• Proceedings of the Korean Vacuum Society Conference
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.139.2-139.2
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• 2013

6" Multi-crystal Silicon wafer has etched suing a remote - type RF Dielectric barrier discharge (RF DBD) at atmospheric pressure. DBD source is composed of Al electrode and coated Al2O3 dielectric as function of Ar/NF3 gas combination and input power used 13.56 MHz power supply. Ar gas flow rate is changed from 2 to 10 Slm, and NF3 flow rate is changed from 0.2~1 slm. At the result, NF3 flow rate Si etching rate also increase whit the increasing of NF3 flow rate But at 2 slm etching rate was decrease. In this experience, Max etching rate is 2.3 ${\mu}m/min$ when the scan time is 45 sec.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.119-125
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• 2002

A rapid, selective and reproducible high-performance liquid chromatographic method has been developed for the determination of terazocin in human plasma. Terazocin plus the internal standard, prazocin hydrochloride, were extracted from alkalified plasma with tert-butylmethyl ether, back-extracted into 0.05% phosphoric acid. Fifty ${\mu}l-portions$ of extract were injected onto a octadecylsilane column and eluted with a mixture of acetonitrile, water and triethylamine (30 : 70 : 0.1 v/v, adjusted to pH 5.0 with dilute phosphoric acid) at a flow rate of 1.0 ml/min. The fluorescence intensity of column eluents was monitored at excitation wavelength of 250 nm and emission wavelength of 370 nm. No interference peaks were observed. The practical limit of quantitation was 5 ng/ml for terazocin. The average intraday and interday coefficients of variation were 4.15 and 3.54%, respectively. Also intraday and interday precisions over the range $5{\sim}60\;ng/ml$ were $0.49{\sim}2.92\;and\;0.38{\sim}5.12%$, respectively. The bioequivalence of two terazosin tablets, the $Hytrine^{\circledR}$ (Il Yang Pharmaceutical Co., Ltd.) and the $Teratonin^{\circledR}$ (Sam-A Pharmaceutical Co., Ltd.), was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers $(24.6{\pm}2.0\;years\;old)$ were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 2 mg of terazosin was orally administered, blood was taken at predetermined time intervals and the concentration of terazosin in plasma was determined with a HPLC method using spectrofluorometric detector. AUC was calculated by the linear trapezoidal method. $C_{max}\;and\;T_{max}$ were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between the two preparations were 0.21 %, 5.53% and 8.82%, respectively. The powers $(1-{\beta})\;for\;AUC_t,\;C_{max}\;and\;T_{max}$ were >99%, 97.49%, and 33.26%, respectively. Minimum detectable differences $({\Delta},\;%)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ and the 90% confidence intervals were all less than ${\pm}20%$ except for $T_{max}.\;AUC_t\;and\;C_{max}$ met the criteria of KDFA for bioequivalence, indicating that $Teratonin^{circledR}$ tablets are bioequivalent to $Hytrine^{circledR}$ tablets.

• Journal of Korean Institute of Industrial Engineers
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• 제37권4호
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• pp.367-381
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• 2011

Reducing waste for the efficiency of production is becoming more important because of the rapidly changing market circumstances and the rising material and oil prices. The dispatching also has to consider the characteristic of production circumstance for the efficiency. The production circumstance has the non-identical parallel machines with rework rate since machines have different capabilities and deterioration levels in the real manufacturing field. This paper proposes a dispatching method, FTLR (Flow Time Loss Index with Rework Rate) for production efficiency. The goal of FTLR is to minimize flow time based on such production environments. FTLR predicts the flow time with rework rate. After assessing dominant position of expected flow time per each machine, FTLR performs dispatching to minimize flow time. Experiments compare various dispatch methods for evaluating FTLR with mean flow time, mean tardiness and max tardiness in queue.

• Proceedings of the KSME Conference
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• 대한기계학회 2000년도 추계학술대회논문집B
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• pp.568-572
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• 2000

A numerical investigation was performed to determine the effect of airfoil thickness on the optimum Gurney flap height using NACA 00XX series airfoils. Seven airfoils which have 3% chord thickness difference were used. These were NACA 0006, 0009, 0012, 0015, 0018, 0021, and 0024. A Navier-Stokes code, FLUENT, was used to calculate the flow field about airfoil. The fully turbulent results were obtained using the standard $k-{\varepsilon}$ two-equation turbulence model. To provide a check case fur our computational method, numerical studies for NACA 4412 airfoil were made and compared with already existing experimental data for this airfoil by Wadcock. For every NACA 00XX airfoil, Gurney flap heights ranging from 0.5% to 2.0% chord were changed by 0.5% chord interval and their effects were studied. With the numerical solutions, the relationship between $(L/D)_{max}$ and airfoil thickness as a function of flap height and the relationship between $(L/D)_{max}$ and flap height as a function of airfoil thickness were investigated. The same relationship for $(C_l)_{max}$ also were shown. From these results, the optimum flap size for each airfoil thickness can be determined and vice versa.

• Natural Product Sciences
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• 제12권2호
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• pp.109-112
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• 2006

The chloroform-soluble fraction of the vinegar treated small black soybean [Glycine max (Leguminosae)] showed antiproliferative activity against human myeloid leukemia HL-60 cells, in terms of inhibition of proliferation and induction of apoptosis. Bioassay-guided chromatography of the chloroform-soluble fraction resulted in the isolation of two isoflavonoid compounds, genistein and daidzein, as active principles. Genistein showed more potent antiproliferative effects against HL-60 cells. Treatment of HL-60 cells with genistein induced apoptosis in a dose dependent manner. Apoptosis was judged by the detection of DNA fragmentation by a flow cytometry and the degree of apoptosis was assayed by RT-PCR.

• Journal of The Korea Institute of Healthcare Architecture
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• 제16권2호
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• pp.37-45
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• 2010

This study is the analysis of characteristics of hospital space for the holistic healing environment of children on the basis of the healing theory on emotion of Max L$\ddot{u}$scher and the healing theory on senses of Rudolf Steiner of the overseas children's hospitals. According to the theory of Rudolf Steiner, children make comprehensive advancement of physical, spirit and soul through the interaction of 12 senses. In addition, Max Luscher asserts that the psychological health can be maintained when the 4 emotional status in content, confidence, self-esteem and liberty make the balance. The 4 elements of Luscher have correspond with spatial expression elements for refuge, flow, prospect and void, and this is analyzed in conjunction with the eight kinds of behavior affordance of ying and yang (-, +) that helps our the advancement of 12 senses of Steiner. WORK & STUDY(+), REST(-), MOBILITY(+), VISUAL SEQUENCE(-), SOCIAL EXCHANGE(+), REFRESHMENT(-), COMMUNITY(+) and MEDITATION (-) would be the 8 kinds of behavioral affordances to make the healing environment as presented in this study and the case analysis for children's hospitals have been undertaken.

• Journal of Life Science
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• 제20권3호
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• pp.437-443
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• 2010

This study was designed to examine the aerobic capacity and ventilatory response during an incremental exercise in elite high school cyclists. Twelve boys ($17{\pm}1\;yr$, $175{\pm}5\;cm$, $70{\pm}9\;kg$) participated in anthropometric measurements, incremental exercise testing, and pulmonary function tests. During incremental exercise testing using a cycle ergometer, their maximal oxygen uptake ($VO_2max$), maximal power output, ventilation, ventilatory equivalents for oxygen ($V_E/VO_2$) and carbon dioxide ($V_E/VCO_2$), respiratory rate, and tidal volume were measured. Time variables such as inspiratory time (Ti), expiratory time (Te), breathing time (Tb), and inspiratory duty cycle (Ti/Tb), as well as inspiratory flow rate ($V_T$/Ti) were assessed. Pulmonary function of vital capacity (FVC), forced expiratory volume in one second ($FEV_1$), $FEV_1$/FVC, and peak expiratory flow were evaluated. Their $VO_2max$, maximal heart rate, and Wmax were $57.5{\pm}3.9\;ml{\cdot}kg^{-1}{\cdot}min^{-1}$, $194.1{\pm}8.6\;beat{\cdot}min^{-1}$, and 452 W, respectively. $VO_2max$ was not related to any anthropometric parameters. Most ventilatory variables progressively increased with exercise intensity. As intensity increased, Ti, Tb, Tb decreased while Ti/Tb was maintained. Below an intensity of 250 W, height, weight, body mass index, and body surface were highly correlated with $V_T$/Ti and Ti/Tb (p<0.05). Collectively, $VO_2max$ appeared to be lower than adult cyclists, suggesting a different pattern of ventilatory control as age advances. Morphological characteristics were not related to $VO_2max$ in the population. Time variables of ventilatory response seemed to be related only at an exercise intensity level of less than 250 W. $V_T$/Ti may be related to exercise endurance capacity, but Ti/Tb was similar to adult cyclists.

• Journal of The Korean Astronomical Society
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• 제29권spc1호
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• pp.271-272
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• 1996

Assuming that particles can be accelerated to high energies via diffusive shock acceleration process at the accretion shocks formed by the infalling flow toward the clusters of galaxies, we have calculated the expected spectrum of high-energy protons from the cosmological ensemble of the cluster accretion shocks. The model with Jokipii diffusion limit could explain the observed cosmic ray spectrum near $10^{19}eV$ with reasonable parameters and models if about $10^{-4}$ of the infalling kinetic energy can be injected into the intergalactic space as the high energy particles.

• International Journal of Contents
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• 제6권3호
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• pp.83-88
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• 2010

Aerobic exercise affects cerebral circulation, action of neurotransmitters, glucose, oxygen, and energetic substances and influence on the central nervous system for cognition. This study suggests that both the intensity of exercise and the level of cognitive task need to be considered. Computerized neurobehavioral testing is a more effective method, compared to conventional methods, of neuropsychological testing when measuring cognition objectively, in cases that we found. The intensity of 80% max HR had effect on more complex tasks such as 3 Digit Addition and Digit Span Backward, and the intensity of 65% max HR had an effect on more simple tasks such as Color Word Vigilance and Digit Span Forward. We can assume that different intensity of aerobic exercise might involve specific areas of the brain as they could have different sensitivities, so further studies measuring regional cerebral blood flow or electroencephalogram are needed to confirm the results.

• Journal of Pharmaceutical Investigation
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• 제40권2호
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• pp.117-123
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• 2010

Ibudilast, 3-isobutyryl-2-isopropyrazolo[1,5-a]pyridine, is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE). It preferentially inhibits PDE 3A, PDE4, PDE10 and PDE11 as well as a number of the other PDE families, albeit to a lesser extent. Ibudilast is used clinically to treat bronchial asthma and cerebrovascular disorders. Thes e clinical uses are based on the ability of ibudilast to inhibit platelet aggregation, improve cerebral blood flow and attenuate allergic reactions. The purpose of the present study was to evaluate the bioequivalence of two ibudilast capsules, Ketas capsule (Handok Pharmaceuticals Co., Ltd.) and Pinatos capsule (Sam Chun Dang Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The in vitro release of ibudilast from the two ibudilast formulations was tested using KP Apparatus method with various dissolution media. Twenty six healthy male subjects, 23.31${\pm}$1.09 years in age and 70.45${\pm}$8.51 kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After a single capsule containing 10 mg as ibudilast was orally administered, blood samples were taken at predetermined time intervals and the concentrations of ibudilast in serum were determined using HPLC/UV detector. The dissolution profiles of two formulations were similar in all tested dissolution media. The pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated, and computer programs (Equiv Test and K-BE Test 2002) were utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, Ketas, were 6.99%, -2.48% and 9.93% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.8791~log 1.1861 and log 0.8347~log 1.1199 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Pinatos capsule was bioequivalent to Ketas capsule.