• 대한두개안면성형외과학회지
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• 제20권3호
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• pp.203-206
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• 2019

Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroectodermal carcinoma arising from mechanoreceptor Merkel cells. Multiple MCCs are even rarer. We report a case of two independent MCCs simultaneously present in the cheek of a patient, which were effectively and esthetically treated using a cheek flap. Punch biopsy performed in a 60-year-old woman admitted with a chief complaint of two skin-colored hard nodules in her left cheek, accompanied by an itching sensation, was suggestive of MCC. Accordingly, we performed sentinel lymph node biopsy through the modified Blair incision under general anesthesia, in cooperation with the head and neck surgery department. The defect was covered with a cheek flap by slightly extending the existing incision following wide excision with a safety margin of 1 cm. This paper is significant in that it introduces an effective reconstruction technique that maintains function using a cheek flap for the management of this rare case. In addition, this paper is the first to classify multiple MCCs according to the time of onset. We believe that this paper presents an effective alternative reconstruction technique with sentinel node biopsy through the modified Blair incision.

• 한국분말재료학회지
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• 제28권3호
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• pp.227-232
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• 2021

The purpose of this study is to optimize the powder formulation and manufacturing conditions for the solidification of an extract of the herb Bangpungtongseong-san (BPTS). To develop BPTS-loaded particles for the tablet dosage form, various BPTS-loaded particles composed of BPTS, dextrin, microcrystalline cellulose (MCC), silicon dioxide, ethanol, and water are prepared using spray-drying and high shear granulation (high-speed mixing). Their physical properties are evaluated using scanning electron microscopy and measurements of the angle of repose, Hausner ratio, Carr's index, hardness, and disintegration time. The optimal BPTS-loaded particles exhibit improved flowability and compressibility. In particular, the BPTS-loaded particles containing silicon dioxide show significantly improved flowability and compressibility (the angle of repose, Hausner ratio, and Carr's index are 35.27 ± 0.58°, 1.18 ± 0.06, and 15.67 ± 1.68%, respectively), hardness (18.97 ± 1.00 KP), and disintegration time (17.60 ± 1.50 min) compared to those without silicon dioxide. Therefore, this study suggests that particles prepared by high-speed mixing can be used to greatly improve the flowability and compressibility of BPTS using MCC and silicon dioxide.

• 한국농공학회논문집
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• 제66권2호
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• pp.1-12
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• 2024

In order to integrate two consolidation theories of Terzaghi's consolidation theory and Mesri's secondary compression theory and to identify a model suitable for analyzing stress-strain behavior over time, numerical analysis on consolidation tests were conducted using a modified cam-clay model and a soft soil creep model and the following conclusions were obtained. The results of numerical analysis applying the theory that a linear proportional relationship is established between the void ratio at logarithmic scale and the permeability coefficient at logarithmic scale is better agreement with the result of oedometer test than the results of applying constant hydraulic conductivity. The modified cam-clay model is a model that does not include secondary compression, but the slope of the normal consolidation line corresponding to the compression index of the standard consolidation test includes secondary compression, so the actual settlement curve over time is lower than the predicted value through numerical analysis. It always gets smaller. Other previous studies that applied Terzaghi's consolidation theory to consolidation test analysis showed the same results and were cross-confirmed. The soft soil creep model, which includes secondary compression in the theory, showed good agreement in all sections including secondary compression in the consolidation test results. It was judged appropriate to use a soft soil creep model when performing numerical analysis of soft clay ground.

• 한국수자원학회논문집
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• 제36권3호
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• pp.495-505
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• 2003

Meteosat-5 IR 위성영상을 사용하여 1999년과 2000년 여름몬순기간 동안 발생한 네팔과 인디아 북쪽 히말라야 산악지역에 발생하는 여러 형태의 대류계 즉, 중규모 대류계들 (Mesoscale Convective Complex, MCC and Convective Cloud Clusters, CCC) 와 보다 약한 Disorganized Short-lived Convection (DSL)의 이동특성 및 시공간적인 생성특성 등을 조사하였다. 대상지역에 발생하는 중규모 대류계의 전형적인 지속시간은 약 11시간이며 크기는 약 $300,000km^2$ 이다. 중규모 대류계의 중심은 히말라야산맥으로부터 원거리에 위치함에도 불구하고 집중강운-는 위도 $25^{\circ}-30^{\circ}N$ 사이의 히말라야 하단에 발생하는 중규모 대류계와 직접적 상관관계를 가진다. 결과는 히말라야 고도 500-4000m에 설치된 강우계로부터 획득된 강우자료의 변화 특성과 대류계 거동 특성이 유사함을 보여주었다(Barros et al. 2000). 집중호우의 강력한 야간발생과 Gangetic Plains에서 발생한 중규모 대류계와의 연관성을 보여주었다(Barros et al. 2000).

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1001-1006
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• 2015

Background: With development and application of new and effective anti-cancer drugs, the median survival post-progression (SPP) is often prolonged, and the role of the median SPP on surrogacy performance should be considered. To evaluate the impact of the median SPP on the correlation between progression-free survival (PFS) and overall survival (OS), we performed simulations for treatment of four types of cancer, advanced gastric cancer (AGC), metastatic colorectal cancer (MCC), glioblastoma (GBM), and advanced non-small-cell lung cancer (ANSCLC). Materials and Methods: The effects of the median SPP on the statistical properties of OS and the correlation between PFS and OS were assessed. Further, comparisons were made between the surrogacy performance based on real data from meta-analyses and simulation results with similar scenarios. Results: The probability of a significant gain in OS and HR for OS was decreased by an increase of the SPP/OS ratio or by a decrease of observed treatment benefit for PFS. Similarly, for each of the four types of cancer, the correlation between PFS and OS was reduced as the median SPP increased from 2 to 12 months. Except for ANSCLC, for which the median SPP was equal to the true value, the simulated correlation between PFS and OS was consistent with the values derived from meta-analyses for the other three kinds of cancer. Further, for these three types of cancer, when the median SPP was controlled at a designated level (i.e., < 4 months for AGC, < 12 months for MCC, and <6 months for GBM), the correlation between PFS and OS was strong; and the power of OS reached 34.9% at the minimum. Conclusions: PFS is an acceptable surrogate endpoint for OS under the condition of controlling SPPs for AGC, MCC, and GBM at their limit levels; a similar conclusion cannot be made for ANSCLC.

• 대한미생물학회지
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• 제21권2호
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• pp.261-270
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• 1986

A total of 339 urethral, vaginal swab and eye discharge materials from the out-patients in the hospitals of Seoul area was microbiologically collected for the detection of Chlamydia trachomatis infection during May through August, 1985. McCoy cell culture system (MCC) and enzyme-likned immunosorbent assay (EIA) methods were employed in this study as the tools for the detection of C. trachomatis, and the detectabilities of two methods were compared. The results obtained in this study are summarized as follows: 1. The positive rate of C. trachomatis in 339 swab specimens was 18.6%, and the rate in females (20.1%) was much higher than that in males (7.1%). 2. The positive rate of C. trachomatis infection the prostitutes was the highest (24.2%), and the rate in the eye discharge specimens obtained from the new barns was 12.8%. 3. The positive rates of C. trachmoatis infection detected in the specimens from the patients with vaginitis and leucorrhea, with infertility, with cystitis and with nongonococcal urethritis were 17.2%, 21.9%. 18.0% and 7.1%, respectively. 4. The positive rate of C. trachomatis infection in 20-25 age group was 30.5%. This rate was the highest among the other age groups. 5. The positive rate of C. trachomatis infection in the randomly screened 89 swab specimens by EIA (30.3%) was much higher than the rate detected by MCC (18.6%). 6. The positive rate of C. trachomatis infection in females detected by EIA was also much higher than in males, and the 20-25 age group showed the highest positive rate as compared to the other age groups. 7. Sensitivity and specificity of EIA for the detection on C. trachomatis were 100% and 88.6%, respectively, in case that MCC was regarded as perfect method. In summarizing the above results, it is known that considerable cases with genital diseases and with eye discharges were associated with C. trachomatis, and that EIA method is recommendable for the detection of C. trachomatis especially in the specimens swabed from the genital tracts.

• Elastomers and Composites
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• 제45권1호
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• pp.51-57
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• 2010

본 연구에서는 친환경적인 특징을 가지면서도 우수한 기계적 특성을 가지고 있어 고분자 복합재료의 보강제로 주목 받고 있는 Cellulose nanowhisker (CNW) 를 염산 혹은 황산을 사용한 산가수분해 방법을 이용하여 Microcrystalline cellulose (MCC) 로 부터 추출하였다. 염산 혹은 황산을 사용하여 추출된 CNW는 직경이 20 에서 30nm 정도였고, 길이가 200 에서 300 nm 로써, 형상학적 측면에서 유사한 특성을 가지는 것을 확인하였다. 또한 전해질 용액의 전기전도도를 이용한 적정 (conductometric titration) 결과 황산을 이용하여 제조되어진 CNW의 경우, 셀룰로오스 표면의 sulfate group 에 의해 나타나는 표면전하 값이 각각 140, 197.78 mmol/kg으로 나타났으며, 염산을 이용하여 제조되어진 CNW 의 경우 셀룰로오스 표면에 약한 전하 값을 가져 표면전하 값을 구할 수 없었다. 황산을 이용하여 추출된 CNW의 열중량 분석 결과 염산을 이용하여 추출된 CNW와 비교하여 열분해 온도가 급격히 감소하는 것을 확인할 수 있었으며, Broido's method를 이용하여 정의 되어진 열분해 거동에 대한 활성화 에너지 역시 상대적으로 낮음을 확인할 수 있었다.

• 한국세라믹학회지
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• 제34권5호
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• pp.449-452
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• 1997

Quick hardened property and compressive strength experimented to the C4A3 quantities. Workability experimented to the hydration behavior as retarder added to the C4A3. Compressive strength reached {{{{ delta }}3h=300~350 kgf/$\textrm{cm}^2$, {{{{ delta }}6h=400~450 kgf/$\textrm{cm}^2$, {{{{ delta }}24h=500~550 kgf/$\textrm{cm}^2$. Flow loss rate reached 70.1% to retarder addition 0.12% after 15 min. Test items were SEM, XRD, TG-DTA, MCC, porosity and zeta potential.

• Journal of Pharmaceutical Investigation
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• 제15권3호
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• pp.140-150
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• 1985

The influences of three binders, hydroxypropyl cellulose(HPC), microcrystalline cellulose (MCC) and polyvinylpyrrolidone(PVP), on the transmittance of compression pressure from upper punch to lower punch and the disintegration of aspirin tablets prepared by direct compression were studied. The optimum concentration of three binders for the disintegration of aspirin tablets was about 20w/w% and several physical properties of the powder and tablets were also investigated. The tablet machine was specially made for the measurement of compression pressure of the tablets.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2013년도 춘계 종합학술대회 논문집
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• pp.273-274
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• 2013

모바일 기술의 발전과 폭발적인 성장으로 모바일 서비스에 관심이 높아만 가고 있다. 최근 새로운 IT 트랜드로 모바일 클라우드 컴퓨팅(MCC: Mobile Cloud Computing)이 새롭게 떠오르고 있다. 특히, 모바일 러닝을 위한 미래의 새로운 IT 서비스가 기대되고 있다. 현재, 모바일 기기의 한계점(장애물) 때문에 극복해야 할 문제들이 산재해 있다. 이들 문제가 되는 잠재적인 장애물을 다루고 있다.