• 제목/요약/키워드: Matrix laboratory

검색결과 752건 처리시간 0.032초

Targeting Cell-Cell and Cell-Matrix Interactions and Its Therapeutic Applications

  • Kim, In-San
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
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    • pp.100-101
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    • 2003
  • Cell-cell and cell-matrix interaction is clearly required for metazoans not only to hold their cells together but also to conduct more sophisticated biological processes. Each cell has adhesion molecules on its cell membrane to link extracellular matrix and adjacent cells to the intracellular cytoskeleton, and also to transduce signals. In complex metazoans, information is transmitted from one cell to another by mechanisms such as direct intercellular communication, soluble signal molecules among distant cells, and local cellular environments formed by highly specialized extracellular matrix. (omitted)

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Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion

  • de Moraes, Izadora Quintela Souza;do Nascimento, Ticiano Gomes;da Silva, Antonio Thomas;de Lira, Lilian Maria Santos Silva;Parolia, Abhishek;de Moraes Porto, Isabel Cristina Celerino
    • Restorative Dentistry and Endodontics
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    • 제45권3호
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    • pp.31.1-31.20
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    • 2020
  • Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were "matrix metalloproteinases", "collagen", and "dentin" and "hybrid layer". MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

Minimum Distance based Precoder Design for General MIMO Systems using Gram Matrix

  • Chen, Zhiyong;Xu, Xiaodong
    • Journal of Communications and Networks
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    • 제17권6호
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    • pp.634-646
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    • 2015
  • Assuming perfect channel state information (CSI) at the transmitter and receiver, the optimization problem of maximizing the minimum Euclidean distance between two received signals by a linear precoder is considered for multiple-input multiple-output (MIMO) systems with arbitrary dimensions and arbitraryary quadrature amplitude modulation (QAM) input. A general precoding framework is first presented based on the Gram matrix, which is shown for 2-dimensional (2-D) and 3-dimensional (3-D) MIMO systems when employing the ellipse expanding method (EEM). An extended precoder for high-dimensional MIMO system is proposed following the precoding framework, where the Gram matrix for high-dimensional precoding matrix can be generated through those chosen from 2-D and 3-D results in association with a permutation matrix. A complexity-reduced maximum likelihood detector is also obtained according to the special structure of the proposed precoder. The analytical and numerical results indicate that the proposed precoder outperforms the other precoding schemes in terms of both minimum distance and bit error rate (BER).

A fast precise integration method for structural dynamics problems

  • Gao, Q.;Wu, F.;Zhang, H.W.;Zhong, W.X.;Howson, W.P.;Williams, F.W.
    • Structural Engineering and Mechanics
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    • 제43권1호
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    • pp.1-13
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    • 2012
  • A fast precise integration method (FPIM) is proposed for solving structural dynamics problems. It is based on the original precise integration method (PIM) that utilizes the sparse nature of the system matrices and especially the physical features found in structural dynamics problems. A physical interpretation of the matrix exponential is given, which leads to an efficient algorithm for both its evaluation and subsequently the solution of large-scale structural dynamics problems. The proposed algorithm is accurate, efficient and requires less computer storage than previous techniques.

Factors Affecting the Rate of Release of 5-Fluorouracil from Ethylene-Vinyl Acetate Matrices

  • Oh, Seaung-Youl;Chung, Hee-Won;Cho, Sun-Hang;Lee, Hai-Bang
    • Journal of Pharmaceutical Investigation
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    • 제24권3호spc1호
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    • pp.33-39
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    • 1994
  • We have studied the effect of loading amount and particle size on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) matrix. Release rate increased as the loading amount and particle size increase. We also studied the effect of additives (lactose and algin) on the rate of release of 5-FU. Both algin and lactose promoted the rate of release. The ability to increase the rate is in the order of algin>lactose>5-FU. Scanning electron microscope study clearly shows that large cavities and cracks are created. The results imply that, by the proper combinations of the amount of the additive, $EVA_c$ and drug, the rate of drug release can be modulated over a wide range of values.

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Interference Management with Block Diagonalization for Macro/Femto Coexisting Networks

  • Jang, Uk;Cho, Kee-Seong;Ryu, Won;Lee, Ho-Jin
    • ETRI Journal
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    • 제34권3호
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    • pp.297-307
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    • 2012
  • A femtocell is a small cellular base station, typically designed for use in a home or small business. The random deployment of a femtocell has a critical effect on the performance of a macrocell network due to co-channel interference. Utilizing the advantage of a multiple-input multiple-output system, each femto base station (FBS) is able to form a cluster and generates a precoding matrix, which is a modified version of conventional single-cell block diagonalization, in a cooperative manner. Since interference from clustered-FBSs located at the nearby macro user equipment (MUE) is the dominant interference contributor to the coexisting networks, each cluster generates a precoding matrix considering the effects of interference on nearby MUEs. Through simulation, we verify that the proposed algorithm shows better performance respective to both MUE and femto user equipment, in terms of capacity.

DIRECTED STRONGLY REGULAR GRAPHS AND THEIR CODES

  • Alahmadi, Adel;Alkenani, Ahmad;Kim, Jon-Lark;Shi, Minjia;Sole, Patrick
    • 대한수학회보
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    • 제54권2호
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    • pp.497-505
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    • 2017
  • The rank over a finite field of the adjacency matrix of a directed strongly regular graph is studied, with some applications to the construction of linear codes. Three techniques are used: code orthogonality, adjacency matrix determinant, and adjacency matrix spectrum.

매트릭스컨버터와 이중여자유도발전기를 사용한 풍력발전시스템 (Wind Power System using Doubly-Fed Induction Generator and Matrix Converter)

  • 이동근;권기현;한병문;리위룽;최남섭;최영도
    • 전기학회논문지
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    • 제57권6호
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    • pp.985-993
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    • 2008
  • This paper proposes a new DFIG(Doubly-Fed Induction Generator) system using matrix converter, which is very effectively used for interconnecting the wind power system to the power grid. The operation of proposed system was verified by computer simulations with PSCAD/EMTDC software. The feasibility of hardware implementation was conformed by experimental works with a laboratory scaled-model of wind power system. The laboratory scaled-model was built using a motor-generator set with vector drive system, and a matrix converter with DSP(Digital Signal Processor). The operation of scaled-model was tested by modeling the specific variable-speed wind turbine using the real wind data in order to make the scaled-model simulate the real wind power system as close as possible. The simulation and experimental results confirm that matrix converter can be applied for the DFIG system.