Objective: Nude mice with orthotopic transplantation of human ovarian epithelial cancer were used to investigate screening criteria for paraneoplastic normal ovarian tissue and the security of the freezing and thawing for ovarian tissue transplantation. Methods: Expression of CK-7, CA125, P53, survivin, MMP-2/TIMP-2 in paraneoplastic normal ovarian tissues were detected by RT-PCR as well as immunohistochemistry. The tissues of the groups with all negative indicators of RT-PCR, all negative indicators of immunohistochemistry, negative expression of CK-7, CA125 and survivin, positive expression of CK-7, CA125 and survivin, cancer tissues and normal ovarian tissues of nude mice were used for freezing and thawing transplantation, to analyze overt and occult carcinogenesis rates after transplantation. Results: When all indicators or the main indicators, CK-7, CA125 and survivin, were negative, tumorigenesis did not occur after transplantation. In addition the occult carcinogenesis rate was lower than in the group with positive expression of CK-7, CA125 and survivin (P<0.01). After subcutaneous and orthotopic transplantation of ovarian tissues, rates did not change (P>0.05). There was no statistical significance among rates after transplantation of ovarian tissues which were obtained under different severity conditions (P>0.05). Conclusion: Negative expression of CK-7, CA125 and survivin can be treated as screening criteria for security of ovarian tissues for transplantation. Immunohistochemical methods can be used as the primary detection approach. Both subcutaneous and orthotopic transplantation are safe. The initial severity does not affect the carcinogenesis rate after tissue transplantation. Freezing and thawing ovarian tissue transplantation in nude mice with human epithelial ovarian carcinoma is feasible and safe.
Koh, Sang-Mo;Lee, Bum Han;Lee, Gilljae;Cicek, Murat
Economic and Environmental Geology
/
v.47
no.5
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pp.541-549
/
2014
The annual borate production in Turkey is about 3 million tons, which occupies approximately 61 percent of total annual world production. Turkey has five boron deposits including Bigadic, Emet, Kestelek, Kirka, and Sultancayir. At present, Bigadic, Emet, and Kirka deposits are operating. Kirka boron deposit is distributed within volcanoclatic sedimentary group as mainly layered, rarely brecciated and massive types. Major borate is borax associated with colemanite and ulexite. They show a horizontal symmetrical zonation from Na borate (borax) in the center of deposit to Na-Ca borate (ulexite) and Ca-borate (colemanite) in margin. Bigadic boron deposit is known as the largest colemanite deposit in the world. This deposit occurs as two borate bearing horizons in Miocene volcanoclastic sedimentary group. Thickness ranges from several meters to 100 meter with a length of several hundreds meters. Borate ore bodies which are mainly composed of colemanite and ulexite are alternated with claystone, mudstone, tuff and layered limestone as lenticular shape. Sultancayir boron deposit is mainly distributed within gray limestone. Main borate minerals of this deposit are pandermite and ulexite. Pandermite and ulexite occur as colloform aggregate and small veinlet, respectively. Turkish boron deposits are evaporite deposit which were formed in Miocene playa-lake environment. Boron was supplied to the deposits by the volcanic and hydrothermal activities.
In building construction, openings of the story-height deep beams are usually required for accessibility and service lines such as air conditioning ducts, drain pipes and electric units. It is known that the main parameters affecting the load bearing capacity of deep beams with web openings are size, shape, location and reinforcements of openings. However, there have been no pertinent theories and national design codes for predicting ultimate shear strength of reinforced concrete deep beams with web openings. In this study, the shear behavior of simply supported reinforced concrete deep beams with web openings subject to concentrated loads has been scrutinized experimentally. A total of 34 specimens, the geometry of openings, its reinforcements and shear span to depth ratio, being taken as the experimental variables, has been cast and tested in the laboratory. The effects of these structural parameters on the shear strength and crack initiation and propagation have been carefully checked and analyzed. From the tests, it has been observed that the failures of all specimens were due to shear mechanism and the ultimate strength of specimens varies according to the location of openings, by which the formation of compression struts between the loading points and supports are deterred. All of the test results of specimens have been compared with the formulas proposed by previous researchers. The results were closely coincident with the formulas given by Ray and Kong's equation except for some X series specimens having a larger dimension of openings beyond the geometric limits of proposed equations.
The Soowang Au-Ag deposits occur as quartz veins which filled fissures in middle Cretaceous porphyritic granite an/or gneiss of the Precambrian Sobaegsan gneiss complex. The paragenetic studies suggest that vein filling can be divided into four identifiable stages (I to IV). Stage I is the main sulfide stage, characterized by the deposition of base-metal sulfide and minor electrum. Stage II is the electrum stage, whereas stage III represents a period of the deposition of silver-bearing sulfosalts and minor electrum. Stage IV is the post ore stage. Mineralogical and fluid inclusion evidences suggest that mineralization of the Soowang deposits were deposited by the cooling of the fluids from initial high temperatures 300$^{\circ}C$ to later low temperatures 150$^{\circ}C$. The salinity of the fluids were moderate, ranging from 10.4wt.% equivalent NaCl in sphalerite to 3.1wt.% equivalent NaCl in barite. The gold-silver mineralization of the Soowang mine occurred at temperatures between 140 and 250$^{\circ}C$ from fluids with log $fs_2$ from -12 to -18 atm. A consideration of the pressure regime during ore deposition, based on the fluid inclusion evidence of boiling, suggests lithostatic pressure of less than 210 bars. This pressure condition indicates that vein system of the Soowang deposit formed at depth around 800 m below the surface at the time of gold-silver mineralization.
Fully cholesteryloxycarbonated and (8-cholesteryloxycarbonyl) heptanoated disaccharide derivatives were synthesized by reacting cellobiose, maltose, and lactose with cholesteryl chloroformate or 8- cholesteryloxycarbonylheptanoyl chloride, and their thermotropic liquid crystalline properties were investigated. All the cholesteryloxycarbonated derivatives (CH1DSs) formed enantiotropic cholesteric phases, whereas all the (8-cholesteryloxycarbonyl) heptanoated derivatives (CH8DSs) exhibited monotropic cholesteric phases with left-handed helicoidal structures whose optical pitches (${\lambda}m's$) decrease with increasing temperature. All the CH1DSs, contrast with the CH8DSs, did not display reflection colors over the full cholesteric range, suggesting that the helicoidal twisting power of the cholesteryl group highly depends on the length of the spacer joining the cholesteryl group to the disaccharide chain. The thermal stability and degree of order in the mesophase and the temperature dependence of the ${\lambda}m$ observed for EH8DSs were entirely different from those reported for the cholesterol-bearing dimers and triplet and the (8-cholesteryloxycarbonyl) heptanoated polysaccharide derivatives. The results were discussed in terms of the difference in the number of the mesogenic units per mole of repeating unit and the flexibility of the main chain.
Journal of the Korean Society of Fisheries and Ocean Technology
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v.31
no.1
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pp.84-92
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1995
The methods by turning circle test and maneuvering indices have been used to study and evaluate the maneuverability of a ship. However recently many studies utilizing the GPS are made on the measurement of the turning circle and in the fishery and hydrographic survey. In this paper, the author carried out the turning circle test using the differential GPS and dumb card together, and compared the data measured by them and analyzed the accuracies of them to obtain the utility basic ones on the measurement of the turning circle by the DGPS. The main results area s follows : 1) To check the accuracies of the GPS, the circling experiments of 50m radius by the DGPS were made on the ground. The accuracies of turning circle measured by the DGPS were found to be very high as the errors of 1.5m. 2) the turning circle by the DGPS could be measured very accurately, by the seed, rudder angle, starboard and port respectively. 3) The turning circle measured by the dumb card was found to be measured accurately as much as the DGPS, when using large rudder angle, the turning circle was large, the turning circle by the dumb car could not be measured accurately on account of large error of bearing of compass. 4) The tactical diameters by the DGPS in case of the rudder angle 35。~5。, were found to be 2.6。15.0 times the Lpp of S.T HAELIM-3 at her slow speed 2.8~16.6 times her Lpp at her half speed, 3.1~17.4 times her Lpp at her full speed. The tactical diameter by the dumb card was found to be 2.4~9.5 times, 2.6~9.6 times, 3.2~12.2 times her Lpp respectively, in the above case and speed.
Journal of the Korea Academia-Industrial cooperation Society
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v.18
no.1
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pp.545-552
/
2017
Ground subsidence can result in the formation of sinkholes, potholes, settlement of structures, and road subsidence. Road subsidence is described as the sudden collapse of the road surface into subsurface cavities caused by the loss of bearing capacity in the ground, such as the dissolution of limestone by fluid flow in the surface causing the formation of voids leading to subsidence at the surface. Road subsidence occurs about 665 times annually, and this incidence has been increasing until 2013. Damaged underground facilities, management negligence, and lowering of the ground water table have been the causes of road subsidence in Seoul. Seoul metropolitan government announced special management counter plans to relieve the anxieties and make the roads safe for passing. Construction sites, such as excavation works, need to be managed properly because they have strong potential to induce road subsidence. The aim of this study was to identify the main causes of road subsidence and suggest management plans. First, life cycle cost analysis revealed the daytime construction to be more appropriate than nighttime. In addition, by analyzing the limitations of using sand as a backfill material, it is proposed to use a flowable backfill material instead of sand. Finally, to reduce the blind spots, which is a problem in surveying the road pavement conditions of local governments, the road to be managed is divided into several zones, and a specialized agency is selected for each zone and a method of surveying the blind spots through collaboration is suggested.
This study was conducted to determine the germination characteristics, oil contents and fatty acid compositions of the different safflower accessions. The safflower accessions had nearly the same germination period of about 12-13 days and the germination rate was more than 87.5%. Plant height grew until 84 days after seeding. The number of leaves did not increase after 70 days from seeding. The accessions had a difference of six loaves from 17 to 23 loaves. Flowering time had a difference of 11 days from 79 days after planting to 90 days after planting. The Jangsung accession had the shortest flowering time of 79 days after planting. In the characteristics of bearing fruit, the number of branches including main stem are from 4.7 to 8.8. The number of head flowers had nearly the same number of branches which were 4.8-8.9, numbers of seed per head flower were 29.3-49.1 and the weight of 100 seeds were 2.9-3.9 g. The crude fat content was 21.8-33.9% and fatty acid content was 66.6-77.6% containing mostly linolenic acid. Oeic acid content was 9.2-16.5% and it contained palmitic acid, stearic acid, venin acid, arachidonic acid etc. Results of this study, the accession Jangsung, which had the shortest flowering time and had the most crude fat content, was observed to be the best accession for the breeding of safflower.
The purpose of this study is to investigate factors that affect corporate CEOs' tax avoidance, ultimately helping find how to fundamentally prevent the avoidance, establish a tax system that ensures tax payers' compliance and revise tax laws and regulations in a positive way. For the purpose, this researcher surveyed corporate CEOs with a questionnaire that contained many questions of various types, which was developed based on previous studies. Findings of the study can be summarized as follows. Main factors affecting tax avoidance were the application of tax provisions, the ability to understand tax laws and the expectation of tax avoidance. The more corporate CEOs' were influenced by the first and the third factors, the higher their propensity for tax avoidance was. On the contrast, corporate CEOs were lower in propensity for tax avoidance when they were more able to understand tax laws. Regarding the three factors' relative influences, tax avoidance was most affected by the expectation of tax avoidance, followed by the ability to understand tax laws and the application of tax provisions in order. Meanwhile, a multi-regression analysis using the sequential deletion technique showed that tax avoidance were affected by the application of tax provisions and the expectation of tax avoidance and that tax avoidance was most influenced by the application of tax provisions, followed by the expectation of tax avoidance. These findings indicate that the degree of corporate CEOs' tax avoidance may vary depending on social and environmental changes that their business face. Meanwhile, positive factors such as tax-bearing capacity and the procedure of tax calculation and negative factors such as management ethics and tax authorities' regulation are all thought to be not helping prevent tax avoidance.
A compression lap splice becomes an important issue due to development of ultra-high strength concrete. Current design codes regarding compression lap splice do not utilize merits of the improved strength of ultra-high strength concrete. Especially, a compression lap splice can be calculated longer than a tension lap splice according to the codes because they do not consider effects of compressive strength of concrete and transverse reinforcement. This anomaly confuses engineers in practice. Design equation is proposed for compression lap splice in 40 to 70 MPa of compressive strength of concrete. The proposed equation is based on 51 specimens conducted by authors. Basic form of the equation includes main parameters which are derived from investigating test results. Through two-variable non-linear regression analysis of measured splice strengths, a strength equation of compression lap splices is then derived. A specified splice strength is defined using a 5% fractile coefficient and a lap length equation is constructed. By the proposed equation, the anomaly of lap lengths in tension and compression is got rid of. In addition, the equation has a reliability equivalent to those of the specified strengths of materials.
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