[KSCI] Korea Science Citation Index Service

Antiproliferative Constituents from the Vinegar Treated Small Black Soybean (Glycine max Merr.)

Oh, Chan-Ho (Dept. of Food Biotechnology, Woosuk University)
Kim, Eun-Jeong (College of Pharmacy, Woosuk University)
Lee, Kyu-Hee (Dept. of Food Biotechnology, Woosuk University)
Moon, Mi-Kyeong (College of Pharmacy, Woosuk University)
Cho, Moon-Gu (Dept. of Food Biotechnology, Woosuk University)
Kim, Jong-Hwa (Dept. of Pharmaceutical Engineering, Woosuk University)
Oh, Suk-Heung (Dept. of Food Biotechnology, Woosuk University)
Lee, Tae-Kyoo (Dept. of Food Industry & Management, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (Dept. of Food Biotechnology, Woosuk University)

Publication Information

Natural Product Sciences / v.12, no.2, 2006 , pp. 109-112 More about this Journal

Abstract

The chloroform-soluble fraction of the vinegar treated small black soybean [Glycine max (Leguminosae)] showed antiproliferative activity against human myeloid leukemia HL-60 cells, in terms of inhibition of proliferation and induction of apoptosis. Bioassay-guided chromatography of the chloroform-soluble fraction resulted in the isolation of two isoflavonoid compounds, genistein and daidzein, as active principles. Genistein showed more potent antiproliferative effects against HL-60 cells. Treatment of HL-60 cells with genistein induced apoptosis in a dose dependent manner. Apoptosis was judged by the detection of DNA fragmentation by a flow cytometry and the degree of apoptosis was assayed by RT-PCR.

Keywords

Glycine max; antiproliferative activity; genistein;

Citations & Related Records

Times Cited By SCOPUS : 0

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