• The Korean Journal of Physiology and Pharmacology
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• v.22 no.2
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• pp.193-201
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• 2018

Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner. AGE-induced CTGF expression was mediated via ERK1/2, JNK, and Egr-1 pathways, but not p38; consequently, cell proliferation and migration and ECM accumulation were regulated by CTGF signaling pathway. AGE-stimulated VSMC proliferation, migration, and ECM accumulation were blocked by fluvastatin. However, the inhibitory effect of fluvastatin was restored by administration of CTGF recombinant protein. AGE-induced VSMC proliferation was dependent on cell cycle arrest, thereby increasing G1/G0 phase. Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs. Taken together, fluvastatin suppressed AGE-induced VSMC proliferation, migration, and ECM accumulation by targeting CTGF signaling mechanism. These findings might be evidence for CTGF as a potential therapeutic target in diabetic vasculature complication.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.4
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• pp.27-32
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• 2014

Two-dimensional hybrid codewords are generated by using each row of identity matrix for spatial encoding and nonideal symmetric balance incomplete block design(BIBD) code for spectral encoding. This spatial/spectral optical code-division multiple-access (OCDMA) network uses single-balanced detectors to abstract the desired information bits and to eliminate the multiple-access interference(MAI). Analytical results show that the number of simultaneous users increases significantly by using the proposed hybrid codes.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.6
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• pp.21-27
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• 2019

The video compression standard required a processing technique for a high resoluion image and increased the coding size to increase the resolution of the image. Accurate motion estimation and increased coding size provide high accuracy and compression rate, but there is a problem of increased computational complexity. In this paper, we use DCT - based motion estimation in the frequency domain to reduce complexity. However, we found that the DCT and quantization process used in a general video encoder are applied to the frequency domain encoder, resulting in problems caused by the scaling process. Therfore, in this paper, we extract the scaling matrix that can be applied in the DCT step and resolve the, and improve the performance of motion estimation using increased coding size.

• International journal of advanced smart convergence
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• v.9 no.2
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• pp.20-27
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• 2020

Sound event detection in real-world environments suffers from the interference of non-stationary and time-varying noise. This paper presents an adaptive noise reduction method for sound event detection based on non-negative matrix factorization (NMF). In this paper, we proposed a deep learning model that integrates Convolution Neural Network (CNN) with Non-Negative Matrix Factorization (NMF). To improve the separation quality of the NMF, it includes noise update technique that learns and adapts the characteristics of the current noise in real time. The noise update technique analyzes the sparsity and activity of the noise bias at the present time and decides the update training based on the noise candidate group obtained every frame in the previous noise reduction stage. Noise bias ranks selected as candidates for update training are updated in real time with discrimination NMF training. This NMF was applied to CNN and Hidden Markov Model(HMM) to achieve improvement for performance of sound event detection. Since CNN has a more obvious performance improvement effect, it can be widely used in sound source based CNN algorithm.

• Polymer(Korea)
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• v.39 no.2
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• pp.200-209
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• 2015

In this study, the influence of dilauroyl peroxide on mechanical and thermal properties of different polypropylene (PP) matrices was investigated. Polypropylene matrices, different molecular weight isotactic PP containing 0.01, 0.02, 0.04, 0.06, 0.08, and 0.1 wt% of dilauroyl peroxide (DLP) were prepared by using a single-screw extruder. The effect of the visbreaking agent (DLP) on mechanical, physical, thermal and morphological properties of different molecular weight PP had been studied. Mechanical properties (tensile strength at break point, at yield and elongation at break point), melt flow index (MFI), scanning electron microscope (SEM) and differential scanning calorimetric (DSC) analyses of these matrices were examined. Melting ($T_m$) and crystallization ($T_c$) temperatures, crystallinity ratio (%) and enthalpies were determined. The microstructure of isotactic polypropylene matrix was investigated by scanning electron microscopy (SEM). From SEM analysis, it was observed that the surface disorder increased by the increasing amount of DLP. As a result of DSC analyses, the crystallinity ratio of the PP matrices has varied between 1.64-7.27%. Mechanical properties of the matrices have been improved. Particularly, the mechanical tests of PP have given interesting results when compounded with 0.06-0.08 wt% dilauroyl peroxide (DLP). Mechanical properties and thermal decomposition processes were all changed by increasing the amount of DLP in the matrix structure.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.4
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• pp.675-681
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• 1998

Low density polyethlene(LDPE0 films of 50${\mu}{\textrm}{m}$ thickness were fabricated with addition of antimicrobial agents of Rheum palmatum extract, Coptis chinensis extract, sorbic acid and Ag-substitude inorganic zirconium matrix in 1% concentration. The films were compared in physical properties, tested in antimicrobial activity against some selected microorganisms on the agar plate medium and then applied for packaging fresh curled lettuce and cucumber to preserve their qualities. The films with Rheum palmatum extract, Coptis chinensis extract, and Ag-substituted inorganic zirconium matrix did not show any antimicrobial activity on the disk test against Escherichia coli, Staphylococcus aureus, Leuconostoc mesenteroides, Saccharomyces cerevisiae, Aspergillus niger, Aspergillus oryzae, Penicilluium chrysogenum, while film with sorbic acid did against E. coli, S. aureus and L. mesenteroides. The added antimicrobial agents changed the color and light transmittance of the films, but did not affect their mechanical tensile strength, heat shrinkage and wettability. For the packaged curled lettuce and cucumber stored at 5$^{\circ}C$ and 1$0^{\circ}C$, all the LDPE films impregnated with antimicrobial agents showed the reduced growth of total aerobic bacteria in the vegetables compared with control film without any additive until it reached the level around 108/g. They did not give any negative effect on other quality attributes during storage.

• The Journal of Natural Sciences
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• v.7
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• pp.27-35
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• 1995

This paper introduces a VLSI (Very Large Scale Integrated Circuit) implementation of the 2-D Discrete Cosine Transform (DCT) with an application to image and video coding. This implementation, which is based upon a state space model, uses both algorithm and data partitioning to achieve high efficiency. With this implementation, the amount of data transfers between the processing elements (PEs) are reduced and all the data transfers are limitted to be local. This system accepts the input as a progressively scanned data stream which reduces the hardware required for the input data control module. With proper ordering of computations, a matrix transposition between two matrix by matrix multiplications, which is required in many 2-D DCT systems based upon a row-column decomposition, can be also removed. The new implementation scheme makes it feasible to implement a single 2-D DCT VLSI chip which can be easily expanded for a larger 2-D DCT by cascading these chips.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.8A
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• pp.829-835
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• 2002

When finite length image signal is decomposed into M-band synthesized using M-band orthogonal wavelet transform, the boundary signal of image are not reconstructed perfectly. for boundary signals to be reconstructed perfectly, different type filter bank or technique is applied to them when the dimension of analysed is proposed. It can be designed using the singular value decomposition of boundary perfect reconstruction matrix which is obtained from paraunitary matrix which is obtained from paraunitary matrix. And it is also discussed to design the boundary filter bank for improving the coding performance when it is applied to subband coder. The proposed boundary filter bank shows 7% gains in PSNR compared with reflected method.

• Journal of Microbiology and Biotechnology
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• v.33 no.1
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• pp.15-27
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• 2023

The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously known endemic regions. Biofilms produced by BP have been associated with antimicrobial therapy limitation and relapse melioidosis, thus making it urgently necessary to understand the mechanisms of biofilm formation and their role in BP biology. Microbial cells aggregate and enclose within a self-produced matrix of extracellular polymeric substances (EPSs) to form biofilm. The transition mechanism of bacterial cells from planktonic state to initiate biofilm formation, which involves the formation of surface attachment microcolonies and the maturation of the biofilm matrix, is a dynamic and complex process. Despite the emerging findings on the biofilm formation process, systemic knowledge on the molecular mechanisms of biofilm formation in BP remains fractured. This review provides insights into the signaling systems, matrix composition, and the biosynthesis regulation of EPSs (exopolysaccharide, eDNA and proteins) that facilitate the formation of biofilms in order to present an overview of our current knowledge and the questions that remain regarding BP biofilms.

• Journal of the Korean Society of Industry Convergence
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• v.4 no.1
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• pp.27-34
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• 2001

Refining of powder particles and their dissolution into the Al matrix during mechanical alloying(MA) were investigated by using X-ray diffraction(XRD) transmission electron microscopy (TEM) functions of alloy composition, milling time and ball to powder ratio(BPR). It is found that Ti particles less than 20nm are observed in a dark field image of mechanically alloyed Al-10wt%Ti whose XHD pattern exhibits no Ti peak. The observed change of lattice constant of AI indicates that about 1 wt%Ti can he solved in Al after MA for a long time, independent of alloy composition, milling time and BPR, suggesting that most of Ti particles arc retained in the Al matrix. It is concluded that the disappearance of XRD peaks in mechanically alloyed Al-10wt%Ti is not simply attributable to the dissolution of Ti into Al, but associated mainly with extreme refining and/or heavy straining of Ti Particles.