• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.231-240
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• 2023

Fabry disease is a lysosomal storage disorder characterized by the lysosomal accumulations of glycosphingolipids in a variety of cytotypes, which include endothelial cells. The disease is inherited and originates from an error in glycosphingolipid catabolism caused by insufficient α-galactosidase A activity, which causes uncontrolled progressive storage of intracellular globotriaosylceramide (Gb3) in the vasculature and extracellular accumulation of lyso-Gb3 (a deacetylated soluble form of Gb3). Necrosis can lead to inflammation, which exacerbates necrosis and creates a positive feedback loop that triggers necroinflammation. However, the role played by necroptosis, a form of programmed necrotic cell death, in the cell-to-cell inflammatory reaction between epithelial and endothelial cells is unclear. Thus, the present study was undertaken to determine whether lyso-Gb3 induces necroptosis and whether necroptosis inhibition protects endothelial dysfunction against lyso-Gb3 inflamed retinal pigment epithelial cells. We found lyso-Gb3 induced necroptosis of a retinal pigment epithelial cell line (ARPE-19) in an autophagy-dependent manner and that conditioned media (CM) from ARPE-19 cells treated with lyso-Gb3 induced the necroptosis, inflammation, and senescence of human umbilical vein endothelial cells. In addition, a pharmacological study showed CM from lyso-Gb3 treated ARPE-19 cells induced endothelial necroptosis, inflammation, and senescence were significantly inhibited by an autophagy inhibitor (3-MA) and by two necroptosis inhibitors (necrostatin and GSK-872), respectively. These results demonstrate lyso-Gb3 induces necroptosis via autophagy and suggest that lyso-Gb3 inflamed retinal pigment epithelial cells trigger endothelial dysfunction via the autophagy-dependent necroptosis pathway. This study suggests the involvement of a novel autophagy-dependent necroptosis pathway in the regulation of endothelial dysfunction in Fabry disease.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4146-4158
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• 2022

Ultra-high performance concrete (UHPC) has been widely utilized in military and civil protective structures to resist intensive loadings attributed to its excellent properties, e.g., high tensile/compressive strength, high dynamic toughness and impact resistance. At present, aiming to improve the defects of the traditional vertical concrete cask (VCC), i.e., the external storage facility of spent fuel, with normal strength concrete (NSC) shield, e.g., heavy weight and difficult to fabricate/transform, the feasibility of UHPC applied in the shield of VCC is numerically examined considering its high radiation and corrosion resistance. Firstly, the finite element (FE) analyses approach and material model parameters of NSC and UHPC are verified based on the 1/3 scaled VCC tip-over test and drop hammer test on UHPC members, respectively. Then, the refined FE model of prototypical VCC is established and utilized to examine its dynamic behaviors and damage distribution in accidental tip-over and end-drop events, in which the various influential factors, e.g., UHPC shield thickness, concrete ground thickness, and sealing methods of steel container are considered. In conclusion, by quantitatively evaluating the safety of VCC in terms of the shield damage and vibrations, it is found that adopting the 300 mm-thick UHPC shield instead of the conventional 650 mm-thick NSC shield can reduce about 1/3 of the total weight of VCC, i.e., about 50 t, and 37% floor space, as well as guarantee the structural integrity of VCC during the accidental drop simultaneously. Besides, based on the parametric analyses, the thickness of concrete ground in the VCC storage site is recommended as less than 500 mm, and the welded connection is recommended for the sealing method of steel containers.

• Nuclear Engineering and Technology
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• v.56 no.1
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• pp.195-206
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• 2024

Shenzhen Innovation Light source Facility (SILF) is a 3.0 GeV fourth generation diffraction limited synchrotron light source currently under construction in Shenzhen. The SILF storage ring is proposed to use two 500 MHz single cell superconducting radio frequency (SRF) cavities to provide 2.4 MV RF voltage. In this study, we examined the geometric structure of mature CESR superconducting cavities and adopted a beam-pipe-type extraction scheme for high-order modes (HOM). One of the objectives of SRF cavity design and optimization in this study is to reduce E_p/E_acc and B_p/E_acc as much as possible to reduce power loss and ensure stable operation of the cavity. To reduce the risk of beam instability and thermal breakdown, the HOM and Multipacting (MP) are simulated. Moreover, the mechanical properties of the cavity are analyzed, including frequency sensitivity from pressure of liquid helium (LHe), stress, tuning, Lorentz force detuning (LFD), the microphone effect, and buckling. By comprehensive design and optimization of 500 MHz single-cell SRF cavities, a superconducting cavity for SILF storage ring was developed. This paper will detailed present the design and simulation.

• Korean journal of food and cookery science
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• v.31 no.4
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• pp.387-394
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• 2015

The red snow crab lives at a depth 200-2,000 m in the east coast. It has a smooth taste with a rich texture. However mostly red snow crab are only utilized materials. For seafood development, research is needed on using red snow crab in various products. In this study, quality changes in fried rice prepared with red snow crab meat, red snow crab emulsion sauce and red snow crab effluent were investigated. Physicochemical, microbiological and sensory characteristics were determined during storage at -20, 4 and $25^{\circ}C$ for 5 weeks to assess changes in the quality of the fried rice. The pH and acidity values did not show any significant differences at $-20^{\circ}C$. The VBN and TBA values of fried rice stored at 4 and $25^{\circ}C$ were significantly higher than those of fried rice stored at $-20^{\circ}C$ during the same storage period. The viable cell count of the fried rice stored at $-20^{\circ}C$ changed little during the storage period. During storage at $25^{\circ}C$, the overall quality was initially 8.0, but rapidly decreased to 1.0 after 5 weeks. In conclusion, the best storage temperature for both quality and safety was $-20^{\circ}C$. The storage condition for instant rice containing red snow crab affects the quality and we confirmed the applicability of using materials from red snow crab.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.2
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• pp.610-630
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• 2020

A large number of people suffered from traffic accidents each year, so people pay more attention to traffic safety. However, the traditional methods use laser sensors to calculate the vehicle distance at a very high cost. In this paper, we propose a method based on deep learning to calculate the vehicle distance with a monocular camera. Our method is inexpensive and quite convenient to deploy on the mobile platforms. This paper makes two contributions. First, based on Light-Head RCNN, we propose a new vehicle detection framework called Light-Car Detection which can be used on the mobile platforms. Second, the planar homography of projective geometry is used to calculate the distance between the camera and the vehicles ahead. The results show that our detection system achieves 13FPS detection speed and 60.0% mAP on the Adreno 530 GPU of Samsung Galaxy S7, while only requires 7.1MB of storage space. Compared with the methods existed, the proposed method achieves a better performance.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.44 no.4
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• pp.316-320
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• 1999

Nine accessions of red rices collected from different regions were tested for germination characteristics in relation to seed maturity and several storage conditions after harvest. No red rice seeds germinated at five days after anthesis (DAA). Wanjuaengmi (long-grain red rice) seeds at 10DAA germinated up to 30% of total samples, producing only abnormal seedlings, whereas 10D-AA-seeds of normal cultivar showed only 3.3% germinability. Some red rice seeds absorbed more water than cultivated varieties, and showed less decrease in germination rate than cultivated varieties when seeds were exposed at -1, -5 or -1$0^{\circ}C$ for up to 60 hours after soaking. Red rice accessions maintained more than 95% germination when stored. indoor for 120 days. Two short-grain red rices showed about 50% germination when overwintered in the field, while other long-grain red rices and cultivated rices germinated less than 10%. Germination of seeds overwintered in clay loam soil was lower than that in loam soil, and seeds on surface germinated less than those in 1~7cm depth.

• Korean Journal of Food Science and Technology
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• v.26 no.6
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• pp.713-717
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• 1994

Effects of packing materials on the gas compositions in package of fresh peeled garlic (Allium sativum L.) were investigated. The fresh peeled garlics packed in $20,\;40,\;60\;{\mu}m$ LDPE and $30\;{\mu}m$ HDPE pouches were stored at $20^{\circ}C$, 76% RH. The variables including respiration characteristics, gas compositions, general appearance, and film permeabilities to $O_2$, $CO_2$ and $H_2O$ vapor were measured. A model was evaluated for the prediction of $O_2$ and $CO_2$ equilibrium concentrations inside packages and for the optimization of packaging parameters. Experimental and simulated gas composition results were found to be in good agreement. The $30\;{\mu}m$ HDPE pouch with 4% $O_2$ and 7.5%$CO_2$ equilibrium concentrations conferred the best appearance of peeled garlic, giving 6 days of storage life. As a result, MA seemed to have a beneficial effect on appearance of fresh peeled garlic, possibly due to reduced microbial activity.

• International Journal of Internet, Broadcasting and Communication
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• v.8 no.2
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• pp.1-22
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• 2016

While many organizations believe that cloud computing has the potential to reduce operational cost by abstracting capital assets like data storage center and processing systems into a readily on demand available and affordable operating expenses, still many of these organizations are not aware of the factors determining the performance of cloud computing technology. This paper provides a systematic literature review focusing on the factors determining the performance of cloud computing. In trying to come up with this review, the following sources were searched for relevant articles: ScienceDirect, Scientific.Net, ACMDigital Library, IEEE Xplore, Springer, World Scientific Journal, Wiley Online Library, Academic Search Premier (via EBSCOHost) and EdITLib (Education & Information Technology Digital Library). In first search strategy, approximately 100 keywords related to the research domain like; "Cloud Computing" and "Cloud Services" were used. In second search strategy, 65 keywords more related to the research domain were selected. In the third search strategy, the primary materials were identified and classified according to the paper types (Journal or Conference), year of publication and so on. Based on this study, twenty (20) factors were found that determine the performance of cloud computing. The IT organization needs to consider these twenty (20) factors in order to adopt cloud computing.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.4 no.2
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• pp.18-23
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• 1998

Weight loss of cucumber packed with corrugated paperboard box after 7 days storage at 20oC was 4.9%, and those of 20LD, 40LD film and EPS box were 0.8, 0.7, and 0.8%. Total ascorbic acid content of EPS was 15% higher than that of control. Hardness of EPS was also similar trend. Chlorophil content of cucumber packed with EPS box was 21% higher than that of control. Decay of control was 1-2 pieces per box, but the others was not found. Overall appearence of LD, EPS was better than that of control.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.4 no.2
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• pp.12-17
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• 1998

Weight loss of pear packed with corrugated paperboard box after 50 days storage at $20^{\circ}C$ was 4.4%, and those of 20LD, 40LD film and EPS box were 0.8-0.7%. Ascorbic acid content of EPS was 20% higher than that of control. Hardness of EPS was also similar trend. Titratable acid and total soluble solid content of pear were not different among the packages. Decay of control was 1-2 pieces per box, but the others was not found. Overall appearences of LD, CE and EPS were better than that of control.