• 한국양식학회지
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• 제19권3호
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• pp.205-209
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• 2006

현재 우리나라에서 종묘방류량이 많은 넙치의 유전적 다양성을 파악하기 위하여 양식산 어미 암컷 31마리, 수컷 52마리로 총 83마리로부터 생산된 종묘의 유효어미수와 근교계수를 microsatellite DNA marker 7개를 이용하여 추정하였다. 어미집단과 종묘집단의 대립유전자수는 어미집단에 비하여 하루 동안 채란한 E1 종묘집단에서 23.5%가 감소하였고, 이틀 동안 채란한 E2 종묘집단에서는 17.6%가 감소하였다. 유전자 동일성검사 결과, 산란에 관여한 어미수는 E1 종묘집단에서 총 23마리였으며 이중 암컷 9마리, 수컷 14마리였고, E2 종묘집단에서는 35마리로 암컷 15마리, 수컷 20마리였다. 유효 어미집단크기(Ne)를 추정하기 위해 산란에 관여한 실제 어미의 암수의 비율을 보정하면, Ne는 E1 종묘집단에서 21.9마리, E2 종묘집단에서 34.3마리로 추정되었다. 이에 따라 근교계수는 El 종묘집단이 0.023, E2종묘집단은 0.015로서 E2종묘집단에서 낮게 나타났다. 이와 같은 결과는 수산생물의 다양성을 보존하기 위한 FAO의 권고 기준보다 높게 나타남에 따라 유전적 다양성을 향상시키는 방류용 종묘생산 방안이 필요할 것으로 나타났다.

• Clinical and Experimental Reproductive Medicine
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• 제45권1호
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• pp.31-37
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• 2018

Objective: To evaluate the pregnancy rate and time to pregnancy after timed coitus with or without superovulation in infertile young women younger than 35 years old with low serum $anti-M{\ddot{u}}llerian$ hormone (AMH) levels ( < 25th percentile). Methods: A total of 202 patients younger than 35 years old were recruited retrospectively between 2010 and 2012. Ninety-eight women had normal serum AMH levels (25-75th percentile), 75 women had low serum AMH levels (5th ${\leq}$ & < 25th percentile) and 29 women had very low serum AMH levels ( < 5th percentile), according to reference values for their age group. Results: The clinical pregnancy rate was positively associated with AMH levels, but this trend did not reach statistical significance (43.9% vs. 41.3% vs. 27.6% in the normal, low, and very low AMH groups, respectively). The time to pregnancy was longer in the very low AMH group than in the normal AMH group ($13.1{\pm}10.9months$ vs. $6.9{\pm}6.1months$, p= 0.030). The cumulative live birth rate over 18 months was lower in the very low AMH group than in the normal AMH group, with marginal significance (20.0% vs. 55.9%, p= 0.051). The duration of infertility was negatively correlated with achieving pregnancy (odds ratio, 0.953; 95% confidence interval, 0.914-0.994; p= 0.026). Conclusion: Conservative management, such as timed coitus with or without superovulation, should be considered in young patients who have low ovarian reserve without any infertility factors. However, for women with a long duration of infertility or very low serum AMH levels, active infertility treatment should be considered.

• 한국임상수의학회지
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• 제27권5호
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• pp.614-617
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• 2010

3년령, 암컷 점박이 하이에나가 분만의 증상을 나타내나 분만이 이루어지지 않아 이를 교정하기 위해 충북대학교 동물의료센터에 의뢰되었다. 분만 징후가 관찰된 후 5일이 경과되었고, 스스로 분만이 불가능하였기 때문에 제왕절개를 계획하였다. 수술 전 혈액화학검사 결과 심각한 질소혈증이 관찰되었으며, 수술 중 골반입구를 폐쇄하고 있는 태아의 두부가 요도를 압박하여 배뇨가 불가능하였음을 확인하였다. 또한 확장된 자궁내의 태아는 견관절굴절위를 나타내고 있었으며, 태아의 두부가 골반입구로 진입할 수 없을 정도의 크기를 나타내고 있었다. 태아의 상태는 폐사 후 부패가 진행된 상태였으며, 과다 체중(모체의 약 5%)을 나타냈다. 이 증례는 점박이 하이에나에서 과대태아 및 견관절굴절위로 인한 난산이 신후성 질소혈증을 일으킨 최초의 보고이다.

• 대한수의학회지
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• 제25권2호
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• pp.103-112
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• 1985

국내에서 분리된 enterovirus의 병원성을 관찰하기 위하여 1~2일령의 자돈 10두와 35일 령의 유돈 6두에 enterovirus 조직배양부유액을 뇌내 또는 근육내 주사한 후 임상 및 병리학적으로 관찰하였던 바 다음과 같은 결과를 얻었다. 임상적으로는 체온의 상승, 보양창랑, 보행실조, 유약성 마비 및 고도의 삭수가 관찰되었다. 병리조직학적으로는 중추신경계 전반에 걸쳐 수막하 세포침윤, 혈관주위 원형세포침윤, 신경세포의 변성, 미만성과 한국성 gliosis, glial nodule의 형성 등이 관찰되었으며 백질부보다 회백질부에서 다소 심한 경향이었고 배측 신경절염이 전 실험예에서 인정되었다. 한편 hog cholera백신과 enterovirus의 공동주사예에서는 중추신경계의 병변이 enterovirus 단독주사예에 비해 급격히 진행되는 경향이었다. 이상의 소견들을 종합해 볼때 국내에서 분리된 enterovirus는 뇌내 또는 근육내에 접종하였을 때 자돈에서 polioencephalomyelitis를 일으킬 수 있는 병원성이 강한 형으로 추측되며 hog cholera백신과 enterovirus를 공동주사한 예에서 병변의 진행이 급격한 점으로 보아 enterovirus의 자연감염에 hog cholera 백신 등의 stress요인이 작용될 것으로 추측된다.

• Journal of the Korean Wood Science and Technology
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• 제15권2호
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• pp.67-78
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• 1987

This study was designed to investigate the effect of board thickness and ring angle on the characteristics including internal check. ring failure, surface check, end check, collapse, thickness shrinkage and width shrinkage of press-drying. The exprimental materials of 6mm-. 9mm- and 12mm-thick board were taken from heartwood and sapwood of oak (Quercus acutissima Carr.) respectively. And boards were numbered according to position in the log(No. 1 to No. 4 for heartwood :md No. 9 for sapwood). Press-drying was at $145^{\circ}C$ platen temperature and 3.5kg/$Cm^2$ platen pressure. The results of this study were summarized as follows. 1. Drying rates for sapwood materials were greater than those for heartwood materials. And drying rates for thinner materials were greater than those for thicker materials. 2. The thinner boards were. the severer surface checking developed in the heartwood materials, and surface checking for heartwood materials had no tendency in board position for the same thickness. Sapwood materials were completely free from surface checking. 3. End checking for heartwood materials had no tendency in board position. The greater deviation of ring angle from perfectly edge-grained was, the severer and checking developed in the sapwood materials. But end checking did not occur in 6mm-thick sapwood materials. 4. The greater deviation of ring angle from perfectly edge-grained was, the severer end checking developed for heartwood and sapwood materials. As board thickness increased, maternal checking developed more severely for heartwood and sapweed materials. 5. For heartwood materials, ring failure, reduced with increasing deviation of ring angle from perfectly edge-grained except 12mm-thick material and showed no significant difference attributable to board thickness. Sapwood materials were completely free from ring failure. 6. For heartwood and sapwood materials, collapse was slight and showed no significant differences attributable to both board thickness and board position. 7. As deviation of ring angle from perfectly edge-grained increased, shrinkage of board thickness decreased for heartwood and sapwood materials. 8. Shrinkage of board width showed no significant differences attributable to both board thickness and board position for heartwood and sapweed materials.

• Clinical and Experimental Pediatrics
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• 제53권3호
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• pp.432-436
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• 2010

일과성 신생아 당뇨병은 6번 염색체의 부친 이체성, 부친으로부터 유래한 염색체 6q24의 중복, ZAC 또는 HYMAI 유전자의 CpG 섬의 메틸화 결함에 의해 야기된다. 저자들은 고혈당, 거설증, 자궁내성장지연으로 발현되어 부친으로부터 유래된 HYMA1 유전자만을 보인 일과성 신생아 당뇨병 1례를 경험하였다. 생후 18일된 여아가 거설증과 반복되는 고혈당으로 입원하였다. 거설증과 함께 큰 대천문, 작은 턱, 두드러진 눈을 보였으며 혈중 포도당 농도는 200-300 mg/dL로 유지되다가 입원 2일 후부터 인슐린 투여 없이도 정상 범위로 유지되었다. 모체로부터 유래된 메틸화된 대립유전자 유무를 확인하기 위하여 말초 혈액으로부터 genomic DNA를 추출하여 bisulfite를 처리한 후, 메틸화 특이 중합 효소 연쇄 반응으로 HYMAI 유전자의 일부분을 증폭시키고, 제한 효소 BssHII를 이용한 제한 효소 절편 길이 다형성 (restriction fragment length polymorphism, RFLP) 분석을 이용하여 HYMAI 유전자의 메틸화 여부를 확인한 결과, HYMAI 유전자의 메틸화 결함을 보여 부친에서 유래된 HYMAI 유전자만을 갖고 있음을 확인하였다. HYMAI 유전자의 메틸화 검사를 통해 6번 염색체의 각인된 유전자가 증명되었으며 메틸화 결함으로 인해 일과성 신생아 당뇨병이 발생하였다.

• Clinical and Experimental Pediatrics
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• 제55권8호
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• pp.280-285
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• 2012

Purpose: The authors analyzed the trend from the birth-related statistics of high birth weight infants (HBWIs) over 50 years in Korea from 1960 to 2010. Methods: We used 2 data sources, namely, the hospital units (1960's to 1990's) and Statistics Korea (1993 to 2010). The analyses include the incidence of HBWIs, birth weight distribution, sex ratio, and the relationship of HBWI to maternal age. Results: The hospital unit data indicated the incidence of HBWI as 3 to 7% in the 1960's and 1970's and 4 to 7% in the 1980's and 1990's. Data from Statistics Korea indicated the percentages of HBWIs among total live births decreased over the years: 6.7% (1993), 6.3% (1995), 5.1% (2000), 4.5% (2000), and 3.5% (2010). In HBWIs, the birth weight rages and percentage of incidence in infants' were 4.0 to 4.4 kg (90.3%), 4.5 to 4.9 kg (8.8%), 5.0 to 5.4 kg (0.8%), 5.5 to 5.9 kg (0.1%), and >6.0 kg (0.0%) in 2000 but were 92.2%, 7.2%, 0.6%, 0.0%, and 0.0% in 2009. The male to female ratio of HBWIs was 1.89 in 1993 and 1.84 in 2010. In 2010, the mother's age distribution correlated with low (4.9%), normal (91.0%), and high birth weights (3.6%): an increase in mother's age resulted in an increase in the frequency of low birth weight infants (LBWIs) and HBWIs. Conclusion: The incidence of HBWIs for the past 50 years has been dropping in Korea. The older the mother, the higher was the risk of a HBWI and LBWI. We hope that these findings would be utilized as basic data that will aid those managing HBWIs.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권1호
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• pp.12-21
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• 2015

In an effort to expand working opportunities for women and encourage childbirth, the government of Korea introduced the free infant care policy in 2013. This policy, however, was controversial with regard to issues, such as budget shortages and dissatisfaction based on socioeconomic status. In addition, the lack of evidence-based data regarding adequate age criteria for the entry of children into childcare facilities was noted as a challenge. As child development professionals who are concerned with mental health issues, we investigated the influence and challenges of the free infant care policy with regard to infant mental health. In this review, we examined the policies enacted by developed countries, such as the United Kingdom (UK), and compared them with those in Korea. The childcare systems in Korea and the UK differ historically and socially, but show some similarities, such as maternal responsibility for parenting and household issues. Like Korea, the need for UK childcare facilities increased in the 1990's in response to market recovery and associated increase in female employment. Among the new policies in the UK, the Sure Start program has begun to provide integrated services for infants, particularly to those 0-4 years of age, who are vulnerable to social exclusion. Similar to the Dream Start program in Korea, it has been successful in providing family-related services, resulting in improvements in problematic behaviors of children, enhanced parenting skills, and decreased rates of severely injured children.

• 대한지역사회영양학회지
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• 제7권2호
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• pp.177-187
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• 2002

This study was done to determine the factors associated with childhood overweight in 721 sixth grade elementary school students, in Busan. The students' heights, weights, waist circumferences and triceps-skinfold thicknesses were measured using standard techniques. Other data were collected using a questionnaire that included information about physical activity, television watching, and the amount of exorcise taken during leisure times, family history of diseases related to obesity: social data including family income, parents'education and occupations, eating behaviors; parental weights and heights; and parental activity levels. Childhood overweight was defined as a body mass index at or above the 85th percentile for age and sex. The prevalence of overweight revealed no significant difference between sexes, (24.2% in boys and 22.03% in girls). The risk of childhood overweight was significantly greater if either the mother or the father were overweight. The odds ratio for childhood overweight associated with maternal overweight was 5.045 (94% CI : 3.262-7.801), and 2.727 (95% CI : 1.764-4.218) was the case for parental overweight. Children having a history of hear diseases had higher odds ratios than those who did not. The odds ratios for overweight associated with income were not different. However, a higher odds ratio for overweight was observed in children whose fathers had only an elementary or middle school education than those whore fathers had a high school or college education. Children whose fathers' occupations were service workers or shopkeepers (OR : 3.314, 95% C = 1.851-5.934) or had no occupation (OR = 3.756, 95% CI : 1.898-7.430) had a treater risk of overweight than those whose fathers'were professionals or once workers. The risk of overweight increased in children having more irregular meal times and faster eating times, rather than those having an intake pattern of high energy and sugar containing floods. The amount of exercise taken during leisure times, and daily physical activity showed no difference between overweight and non-overweight children. However, television watching time, especially on weekends, was greater in overweight children than in non-overweight children. Television watching time was positively correlated with BMI, triceps-skin(31d thickness, waist circumference and waist/height ratio. Therefore, television watching was found to be a useful predictor of overweight in children. Television watching in children was negatively related to paternal activity levels, and positively related to parental television watching time. In fact, fathers whose children were overweight were physically less active than fathers whose children were non-overweight. Parents appeared to be a strong influence on their children's physical activity levels. In conclusion, a low family social class, defined on the basis of the father's occupation or education, parental overweight, increased television watching, and unhealthy physical activity levels in parents were all considered risk factors for childhood overweight. Among these, television watching time and lack of physical activity were considered to be the most important risk factors that could be easily modified for the prevention of and intervention in, overweight in children.

• 대한소아치과학회지
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• 제41권3호
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• pp.247-256
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• 2014

이 연구의 목적은 대전지역 미취학 어린이의 비수유성 빨기 습관의 유병률을 조사하고 이 유병률에 영향을 미치는 기여요인과의 관련성을 평가하며 비수유성 빨기 습관이 유치열의 교합에 어떤 영향을 주는지 알아보고자 하는 것이다. 구강검진을 위해 개인치과에 내원한 만 18개월에서 65개월 사이의 어린이 841명을 검사하고 그 보호자를 대상으로 설문조사를 시행하였다. 전체 설문에 대답한 어린이 중 32.8%에서 비수유성 빨기 습관이 있었으며 여아에서 37.7%로 남아보다 유의하게 더 높았다. 모유 수유의 기간이 길어짐에 따라 비수유성 빨기 습관 유병률은 유의한 감소를 보였으며 출생순서와 엄마의 직업유무는 관련성이 없었다. 손가락빨기가 전체 비수유성 빨기 습관 어린이 중 62.6%로 인공젖꼭지빨기(37.4%)에 비해 더 우세하였고 습관의 지속기간 또한 유의하게 길었다. 비수유성 빨기 습관의 지속기간이 길어질수록 유치열 교합이상이 더 많이 관찰되었다.