• Clinical and Experimental Pediatrics
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• v.49 no.11
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• pp.1223-1226
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• 2006

Sideroblastic anemia is a rare, heterogeneous group of disorders characterized by hyperferremia, microcytic hypochromic anemia, and bone marrow erythroid hyperplasia with the presence of numerous ringed sideroblasts. We describe herewith the case of a rare coincidence of sideroblastic anemia and mitral valve prolapse with resultant regurgitation in a 2-year-old boy. In addition to the inherent propensity for the development of cardiac dysfunction in sideroblastic anemia due to transfusion-associated myocardial iron overload and chronic anemia, a coincidence of MVP will further increase the likelihood of the morbidity or mortality of th patient. in this patient. After response to pyridoxine, the patient remains in good condition with stable hemoglobin levels.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2751-2756
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• 2015

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can specifically induce apoptosis limited to various cancer cells, so this reagent is considered a promising medicine for cancer therapy. TRAIL also exerts effects on non-apoptotic signals, relevant to processes such as metastasis, autophagy and proliferation in cancer cells. However, the mechanisms of TRAIL-regulated non-apoptotic signals are unclear. The purpose of this study was to investigate MADD/CXCR7 effects in TRAIL-mediated breast cancer cell migration. Materials and Methods: The ability of MADD/CXCR7 to regulate MVP signaling in TRAIL-mediated breast cancer cells migration was evaluated by transwell migration assay, quantitative RT-PCR, Western blotting and knock down experiments. Results: In this study, we found that treatment with TRAIL resulted in induced expression levels of MADD and CXCR7 in breast cancer cells. Knock down of MADD followed by treatment with TRAIL resulted in increased cell migration compared to either treatment alone. Similarly, through overexpression and knockdown experiments, we demonstrated that CXCR7 also positively regulated TRAIL-inhibited migration. Surprisingly, knock down of MADD lead to inhibition of TRAIL-induced CXCR7 mRNA and protein expression and overexpression of CXCR7 lead to the reduction of MADD expression, indicating that MADD is an upstream regulatory factor of TRAIL-triggered CXCR7 production and a negative feedback mechanism between MADD and CXCR7. Furthermore, we showed that CXCR7 is involved in MADD-inhibited migration in breast cancer cells. Conclusions: Our work defined a novel signaling pathway implicated in the control of breast cancer migration.

• Journal of Korean Society of Water and Wastewater
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• v.32 no.4
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• pp.317-324
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• 2018

SWRO-PRO hybrid desalination technology is recently getting more attention especially in large desalination markets such as USA, Middle East, Japan, Singapore, etc. because of its promising potential to recover a considerable amount of osmotic energy from brine (a high-concentration solution of salt, 60,000 - 80,000 mg/L) and also to minimize the impact of the discharged brine into a marine ecosystem. By the research and development of the core technologies of the SWRO-PRO desalination system in a national desalination research project (Global MVP) supported by Ministry of Land, Infrastructure, and Transport (MOLIT) and Korea Agency for Infrastructure Technology Advancement (KAIA), it is anticipated that around 25% of total energy consumption rate (generally 3 to $4kWh/m^3$) of the SWRO desalination can be reduced by recovering the brine's osmotic energy utilizing wastewater treatment effluent as a PRO feed solution and an isobaric pressure exchanger (PX, ERI) as a PRO energy converter. However, there are still several challenges needed to be overcome in order to ultimately commercialize the novel SWRO-PRO process. They include system optimization and integration, development of efficient PRO membrane and module, development of PRO membrane fouling control technology, development of design and operation technology for the system scaling-up, development of diverse business models, and so on. In this paper, the current status and progress of the pilot study of the newly developed SWRO-PRO hybrid desalination technology is discussed.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.211-212
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• 2011

플라즈마를 제어하기 위해서는 플라즈마의 온도, 밀도, 에너지 분포등과 같은 플라즈마의 특성을 정확히 측정할 수 있어야한다. 핵융합발전에서는 플라즈마를 발생하기 위하여 플라즈마의 온도, 밀도 등 각종 변수들을 시공간적으로 계측, 분석할 수 있는 진달설비를 사용하고 있으며, 정확한 플라즈마 제어와 측정을 위한 새로운 진단기술을 개발하고 있다. 그리고 중요한 변수중에 하나인 플라즈마 이온온도를 측정하기 위해 중성입자 검출법이 잘 알려져 있다. 이 실험은 수소 중성입자가 토카막 내부의 플라즈마 이온과 충돌하면서 생성된 고속 중성입자의 에너지를 분석하는 실험이다. 본 연구의 실험방법은 수소 중성입자를 이온빔 장치에서 이온화 시킨 후 자체 제작한 가속기를 통하여 가속시켜 에너지 특성을 분석을 하는 것이다. 본 연구의 실험장치로 에너지 교정용 100 keV 이온빔 소스를 제작 하였고 이온빔 장치 내부에 수소기체를 주입하고 기체방전을 일으켜 플라즈마를 발생시켰다. 이온빔 외부에는 팬을 설치하고 전도성이 강한 물 대신 전도성이 약한 오일을 사용하여 냉각 하였다. 이온빔 장치와 결합될 이온 가속장치는 지름 300 mm, 두께 2 mm의 원형 구리판을 여러층으로 쌓아 전극으로 제작하였고 전극과 전극 사이에서 코로나 방전과 스파크를 방지하기 위해 전극 둘레에 코로나링을 설치 하였다. 또한 전극 사이마다 1G${\Omega}$의 저항을 설치한 후 고전압을 생성하여 이온 가속 효율을 증대시켰다. 진공시스템으로는 Alcatel사의 CFF100 터보분자 펌프와 우성진공사의 MVP24 진공로타리펌프를 결합하여 사용하였으며, 진공도측정은 Alcatel사의 ACS1000 장치를 사용하였다. 고진공후 고속 중성입자의 이온화와 에너지 측정을 위한 전하교환기를 설치하였다. 전하교환기로는 진공시스템을 별도로 설치하고 비용이 비교적 많이 드는 기체형 전하교환기 대신 소형화가 가능하고 유지보수가 좋은 고체형 전하교환기 제작하여 실험 하였다. 전하교환기에서 이온화된 고속 중성입자가 전기장이나 자장에 영향을 받았을때 에너지분포를 디텍터를 통해 측정하였다. 즉, 이온화된 중성입자의 에너지가 실리콘 다이오드를 통해 전압 펄스 신호로 변환되고 이차 증폭기를 통해 전압 펄스 신호들이 증폭한다. 에너지 측정을 위한 디텍터는 소형화가 가능하고 비용이 비교적 적게 드는 실리콘 다이오드를 설치하였다. 본 연구결과 중성입자 에너지 분석 장치가 실제 핵융합 장치의 플라즈마 이온온도와 특성 측정에 적용할 수 있으며, 앞으로 개발될 여러 형태의 응용 플라즈마 발생장치의 플라즈마 진단에 이용될 것으로 기대한다.

• Journal of Auto-vehicle Safety Association
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• v.11 no.2
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• pp.35-43
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• 2019

This paper describes the improved environment recognition algorithms using some type of sensors like LiDAR and cameras. Additionally, integrated control algorithm for an autonomous vehicle is included. The integrated algorithm was based on C++ environment and supported the stability of the whole driving control algorithms. As to the improved vision algorithms, lane tracing and traffic sign recognition were mainly operated with three cameras. There are two algorithms developed for lane tracing, Improved Lane Tracing (ILT) and Histogram Extension (HIX). Two independent algorithms were combined into one algorithm - Enhanced Lane Tracing with Histogram Extension (ELIX). As for the enhanced traffic sign recognition algorithm, integrated Mutual Validation Procedure (MVP) by using three algorithms - Cascade, Reinforced DSIFT SVM and YOLO was developed. Comparing to the results for those, it is convincing that the precision of traffic sign recognition is substantially increased. With the LiDAR sensor, static and dynamic obstacle detection and obstacle avoidance algorithms were focused. Therefore, improved environment recognition algorithms, which are higher accuracy and faster processing speed than ones of the previous algorithms, were proposed. Moreover, by optimizing with integrated control algorithm, the memory issue of irregular system shutdown was prevented. Therefore, the maneuvering stability of the autonomous vehicle in severe environment were enhanced.

• The Journal of Information Systems
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• v.31 no.1
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• pp.147-173
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• 2022

Purpose As the use of social network services has become common, it has become possible to freely communicate and establish relationships with other people anytime, anywhere for communication and information sharing. Influencers who have a strong influence on consumers' perceptions and attitudes through their own opinions and stories have appeared on various social media channels such as YouTube. Recently, companies utilize influencers with a large number of followers to check interactions with customers to understand customer attitudes and opinions about products in real time. Start-ups with insufficient resources need to quickly examine customer responses to reduce the probability of failure after product planning. The Lean process of creating an MVP and quickly confirming and learning the market response should be repeated over and over again. Findings In this paper, we try to suggest that the YouTube platform can play a sufficient role as a customer experiment space through examples. The case company is a company that has successfully commercialized products by continuously interacting with customers through the YouTube platform for the first four months of its founding. This paper is expected to be helpful in the experimental process for prospective founders and early founders to examine customer responses to reduce the probability of market failure before commercialization. Design/methodology/approach This paper analyzed the YouTube channel data of case companies based on the netnography methodology and presented the contents of the lean process management carried out in the experimental stage and the post-production stage through interview research.

• Journal of Information Technology Services
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• v.20 no.5
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• pp.89-104
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• 2021

Food delivery service combined with IT technology and HMR (Home Meal Replacement) are rapidly growing due to the COVID-19. Recently, the demand for salads along with HMR has increased among office workers in their 20s and 30s who are interested in health and beauty. Freshcode is a food startup with 6 years of experience that started selling salad products through O2O service. Freshcode applied for a patent for a service that collects orders from nearby areas and delivers them on the same day to a designated delivery address 'FCOSPOT' to save shipping costs. In March 2021, in recognition of the growth potential of the regular delivery service, Freshcode received an investment of 6 billion won in Series A. This study may have practical implications to early-stage startups and scale-up stage startups through a longitudinal case study on the growth of a single company. As for the research method, the lean startup methodology and lean canvas were used in the early stage of startup. In particular, the process of the build-measure and learn feedback-loop, which is the core of lean startup methodology, was applied to each major decision-making step. In the scale-up stage after 5 years, the business model canvas was used to schematize the growth as a food online O2O platform to verify continuous innovation. This case study has three main findings. First, the idea of 'FCOSPOT' was successfully implemented through the Lean Startup methodology. Second, Freshcode demonstrated the scalability of the differentiated business model of shared base delivery O2O. Third, a key factor of success was the digital integrated communication operation strategy that maximizes the experience for the created customers.

• Nuclear Engineering and Technology
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• v.54 no.10
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• pp.3604-3613
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• 2022

The Physical Protection System (PPS) plays an important role and must effectively deal with various adversary attacks in nuclear security. In specific single adversary path scenarios, we can calculate the PPS effectiveness by EASI (Estimated Adversary Sequence Interruption) through Probability of Interruption (P_I) calculation. EASI uses a single value of the probability of detection (P_D) and the probability of alarm communications (P_C) in the PPS. In this study, we develop a multi-path analysis code based on EASI to evaluate the effectiveness of PPS. Our quantification method for P_I considers the variability and uncertainty of P_D and P_C value by Monte Carlo simulation. We converted the 2-D scheme of the nuclear facility into an Adversary Sequence Diagram (ASD). We used ASD to find the adversary path with the lowest probability of interruption as the most vulnerable paths (MVP). We examined a hypothetical facility (Hypothetical National Nuclear Research Facility - HNNRF) to confirm our code compared with EASI. The results show that implementing the variability extension can estimate the P_I value and its associated uncertainty. The multi-path analysis code allows the analyst to make it easier to assess PPS with more extensive facilities with more complex adversary paths. However, the variability of the P_D value in each protection element allows a significant decrease in the PI value. The possibility of this decrease needs to be an important concern for PPS designers to determine the P_D value correctly or set a higher standard for PPS performance that remains reliable.

• Korean Journal of Plant Resources
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• v.9 no.3
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• pp.230-238
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• 1996

The experiment was carried out to find aromatic constituent composition of Codonopsis lanceolata species grown in the native(Mt. lrwol, Youngyang, Kyungpuk Province) and the cultivated(Andong, Kyungpuk Province) areas from 1994 to 1995. The results were as follows : Air temperature and soil temperature at the native area were lower to $2{\sim}3^{\circ}C$, and to $2^{\circ}C$ than the cultivated area. Organic matter contents of plant grown at the native area higher than that of plants at the cultivated area by 4.8%. Crude protein content was higher in plant grown at native area than the plant grown in wild area but in case of crude saponin, plants grown at wild area was higher than that of native area. For inorganic element contents. K content is much higher than in the domesticated area as compared with wild area above ten over. And other elements such as Cu, Mn, Na and Mg were not remarkably different in contents. In the free amino acid compositions, argine was highest compared with other free amino acids, and Arginine content was higher in dometicated area. Recovery yield of essential oil of wild species grown at the cultivated showed 0.005%, but domesticated species was 0.004%. But both species at the native area were the same by 0.004%. Although composition of aromatic constituents in the two areas and species varied, total aromatic constituent was 21 kinds. Most aromatic constituents were aliphatic alcohols such as 1-hexanol, eis-3-hexanol, and trans-2-hexanol occupied by approximately 90% over. But three constituets as amylalcohol, furfuryl acetate, and 2-methoxy-4-vinyl phenol(MVP) were detected only in domesticated species.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.05a
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• pp.183-192
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• 1999

The derivative equation measured of a ${\Delta}MV=Kp*{(EVn-EVn-1)+\frac{1}{Ki/S}* EVn+(Kd/S)*(2PVn-1-PVn-PVn-1)}$ is used on the machine apparatus of industrial field, but this par doesn\`t able to educate now, because we didn\`t have the implementation device of PID module, so the principle implementation system of the PID Module is manufactured and developed. Through this system, the implementation system of PID Module is practiced with that the SV and the set of P, I, D is set on the derivative equation measured of PID. A things to be known of this experiment result is flow. 1)PID module is known that had to be used with the module of A/D and D/A. 2) In process of PV is approached to the SV to follow Kp, Ti and Td to cause a constant of set value on the $MVp=Kp*EV, MV=\frac{1}{Ki}{\int}EVdt, MVd=Td\frac{d}{dt}EV$, the variable rate of E and Kp, Td, Ti in that table 1 is analysed, is same as flow. (1)If Kp is high, PV is near fast to the SV, but Kp is small, PV is near slowly to the SV. (2)If Ki is shot, PV is close fast to the SV, but Ti is high, PV is close slowly to the SV (3)If Td is high, the variable rate of E press hardly when because it doesn\`t increase, but Td is small, the variable rate of E press not hardly, upper with 1), 2), PID module is supposed that be able to do the A/S and an implementation of that apparatus, and getting a success of aim that an engineer want, on control of temperature, tension, velocity, amount of flow, power of wind end so on, to get the principle of automatic implementation in industrial field with cooperation of A/D and D/A module.