharmacokinetic parameters of KR-30075 according to Minimum AIC Estimation.
키워드