• Korean Journal of Biological Psychiatry
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• v.25 no.4
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• pp.89-100
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• 2018

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method that delivers 1-2 mA of current to the scalp. Several clinical studies have been conducted to confirm the therapeutic effect of major depressive disorder (MDD) patients with tDCS. Some studies have shown tDCS's antidepressant effect, while the others showed conflicting results in antidepressant effects. Our aim of this review is to understand the biological bases of tDCS's antidepressant effect and review the results of studies on tDCS's antidepressant effect. For the review and search process of MDD treatment using tDCS, the US National Library of Medicine search engine PubMed was used. In this review, we discuss the biological mechanism of tDCS's antidepressant effect and the existing published literature including meta-analysis, systematic review, control trial, open studies, and case reports of antidepressant effects and cognitive function improvement in patients with MDD are reviewed. We also discuss the appropriate tDCS protocol for MDD patients, factors predictive of response to tDCS treatment, the disadvantages of tDCS in MDD treatment, and side effects.

• BMB Reports
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• v.28 no.6
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• pp.546-551
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• 1995

The conformation studies of myelin P2 protein and two of its major peptides were carried out using circular dichroism and fluorescence spectroscopy in water and in lipid environments. Significant conformational changes occur when the protein or peptides were bound to gangliosides. Similar effects were also found in trifluoroethanol solutions. The conformational features of P2 protein and its major peptides were discussed in relation to the environmental changes and the disease-inducing effects.

• Journal of the Korean Home Economics Association
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• v.46 no.9
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• pp.21-31
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• 2008

Family and child educators have an obligation to ensure that their students understand, conceptually and pragmatically, the major research methods. The purpose of this study was to develop a qualitative methodology course for graduate students majoring in family and child studies. Three stages of course development were followed; investigating how methodology courses are offered in family and child studies, discussing what topics and components should be covered in a qualitative methodology course, and planning how the topics and components should be taught. The proposed qualitative methodology course includes; understanding philosophical and theoretical frameworks, teaming the general process of a qualitative research, comparing different qualitative traditions of inquiry, discussing emerging issues related to qualitative research, and conducting experimental field work. This study can provide an academic syllabus for family and child educators, who are interested in teaching a qualitative methodology course for graduate students.

• Asia pacific journal of information systems
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• v.7 no.1
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• pp.49-66
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• 1997

Matching individual career desire and career path is desirable for individual motivation and organizational effectiveness. Some studies reported that major career orientations of MIS personnel are technical and managerial orientation. Furthermore, dual ladder system is based on the same notion above. However, subsequent research conclusions of this issues have been contradictory. Mnwhile, past studies on the work value of MIS personnel are mainly concentrated on the differences between MIS personnel and other occupations. To date, the study on the differences in the values of job factors between major career orientations is rare. The purpose of this study is to find out major career orientation of Korean MIS personnel and the differences of values of job factors between major orientations. The research result is two conclusions. First, major career orientations of Korean MIS personnel are technical and managerial orientation. Second, both group do not have different values about job property related factors, but managerial orientation group gives high values to the some organization related factors such as company policy, responsibility, authority, salary level and opportunity of promotion.

• Journal of Korean Academy of Rural Health Nursing
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• v.3 no.1
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• pp.5-14
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• 2008

Purpose: The purpose of this study was to analyze the trend of research on clonorchis sinensis in Korea. Method: The study design was a literature analysis in which research studies with 'Clonorchis' in the title were collected from 2001 to 2007. A total of 115 research studies were analyzed based on the year of publication, study design, major or institute of researcher, study sample, and research theme. Results: 10-19% of the research studies were published each year from 2001 to 2007. Experimental study design was the most frequent at 54.8%. Medicine or parasitology as the major of researchers were 43.2% and 41.2% retrospectively, but no nursing studies were found. For study samples, 65.9% were cyst larvae and animals, followed by human beings (29.5%). In research theme, the structure and gene analysis of clonorchis sinensis was the most frequent (32.1%), followed by animal experimental studies (15.7%), epidemic studies of clonorchis sinensis prevalence and changes (13.0%), and methods of diagnosis of clonorchis sinensis and effectiveness (12.2%). Conclusion: Although positive rate of clonorchis sinensis is still high, intervention studies for managing clonorchis sinensis were not found. So, methodological research developing clonorchis sinensis management program and intervention study is needed for high risk groups in rural communities.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.24 no.1
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• pp.37-51
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• 2021

The purpose of this research is to develop the Habitat Suitability Index (HSI) for habitat environments of Aix galericulata (A. galericulata) and Dendrocopos major (D. major), which tend to inhabit urban environments. A. galericulata and D. major are the keystone species representing the ecosystem of wetlands and forests. Based on the analysis of their urban habitat environments, this study selects artificially adjustable levels of the environmental index in order to produce the HSI model, which can be used when either restoring or creating the urban habitats for these species. To develop the HSI, we conducted field surveys at Jungnangcheon Stream, Changgyeonggung, Jangneung, Bangbae Neighborhood Park, Gildong Ecological Park, and Seodalsan Mountain. These surveys were conducted between April and August 2020, and this period includes the breeding season of both A. galericulata and D. major. Based on our findings from the surveys, we conclude that there are six SI factors for A. galericulata. These include (1) the presence of alluvial islands, (2) waterfront vegetation cover rate, (3) type of aquatic plants for food, (4) size of forest patch, (5) type of trees in nearby forests, and (6) connectivity of waterfront and forest. We also conclude that there are five SI factors for D. major, which include (1) size of forest patch, (2) rate of broadleaf trees in forest patches, (3) type of nesting trees, (4) diameter at breast height (DBH) of nesting trees, and (5) density of dead trees. The result of this research can provide future studies with useful guidance when both (1) comparing the habitat suitability of the target species in different environments and (2) restoring or creating habitats for these species.

• Korean Journal of Biological Psychiatry
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• v.7 no.2
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• pp.147-151
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• 2000

Objective : Major depression is known to have immunologic dysfunctions, the recent studies revealed that cytokines including IL-6 and IL-$1{\beta}$ were increased in patients with major depression. Since molecular genetic methods have been progressed, this study was to investigate the relationship between major depression and immunologic aspects by analyzing polymorphism of IL-10 gene. Method : 92 patients with major depression were included and data of 146 normal controls obtained from the Catholic Hemopoietic Stem Cell Information Bank of Korea were used in this study. DNA was extracted from whole blood, thereafter amplified by polymerase chain reaction, and digested by Mae III After that procedure, we obtained and assessed RFLP of two alleles, IL-10T and IL-10C. All data were analyzed by ${\chi}^2$ test. Results : 1) There were no significant difference in genotype frequencies of $IL-10^*T/T$, $IL-10^*T/C$, and $IL-10^*C/C$ between major depression patients group and control group. 2) There were no significant difference in allelic frequencies of $IL-10^*T$ and $IL-10^*C$ between major depression patients group and control group. Conclusion : We did not verified the differences in frequencies of $IL-10^*T/^*IL-10^*C$ gene between the major depression patients group and control group, respectively. But the results of this study do not declare that the IL-10 gene has no association with major depression. We do suggest that further systematic studies including various clinical variables should be conducted.

• Journal of Korean Academy of Rural Health Nursing
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• v.2 no.1
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• pp.43-50
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• 2007

Purpose: The purpose of this study was to analyze the trends of research on Community Nurse Practitioners in Korea in order to suggest future directions for research on Community Nurse Practitioners. Method: A total of 109 studies published from 1980 to 2006 were analyzed according to the year of publication, research design, journal type, subject type, and major study concepts. Results: 1) The number of studies related to Community Nurse Practitioners increased by 28.4% from 1985 to 1989, and also by 28.4% from 2000 to 2004. 2) The most frequently used research design in the studies was a descriptive study design (90.8%). 3) There were 43 master's theses on Community Nurse Practitioners, and 16 studies in the Journal of Korean Community Nursing. 4) The most frequent participants were Community Nurse Practitioners (68.9%). 5) The most frequent major study concept was job analysis of Community Nurse Practitioner programs (27.5%). Conclusion: It is suggested that there should be more studies on Community Nurse Practitioner programs in the future and, particularly, experimental studies to exam the effects of interventions on health promotion by Community Nurse Practitioners are considered necessary.

• Journal of Engineering Education Research
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• v.24 no.3
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• pp.32-41
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• 2021

The purpose of this study is to develop indicators to establishing the education system, focusing the curriculum in each department of H University for quality management of the curriculum. The indicator was developed based on previous studies and cases studies of other universities, and the validation of them was confirmed by the Delphi survey method. The Delphi surveys were conducted by two times, and 16 and 15 people participated for the first and second survey, respectively. We derived the following major results through developing the indicator. First, in order to conduct an education inspection of major courses, , , , , and are required. Second, the checking factors should be evaluated based on the contents in each stage, and can be regarded as a core activity in the curriculum. Accordingly, the checking factors becomes the basis for the establishment of the indicator to establishing the education system, and the indicator can be an expression method that represents the basis data for determining the factors to be evaluated.

• Phonetics and Speech Sciences
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• v.2 no.3
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• pp.37-46
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• 2010

This study investigates acoustic characteristics of English and Korean voiceless sibilant fricatives as they appear before the three vowels, /i/, /$\alpha$/ and /u/. Three measurements - duration, center of gravity and major spectral peak - are employed to compare acoustic properties and vowel effect for each fricative sound. This study also investigates the question of whether Korean sibilant fricatives are acoustically similar to the English voiceless alveolar fricative /s/ or to the palato-alveolar /$\int$/. The results show that in the duration of frication noise, English /$\int$/ is the longest and Korean lax /s/ the shortest of the four sounds. It is also observed that English alveolar /s/ has the highest value, whereas Korean /s/ shows the lowest value in the frequency of center of gravity. In terms of major spectral peak, while English /s/ reveals the highest frequency, English /$\int$/ shows the lowest value. In addition, evidence indicates that there is a strong vowel effect in the fricative sounds of both languages, although the vowel effect patterns of the two languages are inconsistent. For instance, in the major spectral peak, both Korean lax /s/ and tense /$s^*$/ show significantly higher frequencies before the vowel /$\alpha$/ than before the other vowels, whereas both English /s/ and /$\int$/ exhibit significantly higher frequencies before the vowel /i/ than before the other vowels. These results indicate that Korean sibilant fricatives are acoustically distinct from both English /s/ and /$\int$/.