• Title/Summary/Keyword: MML

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Moringa oleifera Prolongs Lifespan via DAF-16/FOXO Transcriptional Factor in Caenorhabditis elegans

  • Im, Jun Sang;Lee, Ha Na;Oh, Jong Woo;Yoon, Young Jin;Park, Jin Suck;Park, Ji Won;Kim, Jung Hoon;Kim, Yong Sung;Cha, Dong Seok;Jeon, Hoon
    • Natural Product Sciences
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    • v.22 no.3
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    • pp.201-208
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    • 2016
  • Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the longevity properties of MML we conducted lifespan assay and MML showed significant increase in lifespan under normal culture condition. In addition, MML elevated stress tolerance of C. elegans to endure against thermal, oxidative and osmotic stress conditions. Our data also revealed that increased activities of antioxidant enzymes and expressions of stress resistance proteins were attributed to MML-mediated enhanced stress resistance. We further investigated the involvement of MML on the aging-related factors such as growth, food intake, fertility, and motility. Interestingly, MML significantly reduced growth and egg-laying, suggesting these factors were closely linked with MML-mediated longevity. We also observed the movement of aged worms to estimate the effects of MML on the health span. Herein, MML efficiently elevated motility of aged worms, indicating MML may affect health span as well as lifespan. Our genetic analysis using knockout mutants showed that lifespan-extension activity of MML was interconnected with several genes such as skn-1, sir-2.1, daf-2, age-1 and daf-16. Based on these results, we could conclude that MML prolongs the lifespan of worms via activation of SKN-1 and SIR-2.1 and inhibition of insulin/IGF pathway, followed by DAF-16 activation.

A design of scan line converter with MML architecture (MML 구조를 적용한 주사선 변환기 설계)

  • 한기웅;김민호;김송욱;김재원;정정화
    • Proceedings of the IEEK Conference
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    • 1998.06a
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    • pp.855-858
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    • 1998
  • 본 연구에서는 MML(merged memory logic)구조를 갖는 스캔라인 컨버터를 설계하여 제안한다. 비월주사 방식인 TV 비디오 신호를 FIFO 메모리에 저장하여 순차주사방식인 VGA 비디오 시모호 변환하는 주사선 변환기를 MML 개념으로 설계하였다. MML 회로는 VHDL로 설계하여 V-system으로 시뮬레이션을 수행하고 altera FPGA에 구현한 후, TV 비디오 신호를 PC 모니터로 보기 위한 외장형 tV 수신 시스템에 적용하여 성능을 검증했다. MML 개념으로 설계된 컨버터는 system-on-a-chip 설계의 첫 단계로 메모리와 로직부분으로 구성된 일반적인 컨버터보다 효율적인 시스템 설계를 할 수 있다.

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An FPGA Implementation of an MML-DFE for Spatially Multiplexed MIMO Systems (공간다중화 MIMO 시스템을 위한 MML-DFE기법의 FPGA 구현)

  • Im, Tae-Ho;Lee, Kyu-In;Park, Chang-Hwan;Jeong, Ki-Cheol;Yu, Sung-Wook;Kim, Jae-Kwon;Cho, Yong-Soo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.11A
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    • pp.1167-1175
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    • 2006
  • The ML-DFE(Maximum Likelihood-Decision Feedback Equalization) can be viewed as either a suboptimal signal detection method for reducing hardware complexity of ML or an enhanced detection method for reducing the effect of error propagation of SIC(Successive Interference Cancellation) in spatially multiplexed MIMO systems such as V-BLAST. The ML-DFE can achieve a higher diversity in rich scattering environments as well as reducing the error propagation effect by combing ML decoding with the DFE. In this paper, an MML-DFE(Modified Maximum Likelihood-Decision Feedback Equalization) is proposed to reduce the hardware complexity of the ML-DFE, without compromising performance. It is shown by FPGA implementation that the proposed MML-DFE can achieve the same performance as the ML-DFE with significantly reduced hardware complexity.

A Study on the Development of Semi-automated Analog Cell Compiler for MML Library (MML(merged memory logic) 라이브러리 구축을 위한 반자동 아날로그 컴파일러 개발에 관한 연구)

  • 최문석;송병근곽계달
    • Proceedings of the IEEK Conference
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    • 1998.10a
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    • pp.695-698
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    • 1998
  • Today SOC(system on a chip) is a trend in VLSI design society. Especially MML(merged memory Logic) process provides designers with good chances to implement SOC which is consists of DRAM, SRAM, Logic and A/D mixed mode ciruit blocks. Designers need good circuit library which is reliable and easy to tune for specific design. For this need we present semi-automated analog compiler methodology. And we aplied this design methodology to resistor-string DAC design.

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Effect of MML on the Wear Behavior of Al/SiCp Composites (Al/SiCp 복합재료의 마모거동에 미치는 MML의 영향)

  • Kim, Yeong-Sik;Kim, Kyun-Tak
    • Tribology and Lubricants
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    • v.25 no.1
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    • pp.66-72
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    • 2009
  • Al-based composites reinforced with SiC particulate were fabricated using a thermal spray process, and dry sliding wear behavior of the composites was investigated. Pre-mixed Al and SiC powders were sprayed on an A16061 substrate by flame spraying, and dry sliding wear test were performed under various sliding speed and applied load conditions against ${Al_2}{O_3}$ ball. Wear behavior of the composites was studied by using scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). And build-up mechanism of MML on the worn surface of the composites was examined. It was revealed that these MML was formed of debris from the contact surface of the composites and effected to wear behavior of the composites protecting the contact surface of the composites.

Design and Analysis of Linear Channel-Selection Filter for Direct Conversion Receiver

  • Jin, Sang-Su;Ryu, Seong-Han;Kim, Hui-Jung;Kim, Bum-Man;Lee, Jong-Ryul
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.4 no.4
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    • pp.293-299
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    • 2004
  • An active RC 2nd order Butterworth filter suitable for a baseband channel-selection filter of a direct conversion receiver is presented. The linearity of the 2nd order Butterworth filter is analyzed. In order to improve the linearity of the filter, the operational amplifiers should have a high linear gain and low 3rd harmonic, and the filter should be designed to have large feedback factor. This second order Butterworth filter achieves-14dBV in-channel (400kHz, 500kHz) IIP3, +29dBV out-channel (10MHz, 20.2MHz) IIP3 and 15.6 $nV/\sqrt{Hz}$ input-referred noise and dissipates 10.8mW from a 2.7-V supply. The analysis and experimental results are in good agreement

Minimum Message Length and Classical Methods for Model Selection in Univariate Polynomial Regression

  • Viswanathan, Murlikrishna;Yang, Young-Kyu;WhangBo, Taeg-Keun
    • ETRI Journal
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    • v.27 no.6
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    • pp.747-758
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    • 2005
  • The problem of selection among competing models has been a fundamental issue in statistical data analysis. Good fits to data can be misleading since they can result from properties of the model that have nothing to do with it being a close approximation to the source distribution of interest (for example, overfitting). In this study we focus on the preference among models from a family of polynomial regressors. Three decades of research has spawned a number of plausible techniques for the selection of models, namely, Akaike's Finite Prediction Error (FPE) and Information Criterion (AIC), Schwartz's criterion (SCH), Generalized Cross Validation (GCV), Wallace's Minimum Message Length (MML), Minimum Description Length (MDL), and Vapnik's Structural Risk Minimization (SRM). The fundamental similarity between all these principles is their attempt to define an appropriate balance between the complexity of models and their ability to explain the data. This paper presents an empirical study of the above principles in the context of model selection, where the models under consideration are univariate polynomials. The paper includes a detailed empirical evaluation of the model selection methods on six target functions, with varying sample sizes and added Gaussian noise. The results from the study appear to provide strong evidence in support of the MML- and SRM- based methods over the other standard approaches (FPE, AIC, SCH and GCV).

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Performance Analysis for Spatial Multiplexing MIMO in MB-OFDM UWB Receivers (MB-OFDM UWB 시스템에서 공간 다중화 MIMO 수신기의 성능 분석)

  • Suh, Jung-Won;Kwon, Yang-Soo;Kim, Seok-Hyeon;Chung, Jea-Hak
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.33 no.2A
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    • pp.121-129
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    • 2008
  • This paper presents the spatial multiplexing MIMO system to increase data rate to double in MB-OFDM UWB system, which is ECMA standards, and compares BER performance of various receiver structures. The complexity and BER performance of various types of spatial multiplexing receivers are compared and analyzed using diagonal and horizontal encoding techniques for $2{\times}2$\;and\;2{\times}3$ antennas systems. Computer simulations exhibit that $2{\times}2$ MML and $2{\times}3$ ZF method show better BER performance than that of SISO system with simple complexity.

A Study on the Built-In Self-Test for AC Parameter Testing of SDRAM using Image Graphic Controller

  • Park, Sang-Bong;Park, Nho-Kyung;Kim, Sang-Hun
    • The Journal of the Acoustical Society of Korea
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    • v.20 no.1E
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    • pp.14-19
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    • 2001
  • We have proposed BIST method and circuit for embedded 16M SDRAM with logic. It can test the AC parameter of embedded 16M SDRAM using the BIST circuit capable of detecting the address of a fail cell installed in an Merged Memory with Logic(MML). It generates the information of repair for redundancy circuit. The function and AC parameter of the embedded memory can also be tested using the proposed BIST method. It is possible to test the embedded SDRAM without external test pin. The total gate of the BIST circuit is approximately 4,500 in the case of synthesizing by 0.25μm cell library and is verified by Verilog simulation. The test time of each one AC parameter is about 200ms using 2Y-March 14n algorithm.

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Wear Behavior of Al-based Composites according to Reinforcements Volume Fraction (강화상의 분율에 따른 알루미늄기 복합재료의 마모거동)

  • Lee, K.J.;Kim, K.T.;Kim, Y.S.
    • Journal of Power System Engineering
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    • v.15 no.5
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    • pp.77-82
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    • 2011
  • SiC particulate reinforced Al matrix composites with different SiC volume fractions were fabricated by thermal spray process. And the dry sliding wear test were performed on these composites using the applied load of 10 N, rotational speed of 30 rpm, radius of rotation 15 mm. Wear tracks on the Al/SiC composites were investigated using scanning electron microscope(SEM) and energy dispersive spectroscopy (EDS). It was observed that wear behavior of Al/SiC composites and formation of MML was changed dramatically according to reinforcement volume fraction.