• 제목/요약/키워드: Mathematical modelling

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Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism

  • Davies, Oluwafemi;Mendes, Pedro;Smallbone, Kieran;Malys, Naglis
    • BMB Reports
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    • 제45권4호
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    • pp.259-264
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    • 2012
  • Accumulation of modified nucleotides is defective to various cellular processes, especially those involving DNA and RNA. To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP, XTP and dXTP. E. coli RdgB has been characterised as a deoxyribonucleoside triphosphate pyrophosphohydrolase that can act on these nucleotides. S. cerevisiae homologue encoded by YJR069C was purified and its (d)NTPase activity was assayed using fifteen nucleotide substrates. ITP, dITP, and XTP were identified as major substrates and kinetic parameters measured. Inhibition by ATP, dATP and GTP were established. On the basis of experimental and published data, modelling and simulation of ITP, dITP, XTP and dXTP metabolism was performed. (d)ITP/(d)XTPase is a new example of enzyme with multiple substrate-specificity demonstrating that multispecificity is not a rare phenomenon

Dynamic response of concrete gravity dams using different water modelling approaches: westergaard, lagrange and euler

  • Altunisik, A.C.;Sesli, H.
    • Computers and Concrete
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    • 제16권3호
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    • pp.429-448
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    • 2015
  • The dams are huge structures storing a large amount of water and failures of them cause especially irreparable loss of lives during the earthquakes. They are named as a group of structures subjected to fluid-structure interaction. So, the response of the fluid and its hydrodynamic pressures on the dam should be reflected more accurately in the structural analyses to determine the real behavior as soon as possible. Different mathematical and analytical modelling approaches can be used to calculate the water hydrodynamic pressure effect on the dam body. In this paper, it is aimed to determine the dynamic response of concrete gravity dams using different water modelling approaches such as Westergaard, Lagrange and Euler. For this purpose, Sariyar concrete gravity dam located on the Sakarya River, which is 120km to the northeast of Ankara, is selected as a case study. Firstly, the main principals and basic formulation of all approaches are given. After, the finite element models of the dam are constituted considering dam-reservoir-foundation interaction using ANSYS software. To determine the structural response of the dam, the linear transient analyses are performed using 1992 Erzincan earthquake ground motion record. In the analyses, element matrices are computed using the Gauss numerical integration technique. The Newmark method is used in the solution of the equation of motions. Rayleigh damping is considered. At the end of the analyses, dynamic characteristics, maximum displacements, maximum-minimum principal stresses and maximum-minimum principal strains are attained and compared with each other for Westergaard, Lagrange and Euler approaches.

자동차 에어컨 비정상과정 시뮬레이션 (Transient Simulation of an Automotive Air-Conditioning System)

  • 오상한;원성필
    • 설비공학논문집
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    • 제13권11호
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    • pp.1089-1096
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    • 2001
  • The cool-down performance after soaking is very important in an automotive air-conditioning system and is considered as the key design variable. Therefore, understanding of the overall transient characteristics of the system is essential to the preliminary design as well as steady-state characteristics. The objective of this study is to develop a computer simulation model and estimate theoretical1y the transient performance of an automotive air-conditioning system. To accomplish this, a mathematical modelling of each component, such as compressor, condenser, expansion valve, and evaporator, is presented first of all. For a detailed calculation, condenser and evaporator are divided into many subsections. Each sub-section is an elemental volume for modelling. In models of expansion valve and compressor, dynamic behaviors are not considered in an attempt to simplify the ana1ysis, but the quasi-static ones are just considered, such as the relation between mass flow rate and pressure drop in expansion device, polytropic process in compressor, etc. The developed simulation model is validated with a comparison to laboratory test data of an automotive air-conditioning system. The overall time-tracing properties of each component agreed fairly well wish those of test data in this case.

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MODELLING OF PYROLYSIS PROCESSES OF POLYACRYLONITRILE

  • Lipanov, A.M.;Kodolov, V.I.;Ovchinnikova, L.N.;Savinsky, S.S.;Khokhriakov, N.V.;Sarakula, V.L.
    • 한국화재소방학회:학술대회논문집
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    • 한국화재소방학회 1997년도 International Symposium on Fire Science and Technology
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    • pp.112-119
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    • 1997
  • The modelling of carbon substances obtaining, for instance, carbon fibers which have high fire resistance, has been realized on the example of the polyacrylonitrile pyrolysis modelling. The pyrolysis is considered as a double step process when the formation of a liquid phase and the oxidation of substance are excluded. Three main reactions are considered: a) with the evolution of ammonia; b) with the evolution of hydrogen cyanide; c) with the evolution of hydrogen. Reactions b) and c) are sequential, and a) and b) are parallel. The problem is formulated as one-dimensional. The equations of energy, masses or concentrations, porosity and thermal conductivity are proposed. The mathematical model of the carbonization process is designed using tile kinetic characteristics of the above reactions and the thermodynamic parameters of reagents and products in these reactions. The equations received are calculated by Runge-Cutta method and by Adams method of the fourth order accuracy.

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NEW LAPLACE TRANSFORMS FOR THE GENERALIZED HYPERGEOMETRIC FUNCTION 2F2

  • KIM, YONG SUP;RATHIE, ARJUN K.;LEE, CHANG HYUN
    • 호남수학학술지
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    • 제37권2호
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    • pp.245-252
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    • 2015
  • This paper is in continuation of the paper very recently published [New Laplace transforms of Kummer's confluent hypergeometric functions, Math. Comp. Modelling, 55 (2012), 1068-1071]. In this paper, our main objective is to show one can obtain so far unknown Laplace transforms of three rather general cases of generalized hypergeometric function $_2F_2(x)$ by employing generalized Watson's, Dixon's and Whipple's summation theorems for the series $_3F_2$ obtained earlier in a series of three research papers by Lavoie et al. [5, 6, 7]. The results established in this paper may be useful in theoretical physics, engineering and mathematics.

기계화 농작업 성능의 수학적 모델링 (The Mathematical Modelling of the Field Performance of Machines)

  • 김학규;정창주
    • Journal of Biosystems Engineering
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    • 제21권3호
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    • pp.357-371
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    • 1996
  • An assessment of the field performance of machines for varied farming conditions may be essential to the development of mechanization program and rational machinery management. The field performance of machines is largely affected by the field capacity of machinery selected, physical size and shape of field plots and their scatterness, farming functions and conditions, and labor requirement and constraints. The study was to develop the mathematical model for the field performance of machines and time requirement of the rice farming systems, considering those factors which affect the field performance of machines. The mathematical models developed were simulated to determine field efficiency and capacity of the different sizes of major machinery for a various size of paddy field plot and for prevailing conditions of farming operations. The effects of the sises of machinery and the plot geometry on the efficiency and field capacity were compared for major rice farming functions.

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AN UNSTRUCTURED MESH FINITE VOLUME METHOD FOR MODELLING SALTWATER INTRUSION INTO COASTAL AQUIFERS

  • Liu, F.;Turner, I.;Anh, V.
    • Journal of applied mathematics & informatics
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    • 제9권2호
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    • pp.561-577
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    • 2002
  • In this paper, a two-dimensional finite volume unstructured mesh method (FVUM) based on a triangular background interpolation mesh is developed for analysing the evolution of the saltwater intrusion into single and multiple coastal aquifer systems. The model formulation consists of a ground-water flow equation and a salt transport equation. These coupled and non-linear partial differential equations are transformed by FVUM into a system of differential/algebraic equations, which is solved using backward differentiation formulas of order one through five. Simulation results are compared with previously published solutions where good agreement is observed.

OPTIMAL INEQUALITIES FOR THE CASORATI CURVATURES OF SUBMANIFOLDS OF GENERALIZED SPACE FORMS ENDOWED WITH SEMI-SYMMETRIC METRIC CONNECTIONS

  • LEE, CHUL WOO;LEE, JAE WON;VILCU, GABRIEL-EDUARD;YOON, DAE WON
    • 대한수학회보
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    • 제52권5호
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    • pp.1631-1647
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    • 2015
  • In this paper, we prove two optimal inequalities involving the intrinsic scalar curvature and extrinsic Casorati curvature of submanifolds of generalized space forms endowed with a semi-symmetric metric connection. Moreover, we also characterize those submanifolds for which the equality cases hold.

A mathematical model of the commercial harvest of Palmaria palmata (Palmariales, Rhodophyta) on Digby Neck, Nova Scotia, Canada

  • Lukeman, Ryan J.;Beveridge, Leah F.;Flynn, Andrea D.;Garbary, David J.
    • ALGAE
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    • 제27권1호
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    • pp.43-54
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    • 2012
  • A mathematical model of the commercial harvest of Palmaria palmata (Dulse) is presented based on a logistic model and field data collected on Digby Neck, Nova Scotia from 14 harvested shores during May to August, 2010. Field observations used to estimate model parameters included cover of Dulse before and after harvest from Dulse dominated boulders for which surface area was estimated, and from which fresh biomass of harvested Dulse was weighed. Over all the surveys the average harvest fraction was about 50%, and the total resource was about $1,600g\;m^{-2}$. With growth rates in excess of 4% per day and a 50% harvest of the standing crop each month, the model suggests that the Dulse resource is sustainable at current harvest levels.

HIV감염과 AIDS의 전파특성에 관한 수학적 모델화 (Mathematical Modelling for The Transmission Dynamics of HIV infection and AIDS)

  • 정형환;주석민;정문규;이광우
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1998년도 하계학술대회 논문집 B
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    • pp.699-702
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    • 1998
  • This study investigates the population model of the spread of HIV/AIDS which the infection is generated by an infectious in dividual in a population of susceptibles. A mathematical model is presented for the transmission dynamics of HIV infection within the communities of homosexual males. The pattern on the epidemic character of HIV, the causative agent of AIDS, was analysed by the mathematical model of AIDS system which is derived according to the ecological relationship between five epidemilogic states of individuals. The computer simulation was performed using real data.

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