• The Korean Journal of Physiology
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• v.17 no.1
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• pp.1-11
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• 1983

1) The two microelectrode method was used to voltage clamp small preparations of rabbit sinoatrial node. The kinetics of hyperpolarization activated inward current, $i_f$ were analysed. 2) The hrperpolarization pulses activated $i_f$ current in the presence of $10^{-7}g/ml$ TTX and 2 mM $Mn^{2+}$. The activation range was in between -45 mV to -75 mV. The current magnitude was increased and time course was faster by strong hyperpolarization pulses. 3) Standard envelope tests indicated that this current is exponentially controlled by single gate. 4) Semilogarithmic plot of $i_f$ activation versus time was found to be linear in the activation range. The decrease in current magnitude and the shifts in activation curve and rate constants curve to the hyperpolarizing direction were obtained with $Ba^{2+}$, indicating that $Ba^{2+}$ shifts the voltage dependence of the gating kinetics, were partially reversed by 24 mM $K^+$.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.2
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• pp.174-180
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• 2016

In this study, the effects of fermented goat milk (F-GM) on immunological activity and physical strength were examined. Splenocytes obtained from mice administered with F-GM showed increased responsinveness to mitogens, concanavalin-A (ConA), and lipopolysaccharide (LPS). Treatment with F-GM also significantly augmented production of interleukin (IL)-2 and interferon (IFN)-${\gamma}$, but not IL-4 or IL-10 from ConA-stimulated splenocytes. The activity of F-GM administration to enhance production of IL-2 and IFN-${\gamma}$ was confirmed based on mRNA expression of these cytokines by reverse transcription polymerase chain reaction. After immunization with keyhole limpet hemocyanin (KLH, 20 mg/mouse), mice administered F-GM showed significantly higher antibody titers against KLH than those of phosphate-buffered saline-treated mice, and showed the highest titer 5 weeks after KLH immunization. Analysis for determining isotypes of antibodies revealed that administration of F-GM elicited KLH-specific antibody titers of IgG1, IgG2a, and IgM. In a delayed type hypersensitivity (DTH) test carried out 7 weeks after the primary immunization, F-GM-treated mice showed a higher DTH reaction than the control mice. Furthermore, the swimming test found that administration of F-GM significantly increased swimming time. These results suggest that administration of F-GM enhances not only immune responses against antigens but also physical strength.

• The Journal of Advanced Prosthodontics
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• v.13 no.5
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• pp.269-280
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• 2021

PURPOSE. The objective of this study was to evaluate the effect of thickness reduction and fatigue on the failure load of monolithic zirconia crowns. MATERIALS AND METHODS. 140 CAD-CAM fabricated crowns (3Y-TZP, inCorisTZI, Dentsply-Sirona) with different ceramic thicknesses (2.0, 1.5, 1.0, 0.8, 0.5 mm, respectively, named G2, G1.5, G1, G0.8, and G0.5) were investigated. Dies of a mandibular first molar were made of composite resin. The zirconia crowns were luted with a resin composite cement (RelyX Unicem 2 Automix, 3M ESPE). Half of the specimens (n = 14 per group) were mouth-motion-fatigued (1.2 million cycles, 1.6 Hz, 200 N/ 5 - 55℃, groups named G2-F, G1.5-F, G1-F, G0.8-F, and G0.5-F). Single-load to failure was performed using a universal testing-machine. Fracture modes were analyzed. Data were statistically analyzed using a Weibull 2-parameter distribution (90% CI) to determine the characteristic strength and Weibull modulus differences among the groups. RESULTS. Three crowns (21%) of G0.8 and five crowns (36%) of G0.5 showed cracks after fatigue. Characteristic strength was the highest for G2, followed by G1.5. Intermediate values were observed for G1 and G1-F, followed by significantly lower values for G0.8, G0.8-F, and G0.5, and the lowest for G0.5-F. Weibull modulus was the lowest for G0.8, intermediate for G0.8-F and G0.5, and significantly higher for the remaining groups. Fatigue only affected G0.5-F. CONCLUSION. Reduced crown thickness lead to reduced characteristic strength, even under failure loads that exceed physiological chewing forces. Fatigue significantly reduced the failure load of 0.5 mm monolithic 3Y-TZP crowns.

• Journal of Korean Society of Forest Science
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• v.105 no.2
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• pp.177-185
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• 2016

Fertilization is required to keep the balance of tissue nutrients and to produce high quality seedlings at the permanent nursery. This study was conducted to verify the optimum fertilization method for Fraxinus rhynchophylla, F. mandshurica, Pinus koraiensis, and Abies holophylla seedlings with vector diagnosis method. Seven treatments include nitrogen (N, $13.8g{\cdot}m^{-2}$), phosphorus (P, $6.1g{\cdot}m^{-2}$), potassium ($7.5g{\cdot}m^{-2}$) fertilization and 1x (N $6.9g{\cdot}m^{-2}$, P $3.05g{\cdot}m^{-2}$, K $3.65g{\cdot}m^{-2}$), 2x (twice of 1x), 4x (four times of 1x) fertilization and no fertilization. Soil pH decreased as fertilization increased. Nitrogen and NPK fertilization decreased exchangeable $Ca^{2+}$ and $Mg^{2+}$ concentrations. Height and root collar diameter of F. rhynchophylla and F. mandshurica significantly increased with N and NPK fertilization, but those of P. koraiensis and A. holophylla did not. The biomass of F. rhynchophylla and F. mandshurica was about twice higher at NPK fertilization compared to the control. The responses of vector diagnosis were different by tree species and fertilization treatment: F. rhynchophylla was in the status of N "dilution", which means the N concentration decreases with N content. Phosphorus and K were "sufficiency" state with 4x fertilization. F. mandshurica showed "retranslocation" as N content decreased without change of dry weight at N, P, K fertilization, but "dilution" state at NPK fertilization. This result suggested that optimal fertilization was required for F. rhynchophylla and F. mandshurica in seedling production stage, but was not essential for P. koraiensis and A. holophylla.

• Communications of the Korean Mathematical Society
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• v.20 no.4
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• pp.775-779
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• 2005

On a compact n-dimensional manifold $M^n$, a critical point of the total scalar curvature functional, restricted to the space of metrics with constant scalar curvature of volume 1, satifies the critical point equation (CPE), given by $Z_g\;=\;s_g^{1\ast}(f)$. It has been conjectured that a solution (g, f) of CPE is Einstein. The purpose of the present paper is to prove that every compact stable minimal hypersurface is in a certain hypersurface of $M^n$ under an assumption that Ker($s_g^{1\ast}{\neq}0$).

• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.1-5
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• 2001

The aggregation behavior of nystatin (NYS) in the presence of pluronic F127, triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), was measured and correlated with hemolytic activity. Antifungal activity was also studied using Saccharomyces cerevisiae as a model strain. The critical aggregation concentrations (CAC) of the drug were 50.1, 108.0, 134.2, 154.3, and $217.9\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. The levels of NYS required to start lysis of erythrocytes were about 80, 100, 125, 150, and $200\;{\mu}M$ at 0.1%, 0.5%, 1.0%, 1.5%, and 2.0% pluronic F127 solution, respectively. It was $50\;{\mu}M$ in the absence of the polymer. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of NYS-pluronic F127 lyophilizate were same at $3\;{\mu}g/ml$, while MIC and MFC of pure NYS are $3\;{\mu}g/ml$ and $12\;{\mu}g/ml$, respectively. By modulating the aggregation behavior of NYS, pluronic F127 was able to reduce the toxicity of the drug without compromising the MIC and MFC.

• East Asian mathematical journal
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• v.26 no.3
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• pp.389-395
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• 2010

In this paper, a class of g-demi-pseudomonotone mappings is introduced and the solvability of a class of generalized vector F-complementarity problems with the mappings in Banach spaces is considered.

• Proceedings of the KIEE Conference
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• 1990.07a
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• pp.439-442
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• 1990

GaAs MESFETs with the submicron gat are fabricated. $G_{m,mas}$ = 195mS/mm with the $0.5{\mu}m$ gate length and $G_{m,mas}$ = 170mS/mm with the $0.6{\mu}m$ gate lenth. $f_{mas}$ = 7GHz with the $1.5{\mu}m$ gate length and the $120{\mu}m$ gate width. We can estimate that $f_{mas}$ = 15GHz with $0.6{\mu}m$ gate length and that $f_{mas}$ = 18 ${\sim}$ 20GHz with the $0.5{\mu}m$ gate length.

• Korean Journal of Mathematics
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• v.25 no.2
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• pp.279-301
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• 2017

An L(3, 2, 1)-labeling for the graph G = (V, E) is an assignment f of a label to each vertices of G such that ${\mid}f(u)-f({\upsilon}){\mid}{\geq}4-k$ when $dist(u,{\upsilon})=k{\leq}3$. The L(3, 2, 1)-labeling number, denoted by ${\lambda}_{3,2,1}(G)$, for G is the smallest number N such that there is an L(3, 2, 1)-labeling for G with span N. In this paper, we compute the L(3, 2, 1)-labeling number ${\lambda}_{3,2,1}(G)$ when G is a cylindrical grid, which is the cartesian product $P_m{\Box}C_n$ of the path and the cycle, when $m{\geq}4$ and $n{\geq}138$. Especially when n is a multiple of 4, or m = 4 and n is a multiple of 6, then we have ${\lambda}_{3,2,1}(G)=11$. Otherwise ${\lambda}_{3,2,1}(G)=12$.

• Bulletin of the Korean Mathematical Society
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• v.43 no.1
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• pp.179-188
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• 2006

For a given p-valent analytic function g with positive coefficients in the open unit disk $\Delta$, we study a class of functions $f(z) = z^p - \sum\limits{_{n=m}}{^\infty} a_nz^n(a_n{\geq}0)$ satisfying $$\frac 1 {p}{\Re}\;(\frac {z(f*g)'(z)} {(f*g)(z)})\;>\;\alpha\;(0{\leq}\;\alpha\;<\;1;z{\in}{\Delta})$$ Coefficient inequalities, distortion and covering theorems, as well as closure theorems are determined. The results obtained extend several known results as special cases.