• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.915-921
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• 2015

Context: In the last half century, discovering, developing and introducing of clinical agents from marine sources have seen great successes, with examples including the anti-cancer compound trabectedin. However, with increasing need for new anticancer drugs, further exploration for novel compounds from marine organism sources is strongly justified. Objective: The major aim of this study was to evaluate the antitumor and antioxidant potential of Sargassum tenerrimum J.Agardh (Sargassaceae) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Materials and Methods: An ethanol extract of S. tenerrimum (EEST) from whole algae was used to evaluate cytotoxicity followed by in vivo assessment of toxicity, using biochemical parameters including hepatic and non-hepatic enzymes. Antioxidant properties were examined in animals bearing EAC treated with daily oral administration of 100-300 mg/kg extract suspension. Results: Antitumor effects of EEST in EAC bearing mice was observed with LD50 1815 mg/kg. Parameters like body weight, tumor volume, packed cell volume, tumor cell count, mean survival time and increase in life span in animals in the EAC bearing animals treated with EEST 300 mg/kg was comparable with control group. Significant differences were also seen with changes in total protein content, hepatic enzymes contents, MDA level, and free radical scavenging enzymes in untreated vs. EEST treated group animals. Conclusions: Evaluation of antioxidant enzymes and hepatic enzymes in the EAC animal model treated with EEST exhibited similar effects as the positive control drug 5-flurouracil. S. tenerrimum extracts contain effective antioxidants with significant antitumor activity.

• Fisheries and Aquatic Sciences
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• 제11권4호
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• pp.209-211
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• 2008

Heterotrophic dinoflagellate Pfiesteria piscicida (Dinophyceae) has been claimed to produce potent ichthyotoxins that cause disorientation and eventually death of fish and other marine animals. A real-time PCR probe targeting for SSU rRNA gene was used for detection of P. piscicida in Chinhae Bay, Korea. PCR inhibitors were successfully removed by dilution of template DNA. Positive detections were shown from surface water samples indicating the presence of P. piscicida in Chinhae Bay.

• ALGAE
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• 제18권4호
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• pp.349-354
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• 2003

This paper reports that the heavy metal accumulation in marine seaweeds. Algal samples collected from Korean coast were analyzed to determine the concentrations of Cu, Cd, Cr, Zn and Pb. In general, heavy metals were found to be concentrated in many kinds of Korean seaweeds. The concentration levels of accumulated heavy metals in the marine seaweeds was in the following order: Zn > Cu > Cr > Pb > Cd. The concentrations of the heavy metals in the seawater were the highest in Iyajin harbor. Sargassum horneri, a brown alga accumulated high concentrations of Cu (80.66 ${\mu}g{\cdot}g^{-1}$ dw) and Cr (31.54 ${\mu}g{\cdot}g^{-1}$ dw). The high concentrations of heavy metals were accumulated in the brown algae.

• 수산경영론집
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• 제40권3호
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• pp.29-49
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• 2009

There are various types of predictable economic benefits to restoring beneficial uses from contaminated marine sediment cleanup. These benefits can be derived from reduction in aquatic animals died or infected, increase in their consumption recovery, increase in tourism including recreational fishing, reduction in human health risk, increase in amenity and aesthetics, increase in ecosystem integrity, and so on. The paper focuses on estimating the net increase in value for producers and consumers from producing and consuming those fish due to the pollution reduction of marine contaminated cleanup project. Almost Ideal Demand System(AIDS) is employed for estimate of the demand for fish, and the production cost function for fish are determined using market data. The result shows 10.8 billion won per year for economic surplus to the net increase for producers and consumers.

• 수산경영론집
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• 제54권2호
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• pp.91-107
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• 2023

Offshore wind power development has been promoted in countries around the world to cope with global warming. Despite its many advantages, offshore wind power affects the marine environment during construction and operation. As a result, the reduction of fishing areas, changes in the habitat of marine animals, damage to fishing gear, and impeding the safety of fishing activities are occurring. If the offshore wind power generation project is carried out, a fishing damage investigation is nescssary. There are only four fishing damage investigations related to offshore wind power, which are being conducted similarly to the existing fishing damage investigation related to offshore construction. Therefore, this study reviewed and analyzed the report on fisheries damage investigation related to offshore wind power conducted in Korea and suggested problems and improvement measures accordingly.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5071-5074
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• 2016

Background: Azoxymethane (AOM) is a well-known colon cancer-inducing agent in experimental animals via mechanisms that include oxidative stress in rat colon and liver tissue. Few studies have investigated AOM-induced oxidative stress in rat liver tissue. Red seaweeds of the genera Hypnea Bryodies and Melanothamnus Somalensis are rich in polyphenolic compounds that may suppress cancer through antioxidant properties, yet limited research has been carried out to investigate their anti-carcinogenic and antioxidant influence against AOM-induced oxidative stress in rat liver. Objective: This study aims to determine protective effects of red seaweed (Hypnea Bryodies and Melanothamnus Somalensis) extracts against AOM-induced hepatotoxicity and oxidative stress. Materials and Methods: Sprague-Dawley rats received intraperitoneal injections of AOM, 15 mg/kg body weight, once a week for two consecutive weeks and then orally administered red seaweed (100 mg/kg body-weight) extracts for sixteen weeks. At the end of the experiment all animals were overnight fasted then sacrificed and blood and liver tissues were collected. Results: AOM treatment significantly decreased serum liver markers and induced hepatic oxidative stress as evidenced by increased liver tissue homogenate levels of nitric oxide and malondialdehyde, decreased total antioxidant capacity and glutathione, and inhibition of antioxidant enzymes (catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase and superoxide dismutase). Both red seaweed extracts abolished the AOM-associated oxidative stress and protected against liver injury as evidenced by increased serum levels of liver function markers. In addition, histological findings confirmed protective effects of the two red seaweed extracts against AOM-induced liver injury. Conclusion: Our findings indicate that red seaweed (Hypnea Bryodies and Melanothamnus Somalensis) extracts counteracted oxidative stress-induced hepatotoxicity in a rat model of colon cancer.

• Journal of Ecology and Environment
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• 제40권3호
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• pp.136-143
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• 2016

Background: Mussels are stubborn organisms attached to solid substrata by means of byssus threads. The abundance of marine mussel Mytilus edulis in marine facilities like power stations was reason to select among fouling animals. Methods: Mortality patterns as well as physiological behavior (oxygen consumption, foot activity, and byssus thread production) of two different size groups (14- and 25-mm shell length) of M. edulis were studied at different hydrogen peroxide concentrations ($1-4mg\;l^{-1}$). Results: Studied mussels showed progressive reduction in physiological activities as the hydrogen peroxide concentration increased. Mussel mortality was tested in 30 days exposure, and 14 mm mussels reached the highest percentage of 90% while 25 mm mussels reached 81%. Produced data was echoed by Chick-Watson model extracted equation. Conclusions: This study points that, while it could affect the mussel mortality moderately in its low concentrations, hydrogen peroxide has a strong influence on mussels' physiological activities related to colonization. Therefore, hydrogen peroxide can be an alternative for preventing mussel colonization on facilities of marine environment.

• Fisheries and Aquatic Sciences
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• 제18권3호
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• pp.273-281
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• 2015

The follistatin (FST) gene encodes a monomeric glycoprotein that plays a role in binding and inhibiting the functions of members of the transforming growth factor (TGF)-${\beta}$ superfamily. Thus, FST facilitates a wide variety of functions, ranging from muscle growth, to inflammation and immunity. In this study, we sought to characterize an FST counterpart, RbFST, which was identified from rock bream Oplegnathus fasciatus. The RbFST cDNA sequence (2,419 bp) contains a 933-bp open reading frame (ORF) that encodes a putative amino acid sequence for RbFST (35 kDa). The putative amino acid sequence contains a Kazal-type serine protease inhibitor domain (51-98 residues) and an EF-hand, calcium-binding domain (191-226 residues). Additionally, this sequence shares a high identity (98.7%) with the Siniperca chuatsi FST sequence, with which it also has the closest evolutionary relationship according to a phylogenetic study. Omnipresent distribution of RbFST transcripts were detected in the gill, liver, spleen, head kidney, kidney, skin, muscle, heart, brain, and intestine of healthy animals, with significantly higher expression levels in the heart, followed by the liver tissue. Under pathogenic stress caused by two bacterial pathogens, Streptococcus iniae and Edwardsiella tarda, RbFST transcription was found to be significantly up-regulated. Altogether, our findings suggest the putative role of RbFST in immune related responses against pathogenic infections, further prefiguring its significance in rock bream physiology.

• Ocean and Polar Research
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• 제23권2호
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• pp.109-119
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• 2001

영광원전 주변 해역의 조간대에 서식하는 중형저서생물의 군집 조성은 여름 (6월)과 가을 (10월)의 두 시기, 각 조사 지선의 각 조사정점에서 모두 총 18개의 분류군이 출현하였다. 두 계절 모두 각 조사 지선에서 개체수나 서식 비율에 있어 선충류가 가장 높게 나타났지만 영광원전의 배출구 주변에 위치한 조사 지선 A, B의 경우는 일반적인 해역에서의 값보다는 현저하게 낮은 값을 보였다. 또한, 우점하는 분류군의 하나이며 환경의 변화에 민감한 저서성 요각류의 경우도 조사 지선 A, B의 경우 현저하게 낮게 나타났고, 그 다음 우점하는 분류군도 갯지렁이나 패충류 등이 차지하여 다른 일반 해역과의 상이점을 보였다. 조사 지선 C의 경우만 개체수나 출현 분류군에 있어서 일반적인 천해계의 값을 보였다. 수평 분포에 있어서도 조사 지선 A, B의 경우는 전반적으로 조간 대 상 중부 지역에서 서식밀도가 높게 나티났고, 원전의 배수구와 가장 멀리 떨어진 조사지선 C의 경우에서는 상부에서 하부로 갈수록 개체수가 증가하는 경향을 나타냈다. 크기별 개체수에 있어서는 체 크기 0.125 mm에 들어가는 크기의 생물들이 높게 나타났다. 두 계절에 있어서 중형저서동물이 퇴적물 내에서 수직 분포를 보면, 전반적으로 표층 0${\sim}$1cm에 가장 높은 서식밀도를 보이고 퇴적물내의 깊이가 깊어감에 따라 서서히 감소하는 경향을 보였다. 각 분류군에 있어서는 분류군별로 수직 분포의 차이를 나타냈다. 유사한 환경을 나타내는 다른 조간대 갯벌과의 비교에선 조사 지선 A, B의 경우는 극히 불안정한 서식 환경임을 보여주었다.

• 수산해양교육연구
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• 제23권4호
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• pp.549-567
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• 2011

The purpose of this study was to analyze and to compare the use of illustrations of the elementary practical arts textbooks and to make suggestions for an improvement of the use of illustrations in elementary practical arts textbooks. It is expected that the results of this study can be used by textbook developers, publishers, and teachers in their efforts to improve the quality of elementary practical arts textbooks. For the study, 'Units of Raising Animals' in the sixth grade practical arts textbooks in Korea was selected and analyzed according to the three criteria: kinds of illustrations, sizes of illustrations and purposes of illustrations. In this study, the following facts were found. First, 2007 revised practical arts textbooks have about 5.2 illustrations per page whereas 7th practical arts ones have 4.2. Second, even though 2007 revised practical arts textbooks are highly dependent on photographs, kinds of illustrations of 2007 revised practical arts textbooks have more ratio of pictures, cartoons and diagrams than the ones in the 7th practical arts textbooks. Third, sizes of illustrations of the 2007 revised practical arts textbooks are ordered in small, medium, large size illustrations and there was an increase in medium sized illustrations. Lastly, the purpose of the illustrations from the 2007 revised practical arts textbooks are on the decrease the supply of learning materials but there was an increase in the learning motive induction and guidance for experiment.