• 제목/요약/키워드: MAP3K

검색결과 2,998건 처리시간 0.035초

Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP kinase phosphatase 3 (MKP3) in NIH3T3 cells

  • Park, Young Jae;Lee, Jong Min;Shin, Soon Young;Kim, Young Ho
    • BMB Reports
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    • 제47권12호
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    • pp.685-690
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    • 2014
  • The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about the modulation of Erk1/2 activity by active Ras. Here, we show that overexpression of active H-Ras (H-RasG12R) in NIH3T3 fibroblasts impaired FGF2-induced Erk1/2 phosphorylation, as compared to wild-type cells. Northern blot analysis revealed that prolonged expression of active Ras increased MAP kinase phosphatase 3 (MKP3) mRNA expression, a negative regulator of Erk MAPK. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway abrogated active Ras-induced up-regulation of MKP3 expression, leading to the rescue of Erk1/2 phosphorylation. Our results demonstrated that the Ras/Raf/MEK/Erk signaling cascade is negatively regulated by the PI3K/Aktdependent transcriptional activation of the MKP3 gene.

3D Map Building of The Mobile Robot Using Structured Light

  • Lee, Oon-Kyu;Kim, Min-Young;Cho, Hyung-Suck;Kim, Jae-Hoon
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2001년도 ICCAS
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    • pp.123.1-123
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    • 2001
  • For Autonomous navigation of the mobile robots, the robots' capability to recognize 3D environment is necessary. In this paper, an on-line 3D map building method for autonomous mobile robots is proposed. To get range data on the environment, we use an sensor system which is composed of a structured light and a CCD camera based on optimal triangulation. The structured laser is projected as a horizontal strip on the scene. The sensor system can rotate $\pm$ $30{\Circ}$ with a goniometer. Scanning the system, we get the laser strip image for the environments and update planes composing the environment by some image processing steps. From the laser strip on the captured image, we find a center point of each column, and make line segments through blobbing these center poings. Then, the planes of the environments are updated. These steps are done on-line in scanning phase. With the proposed method, we can efficiently get a 3D map about the structured environment.

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3D Map Building of the Mobile Robot Using Structured Light

  • Lee, Oon-Kyu;Kim, Min-Young;Cho, Hyung-Suck;Kim, Jae-Hoon
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2001년도 ICCAS
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    • pp.123.5-123
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    • 2001
  • For autonomous navigation of the mobile robots, the robots' capability to recognize 3D environment is necessary. In this paper, an on-line 3D map building method for autonomous mobile robots is proposed. To get range data on the environment, we use a sensor system which is composed of a structured light and a CCD camera based on optimal triangulation. The structured laser is projected as a horizontal strip on the scene. The sensor system can rotate$\pm$30$^{\circ}$ with a goniometer. Scanning the system, we get the laser strip image for the environments and update planes composing the environment by some image processing steps. From the laser strip on the captured image, we find a center point of each column, and make line segments through blobbing these center points. Then, the planes of the environments are updated. These steps are done on-line in scanning phase. With the proposed method, we can efficiently get a 3D map about the structured environment.

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ON THE GAUSS MAP OF SURFACES OF REVOLUTION WITHOUT PARABOLIC POINTS

  • Kim, Young-Ho;Lee, Chul-Woo;Yoon, Dae-Won
    • 대한수학회보
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    • 제46권6호
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    • pp.1141-1149
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    • 2009
  • In this article, we study surfaces of revolution without parabolic points in a Euclidean 3-space whose Gauss map G satisfies the condition ${\Delta}^hG\;=\;AG,A\;{\in}\;Mat(3,{\mathbb{R}}),\;where\;{\Delta}^h$ denotes the Laplace operator of the second fundamental form h of the surface and Mat(3,$\mathbb{R}$) the set of 3${\times}$3-real matrices, and also obtain the complete classification theorem for those. In particular, we have a characterization of an ordinary sphere in terms of it.

드론의 안전비행을 위한 국부 및 전역지도 인터페이스 (Local and Global Navigation Maps for Safe UAV Flight)

  • 유상형;전종우;조광수
    • 로봇학회논문지
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    • 제13권2호
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    • pp.113-120
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    • 2018
  • To fly a drone or unmanned aerial vechicle(UAV) safely, its pilot needs to maintain high situation awareness of its flight space. One of the important ways to improve the flight space awareness is to integrate both the global and the local navigation map a drone provides. However, the drone pilot often has to use the inconsistent reference frames or perspectives between the two maps. In specific, the global navigation map tends to display space information in the third-person perspective, whereas the local map tends to use the first-person perspective through the drone camera. This inconsistent perspective problem makes the pilot use mental rotation to align the different perspectives. In addition, integrating different dimensionalities (2D vs. 3D) of the two maps may aggravate the pilot's cognitive load of mental rotation. Therefore, this study aims to investigate the relation between perspective difference ($0^{\circ}$, $90^{\circ}$, $180^{\circ}$, $270^{\circ}$) and the map dimensionality matches (3D-3D vs. 3D-2D) to improve the way of integrating the two maps. The results show that the pilot's flight space awareness improves when the perspective differences are smaller and also when the dimensionalities between the two maps are matched.

ON THE SIMPLICIAL COMPLEX STEMMED FROM A DIGITAL GRAPH

  • HAN, SANG-EON
    • 호남수학학술지
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    • 제27권1호
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    • pp.115-129
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    • 2005
  • In this paper, we give a digital graph-theoretical approach of the study of digital images with relation to a simplicial complex. Thus, a digital graph $G_k$ with some k-adjacency in ${\mathbb{Z}}^n$ can be recognized by the simplicial complex spanned by $G_k$. Moreover, we demonstrate that a graphically $(k_0,\;k_1)$-continuous map $f:G_{k_0}{\subset}{\mathbb{Z}}^{n_0}{\rightarrow}G_{k_1}{\subset}{\mathbb{Z}}^{n_1}$ can be converted into the simplicial map $S(f):S(G_{k_0}){\rightarrow}S(G_{k_1})$ with relation to combinatorial topology. Finally, if $G_{k_0}$ is not $(k_0,\;3^{n_0}-1)$-homotopy equivalent to $SC^{n_0,4}_{3^{n_0}-1}$, a graphically $(k_0,\;k_1)$-continuous map (respectively a graphically $(k_0,\;k_1)$-isomorphisim) $f:G_{k_0}{\subset}{\mathbb{Z}}^{n_0}{\rightarrow}G_{k_1}{\subset}{\mathbb{Z}^{n_1}$ induces the group homomorphism (respectively the group isomorphisim) $S(f)_*:{\pi}_1(S(G_{k_0}),\;v_0){\rightarrow}{\pi}_1(S(G_{k_1}),\;f(v_0))$ in algebraic topology.

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마인드맵, 컨셉트맵 그리고 브이맵과 수학학습 (Learning Mathematics with Mind map, Concept map and Vee maps)

  • 정인철
    • 한국학교수학회논문집
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    • 제9권3호
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    • pp.385-403
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    • 2006
  • 본 연구는 마인드맵, 컨셉트맵 그리고 브이맵을 활용하여 수학학습하는 방법에 대해서 모색한다. 각각의 맵의 특성, 맵의 구조, 맵의 작성방법과 활용가능성 및 의의를 상세히 분석하고 수학교육과 어떻게 활용될 수 있는지 제시한다. 마인드맵은 인간의 사고를 최대한 가능하게 해주는 새로운 학습의 개념으로서 시간을 효과적으로 활용하고 그 학습효과를 최대로 할 수 있으며 컨셉트맵은 학습자들이 학습한 수많은 개념들을 체계적으로 제시할 뿐만 아니라 그들 사이의 관계를 시각적으로 구성하여 제시한다. 마지막으로 브이맵은 학습자들의 살아있는 생생한 지식이 되고 또 다른 탐구를 유도하는 그런 역할을 수행하는데 특히 도움이 되며 탐구를 시작하기 전에 알고자하는 질문을 던짐으로써 시작한다.

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환경정보체계의 효과적 이용에 관한 고찰 - 원자료의 정확성을 중심으로 - (A study on the Effective Use of Environmental Information System - focused on the accuracy of raw data -)

  • 이규석
    • 환경영향평가
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    • 제7권2호
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    • pp.27-35
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    • 1998
  • In Korea, the initial installation of GIS requires lots of cost, time, and human efforts. If the accuracy of GIS data does not meet the certain standard for use, the system may not work as expected. So, it needs to be investigated for the accuracy of raw data. However, there is little study for the accuracy of raw data in Korea. Therefore, the purpose of this study is to review the data accuracy of raw data - geologic map, 1:5,000 and 1:25,000 scale topographic map, forest stand map, degree of green naturality(DGN) map, and detailed survey data of DGN map-, which are to be used in Environmental Information System(EIS) in Korea. After this study, some errors in data were surveyed and following conclusions were derived. (1) There is no map data, e. g, wildlife habitat map. (2) Some data are misinterpreted depending on the location in the geologic map. (3) Some data are not updated properly after change of topography in the topographic map or the elevation and location is different depending on the scale.. (4) Some data are not edited properly in the forest stand map, e. g. two attributes in one polygon. (5) DGN classification system does not reflect the characteristic of Korean vegetation community. So, it needs to be refined and restructured.

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Butterfly Log-MAP Decoding Algorithm

  • Hou, Jia;Lee, Moon Ho;Kim, Chang Joo
    • Journal of Communications and Networks
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    • 제6권3호
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    • pp.209-215
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    • 2004
  • In this paper, a butterfly Log-MAP decoding algorithm for turbo code is proposed. Different from the conventional turbo decoder, we derived a generalized formula to calculate the log-likelihood ratio (LLR) and drew a modified butterfly states diagram in 8-states systematic turbo coded system. By comparing the complexity of conventional implementations, the proposed algorithm can efficiently reduce both the computations and work units without bit error ratio (BER) performance degradation.

Deep Web and MapReduce

  • Tao, Yufei
    • Journal of Computing Science and Engineering
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    • 제7권3호
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    • pp.147-158
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    • 2013
  • This invited paper introduces results on Web science and technology obtained during work with the Korea Advanced Institute of Science and Technology. In the first part, we discuss algorithms for exploring the deep Web, which refers to the collection of Web pages that cannot be reached by conventional Web crawlers. In the second part, we discuss sorting algorithms on the MapReduce system, which has become a dominant paradigm for massive parallel computing.