• Korean Journal of Acupuncture
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• v.25 no.4
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• pp.205-217
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• 2008

Background : One of the characteristics of acupuncture, a popular modality for treating musculoskeletal pain, is a plurality in diagnosis and treatment that can profoundly influence the treatment outcome. This multiplicity in treatment modality has to be considered in any research on the effectiveness of acupuncture. Many practitioners stress the necessity for individualized patient treatment, including acupuncture point selection and manipulation technique. However, the importance of individualization in acupuncture treatment, compared with standardization, has received little attention in clinical trials. The aim of the future study described here is therefore to compare the effectiveness of individualized acupuncture for knee osteoarthritis with standardized acupuncture and no acupuncture in patients with knee osteoarthritis. Methods : A total of 195 patients aged 50 years and over with knee pain, will be randomly divided into three treatment groups: individualized acupuncture, standardized acupuncture, and waiting list. Outcome data will be collected through patient.completed questionnaires before randomization, and at 4, 8 and 12 weeks after randomization. The questionnaires will be investigated demographic details as well as information on pain, movement and function of the affected knee, general health and quality of life. Discussion : This paper presents details on the rationale, design, and methods of the trial.

• Korean Journal of Acupuncture
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• v.31 no.4
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• pp.179-187
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• 2014

Objectives : Saam acupuncture initiated by Saamdoin is traditional and originative method, which is characterized by applying the five phases theory and mother-child reinforcement-reduction principle to the selection of acupoints and needling manipulation. Our study was aimed to summarize and assess the use of acupoint SP3(Taebaek) in Saam acupuncture treatment and to further understand Saam acupuncture in an aspect of the combination of acupoints. Methods : We searched the data based on "(Do Hae Kyo Kam) Sa-Ahm's acupuncture method" for SP3 used and acupoint combination including SP3. We performed frequency analysis, network analysis, and cluster analysis for quantitative aspect. To understand clinical implication of SP3 with another acupoint, qualitative and descriptive methods were also carried out. Results and Conclusions : In our study, SP3 was frequently used for tonification of lung, spleen, heart, and kidney meridian and sedation of kidney, heart, and lung meridian. For this, many acupoints such as LU8, LU9, KI3, HT8, KI7, LU10 and LR1 were used with SP3. The combination of SP3 and other acupoints were used to treat stroke, common cold, and pain conditions including headache, low back pain, respiratory disease as well as gastroenteric troubles including stomachache, indigestion, vomiting, and constipation. To further understand Saam acupuncture, an understanding of the five transport points based on five elements characters, pathological changes (deficiency and excess) of viscera and bowels, and concept of source point should be preceded.

• Molecules and Cells
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• v.39 no.4
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• pp.330-336
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• 2016

Long non-coding RNAs (lncRNAs) are involved in multiple cellular events, as well as in tumorigenesis. Colon cance-rassociated transcript-1 (CCAT1) gene encodes an lncRNA whose over-activation was observed in an expanding list of primary human solid tumors and tumor cell lines, however its biological roles in acute myeloid leukaemia (AML) has not been reported yet at present. In this study, the aberrant upregulation of CCAT1 was detected in French-American-British M4 and M5 subtypes of adult AML patients. By gain- and loss-of-function analysis, we determined that CCAT1 repressed monocytic differentiation and promoted cell growth of HL-60 by sequestering tumor suppressive miR-155. Accordingly, a significant decrease in miR-155 level was detected in AML patients. Reintroduction of miR-155 into HL-60 cells restored monocytic maturation and repressed cell proliferation. Furthermore, CCAT1 could up-regulated c-Myc via its competing endogenous RNA (ceRNA) activity on miR-155. In conclusion, these results revealed new mechanism of lncRNA CCAT1 in AML development, and suggested that the manipulation of CCAT1 expression could serve as a potential strategy in AML therapy.

• Communications of Mathematical Education
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• v.24 no.3
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• pp.611-626
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• 2010

The purpose of this study is to explore the composite properties of linear functions using CAS calculators. The meaning and processes in which technological tools such as CAS calculators generated to instrument are reviewed. Other theoretical topic is the design of an exploring model of observing-conjecturing-reasoning and proving using CAS on experimental mathematics. Based on these background, the researchers analyzed the properties of the family of composite functions of linear functions. From analysis, instrumental capacity of CAS such as graphing, table generation and symbolic manipulation is a meaningful tool for this exploration. The result of this study identified that CAS as a mediator of mathematical activity takes part of major role of changing new ways of teaching and learning school mathematics.

• Journal of the Korea Convergence Society
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• v.11 no.3
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• pp.27-35
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• 2020

The purpose of this study is to study the technical implementation methods to prevent problems such as the record of important educational activities of the student life record department or the continuous illegal leakage and manipulation. To this end, in this paper, by applying a private blockchain that can be participated only by a given organization or individual, it prevents outsiders from participating in the block network, and creates legitimate authority by creating two types of block data: student information block and access record block in the life record book. We proposed a block mechanism that can be registered, modified, and accessed only by authorized staff members. As a result, we have prepared an alternative to prevent forgery and alteration of the living records by third parties and to secure the integrity of the living records. If applied to the educational administrative information system, social consensus will be established that the operation and management of the life record book is reliable.

• Journal of Ecology and Environment
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• v.30 no.2
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• pp.109-119
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• 2007

The effect of water flow on the growth of Gafrarium tumidum was studied in the field using open cages constructed with stainless steel net and perspex in which holes were drilled. Cages with different flows (25, 50 and 75% of the control) were made by varying the area of perspex being drilled. Reduction in flow rate was directly proportional to the undrilled area, and the mean flow rate of the different treatment groups varied from 3.12 cm/s for the 25% exposure to 12.48 cm/s for the control cages. At the end of the 3-month experiment, no significant differences in sediment characteristics were found among the treatments. Growth in shell length, shell weight and tissue dry weight was, however, positively correlated with flow rate. Percentage increases ranged from $3.0{\sim}8.3%$ for shell length, $9.9{\sim}23.1%$ for shell weight and $17.2{\sim}53.3%$ for tissue dry weight. Condition index of the clam was not significantly different among the treatments. Seston depletion effect could reduce growth in G. tumidum only when water flow was reduced to 25% of the control. G. tumidum also exhibited different responses in shell and tissue growth at low flow rates, in which shell growth continued to decrease as flow rate decreased whereas tissue growth was relatively independent of low flows at 25 and 50% of the control. It was suggested that when seston flux was reduced at slow flows, it would be a better strategy for G. tumidum to channel energy for gonad development instead of shell growth during the reproductive stage.

• Journal of Gastric Cancer
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• v.19 no.4
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• pp.473-483
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• 2019

Surgical therapy for adenocarcinoma of the esophagogastric junction II requires distal esophagectomy, in which a transhiatal management of the lower esophagus is critical. The 'dorsal track control' (DTC) maneuver presented here facilitates the atraumatic handling of the distal esophagus, in preparation for a circular-stapled esophagojejunostomy. It is based on a ventral semicircular incision in the distal esophagus, with an intact dorsal wall for traction control of the esophagus. The maneuver facilitates the proper placement of the purse-string suture, up to its tying (around the anvil), thus minimizing the manipulation of the remaining esophagus. Furthermore, the dorsally-exposed inner wall surface of the ventrally-opened esophagus serves as a guiding chute that eases anvil insertion into the esophageal lumen. We performed this novel technique in 21 cases, enabling a safe anastomosis up to 10 cm proximal to the Z-line. No anastomotic insufficiency was observed. The DTC technique improves high transhiatal esophagojejunostomy.

• Journal of Ocean Engineering and Technology
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• v.31 no.4
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• pp.274-280
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• 2017

Generally, global performance analysis in offshore platforms is performed using potential-based numerical tools, which neglect hydrodynamic viscous effects. In comparison with the potential theory, computational fluid dynamics (CFD) methods can take into account the viscous effects by solving the Navier-Stokes equation using the finite-volume method. The open-source field operation and manipulation (OpenFOAM) C++ libraries are employed for a finite volume method (FVM) numerical analysis. In this study, in order to apply CFD to the global performance analysis of a hull-mooring coupled system, we developed a numerical wave basin to analyze the global performance problem of a floating body with a catenary mooring system under regular wave conditions. The mooring system was modeled using a catenary equation and solved in a quasi-static condition, which excluded the dynamics of the mooring lines such as the inertia and drag effects. To demonstrate the capability of the numerical basin, the global performance of a barge with four mooring lines was simulated under regular wave conditions. The simulation results were compared to the analysis results from a commercial mooring analysis program, Orcaflex. The comparison included the motion of the barge, catenary shape, and tension in the mooring lines. The study found good agreement between the results from the developed CFD-based numerical calculation and commercial software.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.7
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• pp.1417-1426
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• 2011

Radiofrequency ablation through cardiac catheterization is one of minimally invasive intervention procedures used in drug resistant arrhythmia treatment. To facilitate more accurate and precise catheter navigation, systems for robotic cardiac catheter navigation have been developed and commercialized. The authors have been developing a novel robotic catheter navigation system. The system is a network-based master-slave configuration 3-DOF (Degree-Of-Freedom) robotic manipulator for operation with conventional cardiac ablation catheter. The catheter manipulation motion is composed of the translation (forward/backward) and the roll movements of the catheter and knob rotation for the catheter tip articulation. The master manipulator comprises an operator handle compartment for the knob and the roll movement input, and a base platform for the translation movement input. The slave manipulator implements a robotic catheter platform in which conventional cardiac catheter is mounted and the 3-DOF motions of the catheter are controlled. The system software that runs on a realtime OS based PC, implements the master-slave motion synchronization control in the robot system. The master-slave motion synchronization performance tested with step, sinusoidal and arbitrarily varying motion commands showed satisfactory results with acceptable level of steady state error. The developed system will be further improved through evaluation of safety and performance in in vitro and in vivo tests.

• Restorative Dentistry and Endodontics
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• v.39 no.1
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• pp.39-44
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• 2014

Objectives: The purpose of this study was to evaluate in vitro cytotoxicity of the pozzolan cement and other root-end filling materials using human periodontal ligament cell. Materials and Methods: Endocem (Maruchi), white ProRoot MTA (Dentsply), white Angelus MTA (Angelus), and Super EBA (Bosworth Co.) were tested after set completely in an incubator at $37^{\circ}C$ for 7 days, Endocem was tested in two ways: 1) immediately after mixing (fresh specimens) and 2) after setting completely like other experimental materials. The methods for assessment included light microscopic examination, cell counting and WST-1 assay on human periodontal ligament cell. Results: In the results of microscopic examination and cell counting, Super EBA showed significantly lower viable cell than any other groups (p < 0.05). As the results of WST-1 assay, compared with untreated control group, there was no significant cell viability of the Endocem group. However, the fresh mixed Endocem group had significantly less cell viability. The cells exposed to ProRoot MTA and Angelus MTA showed the highest viability, whereas the cells exposed to Super EBA displayed the lowest viability (p < 0.05). Conclusions: The cytotoxicity of the pozzolan cement (Endocem) was comparable with ProRoot MTA and Angelus MTA. Considering the difficult manipulation and long setting time of ProRoot MTA and Angelus MTA, Endocem can be used as the alternative of retrofilling material.