• 한국미생물·생명공학회지
• /
• 제47권1호
• /
• pp.132-138
• /
• 2019

제주 연안에서 분리한 해양유래 미생물 중에서 어류질병 세균에 대한 항균활성이 있는 Bacillus subtilis MD-02를 이용하여 넙치에 적용했을 때 나타나는 비특이적 면역반응과 어류질병세균에 대한 병 저항성을 알아보고자 하였다. B. subtilis MD-02를 $1.2{\times}104CFU/100g$, $1.2{\times}10^6CFU/100g$, $1.2{\times}10^8CFU/100g$의 농도로 사료를 제작하여 넙치에게 급이 한 결과 4주차때 hematocrit이 대조구에 비해 증가하였다. AST와 ALT는 각각 $1.2{\times}10^8CFU/100g$와 $1.2{\times}10^4CFU/100g$에서 대조구에 비해 낮은 값을 보였다. Amylase의 결과 3주차 때부터 $1.2{\times}10^4CFU/100g$에서 유의적으로 증가하였으며, total protein의 경우 3주차 때부터 $1.2{\times}10^4CFU/100g$에서 대조구에 비해 유의적으로 증가하였다. 비특이적 면역반응인 라이소자임 활성과 대식세포 활성 결과 $1.2{\times}10^8CFU/100g$에서 대조구에 비해 높은 활성을 나타냈다. 또한 Streptococcus parauberis를 $1.2{\times}10^6CFU/ml$로 넙치에 접종 한 후 폐사율을 확인한 결과 대조구에선 전량 폐사가 일어난 반면 B. subtilis MD-02를 투여한그룹에서는 40-60%의 폐사율을 보여 어류질병세균에 대한 병 저항성을 가지는 것을 확인하였다. 따라서 제주연안에서 분리한 해양유래 미생물인 Bacillus subtilis MD-02를 넙치에게 급이 할 때 비특이적 면역반응과 어류질병세균에 대한 병 저항성을 가지는 것을 확인하였으며, 향후 사료 첨가제로 개발 시 좋은 효과가 있을 것으로 사료된다.

• 한국멀티미디어학회논문지
• /
• 제10권9호
• /
• pp.1093-1105
• /
• 2007

본 논문에서는 XML 데이터베이스의 색인구조로 다차원 화일구조를 이용하는 다차원 타입상속 색인기법인 MD-TIX를 제안한다. 일차원 색인구조를 이용하는 기존의 XML 데이터베이스 색인기법에서는 타입상속계층과 중첩요소가 포함된 복합 형태의 질의들에 대한 처리를 잘 지원하지 못한다. MD-TIX에서는 XML 데이터베이스의 중첩요소에 대한 색인기법을 위하여 이차원 타입상속 계층 색인기법(2D-THI)을 다차원으로 확장하여 사용한다. 2D-THI는 타입상속 계층의 단순요소에 대한 색인기법으로 킷값 도메인과 타입식별자 도메인으로 구성된 이차원 도메인 공간상에서 요소들의 클러스터링을 다루는 색인기법이다. 본 논문의 MD-TIX에서는 색인된 중첩요소를 표현하는 경로상의 각 타입상속 계층마다 하나의 타입식별자 도메인을 할당하여 구성된 다차원 도메인 공간상에서 색인 엔트리들의 클러스터링을 다룬다. 따라서 HD-TIX에서는 기존의 색인기법에서 지원하기 어려운 질의의 대상 범위가 타입상속 계층상의 임의의 타입들로 제한되거나, 질의에 포함된 복합요소들의 도메인이 타입상속 계층상의 임의의 타입들로 제한되는 경우에도 잘 지원할 수 있다.

• 대한한방내과학회지
• /
• 제43권3호
• /
• pp.423-435
• /
• 2022

Purpose: The purpose of this study was to confirm the clinical efficacy of Gyeongok-go. Methods: Public/Publisher MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), Excerpta Medica dataBASE (EMBASE), Research Information Sharing Service (RISS), ScienceON, Korean Traditional Knowledge Portal (KTKP), and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled clinical trials administering Gyeongok-go as an intervention, published from inception to December 31, 2021. The risk-of-bias of the included trials was assessed with the Cochrane risk-of-bias tool for randomized trials version 2. From the experimental and control groups of the selected trials, the mean value (or rate) of each outcome was extracted and statistically compared. Results: Statistically significant mean differences were in VO₂max (MD 6.82), post-exercise heart rate (MD -8.76 at 5 min, -11.58 at 30 min, -14.6 at 60 min), senescence scale (MD -6.52), Th1 cells and Th2 cells in pulmonary tuberculosis (MD 2.79 and -1.64), yin-deficient and qi-deficient score (MD -9.64 and -9.76), and phlegm-dampness score (MD 5.56). Overall risk-of-bias was 20% low risk, 80% some concerns, and 0% high risk. There were no reports of adverse events. Conclusions: Gyeongok-go is likely to have the effect of improving cardiorespiratory endurance, increasing fatigue recovery ability, reducing senescence, and enhancing immune function in tuberculosis patients. Also, it is more suitable for those who are yin-deficient or qi-deficient, and those with phlegm-dampness probably need caution.

• Interaction and multiscale mechanics
• /
• 제2권4호
• /
• pp.353-374
• /
• 2009

A new seamless multiscale simulation was developed for coupling the continuum model with its molecular dynamics. Kriging-based Finite Element Method (K-FEM) is employed to model the continuum base of the entire domain, while the molecular dynamics (MD) is confined in a localized domain of interest. In the coupling zone, where the MD domain overlaps the continuum model, the overall Hamiltonian is postulated by contributions from the continuum and the molecular overlays, based on a quartic spline scaling parameter. The displacement compatibility in this coupling zone is then enforced by the Lagrange multiplier technique. A multiple-time-step velocity Verlet algorithm is adopted for its time integration. The validation of the present method is reported through numerical tests of one dimensional atomic lattice. The results reveal that at the continuum/MD interface, the commonly reported spurious waves in the literature are effectively eliminated in this study. In addition, the smoothness of the transition from MD to the continuum can be significantly improved by either increasing the size of the coupling zone or expanding the nodal domain of influence associated with K-FEM.

• 대한수의학회지
• /
• 제38권3호
• /
• pp.450-454
• /
• 1998

We have studied Meckel's diverticulum(MD) of the duck(Anas platyrhynchos platyrhyncos, Linne) by histological and immunohistochemical methods. Because MD were first observed in 2 weeks after hatching, tissues were taken from 2 weeks to 32 weeks after hatching groups. MD were observed as like any parts of intestinal tract that composed with simple columnar epithelium and numerous mucosal gland especially, cecum except that many lymphocytes were exist in this study. Also a number of bovine chromogranin(BCG)-, serotonin, and somatostatin(SOM)-immunoreactive cells were observed in epithelium and submucosal gland in this study, so it could be suggest that the MD of the duck serve as some digestive and lymphatic functions.

• Interaction and multiscale mechanics
• /
• 제5권2호
• /
• pp.115-129
• /
• 2012

Nanowires (NWs) have attracted intensive researches owing to the broad applications that arise from their remarkable properties. Over the last decade, immense numerical studies have been conducted for the numerical investigation of mechanical properties of NWs. Among these numerical simulations, the molecular dynamics (MD) plays a key role. Herein we present a brief review on the current state of the MD investigation of nanowires. Emphasis will be placed on the FCC metal NWs, especially the Cu NWs. MD investigations of perfect NWs' mechanical properties under different deformation conditions including tension, compression, torsion and bending are firstly revisited. Following in succession, the studies for defected NWs including the defects of twin boundaries (TBs) and pre-existing defects are discussed. The different deformation mechanism incurred by the presentation of defects is explored and discussed. This review reveals that the numerical simulation is an important tool to investigate the properties of NWs. However, the substantial gaps between the experimental measurements and MD results suggest the urgent need of multi-scale simulation technique.

• International Journal of Oral Biology
• /
• 제46권1호
• /
• pp.45-50
• /
• 2021

This study evaluated the antimicrobial activity of Endoseal TCS, an mineral trioxide aggregate-based root canal sealer, mixed with water-soluble mangostin derivatives (WsMD) of Garcinia mangostana L. (mangosteen) ethanol extract against Enterococcus faecalis and Staphylococcus aureus. The antibacterial activity of Endoseal TCS mixed with WsMD against three strains of E. faecalis and three strains of S. aureus was performed using agar diffusion test. The data showed that Endoseal TCS mixed with 0.115% WsMD had a zone of inhibition of 0.7 ± 0.2-2.4 ± 0.1 mm. The results suggest that Endoseal TCS mixed with WsMD of Garcinia mangostana L. ethanol extract is useful as a root canal sealer with antibacterial activity against E. faecalis and S. aureus.

• Journal of Forest and Environmental Science
• /
• 제26권2호
• /
• pp.103-111
• /
• 2010

Wetlands perform various functions of vital socio-ecological significance playing fundamental role in moderating monsoon tidal floods and coastal protection and generate goods and products such as fish and forest resources. The depletion of mangroves is a cause of serious environmental and economic concern to many developing countries. Problems of sustainability of mangrove ecosystems are not only technical but also socio-economic. Functions played by mangrove wetlands are of fundamental importance for society. The present study aims to identify the challenges of the mangrove wetlands of Southeast coast of Chittagong, their uses and socio-economic influence on local people, and the value of ecosystem services, and to suggest how to conserve this ecosystem in a more equitable way.

• 천문학회보
• /
• 제29권2호
• /
• pp.37.2-37.2
• /
• 2004

• 펄프종이기술
• /
• 제36권3호
• /
• pp.60-66
• /
• 2004

The effects of roll diameter, winding time, winding methods and relative humidity on curl In newsprints(46$g/m^2$, 54 $g/m^2$, and 54 $g/m^2$ SNC) are examined. The larger MD curl appears at smaller roll diameter, with the extension of winding time, and at the treat ment of soft nip calendering. The MD curl shows the back side curl at winding methods with top side as outer side(TSO), and the top side curl with top side as inner side(TSI). While the CD curl in newsprints( 46 $g/m^2$, and 54 $g/m^2$ SNC) treated with calender is hardly influenced by the storage times, roll diameter, and winding methods. However the CD curl in newsprint(54 $g/m^2$) gradually increases to a two weeks, and then hold constant regardless of roll diameter and winding methods.. The CD curl shows always the top side curl regardless of winding methods. At high relative humidity, the CD curl largely reduces, but the MD curl is not nearly changed. Especially, the CD curl in news-prints(54 $g/m^2$ SNC) is little affected by the changes of relative humidity.