• Childhood Kidney Diseases
• /
• v.22 no.1
• /
• pp.1-6
• /
• 2018

Rituximab (RTX) is a chimeric monoclonal antibody that inhibits CD20-mediated B-cell proliferation and differentiation. Several studies have examined its use in intractable nephrotic syndrome (NS) with some positive results. However, those studies examined such effects for a short-term period of 1 year, and some patients continued to relapse after a lapse in RTX treatment. Our use of RTX as a maintenance therapy (RTX injection when the CD19 cell count exceeded $100-200/{\mu}L$ before relapse) showed some noticeable efficacy. We used RTX in 19 patients with steroid-dependent NS (SDNS). In 12 patients treated with RTX maintenance therapy, only one relapse occurred. The mean treatment period was $23.4{\pm}12.7months$, and the mean number of RTX administrations was $3.9{\pm}1.6$. The relapse rates were decreased (from 2.68/year to 0.04/year), and the drug-free period also increased (from 22.5 days/year to 357.1 days/year) during maintenance therapy. The other seven patients were treated with one cycle of RTX or additional cycles in case of relapse (non-maintenance therapy). Relapse rates were significantly decreased after RTX treatment (from 1.76/year to 0.96/year, P=0.017). The relapse-free period was $15.55{\pm}7.38$ (range, 5.3-30.7) months. No severe side effects of RTX were found except for a hypersensitivity reaction such as fever and chills during its infusion. In conclusion, RTX is considered an effective and safe option to reduce the relapse rate by a single- or maintenance-interval therapy in SDNS.

• Journal of Korean Institute of Industrial Engineers
• /
• v.40 no.1
• /
• pp.118-127
• /
• 2014

The configuration such as series, parallel and k-out-of-n of a repairable system directly affects its reliability. The maintenance strategy can also affect the overall performance of the system. The objective of this work is to investigate the possible trade-off between the configuration of a repairable k-out-of-n system and its maintenance strategy. The redundancy is considered to be the design decision variables, whereas the preventive maintenance period is considered to be the maintenance decision variables. The optimization model is used to minimize the overall life cycle cost associated with the system, considering constraint on reliability. Finally, genetic algorithm is used to find the optimal values for the decision variables. The result is compared with optimal values for considering redundancy and maintenance respectively.

• Journal of the military operations research society of Korea
• /
• v.37 no.1
• /
• pp.147-159
• /
• 2011

Recently, the military service period has been shortened continuously. Meanwhile, more skilled airmen are needed as the complexity of weapon systems increase. This phenomenon could lead to a disastrous result such as deteriorating the level of the readiness and the fighting power. We suggest a method to improve recruit's maintenance capability rapidly by assigning airmen to jobs appropriate to their characteristics using Datamining methods (K-menas and CART). We focus on the assigning method for air force's air-munition maintenance airmen since they are requested more skilled than other airmen. Grouping airmen with k-means method and devising classification rule with CART algorithm, we found that airmen's proficiency arrival period could be shortened by 1.79 months when they are assigned in the suggested way.

• Proceedings of the KSR Conference
• /
• 2008.06a
• /
• pp.243-248
• /
• 2008

Seoul subway is an safety, quick, and clean public transportation to secure citizens safety. One of the most important elements of train is optimizing railroad function and need to conform railroad inspection for function maintenance. Railroad is the most biggest part of the railroad facility and it is a structure which requires sustainable maintenance. The purpose of study is to improve domestic metropolitan railroad facility inspection method and period. For this, we refer documents about present roving method, roving members and period of railroad roving. In addition, analyzed problems of railroad roving investigation method and period by examining the type and standards of railroad investigation and interviewing experts. By this, we analyzed improving plan and expectations of railroad maintenance and repair operation.

• Journal of Korean Society of Disaster and Security
• /
• v.7 no.2
• /
• pp.9-16
• /
• 2014

Though the maintenance monitoring of structurally weak parts of the tunnel structure in public service must be judged in connection with the monitoring during the construction period for analysis of the behavior of the ground and surrounding structures following the tunnel excavation for the effective management, the monitoring during the construction period and the maintenance monitoring are implemented separately on the basis of the periods of construction and maintenance, so the connectivity and systematic management of the related data are mostly inadequate. The improvement direction is suggested in this thesis, by analyzing the problems of tunnel monitoring in the domestic design criteria. And, it is anticipated that from now on the use of hi-tech sensors and wireless communications technology will proceed vigorously in the maintenance, so considering these situations, the development and application of the maintenance monitoring system and the revision of the domestic design criteria and specification are needed in the future.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.7 no.4
• /
• pp.41-47
• /
• 2012

Railroad rolling stock has long service life and a lot of maintenance cost running on rail by wear and vibration. And it is very important to get optimization of maintenance. This paper want to analyze rolling stock maintenance situation of KORAIL and find out its improvement methods. Especially, the purpose of this paper is to adopt the most effective maintenance period and methods to daily inspection which needs many maintenance manpower in rolling stock. Rolling stock has self-diagnosis function using computer system and the quality of rolling stock has much improved these days but current daily inspection repeat for short period routinely and it is very ineffective. Therefore, the paper adopt improved daily inspection period reflecting the characteristics of rolling stock, and want to secure reliability of rolling stock and minimize maintenance cost.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.6 no.1
• /
• pp.1-8
• /
• 2010

The existing maintenance program is focused on time-based maintenance to inspect and repair components according to maintenance period, rather than condition-based maintenance or predictive maintenance. The preventive maintenance template of the steam turbine has been developed for optimizing maintenance procedure and improving reliability and availability of the steam turbine of nuclear power plants based on EPRI PM template methodology and EPRI technical reports about preventive maintenance.

• Proceedings of the KSR Conference
• /
• 2011.05a
• /
• pp.1174-1181
• /
• 2011

This paper investigates the current established preventive maintenance and its corresponding data on a point machine among railway signalling facilities and suggests a part of considerable plans when the policy of the preventive maintenance is modified. It is not appropriated to apply the optimized preventive replacement period considered with the cost simply. In that case, it is suggested that the reliability should be analyzed failure mode and effects through collecting the on-site failure data sufficiently. Then, that result can be proposed to adjust the proper criteria into the rational way by comparing the initial maintenance criteria. In this paper, the alternative way to determine the feasibility of the inspection period using failure probability is introduced.

• Proceedings of the KSR Conference
• /
• 2009.05a
• /
• pp.1179-1186
• /
• 2009

The high-speed train(KTX) was operated in domestic since 2004 and 4years have been passed since then. At the beginning most of the KTX component maintenance period was followed by the France SNCF. It was settled by the TBO(Time Between Overhauls). But the environment and operation condition are different form each other, so the TBO maintenance period can be different in some component. Therefore new TBO is necessary based on our own circumstances. This paper introduces failure analysis case on some components to set TBO in domestic. KTX-RCM(Reliability Centered Maintenance System), MICS(Maintenance Information Computer System) and KOVIS(KORAIL ERP System) Data was investigated.

• Journal of the Korean housing association
• /
• v.12 no.3
• /
• pp.75-83
• /
• 2001

The deteriorted high-rise apartments make a social problem in now days. As a result, and new alternative plan for deteriorted high-rise apartments such as the remodeling concept must be considered. This study aims to develop the remodeling items which is the guide lines when remodeling of the apartment will be conducted. Thorough the case studies of maintenance and repair status of the deteriorted apartments in seoul, reasonable guidelines for selection of remodeling items were developed. Physical maintenance items includes those that need major repair activity like wall painting, water proof roof, change/repairs/implement of heating system, boiler, city gas pipelines, cold and hot water pipes, elevators, cleaning of water tanks. The period of repair is shorter than the durable year of law or codes. As a result of the study, basic maintenance items and actual repair period were proposed. This result will be the basic guidelines for remodeling items.