• BMB Reports
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• v.41 no.2
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• pp.139-145
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• 2008

We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, spleen, stomach, colon, and modestly in the small intestine. CysLTs accelerated the proliferation of gpCysLT2-expressing HEK293. Leukotriene C4 (LTC4) and Leukotriene D4 (LTD4) enhanced the cell proliferation higher than Bay-u9773, a CysLT2 selective partial agonist and a nonselective antagonist for CysLT receptors. Bay-u9773 did not antagonize the cell proliferation by LTC4 and LTD4. Despite the equipotency of the mitogenic effect among these chemicals, calcium mobilization (CM) levels were variable (LTC4 > LTD4 >> Bay-u9773), and Bay-u9773 antagonized the CM by LTC4. Moreover, the Gi/o inhibitor pertussis toxin perfectly inhibited agonist-induced cell proliferation. These results reveal that cell proliferation via CysLT2 signaling was mediated by Gi/o signaling but independent of calcium mobilization.

• Atmosphere
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• v.29 no.1
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• pp.105-112
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• 2019

Measurements of vertical air motion and microphysics are essential for improving our understanding of convective clouds. In this paper, the author reviews the current research on the retrieval of vertical air motions using the cloud radar. At radar wavelengths of 3 mm (W-band radar; 94-GHz radar; cloud radar), the raindrop backscattering cross-section (${\sigma}b$) varies between successive maxima and minima as a function of the raindrop diameter (D) that are well described by Mie theory. The first Mie minimum in the backscattering cross-section occurs at D~1.68 mm, which translates to a raindrop terminal fall velocity of ${\sim}5.85m\;s^{-1}$ based on the Gunn and Kinzer relationship. Since raindrop diameters often exceed this size, the signal is captured in the radar Doppler spectrum, and thus, the location of the first Mie minimum can be used as a reference for retrieving the vertical air motion. The Mie technique is applied to radar Doppler spectra from the surface-based and airborne, upward pointing W-band radars. The contributions of aircraft motion to the vertical air motion are also described and further the first-order aircraft motion corrected equation is presented. The review also shows that the separate spectral peaks due to the cloud droplets can provide independent validation of the Mie technique retrieved vertical air motion using the cloud droplets as a tracer of vertical air motion.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.463-466
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• 2016

Glioblastoma (GBM) is the most common and aggressive type of primary brain neoplasm. The current standard therapy for GBM consists of maximal surgical resection within safe limits, followed by radiation therapy (RT) and chemotherapy with temozolomide. Despite advances in treatment, the prognosis of GBM remains poor. Epileptic seizure is one of the most common symptoms in patients with GBM. Valproic acid (VPA), a histone deacetylase inhibitor, is often used as an anti-epileptic drug in patients with brain neoplasms due to its effectiveness and low toxicity profile. Several in vivo and in vitro studies have indicated that VPA has radiosensitizing effects for gliomas and radioprotective influence on normal brain tissue or hippocampal neurons. The results of several retrospective studies have also indicated potential benefit to improve survival of patients with GBM. Moreover, the promising treatment results of a phase 2 trial of concurrent radiation therapy, temozolomide, and VPA for patients with GBM have been recently reported. The use of VPA in patients with GBM has thus recently receiving more attention. In this article, we review the role of VPA in radiation therapy for GBM, focusing on the clinical evidence.

• Korean Journal of Optics and Photonics
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• v.25 no.4
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• pp.193-199
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• 2014

The net effect of the emitter orientation, Mie scatters, and pillow lenses on the outcoupling efficiency (OCE) of a bottom-emitting OLED having an internal photonic crystal layer was investigated by a combined optical simulation based on the finite-difference time-domain method (FDTD) and the ray-tracing technique. The simulation showed that when the emitter orientation was horizontal with respect to the OLED surface, the OCE could be increased by 54% when a photonic crystal layer was employed, while it could be improved by 86% under optimized conditions of Mie scatters and pillow lenses applied to the glass substrate. The peculiar intensity distribution of the OLED, caused by the periodic lattice structure of the photonic crystal layer, could be ameliorated by inserting Mie scatters into the glass substrate. This study suggests that conventional outcoupling structures combined with control of the emitter orientation could improve the OCE substantially.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.11a
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• pp.962-967
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• 2011

Radiative properties of alumina particles which is the main element of the plume from booster and kick motor used for increasing thrust and insertion into the orbit is analyzed. In order to derive the wavelength integrated (i.e., gray) emissivity, emission term in radiative transfer equation is rearranged to be able to tie up with the parameters induced from fundamental particle scattering Mie theory. Result shows that derived gray emissivity with optical properties increases with temperature rising.

• Proceedings of the KWS Conference
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• 2005.06a
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• pp.393-395
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• 2005

The bonding for Aluminum and Copper in the air is investigated in this study. This bonding method does not include the special process of removing aluminum oxide films. In case of this bending, each metal Is heated at bonding temperature where is above eutectic temperature of Al-Cu system and below melting point of Aluminum. The liquefaction around the bonding surface occurs after the diffusion at solid state of each metal. This phenomenon is predicted by the temperature range above eutectic temperature of Al-Cu equilibrium phase diagram.

• Korean Journal of Optics and Photonics
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• v.12 no.6
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• pp.437-445
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• 2001

We examine theoretically the properties of the force on Mie particles induced by evanescent fields at a system of multilayer films (including a metal film), at which the surface plasmon resonance is excited by a p-polarized plane electromagnetic wave. An expression of the surface plasmon-coupled evanescent fields produced in Kretschmann (or Sarid) geometry is expanded in terms of vector spherical wave functions, while multiple reflections between the Mie particle and the metal boundary are taken into account. The Cartesian components of the force on Mie particles by the evanescent fields are analytically formulated and numerically evaluated. The force components are increased by one or two orders of magnitude at metal boundaries over those at dielectric boundaries. As a result, we can confirm the possibility of stable manipulation or rotation of a finite-sized object by forces of surface plasmon-coupled evanescent fields.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.1
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• pp.44-49
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• 2003

Effects of supplementation with ruminal epithelial cells on fiber-degrading activity and cell growth of Ruminococcus albus (R. albus, strain 7) was tested using a basal substrate of rice straw and formulated concentrate. Cultures of R. albus alone and R. albus with rumen protozoa were grown at $39^{\circ}C$ for 48 h with an 8.4% crude protein (CP) substrate, 33% of the CP supplemented with either ruminal epithelial cells or defatted soybean meal. The ruminal epithelial cells had lower amounts of rumen soluble and degradable protein fractions as compared to defatted soybean meal, as determined by an enzymatic method, and the same was found with amino acid composition of protein hydrolysates. Ruminal epithelial cells were directly utilized by the R. albus, and resulted in greater growth of cell-wall free bacteria compared to defatted soybean meal. The effect of epithelial cells on bacterial growth was enhanced by the presence of rumen protozoa. In consistency with cultures of R. albus and R. albus with rumen protozoa, fermentative parameters such as dry matter degradability and total volatile fatty acid did not differ between supplementation with ruminal epithelial cells or defatted soybean meal.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.9
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• pp.1219-1227
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• 2000

Rumination behavior, in vivo digestibility of cell wall constituents, particle size reduction in the rumen, and retention time in the digestive tract of sheep were examined using rice and oat straw as roughage sources. The in sacco digestibility, rumen fermentation, and microbial population and internal adenosine 5-triphosphate (ATP) content were also determined under feeding conditions of high-roughage and high-concentrate diets. Chewing number and time in rumination behavior were higher with rice straw than with oat straw, while the in sacco and in vivo DMD of rice straw were consistently lower than those of oat straw. Rice straw also showed higher frequency of thinner and longer particles in the rumen contents and lower retention time in the whole digestive tract as compared to those of oat straw. Rice straw was more effective to maintain the ruminal pH than oat straw, being reflected in higher internal ATP content of large-type protozoa on the high- concentrate diet. Changes in the ruminal microflora by shifting from the low- to the high- concentrate diet were also different between rice and oat straw.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.4-15
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• 2004