• Archives of Pharmacal Research
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• 제13권2호
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• pp.180-186
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• 1990

A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak ($C_{max1}$) of the two preparations was proven to be equal when analyzed satistically according to the criteria of the guidline;i. e., statistical power (1-$\beta$)was calculated to be over 0.8 under the condition of $\alpha$ = 5% and $\Delta$(minimum detectable difference) = 20%, and the confidence interval of the difference in AUC at 95% confidence level was in the range of $\pm$ 20%, which statisfied the criteria of bioequivalence. Equivalence of the peak concentration of ranitidine at the second peak ($C_{max2}$), and the time to reach the first ($T_{max1}$) and second verify the bioequivalence of $c_{max2}$ , $T_{max1}$ and $T_{max2}$ between the two tablets. However, we conclude that the test and reference tablets are bioequivalent taking the therapeutic characteristics of the ranitidine preparations into consideration.

• Archives of Pharmacal Research
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• 제18권4호
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• pp.237-242
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• 1995

For the vioequivalence study of two ceftriaxone injection formulations ($Rocephin{\circledR}$ ; Roche, and Triaxone ; Hanmi0, the HPLC analytical method for the analysis of ceftriaxone in plasma was used. Fourteen healthy volunteers completed the study and each subject were IM in jected signle doses (1 g) of the test and the reference formulations in a two-way crossover design with an one week drug free interval between doses. Following each administration, plasma concentrations of ceftrixone were monitored over a period of 24 h. Bioequivalence parameters $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT determined from the data obtained for the two formulations were examined by analyses of variance (ANOVA) and other criteria and tests for bioequivalence. Results of ANOVA and confidence limits of test/reference ratios of $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\pm}20%$) except for $T_{max}$ The mean of $T_{max}$ showed only 6. 9% difference from the reference but the detection limit was 22.5% which is slightly over the 20% criteria. No pharmacokinetic parameters including Ka, Kel, Vd and Cl indicated significant difference in between the two fomulations. It was concluded that the data yielded fro the two cefriaxone formulations demonstrated that they were bioequivalent.

• 대한의용생체공학회:의공학회지
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• 제16권3호
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• pp.271-278
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• 1995

An ECG data compression algorithM using max-min slope update is proposed and a real time 3 channel ECG transmission system is implemented using the proposed algorithm. In order to effectively compress ECG data, we compare a threshold value with the max-min slope difference (MMSD) which is updated at each sample values. If this MMSD value is smaller than the threshold value, then the data is compressed. Conversely, when the MMSD value is larger than threshold value, the data is transmitted after storing the value and the length between the data which is beyond previous threshold level. As a result, it can accurately compress both the region of QRS, P, and T wave that has fast-changing and the region of the base line that slope is changing slow. Therefore, it Is possible to enhance the compression rate and the percent roms difference. In addition, because of the simplicity, this algorithm is more suitable for real-time implementation.

• 대한물리의학회지
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• 제9권4호
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• pp.339-345
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• 2014

PURPOSE: This study is to investigate the effect of 4 weeks of gym ball exercise on the pelvis and spine of women in 20s. METHODS: Randomly selected 10 of 20 subjects are allocated to experimental group who will practice gym-ball exercise while the rest 10 subjects are allocated to control group. Values for pelvic obliquity DL-DR, pelvic torsion DL-DR, pelvic rotation, kyphotic angle ICT-ITL (max), and lordotic angle ITL-ILS (max) were measured through recording using 3-dimensional image analyzer as a preliminary inspection. Gym-ball exercise was implemented 3 sessions a week for 4 weeks. Each session consisted of 10 minutes of warm up exercise, 30 minutes of main exercise, and 10 minutes of cool down exercise totaling 50 minutes. Post inspections were measured after exercise. RESULTS: Experimental group showed statistically significant difference in pelvic obliquity DL-DR, pelvic torsion DL-DR, and kyphotic angle ICT-ITL (max) (p<.05) and values of pelvic obliquity DL-DR showed statistically significant difference between two groups (p<.05). However pelvic rotation, lordotic angle ITL-ILS (max) did not show a significant difference. CONCLUSION: These results showed that gym-ball exercise has positive effect in the pelvic obliquity, torsion and spine kyphotic angle and expected to have positive effect on the body balance, body lineup, and coordination.

• 한국융합학회논문지
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• 제11권7호
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• pp.289-295
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• 2020

아름다움을 추구하려는 외모의 중대성이 부각됨에 따라 모발 염색을 포함한 미용 산업의 시장규모도 점점 커지고 있다. 헤어살롱에서 보편적으로 사용되는 산화염모제를 지속적으로 시술할 경우 모발 손상은 피할 수 없게 되므로 중명도 산화염모제를 시술한 모발의 형태학적 변화에 관하여 연구하였다. 실험결과 control과 6N-7N 실험군 간에 Max. load, Max. stress, Max. elongation, Break load, Break stress, Break elongation, strain 구간에 따른 Max. modulus 및 Tangential modulus는 유의적인 차이를 보였다. Max. load, Max. stress, Max. elongation, Break load, Break stress 및 Break elongation은 모두 대조군이 가장 높은 값으로 나타났으며, 실험군의 처리에 따른 유의적으로 감소하는 경향은 보이지 않았다. strain 평가구간에 따른 Max. modulus와 Tangential modulus는 대조군과 실험군 간에 차이가 있음에도 일정하게 증가하거나 감소하는 경향이 뚜렷하게 나타나지 않았다. 본 연구를 통해 모발손상을 최소화하는 산화염모제 개발 연구의 기초자료 제공 및 헤어디자이너들의 산화염모제와 모발 건강과의 상관관계 이해를 위한 초석을 다지고자 한다.

• 대한치과기공학회지
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• 제33권4호
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• pp.313-321
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• 2011

Purpose: The purpose of this study was to compare color parameters of different fabrication method of Lava ceram powder, Lava DVS blocks, IPS e.max ceram and IPS e.max zirpress. Methods: The three available shades(A1, A2, A3.5) of Lava & Kavo zirconia blocks were examined. For each of three colors, three different thickness were tested, 5 times of measurement frequency. The measurements were made using a spectrophotometer equipped with an integrating sphere using the CIE $L^*$, $a^*$, $b^*$ colorimetric system. Results: Lava build-up group and Lava DVS group showed clinically perceived color difference, on the other hand IPS e.max build-up group and IPS e.max zirpress group did not show clinically perceived color difference to shade allowed on core. When the thickness of porcelain veneer increased from Lava and IPS e.max groups, color differences(${\Delta}E$) were decreased. Conclusion: All-ceramic system has color characteristics that clinicians have to consider when selecting materials. Also, manufacturers of different porcelain systems must make every effort to achieve color reproducibility.

• Journal of Pharmaceutical Investigation
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• 제29권2호
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• pp.145-149
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• 1999

Bioequivalence of two cefixime capsules, test drug ($Cepirin^R$ capsule: Cheiljedang Corp.) and reference drug ($Suprax^R$ capsule: Dong A Pharm. Com.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 400 mg as cefixime in a $2{\times}2$ crossover study. There was a 1-week washout period between the administrations. Blood samples were taken at predetermined time intervals for 12 hour and the plasma concentration of cefixime was determined with a HPLC method. $AUC_{0-12hr}$ (area under the plasma concentration-time curve form time zero to 12 hour), $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were estimated from the plasma drug concentrationtime data. Analysis of variance (ANOVA) revealed no difference in $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences of these parameters between the formulations were less than 20% (i.e., 8.62, 11.10 and 0.00% for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$,respectively). The powers $(1-{\beta})$ for $AUC_{0-12hr}$ $C_{max}$ and $T_{max}$ were over 0.9. Minimal detectable difference $({\Delta})$ at ${\alpha}=0.05$, $1-{\beta}=0.8$ were less than 20% (i.e., 12.84, 11.05 and 17.99% for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals $({\delta})$ for these parameters were also within ${\pm}20%$ (i.e., $-0.53{\le}{\delta}{\le}17.76$, $3.23{\le}{\delta}{\le}18.97$ and $-12.81{\le}{\delta}{\le}12.81$ for $AUC_{0-12hr}$, $C_{max}$ and $T_{max}$, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating the two formulations of cefixime were bioequivlent.

• 대한치과보철학회지
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• 제47권1호
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• pp.21-28
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• 2009

연구목적: 2종의 열가압 도재 (e.max Press, Empress Esthetic)와 법랑질 간의 마모양상을 알아보기 위하여 장석계 도재 및 제 3형 금합금과 비교, 관찰하였다. 연구 재료 및 방법: 열가압 도재 e.max Press, Empress Esthetic 및 금속도재관 제작용 장석계 도재 Cermaco 3, 제 3형 금합금으로 원반형 시편을 제작하고, 상대 마모재로는 발거된 건전한 소구치의 교두를 이용하여 Pin-on-disk tribometer 상에서 마모시험 하였다. 법랑질의 마모량은 마모 전후 치아 시편의 무게 변화를 측정하여 부피로 환산하였고, 도재 및 금합금 시편의 평균 표면 조도와 마모트랙 깊이를 표면조도기로, 마모트랙 폭을 주사전자현미경으로 측정하여 마모 양상을 비교하였다. 결과: 1. 법랑질의 마모량은 Ceramco 3군에서 가장 크고 Empress Esthetic군, e.max Press군, 금합금군 순으로 작았으며, Ceramco 3군과 Empress Esthetic군 사이와, Empress Esthetic군, e.max Press군 및 금합금군 사이에는 유의한 차이가 없었다 (P>.05). 2. 마모시험 후 도재 시편의 평균 표면 조도는 Ceramco 3군, Empress Esthetic군, e.max Press군 순으로 작았으며, Empress Esthetic군과 Ceramco 3군 사이에는 유의한 차이가 없었다 (P>.05). 3. 마모트랙의 깊이는 모든 군 사이에 유의한 차이는 없었고 (P>.05), 마모트랙의 폭은 법랑질 마모량 순서와 동일하게 Ceramco 3군, Empress Esthetic군, e.max Press군, 금합금군 순으로 작았으며, e.max Press군과 Empress Esthetic군 사이 및 Empress Esthetic군과 Ceramco 3군 사이에 유의한 차이는 없었다 (P>.05). 결론: 열가압 도재는 장석계 도재보다 법랑질을 더 마모시키지는 않았다.

• 제어로봇시스템학회논문지
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• 제18권4호
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• pp.375-383
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• 2012

Together with the GPS-based approach, geolocation through mobile communication networks is a key technology for location-based service. Since the Mobile WiMAX system is considered as a candidate for fourth-generation mobile systems, it is important to investigate its location capability. The geolocation of Mobile WiMAX can be realized when the preamble symbols in the down-link channel are appropriately used for a TDOA (Time-Difference-of-Arrival) approach. However, the cellular structure of Mobile WiMAX inevitably generates co-channel interference, and it is difficult for the mobile terminal to acquire distance measurements from multiple base stations. Therefore, for geolocation via multilateration using the Mobile WiMAX network, it is very important to increase hearability. This paper proposes a geolocation method for Mobile WiMAX which employs interference cancellation and preamble signal overlapping for the enhancement of hearability. A novel interference cancellation strategy for complex-valued Mobile WiMAX signals is presented which has an iterative structure. Simulation results show that the proposed geolocation method provides the user's position with an accuracy of less than 20 m through the Mobile WiMAX cellular network if there is no multi-path or NLOS (None-Line-of-Sight).

• 한국지능시스템학회논문지
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• 제14권6호
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• pp.776-782
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• 2004

Generally, Max-Min CRI (Compositional Rule of Inference ) method by Zadeh and Mamdani is used in the conventional fuzzy inference. However, owing to the problems of Max-Min CRI method, the inference often results in significant error regions specifying the difference between the desired outputs and the inferred outputs. In this paper, I propose a New Max-Min CRI method which can solve some problems of the conventional Max-Min CRI method. And then this method is simulated in a D.C.series motor, which is a bench marking system in control systems, and showed that the new method performs better than the other fuzzy inference methods.