Journal of Pharmaceutical Investigation
- Volume 15 Issue 3
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- Pages.140-150
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- 1985
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effects of Binders on Pharmaceutical Properties of Aspirin Tablets
- Kwon, Kwang-Hyen (College of Pharmacy, Pusan National University) ;
- Shin, Young-Hee (College of Pharmacy, Pusan National University) ;
- Lee, Chi-Ho (College of Pharmacy, Pusan National University)
- Published : 1985.09.20
Abstract
The influences of three binders, hydroxypropyl cellulose(HPC), microcrystalline cellulose (MCC) and polyvinylpyrrolidone(PVP), on the transmittance of compression pressure from upper punch to lower punch and the disintegration of aspirin tablets prepared by direct compression were studied. The optimum concentration of three binders for the disintegration of aspirin tablets was about 20w/w% and several physical properties of the powder and tablets were also investigated. The tablet machine was specially made for the measurement of compression pressure of the tablets.
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