• Therapeutic Science for Rehabilitation
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• v.11 no.4
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• pp.69-83
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• 2022

Objective : This study aimed to confirm the possibility of the clinical application of oral motor facilitation technique (OMFT) protocol and neuromuscular electrical stimulation (NMES) in patients with Wallenberg syndrome. Methods : One patient with Wallenberg syndrome was treated with OMFT and NMES applied 40 times each, 5 days a week, twice a day for 4 weeks. The Comprehensive Oral-Facial Function Scale (COFFS), Korean-Mann Swallowing Ability Assessment (K-MASA), and Penetration-Aspiration Scale (PAS) were used to compare the changes before and after the intervention. Data analysis was used to compare the score changes before and after the intervention. Results : Orofacial function and swallowing ability improved after the intervention in the individual who participated in this study. Among oral motor functions, relatively greater functional improvement was observed in tongue movement compared to other functions, which was evaluated to the extent that pharyngeal swallowing was possible. Conclusions : Early swallowing rehabilitation using systematic OMFT and NMES of exercise intensity confirmed the possibility of improving oral motor function and dysphagia. In the future, complementary studies on the effects of interventions applying the OMFT and NMES will be needed.

• Journal of Positioning, Navigation, and Timing
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• v.3 no.1
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• pp.25-30
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• 2014

Differential Global Positioning System-Correction Projection (DGPS-CP) algorithm, which has been suggested as a method of correcting pre-calculated position error by projecting range-domain correction to positional domain, is a method to improve the accuracy performance of a low price GPS receiver to 1 to 3 m, which is equivalent to that of DGPS, just by using a software program without changing the hardware. However, when DGPS-CP algorithm is actually realized, the error is not completely eliminated in a case where a reference station does not provide correction of some satellites among the visible satellites used in user positioning. In this study, the problem of decreased performance due to the difference in visible satellites between a user and a reference station was solved by applying the Multifunctional Transport Satellites (MTSAT) based Augmentation System (MASA) correction to DGPS-CP, instead of local DGPS correction, by using the Satellite Based Augmentation System (SBAS) operated in Japan. The experimental results showed that the accuracy was improved by 25 cm in the horizontal root mean square (RMS) and by 20 cm in the vertical RMS in comparison to that of the conventional DGPS-CP.

• Proceedings of the Korean Society of Toxicology Conference
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• 2000.11a
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• pp.31-41
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• 2000

The major issue in the post genome sequencing era is determination of gene expression patterns in variety of biological systems. A microarray system is a powerful technology for analyzing the expression profile of thousands of genes at one experiment. In this study, we constructed cDNA microarray which carries 2,304 cDNAS derived from oligo-capped mouse cDNA library. Using this hand-made microarray we determined gene expression in various biological systems. To determine tissue specific genes, we compared Nine genes were highly-expressed in adult mouse brain compared to kidney, liver, and skeletal muscle. Tissue distribution analysis using DNA microarray extracted 9 genes that were predominantly expressed in the brain. A database search showed that five of the 9 genes, MBP, SC1, HiAT3, S100 protein-beta, and SNAP25, were previously known to be expressed at high level in the brain and in the nervous system. One gene was highly sequence similar to rat S-Rex-s/human NSP-C, suggesting that the gene is a mouse homologue. The remaining three genes did not match to known genes in the GenBank/EMBL database, indicating that these are novel genes highly-expressed in the brain. Our DNA microarray was also used to detect differentiation specific genes, hormone dependent genes, and transcription-factor-induced genes. We conclude that DNA microarray is an excellent tool for identifying differentially expressed genes.

• Computers and Concrete
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• v.3 no.1
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• pp.29-42
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• 2006

In this study, a novel education system for inspection of concrete bridges is presented. The new education approach uses virtual reality (VR) and three-dimensional computer graphics (3DCG) in training engineers to become bridge inspection specialists. The slow time-dependent deterioration of concrete bridges can be reproduced on the computer screen in any chosen time frame, thus providing the trainees with illustrative and educative insight into the deterioration problem. In the proposed VR/3DCG approach a three-dimensional model of concrete bridge, including surfaces, viewpoints and walkthrough paths is created. With the help of this virtual bridge model, an experienced bridge inspection specialist teaches the different deterioration phenomena of concrete bridges to the trainees. The new system was tested, and the inspection results from the case bridge showed that in comparison with the traditional Japanese bridge inspection education system, the new system gives better results. In addition to the improvement of quality of bridge inspections, the new VR/3DCG system-based education brings along some other, more intangible benefits.

• Genomics & Informatics
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• v.5 no.3
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• pp.107-112
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• 2007

MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown. In this study, we performed microarray-based experiments using lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type, MyD88 knockout (KO), TRIF KO, and MyD88/TRIF double KO mice. We employed a statistical approach to determine the importance of the commonality and specificity of miRNA binding sites among groups of temporally co-regulated genes. We demonstrate that both commonality and specificity are irrelevant to define a priori groups of co-down regulated genes. In addition, analyzing the various experimental conditions, we suggest that miRNA regulation may not only be a late-phase process (after transcription) but can also occur even early (1h) after stimulation in knockout conditions. This further indicates the existence of dynamic interactions between miRNA and signaling molecules/transcription factor regulation; this is another proof for the need of shifting from a 'hard-wired' paradigm of gene regulation to a dynamical one in which the gene co-regulation is established on a case-by-case basis.

• Macromolecular Research
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• v.14 no.1
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• pp.52-58
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• 2006

A novel fabrication of the patterned surfaces in the polymer films was demonstrated by using the self-organizing character of the block copolymers of polystyrene-b-oligothiophenes and polystyrene-b-aromatic amide dendron. Hexagonally arranged open pores with a micrometer-size were spontaneously formed by casting the polymer solutions under a moist air flow. The amphiphilic character of the block copolymers played the crucial role as a surfactant to stabilize the inverse emulsion of water in the organic solvent, and subsequently the aggregated structure of the hydrophilic oligothiophene or aromatic amide dendron segments remained on the interiors of the micropores. The chemical composition on the top of the surface of the microporous films was characterized by energy-filtering transmission electron microscopy (EFTEM) or a time-of-flight secondary ion mass spectrometer (ToF-SIMS). The characterizations clearly indicated that the patterned surfaces in the self-organized block copolymer films with the hexagonally ordered microporous structures were fabricated in a single step.

• Tuberculosis and Respiratory Diseases
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• v.45 no.1
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• pp.77-89
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• 1998

Background: Genetic and environmental factors are known to affect the incidence and severity of asthma. Stimulation of $\beta_2$-Adrenergic Receptor ($\beta_2$AR) results in smooth muscle relaxation, leading to decrease in resistance of airflow. The gene encoding the $\beta_2$AR has recently been seguenced. The $\beta_2$AR genotype at the polymorphic loci of codons 16, 27, 34, and 164 was known to cause changes in the amino acids. The relationships between the structure of the $\beta_2$AR and its functions are being elucidated. Purpose : The gene encoding the $\beta_2$AR was carried out to assess the frequency of polymorphisms in bronchial asthma, to determine wheather these polymorphisms have any relation to the severity, or nocturnal symptoms in bronchial asthma. Methods: The subjects studied were 103 patients with bronchial asthma, which consisted of 30 mild episodic, 32 mild persistent, 17 moderate, and 24 severe asthma patients. The polymorphisms of the $\beta_2$AR gene were detected by mutated allele specific amplification (MASA) method at the codons 16,27,34, and 164. Results: The most frequent polymorphism was arginine 16 to glycine. The other two polymorphisms, valine 34 to methionine and glutamine 27 to glutamic acid occured in 11 and 6 patients respectively. The polymorphism of threonine 164 to isoleucine was not found in our enrolled patients. The homozygous polymorphism of $\beta_2$AR gene was found in only arginine 16 to glycine (12.6%). The heterozygous polymorphisms of $\beta_2$AR gene were in arginine 16 to glycine, valine 34 to methionine, and glutamine 27 to glutamic acid, as 65.1 %,10.7%, and 5.8% respectively in asthma patients. The presence of agrginine 16 to glycine heterozygous or/and homozygous polymorphism was associated in severe asthma (p=0.015), but there was no association between the other three polymorphisms and the severity of asthma. The frequency of the $\beta_2$AR gene polymorphisms was no relation in nocturnal asthma as compared with non-nocturnal asthma. Conclusion: The arginine 16 to glycine polymorphism of the $\beta_2$AR gene is the most frequently found in asthma patients and association with severe asthma. But there was no association between the polymorphism of the $\beta_2$AR gene and nocturnal asthma.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.2
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• pp.121-132
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• 2018

Along with climate change, it is reported that the extreme climate events such as severe drought could cause difficulties of agricultural water supply. To minimize such damages, it is necessary to secure the agricultural water resources by using or saving the amount of irrigation water efficiently. The objectives of this study were to develop paddy water management scenarios and to evaluate their effectiveness on water saving. Three water management scenarios (a) deep irrigation with ponding depth of 20~80 mm (control, CT), (b) no/intermittent irrigation until paddy cracks (water management A, WM-A), and (c) intermittent irrigation with ponding depth under 20 mm (water management B, WM-B) were developed. Water saving effects were analyzed using monitored data from experimental paddy fields, and agricultural water supply was analyzed on a reservoir-scale using MASA model. The observed irrigation amounts were reduced by 21 % and 17 % for WM-A and WM-B compared to CT, respectively, and mainly occurred by the increase of effective rainfall. The simulation results showed that water management scenarios could reduce irrigation by 21~51 % and total inflow by 10~24 % compared to CT. The long-term simulated water level change of agricultural reservoir resulted in the decrease of dead level occurrence for WM-A and WM-B. The study results showed that WT-A and WT-B have more benefit than CT in the aspect of agricultural reservoir water supply.

• Advances in Energy Research
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• v.2 no.1
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• pp.33-45
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• 2014

Photocatalytic hydrogen generation by water splitting ($H_2O_{(1)}{\rightarrow}H_2_{(g)}+1/2O_2_{(g)}$) has been studied on photocatalysts based on Zn, Cd, Fe and Cu, synthesized by coprecipitation. Iron and copper nanoparticles were incorporated as cocatalysts to enhance the photocatalytic activity of the ZnCd solid solution. The effect of the different synthesis parameters (temperature, elemental atomic ratios, amount of Cu and Fe incorporated in the catalyst and calcination temperature) on the photocatalytic production of hydrogen has been studied in order to determine the best experimental synthesis conditions. The catalysts have been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and BET. The experiments of photocatalytic water splitting were performed in aqueous solution of the photocatalysts previously dispersed in a soft ultrasound bath. The photocatalysts were irradiated under different lights ranging from 220 to 700 nm. The photocatalytic activity was found to be clearly dependent on the specific area of the photocatalyst.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.5 no.2
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• pp.34-38
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• 2002

This studies were performed to determine the effects of indoor relative humidity conditions on the growth of Arachniodes aristata and Pyrrosia lingua in native fern and investigate an applicable possibility of indoor plants. The response of Arachniodes aristata and Pyrrosia lingua was evaluated in growth chamber (KG-8407-87) to 3 relative humidity and 3 soils. Relative humidity was applied to 25%, 50%, 90%; soils were prepared based on soil mixture(SM), top field soil(TF), masa soil(MS). Results of experiments are as follows ; 1. Under a low humidity condition, such as 25%, Water contents, chlorophyll content, ornamental value of Arachniodes aristata and Pyrrosia lingua decreased much more a 50-90%. 2. The growth of Arachniodes aristata were best in pots under a soil mixture(SM) but Pyrrosia lingua were field top soil(FT) under 25%. It seemed that Pyrrosia lingua due to tolerance of desiccation more than Arachniodes aristata. Though these studies, coefficient of relative humidity and soil was plays an important role in Arachniodes aristata and Pyrrosia lingua growth in indoor environments.