• Title/Summary/Keyword: MFG

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Milk Fat Globule-Epidermal Growth Factor VIII Ameliorates Brain Injury in the Subacute Phase of Cerebral Ischemia in an Animal Model

  • Choi, Jong-Il;Kang, Ho-Young;Han, Choongseong;Woo, Dong-Hun;Kim, Jong-Hoon;Park, Dong-Hyuk
    • Journal of Korean Neurosurgical Society
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    • v.63 no.2
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    • pp.163-170
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    • 2020
  • Objective : Milk fat globule-epidermal growth factor VIII (MFG-E8) may play a key role in inflammatory responses and has the potential to function as a neuroprotective agent for ameliorating brain injury in cerebral infarction. This study aimed to determine the role of MFG-E8 in brain injury in the subacute phase of cerebral ischemia in a rat model. Methods : Focal cerebral ischemia was induced in rats by occluding the middle cerebral artery with the modified intraluminal filament technique. Twenty-four hours after ischemia induction, rats were randomly assigned to two groups and treated with either recombinant human MFG-E8 or saline. Functional outcomes were assessed using the modified Neurological Severity Score (mNSS), and infarct volumes were evaluated using histology. Anti-inflammation, angiogenesis, and neurogenesis were assessed using immunohistochemistry with antibodies against ionized calcium-binding adapter molecule 1 (Iba-1), rat endothelial cell antigen-1 (RECA-1), and bromodeoxyuridine (BrdU)/doublecortin (DCX), respectively. Results : Our results showed that intravenous MFG-E8 treatment did not reduce the infarct volume; however, the mNSS test revealed that neurobehavioral deficits were significantly improved in the MFG-E8-treated group than in the vehicle group. Immunofluorescence staining revealed a significantly lower number of Iba-1-positive cells and higher number of RECA-1 in the periinfarcted brain region, and significantly higher numbers of BrdU- and DCX-positive cells in the subventricular zone in the MFG-E8-treated group than in the vehicle group. Conclusion : Our findings suggest that MFG-E8 improves neurological function by suppressing inflammation and enhancing angiogenesis and neuronal proliferation in the subacute phase of cerebral infarction.

Temperature Effect on the Retention Behavior of Sugars in Ion Exchange Chromatography (이온 교환 크로마토그래피에서 온도가 당의 체류 특성에 미치는 영향)

  • Kim, Jin-Il;Lee, Chong-Ho;Koo, Yoon-Mo
    • Korean Chemical Engineering Research
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    • v.43 no.6
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    • pp.722-727
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    • 2005
  • Dow99Ca350 (Dowex monosphere 99Ca/350 separation resin), MFG-220, and Finex CS-10GC are ion-exchange resins, and primarily used to separate sugars, and all of these resins have poly styrene DVB backbone, and sulfonyl group. These resins are already used to separate sugars continuously at sugar industry at constant temperature. These resins are used in experiments for understanding temperature effect on retention or adsorption behavior. Using Dow99Ca350, swelling test, porosity test, pulse test, and frontal analysis at various temperatures were performed. In the cases of MFG-220, and Finex CS-10GC, the effect of temperature variation was verified by pulse test. The experimental results are shown that Dow99Ca350, MFG-220, and Finex CS-10GC, which are commercial resins for sugar separation, are stable to temperature variation because the maximum change of retention time of fructose, and glucose are 1.76, and 3.37% respectively.

Design of Induction Motor for Electric Vehicles using Optimization Technique (최적설계기법을 이용한 전기자동차용 유도전동기 설계)

  • Kim, Y.K.;Lim, K.M.;Yeom, K.N.;Bae, S.H.;Yoo, Y.S.;Yoo, W.H.
    • Proceedings of the KIEE Conference
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    • 1996.07a
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    • pp.6-8
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    • 1996
  • Induction Motors are preferred because of their ability to achieve higher power density, efficiency and reliability than permanent DC Motors for Electric Vehicle Drives. This paper describes induction motor design procedure to achieve high power density for EV using nonlinear optimization technique. Objective functions are considered to improve power density and a set of eight design variables is identified. As a numerical example, an induction motor of 15kW, 3 phase and 4 pole is designed.

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A Development of Unified Digital Generator Controller (발전기 통합제어장치 개발)

  • Yoo, Young-Suk;Kwon, Hyuk;Lee, Sang-Jeong;Lee, Sun-Hee;Choi, Yong-Sil
    • Proceedings of the KIEE Conference
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    • 1996.07b
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    • pp.1164-1166
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    • 1996
  • This system is an unified Digital Generator Controller. It has an Electronical Generator Sequencer which control the sequence of a generator, an AVR(Automatic Voltage Regulator) which perform the regulation of generator terminal voltage optimally to user's needs, and an Auto Synchronizer, it can switch the power source on from generally used an the generator to load automatically. It also possesses a Battery Charger which charge a storage battery to appropriate voltage level. Here we describe it's configuration, specifications, the way of control, figure, functions and waveforms.

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Improvement in the MIM Sintering Properties of 440C Stainless Steel

  • Soda, Yuji;Hurusaki, Takashi;Aihara, Michitaka
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09a
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    • pp.217-218
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    • 2006
  • More and more applications or demands for machine parts etc are expected for AISI 440C (hereinafter referred to as "440C") Stainless Steel because of its characteristic features, i.e. high-strength as well as high-corrosion resistance. This research has enabled us to obtain sintered products with good quality even under a wide range of temperature by utilizing the pinning effect of NbC, improving the relevant sintering feature of 440C Stainless Steel in the MIM method.

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Parameter estimation of the inverter-driven squirrel cage induction motor (인버터구동시 농형 유도전동기의 파라메타 추정)

  • Kang, Sei-Hyung;Ahn, Jong-Bo;Kim, Keun-Woong;Kim, Young-Kwan
    • Proceedings of the KIEE Conference
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    • 1992.07b
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    • pp.695-698
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    • 1992
  • When the inverter driven Induction motor is compared with sinusoidal voltage driving, the loss is increased and efficiency in the same output is decreased by the time harmonics in inverter output. These are based on the eddy current on stator and the skin effects of rotor bar current induced from time harmonic. The aim of this paper is to estimate the equivalent circuit parameter of squirrel cage induction motor fed from inverter considering this effects.

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A Study on Developing the Magnetic Wedge Material and its Application (자성웨지 국산화 개발 및 그 적용에 관한 연구)

  • Choi, Jong-Koo;Kang, Yi-Kuk;Bae, Byeong-Choon;Hong, Sung-Il
    • Proceedings of the KIEE Conference
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    • 1996.07c
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    • pp.1482-1484
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    • 1996
  • To apply Magnetic wedges to the motor, comparing with not applying, showes its performance change of efficiency increse, reduction of temperature rise, harmonics, and magnetic noise. The motor specification and test condition are 37kW-4P-380V-60Hz,squirrel-cage, three phase induction motor with semiclosed type slots. The result of load test to compare with nonmagnetic wedges showed 1.5% increment of efficiency at 100% load and $8.0^{\circ}C$ decrement of temperature rise at stator coil. And for developing the magnetic wedge matrial, its manufacturing process was setting and TG-DTA, optical microscope, SEM, bending strength and permeability were investigated into the material made of through the process.

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Performance Test of Three Phase PCS Prototype for smart ESS Power Control Module (스마트 ESS 전력제어모듈용 3상 PCS 시제품 성능시험)

  • Lee, Tae Seung;Hwang, Dong Ok;Lee, Dong Ju;Paik, Seok Min
    • Proceedings of the KIPE Conference
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    • 2015.07a
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    • pp.532-534
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    • 2015
  • 본 연구에서는 'Open Framework 기반 Smart ESS 전력제어 모듈'과 연동을 위해 설계, 제작한 3상 PCS 시제품의 동작 모드별 주요 전기적 특성을 분석하였다. 충전모드에서 운전시 PWM 컨버터의 입력역률, 입력전류 THD 및 전력변환 효율과 방전모드로 운전시 계통으로 주입되는 전류의 역률, THD 및 전력변환 효율을 각각 측정, 분석하였다. 또한 독립운전시 부하량에 따른 PWM 컨버터의 출력전압 THD 및 전력변환 효율을 측정, 분석하였다.

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