• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.2
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• pp.1-13
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• 2014

Objective : The purpose of this study is to understand conspicuous features of geroderma with visceral manifestation theory(臟象論). Methods : We categorized skin aging into wrinkles, hyperpigmentation, dry skin and face flush. After investigating the reason, histological changes and mechanism of each classification in western medicine, we interpreted them according to the malfunction of five viscera(五臟) in Korean medicine. Result : The results are as follows. 1. Pathologic change of dermis and subcutaneous fat makes wrinkles. We consider wrinkles as the malfunction of the spleen(脾). 2. Irregular synthesis and disproportion of melanin makes hyperpigmentation. We consider hyperpigmentation as the malfunction of the liver(肝). 3. Dry skin is attributed to a subtle disorder of epidermal maturation. We consider dry skin as the malfunction of the lung(肺). 4. Facial flush is detected in rosacea and menopausal hot flush, which are both related with blood vessel abnormality. We consider facial flush as the malfunction of the heart(心) Conclusion : We interpreted the pathologic changes and mechanism of skin aging in western medicine as the decrease of five viscera(五臟) in visceral manifestation theory(臟象論) of Korean medicine. Further studies are needed to apply these hypothesis to clinical diagnosis and treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.652-661
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• 2020

Recently, the Korean government developed the RE3020 (renewable energy) policy to overcome environmental problems, such as fine dust, climate change, and large-scale PV systems interconnected with a distribution system. When a large-scale PV system is interconnected in the distribution system, however, a malfunction can occur, and the protection devices may not be operated because of the dividing effect depending on the magnitude and direction of fault current as well as connection types and location of the PV system. Therefore, this paper proposes a search algorithm for the malfunction pattern of protection devices based on various scenarios, when large-scale PV systems are operated and interconnected in a distribution system. This paper presents a malfunction mechanism of protection devices according to the installation locations of recloser (R/C). Furthermore, the modeling of a distribution system with large-scale PV systems was performed using Off-DAS S/W, and the malfunction patterns of protection devices were analyzed based on a range of scenarios. From the simulation results with the proposed model and algorithm for searching for protection devices, it was confirmed that they are useful and effective in identifying a malfunction phenomenon depending on the installation location of the R/C and connection type of PV system.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2263-2268
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• 2008

We investigated the malfunction and destruction characteristics of microcontroller devices under high power electromagnetic(HPEM) wave by magnetron. HPEM was rated at a microwave output of 0 to 1,000 W, at a frequency of 2,450${\pm}$50 MHz and was radiated from the open-ended standard rectangular waveguide(WR-340) to free space. The influence of different reset-, clock-, data-, and power supply-line lengths has been tested. The variation of the line length was done with flat cables. The susceptibility of the tested microcontroller devices was in general much influenced by clock-, reset-, and power supply-line length, little influenced by data-line length. Further the line length was increased, the malfunction threshold was decreased as expected, because more energy couples to the devices. The surfaces of the destroyed microcontroller devices were removed and the chip conditions were investigated with microscope. The microscopic analysis of the damaged devices showed component and bondwire destructions such as breakthroughs and melting due to thermal effects. The obtained results are expected to provide fundamental data for interpreting the combined mechanism of microcontroller devices in an intentional microwave environment.

• BMB Reports
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• v.54 no.6
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• pp.285-294
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• 2021

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.5
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• pp.552-558
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• 2016

A control rod drive mechanism(CRDM) is a reactor regulating system, which inserts, withdraws or maintains a control rod within a reactor core to control the reactivity of the core. The CRDM for Jordan Research and Training Reactor with 5MW power has been designed and fabricated based on the HANARO’s experience through KAERI and DAEWOO consortium. This paper describes the seismic test results to demonstrate the operability, the drop performance and the structural integrity of CRDM during or after seismic excitations. The seismic tests are carried out under 5 OBE and 1 SSE loads at three Test Rigs simulating the reactor structure and the pool top. From the tests, the CRDM is smoothly driven without a malfunction of stepping motor under OBE load. The pure drop time under OBE and SSE loads is measured as 1.169s and 1.855s to meet the design requirement. Also, it is found that the CRDM maintains the structural integrity without a change of the function and natural frequency before and after seismic loads.

• BMB Reports
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• v.57 no.6
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• pp.263-272
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• 2024

Amyloid-β (Aβ) is one of the amyloidogenic intrinsically disordered proteins (IDPs) that self-assemble to protein aggregates, incurring cell malfunction and cytotoxicity. While Aβ has been known to regulate multiple physiological functions, such as enhancing synaptic functions, aiding in the recovery of the blood-brain barrier/brain injury, and exhibiting tumor suppression/antimicrobial activities, the hydrophobicity of the primary structure promotes pathological aggregations that are closely associated with the onset of Alzheimer's disease (AD). Aβ proteins consist of multiple isoforms with 37-43 amino acid residues that are produced by the cleavage of amyloid-β precursor protein (APP). The hydrolytic products of APP are secreted to the extracellular regions of neuronal cells. Aβ 1-42 (Aβ42) and Aβ 1-40 (Aβ40) are dominant isoforms whose significance in AD pathogenesis has been highlighted in numerous studies to understand the molecular mechanism and develop AD diagnosis and therapeutic strategies. In this review, we focus on the differences between Aβ42 and Aβ40 in the molecular mechanism of amyloid aggregations mediated by the two additional residues (Ile41 and Ala42) of Aβ42. The current comprehension of Aβ42 and Aβ40 in AD progression is outlined, together with the structural features of Aβ42/Aβ40 amyloid fibrils, and the aggregation mechanisms of Aβ42/Aβ40. Furthermore, the impact of the heterogeneous distribution of Aβ isoforms during amyloid aggregations is discussed in the system mimicking the coexistence of Aβ42 and Aβ40 in human cerebrospinal fluid (CSF) and plasma.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.8
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• pp.1485-1491
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• 2011

This paper deals with the technical problems for the protection devices, by simulating test facilities of protection coordination for Photovoltaic systems. In order to analyze the operation characteristics for the protection devices in the case that the Photovoltaic systems with bi-directional power supply are located in the feeder, this paper proposes the test facilities composed of model distribution system, protection device and model Photovoltaic systems. By performing the simulation for operation characteristics for the protection devices based on the test facilities, this paper presents the malfunction mechanism for the protection devices. The test results show that this paper is practical and effective for the technical guideline for the Photovoltaic systems.

• Journal of Korean Neurosurgical Society
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• v.50 no.2
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• pp.143-146
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• 2011

A ventriculo-peritoneal shunt is a standard surgical management for hydrocephalus, but complications may impede the management of this disease. Obstruction of the catheter is one of the most common complications and manifests clinically in various ways. Intraparenchymal cyst development after shunt malfunction has been reported by several authors, but the underlying mechanism and optimal treatment methods are debatable. The authors report a case of intraparenchymal cyst formation around a proximal catheter in a premature infant after a ventriculo-peritoneal shunt and discuss its pathogenesis and management.

• Journal of Applied Reliability
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• v.11 no.4
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• pp.357-369
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• 2011

Eco-robot for collecting recycling products is the machine which collects non-industrial wastes such as cans, PET bottles and etc. to reuse them as recycling resources. This eco-robot is operated in the condition that it should compress and hold various products without knowing their geometric shapes and material properties. For this reason reliability problems like malfunction or failure. comes to emerge, but the reliability test conditions to assess its performance and durability have not been founded yet. Therefore in this research failure mechanism of the eco-robot was analyzed and life test equipment which can reproduce actual usage conditions was developed. The compression levels in the life test were determined by measuring the crushing force acting on test products and Furthermore the test specimens which have equivalent shape and material properties with those of cans and PET bottles were proposed by simulating the deformation characteristics so that the actual compression conditions were set up in the test.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.10 no.4
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• pp.76-83
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• 2001

In this study, the static and dynamic characteristics of turning process was modelled and the analytic realization of regen-erative chatter mechanism was discussed. In this regard, we have discussed on the comparative assessment of recursive times series modeling algorithms that can represent the machining process and detect the abnormal machining behaviors in precision turning operation. In this study, simulation and experimental work were performed to show the malfunction behaviors. For this purpose, new Recursive Extended Instrument Variable Method(REIVM) was adopted for the on-line system identification and monitoring of a machining process. Also, we can apply REIVE algorithms in real process for the detection of chatter frequency and dynamic property and analyze the stability lobe of the system by changing a parameter of cutting dynamics in regenerative chatter mechanics, if it is stable or unstable, Also, The stability lobe of chatter was analysed.