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Impact of Methylation of the Gene $p16^{INK4a}$ on Prognosis of Head and Neck Osteosarcoma

  • Kim, Yong-Deok;Hwang, Dae-Seok;Kim, Cheol-Hoon;Shin, Sang-Hun;Kim, Uk-Kyu;Kim, Jong-Ryoul;Chung, In-Kyo
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.33 no.1
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    • pp.46-54
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    • 2007
  • PURPOSE Osteosarcoma occurring in the head and neck region is known as a malignant tumor that shows a relatively poor prognosis and, despite various treatments, clinicians have often been confounded by it. The existence or non-existence of the mutation of the gene $p16^{INK4a}$ has been used in prognosis assessment. In this study, author have attempted to determine whether methylation of the gene $p16^{INK4a}$ could be applied to forecast the progress of osteosarcomas in the head and neck region having been given poor prognoses in the diagnostic process and the early stage of treatment. RESEARCH SUBJECT AND METHOD Clinicopathologic investigations, immunohistochemical examinations, a methylation specific polymerase reaction (MSP) analysis, and a survival analysis were conducted on the tissues of 20 patients with mandibulofacial osteosarcoma. RESULTS Neither age, sex, size, smoking or non-smoking, nor region have showed a statistical significance with methylation or unmethylation of the gene $p16^{INK4a}$ and expression rates demonstrated by immunohisto- chemical examinations. A chi-square test indicated that recurrence inclination has no relation with the expression rate of p16 protein (p=0.6615), but it showed a statistical significance with methylation of the gene $p16^{INK4a}$ (p=0.0033). With respect to investigations of the survival rates, a Kaplan-Meier survival analysis found that the manifestation rate of p16 protein did not have an impact on survival (p=0.8864), but that the methylation of the gene $p16^{INK4a}$ resulted in significant differences in survival rates (p=0.0105). CONCLUSIONS The above results show that methylation of the gene $p16^{INK4a}$ could be one of the major factors that help determine the recurrence inclination and prognosis of osteosarcomas occurring in the head and neck region.

Exploring Pre-service Science Teachers' Motivation for Career Choice and Their Self-Image as a Science Teacher (예비과학교사들의 교사가 되고자 하는 동기와 교사상에 나타나는 특성)

  • Chang, Hyun-Sook;Lee, Hyun-Ju
    • Journal of The Korean Association For Science Education
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    • v.31 no.1
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    • pp.14-31
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    • 2011
  • This study investigated pre-service science teachers' motivation for career choice and their self-image as a science teacher. Although their motivations for becoming science teachers were very personal, three major characteristics emerged. First, during the process of their growth, their interest in education and science existed separately, and later the two interest were naturally focused on the job of a science teacher. When they find out that teaching science is right for them, they developed their inner motivation. Second, teaching opportunities to teach science subjects, including classroom observations, TA, tutor, and teacher-aid, played an essential role for them in finding their aptitude for science teaching. Third, their teaching-related experiences were very effective in building up their self-image as a science teacher and in preparing for the job. It also reinforced their inner motivation, which was important in finding their direction in life as a science teacher. Fourth, there were two categories for the self-image as a science teacher. One was teaching-oriented and the other was science subject-oriented. These images for the science teacher were closely connected with their inner motivation for science teaching.

Consciousness and behavior of married-teachers to support their aged parents (기혼교사의 노부모부양의식과 부양행동)

  • Choi, Jeong-Hye
    • Journal of Korean Home Economics Education Association
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    • v.19 no.2
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    • pp.171-184
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    • 2007
  • This research focused on the consciousness and behavior of married-teachers to support their aged-parents. The subject of this study was 239 married-teachers, in the Gyeongnam area, Korea, living with at least one of their old-parents. Statistical analysis was carried out using SPSS/WIN programs including frequencies, t-test, one-way ANOVA, correlation analysis and stepwise regression. The major findings in this study are as follows; 1) Degree of consciousness in supporting married-teachers' aged parents was 3.98 on a scale of 0-5.0. The significant variables affecting the results were sex, living-distance, and familism. 2) Degree of behavior in supporting married-teachers' aged parents was 3.07 on a scale of 0-4.0. The significant variables affecting the results were number of child, living-distance, economic level of aged parents, and self-esteem. 3) There was a close relationship between the consciousness and behavior of married-teachers to support their aged-parents. 4) Stepwise regression analysis showed that the most effective variable of the married-teachers' behavior for supporting aged-parents was supporting consciousness.

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Improvement of the performance and emission in a four-stroke diesel engine using fuel additive (4행정 디젤엔진에 연료첨가제 사용에 따른 성능 및 배기배출물 개선에 관한 연구)

  • Ryu, Younghyun;Lee, Youngseo;Nam, Jeonggil
    • Journal of Advanced Marine Engineering and Technology
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    • v.40 no.9
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    • pp.762-767
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    • 2016
  • High thermal efficiency and the ability to use various types of fuel are a few of the many advantages of diesel engines. However, a major disadvantage is that their exhaust emissions are more harmful to humans and the environment than that of conventional engine. Consequently, the provisions of the international emissions standards for diesel engine equipped passenger cars, commercial vehicles, and ships have become more stringent. These standards include the EU Euro 6, the IMO MEPC Tier 3, and the US EPA Tier 4. Ryu et al. published a study that applied fuel additives to two-stroke diesel engines. In this study, a four-stroke diesel engine using diesel oil for a generator is utilized as the test subject, and an experiment is performed to verify whether fuel additive can be used to improve performance and exhaust emissions. In addition, this experimental study presents research results for the application of fuel additives in both two-stroke and four-stroke diesel engines. The experimental results were compared and analyzed by placing an oil-soluble calcium-based organometallic compound in diesel oil. The results confirmed that the addition of fuel additive improved the performance (fuel consumption rate, exhaust gas temperature) and exhaust emissions (NOx, CO) of the diesel engine.

A Study on the Improvement of Service Quality Measurement (서비스 품질 측정 개선에 대한 탐색적 연구)

  • Su, Li;Kim, Hyunsoo
    • Journal of Service Research and Studies
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    • v.8 no.2
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    • pp.67-76
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    • 2018
  • Service quality research has been the subject of service studies for many years. This study is an exploratory study to improve the service quality measurement factor, and the research has been carried out reflecting the nature of the service; relationship quality, interactivity, horizontality, and harmony. Also, among the developed service quality measurement factors, the research model is reconstructed considering the major factors such as environmental quality, result quality, and convenience quality. Relationality and interactivity redesigned the quality factor, which is called interactive quality. The redesigned service quality factors consisted of interaction quality, result quality, environmental quality, convenience quality, harmonious quality, and horizontal quality. Experimental group evaluation was conducted on the quality factors and 18 measurement items were derived. A questionnaire was conducted to verify the validity of the 18 items. As a result of the questionnaire analysis, 6 factors and 15 items among the 18 items of service quality measurement factor were found valid. The six factors for the service quality measurement presented in this study are the results of the early stage research, but they can be used to improve the service quality factor in the future. However, this is significant because it reflects the characteristics of services that are consistent with the service economy. In particular, the horizontal quality and harmony quality factors are new factors not mentioned in the previous studies and need to be verified through further detailed studies. Further research is needed to improve the service quality measurement factors reflecting the nature of services and the characteristics of new services.

The Comparison of Effective of Stretching Exercise and Stabilizing Exercise for The Patients with Myofascial Pain Syndrome at The Shoulder Girdle (견관절부 근막동통증후군의 근육내 전기자극치료시 신장운동과 안정화운동의 효과 비교)

  • Kim, Sang-Eun;Lee, Hyun-Ok;Kim, Jong-Soon;Kim, Suhn-Yeop
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.11 no.2
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    • pp.49-61
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    • 2005
  • Summary of Background Data: Myofascial pain syndrome (MPS) is a common painful muscle disorder caused by trigger points occurring in myofascial. MPS is a major cause of chronical pain and is the subject of further clinical examination. Purpose: To uncover effective intramuscular stimulation therapy (IMS), the patients' actively participation stretching exercise and stabilizing around shoulder girdle where trigger point provoking myofascial pain syndrome in usually occurred. Methods: 45 myofascial pain syndrome patients were randomly chosen and divided into 3 groups. The first group (G1) received only IMS therapy, The second group (G2) had both IMS and active stretching exercises administered and the final group (G3) was given IMS therapy and stabilizing exercises. Therapy intervention was given for 3 weeks, 3 times a week and then only stretching exercise for the second group and stabilizing exercise for the third group was given for another 3 weeks. The visual analogue scale was dine before the experiment, 3 weeks after the experiment and 6weeks after the experiment to measure subjective degrees of pain and pressure pain threshold to measure sensitivity improvement of trigger point and functional ability questionnaire to measure daily life performance. Results: There were no significant changes after 3 weeks but after 6 weeks, between GI and G2 and between G1 and G3 showed significant change of pain, pressure pain threshold and daily life performance. There were significant improvement of the measurement of degrees of pain, pressure pain threshold and improvement of daily life performance at different times for G1 showed change 3 weeks after the experiment, but there were no changes 6 weeks after the experiment. There were significant improvement of the measurement at different times for G2 and G3 showed change 3 weeks after the experiment and 6 weeks after the experiment. Conclusions: IMS therapy proved to be effective in inactivation of trigger points of the myofascial pain syndrome patients and stretching and stabilizing exercises beside it keep remedial value longer by improvement of pain and dysfunction that occurred by the trigger point.

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The Analysis of Research Trends of Elderly in the Dental Hygiene Discipline (치위생학에서의 노인연구동향)

  • Goong, Hwa-Soo;Seo, Kawoun
    • Journal of dental hygiene science
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    • v.18 no.4
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    • pp.201-209
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    • 2018
  • The aim of this study was to identify bibliographic characteristics and research trends of articles published on the elderly people in dental hygiene. An analysis was done of 191 articles published from 1999 to 2017. Bibliographic characteristics were nine items such as publication journal, research design, research participants, number of researchers, data analysis method, keywords, research topic, and validity and reliability report. The collected data were analyzed using descriptive statistics of statistical program. First, the research on the elderly, which was published in dental hygiene, started to be published in 1999 and on going. Though major publications have been published in Journal of Korean Society of Dental Hygiene and Journal of Dental Hygiene Science, the kinds of journals are becoming diverse. Second, cross-sectional research was the most. Third, the elderly were the most studied subjects, but the criteria varied. Fourth, the number of authors was largest in order of two and three person. Fifth, data analysis method was in order of descriptive statistics, t-test, and ANOVA. Sixth, there were many duplication of keywords about oral, elderly, and health. Seventh, oral health behavior science was the most studied subject. Eighth, validity and reliability were reported at 27.4% and 51.6%, respectively. Ninth, only 15.7% of study was founded research funding. Based on the results of this study, we consider increase experimental research further. Therefore, it is recommeded that validity and reliability should be reported in research paper, and the keywords used in the field of dental hygiene should be agreed upon.

A Study on the Relationships between Busan Port and the Regional Economy (부산시 지역경제와 항만의 경제적 연계성 분석과 그 시사점)

  • Jung, Bong Min
    • Journal of Korea Port Economic Association
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    • v.30 no.4
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    • pp.199-217
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    • 2014
  • There have been relatively lots of studies on the relationships beteen port and city. And, most of the recent studies on the subject shows that the relationship between the two parties is weakening. The contributions of a port to the city economy such as convenience of logistics service utilization, cost reduction, creation of job opportunities and value added production etc. are diminishing, whereas negative effects of port such as environmental effects, limitation of waterfront activities etc. have been increasing. On the other hand, port logistics service demand from city economy is decreasing. As for Busan city, the trend of major economic indicators and growth factor analysis results show that there is hardly any relationships between the development of transportation industry(including port logistics) and the regional economy. Especially, it is identified that most regional industry sectors excluding transportation industry failed to secure competitive advantage. Accordingly, it can be concluded that Busan city economy fails to take advantage of advanced transportation industry sector, which supports overall economic activities. On the other hand, it can be a problem for enhancement of port-city relationships that related and supporting industries of transportation industry such as information and communication industry, financial and insurance industry, and processing and assembling manufacture industry fail to secure competitive advantage in Busan city.

Study on Sanjungjapgok(山中雜曲) written by Kim Deuk-yeon(金得硏) (김득연의 <산중잡곡> 연구 - 지수정 경영과 관련하여 -)

  • Nam, Dong-Geol
    • Sijohaknonchong
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    • v.43
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    • pp.123-148
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    • 2015
  • Kim Deuk-yeon(金得硏), who lived at the age of Chosun Dynasty, was the person who kept the parents's will of not serving as a government officias even though he had the ability of serving those positions. He made his composition at the Jisujeong(止水亭), a kind of pavilion which he had built, and the Sijo(時調) Sanjungjapgok(山中雜曲) is one of those compositions. This sugggestes that Sanjungjapgok has a close relation with the Jisujeong(止水亭) which he opreated on his own. So the purpose of this study is focused on analyzing the Sanjungjapgok based on his goal of operating the Jisujeong. The middle age of Chosun dynasty was the era when the pavilion had been prevail even to the average aristocrats who stayed just in local area. Kim Deuk-yeon seems to have had a great endeavor of operating his own pavilion; he had prepared to build Jisujeong for about 30 years. This resulted in his affection of the Jisujeong, which caused him to spend the last part of his life there. Sanjungjapgok consists of 49 pieces of peom and seems to have been written after compositing Jisujeongga(止水亭歌). Even though it has the same title, it doesn't have lots of relations for us to regard this as a Yeonsijo(聯詩調). But this also has the properties of Yeonsijo, whoch contatins 14 Yeonjaksijo(聯作時調) composed of Yeonsijo which has 2 to six lines. The subject of the Sanjungjapgok can be classified as a four major parts: appreciating the nature, study, gathering to make the poem, and taking a rest while satisfied with his own situation. These four properties reflect the function of the private pavilion. In the light of these four properties, I noticed that there were some contents dealing with the private pavilion. Given his social status, I was able to confirm that he had the considerable satisfaction with his life of operating the private pavilion, which was reflected by the Sanjungjapgok.

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The Behavioral and Educational Factors Affecting the Breast Self-examination and Breast Cancer Screening (일부 보건소 내소 여성의 유방자가검진과 유방암 검진의 관련요인)

  • 최종숙;박재용;한창현
    • Korean Journal of Health Education and Promotion
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    • v.18 no.1
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    • pp.61-78
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    • 2001
  • The purpose of this research was to find out plans to promote the fulfillment of the breast self-examination and breast cancer screening, which is preventive health behavior about women's having breast cancer exam in some part of our country with searching for the primary causes which have an effect on their fulfillment. The subjects of the study were 540 literate volunteers who were of age from 20 to 69 and who visited 8 health centers in Taegu. The survey research was made through questionares in the 8 health centers in Taegu from the 15th to the 30th of September, 1998. Based on Becker's health belief model asking medical staff's opinions with bibliographies, the major findings from the survey was as follow. The fulfillment rate of the breast self-examination and the breast cancer screening was 37.8%(204 subjects), 27.6% (149 subjects) each. Getting breast self-exam varied significantly depending on subject's age, income of family, religion, occupation and the number of children. As far as the breast cancer screening was concerned, there was remarkably significant difference in accordance with their age, marital status, religion, occupation, income of family, the number of children, ways of nursing and parturition age of the first baby. The subjects in their forties accounted for the highest rate. Based on the fulfillment of the breast self-examination and the breast cancer screening, the average points of all the variables presented from the health belief as well as the points of the susceptibility, seriousness, benefits, knowledge and level of health concern of interest in health were significantly higher than the points of non-fulfillment of them in the statistical analysis whereas the barriers was lower than them. In consequence of the multiple-logistic regression analysis putting the breast self-examination and the breast cancer screening in dependent variables, occupation, knowledge, seriousness, benefits, barriers and cues to action had significant effects on breast self-examination against breast cancer. Looking more attainments, thinking diseases more seriously, feeling more usefulness and there being any patient around with breast cancer led to the higher rate of the breast self-examination against it. On the other hand, feeling more impedition as well as housewives caused the lower rate of it. The breast cancer screening was significantly affected by age, sensitivity, usefulness, impedition and behavior momentum as well. The cases who are older, feeling more sensitivity against breast cancer, more usefulness of the examination and where any patient around, the fulfillment rate was higher. Contrarily the more impedition they felt, the lower the fulfillment rate was. Accordingly, the study of the causes, which have significant effects on the fulfillment of the self-examination and the breast cancer screening in order to find it in an early stage, and the development of health education programs as well as proper education for public health through carrying on campaigns and stepping up public relations must be indispensable.

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