• 동의생리병리학회지
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• 제26권5호
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• pp.724-731
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• 2012

This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L. (MPM), traditional treatment for diabetes, ameliorates on high fructose-induced steatohepatitis and vascular inflammation. Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose diet alone for 8 weeks, with supplementation with MPM or rosiglitazone, peroxisome proliferators-activated receptor gamma ($PPAR{\gamma}$) agonist, occurring during the final 6 weeks. Treatment with MPM significantly prevented the increase in c-reactive protein (CRP) levels in the high fructose group. MPM suppressed high fructose diet-induced vascular inflammation marker expression such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. MPM also reduced intima/media thickness of thoracic aorta. Histologic observation and oil red O staining demonstrated hepatic tissue damage and lipid accumulation were severe in high fructose group. Treatment with MPM ameliorated hepatic tissue morphology with minimized steatosis. In addition, MPM attenuated hepatitis by inhibition of monocyte chemoattractant protein-1 (MCP-1) expression. MPM-fed group showed lower serum GOT and GPT levels comparing with high fructose group. MPM and rosiglitazone (positive control) significantly decreased the size of epididymal adipocytes. Taken together, the administration of MPM inhibited high fructose-induced steatohepatitis and vascular inflammation. These results suggested that MPM is useful in the prevention or treatment of metabolic syndrome-related disorders such as fatty acid metabolism and vascular homeostasis.

• 전기학회논문지
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• 제63권11호
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• pp.1526-1532
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• 2014

The Electronic Interlocking unit in railway signalling system is safety-related facilities to determine route and speed for train running. In particular, the SSI(Solid State Interlocking) is Electronic Interlocking unit for high-speed railway, and it performs safety-critical function by MPM(Micro-Processor Module). Meanwhile, MPM is composed of the PES(Programmable Electronic System)-based system, and the PES-based system in railway safety-related facilities should be implemented by complying with the safety requirements defined in IEC 62425 and IEC 61508. In this paper, we performed modeling of failure rate and reliability for MPM implemented by fault tolerance methods and analyzed functional safety for MPM. Moreover, we determined SIL(Safety Integrity Level) for MPM according to the safety requirements defined in IEC 61508 based on an analyzed functional safety.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3533-3538
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• 2015

Background: Multiple primary malignancies (MPM) have become increasingly prevalent worldwide. This investigation was aimed at establishing the clinicopathological characteristics of MPM patients and evaluating the impact of the living environment on MPM in the Taiwanese population. Materials and Methods: From January 2009 to December 2013, a total of 8,268 cancer patients were identified in our institutional center. Of these, 125 were diagnosed as MPM and thus enrolled. Data for clinicopathological features and treatment approaches for these MPM patients living in urban or suburb zone were obtained. Findings for the air pollution status in Taiwan were also collected. Results: The most common cancer match of MPM was esophageal cancer with hypopharyngeal cancer (12.8%), followed by colorectal cancer with gastric cancer (6.4%) and colorectal cancer with breast cancer (5.6%). The air quality was significantly worse in the urban than in the suburban zone and there was a remarkably higher portion of MPM patients in the urban zone suffering from grade III and IV post-chemotherapeutic neutropenia (30.8% vs 15.1%, P=0.036). Conclusions: The tumor frequency and site distribution should be taken into the clinical evaluation because there is a relatively high risk of developing MPM. This study also highlighted the potential influence of environmental factors on post-chemotherapeutic neutropenia for patients with MPM.

• 방송공학회논문지
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• 제25권1호
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• pp.109-112
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• 2020

VVC는 화면 내 예측에서 67가지의 모드를 사용한다. 이때 화면 내 예측 모드 표현을 위한 데이터를 감소시키기 위하여 MPM(Most Probable Mode)을 사용한다. 시그널링 되는 모드가 MPM 후보 내에 존재하는 경우 MPM 리스트의 해당 index를 송신하는 방법을 사용하고 MPM 후보 내에 존재하지 않는 경우에는 TBC 부호화를 적용한다. 화면 내 예측에서 TBC가 적용될 때 MPM 후보를 제외하고 낮은 번호의 모드 순서대로 3가지가 선택되어 5비트로 부호화되고 나머지 모드는 6비트로 부호화된다. 본 논문에서는 VVC의 화면 내 예측에서 사용하는 TBC 기술의 한계점을 알아보고 화면 내 예측에서 TBC를 사용할 때 기존의 방법보다 효율적으로 부호화 할 수 있는 적응적인 방법을 제안한다. 그 결과 기존의 부호화 방법과 비교해서 overall 부호화 성능이 AI와 RA에서 각각 0.01%, 0.04%의 부호화 효율이 증대되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3025-3029
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• 2012

The aim of this study was to investigate the possible relationship between antioxidant vitamin levels and malignant pleural mesothelioma (MPM). For this purpose, we measured the serum levels of 4 antioxidant vitamins, ${\beta}$-carotene, ${\alpha}$-tocopherol, retinol, and ascorbic acid, in patients with environmentally induced MPM and in healthy controls from one tremolite village (Kureysler), the biggest erionite village (Tuzkoy) and Ankara. A total of 160 subjects were enrolled in the study, 42 (26.3%) diagnosed with MPM and 118 (73.7%) healthy subjects. A comparison was made between the MPM group and three control groups of which two were exposed and one was unexposed to mineral fibers. The study population consisted of 82 males (51%) and 78 females (49%) with a mean of age of $44.8{\pm}14$ years (range; 20-65 years). Lowest levels of ${\beta}$-carotene, ascorbic acid, and ${\alpha}$-tocopherol were found in MPM patients (MPM vs control groups combined, p<0.0001 for each antioxidant vitamin), without any relation to age or sex. There was no significant difference between the antioxidant levels of healthy controls of Tuzkoy and Ankara. In conclusion; our findings suggested an increased risk of MPM being associated with low levels of ${\alpha}$-tocopherol and ascorbic acid in patients with MPM.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2010년도 하계학술대회 논문집
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• pp.256-258
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• 2010

MPM(Microwave Power Module)은 진공 전력증폭기인 진행파관(TWT,Traveling Wave Tube)과 반도체 전력증폭기(SSA, Solid State Amplifier)를 결합한 구조로서, 미세한 RF신호를 입력 받아 고출력의 RF 신호로 증폭하는 장치이다. 본 논문은 MPM을 구동하기 위해, 필요한 수 kV이상의 높은 전압을 TWT에 공급해주는 고전압 전원공급기(HVPS, High Voltage Power Supply)에 관한 것이다. Main Topology는 Resonant Phase Shift Full Bridge Converter이며, 승압의 효과를 높이기 위해 2차 측에는 Voltage Multiplier를 사용하였다. MPM을 구동하는데 필요한 전압인Cathode(-4kV), FE_Bias(-5.25kV), Collector(-2kV)를 생성하며, FE_ON, OFF신호에 따라 고전압 스위칭 동작을 하여, RF 증폭을 제어 할 수 있다. 최종적으로 Prototype을 제작하고, 고찰된 실험결과를 제시하여 개발된 HVPS의 우수성을 검증한다.

• Elastomers and Composites
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• 제53권4호
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• pp.207-212
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• 2018

Taylor rod impact tests have been the subject of many theoretical and experimental investigations. This paper discusses the numerical methods for simulating the Taylor impact test, which is widely used to obtain constitutive equations and failure conditions under high-velocity collisions of materials. With this in mind, a particle-based MPM (material point method) for linear viscoelastic solid materials was implemented, and MPM simulations for viscoelastic deformation behavior were numerically verified and confirmed by comparing the MPM and FEM results. In addition, this modeling and numerical approach could be extended to more complex viscoelastic models for basic understanding and to analyze the deformation and fracture behavior of more complicated viscoelastic material systems.

• 한국통신학회논문지
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• 제31권6C호
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• pp.629-636
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• 2006

Array 신호처리에서 복소 지수함수의 합으로 구성된 신호의 파라미터를 추정하는데 고차 통계를 이용할 수 있다. 본 논문에서는 기존의 MPM(matrix pencil method)보다 효과적으로 DOA를 판별하기 위해 MPM에 4차 cumulant와 moment 통계량을 적용하였다. 4차 cumulant 통계량은 선형 배열안테나에 입사하는 신호에 포함된 Gaussian 잡음을 효과적으로 감소시킬 수 있다. Gaussian 잡음이 존재하는 환경에서 기존의 방법과 4차 통계량을 이용한 방법을 시뮬레이션 함으로써 SNR과 DOA 분해능에 대하여 성능을 분석하였다. 결과로써 4차 통계량을 이용한 MPM이 기존의 MPM보다 우수함을 보였으며, 또한 4차 moment보다는 4차 cumulant 적용이 더 우수함을 증명하였다.

• Genomics & Informatics
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• 제19권2호
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• pp.16.1-16.14
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• 2021

Even in the current age of advanced medicine, the prognosis of malignant peritoneal mesothelioma (MPM) remains abysmal. Molecular mechanisms responsible for the initiation and progression of MPM are still largely not understood. Adopting an integrated bioinformatics approach, this study aims to identify the key genes and pathways responsible for MPM. Genes that are differentially expressed in MPM in comparison with the peritoneum of healthy controls have been identified by analyzing a microarray gene expression dataset. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of these differentially expressed genes (DEG) were conducted to gain a better insight. A protein-protein interaction (PPI) network of the proteins encoded by the DEGs was constructed using STRING and hub genes were detected analyzing this network. Next, the transcription factors and miRNAs that have possible regulatory roles on the hub genes were detected. Finally, survival analyses based on the hub genes were conducted using the GEPIA2 web server. Six hundred six genes were found to be differentially expressed in MPM; 133 are upregulated and 473 are downregulated. Analyzing the STRING generated PPI network, six dense modules and 12 hub genes were identified. Fifteen transcription factors and 10 miRNAs were identified to have the most extensive regulatory functions on the DEGs. Through bioinformatics analyses, this work provides an insight into the potential genes and pathways involved in MPM.

• 대한본초학회지
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• 제27권6호
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• pp.99-105
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• 2012

Objectives : Korean red ginseng and Morus alba L. are used as a traditional treatment for diabetes. This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L. (MPM) ameliorates metabolic syndrome in fructose-fed rats. Methods : Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose (HF) diet alone for 8 weeks, with supplementation with MPM or rosiglitazone occurring during the final 6 weeks. Results : MPM and rosiglitazone, synthetic $PPAR{\gamma}$ agonist, treatment significantly prevented the increase in fasting serum glucose, leptin, triglyceride, and low density lipoprotein in the HF group when comparing with the control group. MPM and rosiglitazone also led to an increase in high density lipoprotein level in the HF group. The administration of MPM and rosiglitazone prevented the development of the metabolic disturbances such as impaired glucose tolerance, and blood pressure. MPM suppressed increased expressions of endothelin-1 (ET-1) in HF rat aorta. In addition, MPM significantly increased IR-${\beta}$ and PPAR-${\gamma}$ expression in muscle. Conclusions : Based on these results, we suggest that the administration of MPM improves metabolic syndrome through the alteration in lipid profiles and suppression of insulin resistant and blood pressure.