• Geomechanics and Engineering
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• v.25 no.2
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• pp.123-134
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• 2021

In this paper, the carbon fiber reinforced plastic (CFRP) grids embedded in polymer cement mortar (PCM) shotcrete (CFRP-PCM method) was conducted to repair the degraded tunnel linings with a cavity. Subsequently, the reinforcing effect of the CFRP-PCM method under different degrees of lining deterioration was quantitatively evaluated. Finally, the limit state design method of the M-N interaction curve was conducted to determine whether the structure reinforced by the CFRP-PCM method is in a safe state. The main results indicated that when the cavity is at the shoulder, the lining damage rate is more serious. In addition, the remarkably reinforcing effect on the degraded tunnel linings could be achieved by applying a higher grade of CFRP grids, whereas the optimization effect is no longer obvious when the grade of CFRP grids is too high (CR8); Furthermore, it is found that the M-N numerical values of the ten reinforcing designs of the CFRP-PCM method are distributed outside the corresponding M-N theoretical interaction curves, and these designs should be avoided in the corresponding reinforcing engineering.

• Journal of the Korean Society of Hazard Mitigation
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• v.7 no.5
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• pp.19-25
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• 2007

In this study, a program based on the P-M interaction curve is developed to calculate the nominal strength of concrete pole. Using this, it is verified to compare with previous studies and the nominal strength$(M_n)$ of concrete pole is calculated. It is less than the rupture strength$(M_r)$ of the design standard. Thus, to increase nominal strength, several parameters are selected like as size of tension and reinforced bars, position of those, number of reinforcement bars, thickness of concrete pole, and diameter of it. The effects of those are analysed in the study. It is supposed that section of concrete pole are satisfied rupture strength.

• Earthquakes and Structures
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• v.22 no.3
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• pp.219-230
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• 2022

Knowing that the variability of soil properties is an important source of uncertainty in geotechnical analyses, we will study in this paper the effect of this variability on the seismic response of a structure within the framework of Soil Structure Interaction (SSI). We use the proposed and developed model (N2-ISS, Mekki et al., 2014). This approach is based on an extension of the N2 method by determining the capacity curve of the fixed base system oscillating mainly in the first mode, then modified to obtain the capacity curve of the system on a flexible basis using the concept of the equivalent nonlinear oscillator. The properties of the soil that we are interested in this paper will be the shear wave velocity and the soil damping. These parameters will be modeled at first, as independent random fields, then, the two parameters will be correlated. The results obtained showed the importance of the use of random field in the study of SSI systems. The variability of soil damping and shear wave velocity introduces significant uncertainty not only in the evaluation of the damping of the soil-structure system but also in the estimation of the displacement of the structure and the base-shear force.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.3 s.192
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• pp.140-146
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• 2007

To understand adhesive phenomena, we need to get force curve between two surfaces. And it is said that high stiffness force analysis system is needed to get precise force curve and more information of the surfaces. Usually the stiffness of the force measurement system is under the order of 10N/m. The stiffer force measurement system, however, results in more information on the surface, because higher stiffness lead to the wider range of force curves, secondly because the force curve obtained through the stiffer one describes more precise relationship between relative tip-sample separation and interaction force. In this paper, considering for stiffness and resolution, the cantilever was designed and we made adhesion force measurement apparatus with high stiffness and high resolution, so we measured adhesive force between Ag-ball and wafer.

• Journal of the Korean Magnetics Society
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• v.11 no.5
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• pp.232-238
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• 2001

Experimentally it is well known that the magnetic properties significantly deteriorate when nanocomposite bonded magnet are made from nanocomposite ribbon. A decrease in maximum energy product of F $e_3$B+N $d_2$F $e_{14}$B nanocomposite from 14 MGOe in nanocomposite ribbon to 6.5 MGOe in powder compact was fecund to be general. Thus, the present study is focused on finding out the root of exchange decoupling of N $d_4$F $e_{73.5}$ $Co_3$H $f_{0.5}$G $a_{0.5}$ $B_{18.5}$ nanocomposite powder compacts. The exchange decoupling behavior of the powder compact of F $e_3$B+N $d_2$F $e_{14}$B composition was studied by measuring DC demagnetization and isothermal remanent demagnetization curves, which are essential for plotting produced $\delta$M curve. From the $\delta$M plot the deterioration in the magnetic properties resulted from the fact that the magnetostatic interaction became dominant rather thanthe exchange interaction in powder compact. It is concluded that the demagnetization behavior governed by the dominant magnetostatic interaction reduced the remanence magnetization, which caused the reduction of maximum energy Product of the powder compact. We also found that the elimination of residual stress which is unavoidably accumulated during grinding process enhanced the magnetic properties considerably.bly.bly.

• YAKHAK HOEJI
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• v.34 no.4
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• pp.224-237
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• 1990

A single uniform population of specific, saturable, high affinity binding site of $[^3H]QNB$ guinuclidinyl benzilate(QNB) was identified in the rat cerebral microsomes. The Kd value(37.2 pM) for $[^3H]QNB$ calculated from the kinetically derived rate constants was in agreement with the Kd value(48.9 pM) determined by analysis of saturation isotherms at various receptor concentrations. Dimenhydrinate(DMH), histamine $H_1-blocker$, increased Kd value for $[^3H]QNB$ QNB without affecting the binding site concentrations and this effect resulted from the ability of DMH to slow $[^3H]QNB-receptor$ association. Pirenzepine inhibition curve of $[^3H]QNB$ binding was shallow(nH = 0.52) indicating the presence of two receptor subtypes with high ($M_1-site$) and low($M_2-site$) affinity for pirenzepine. Analysis of these inhibition curves yielded that 68% of the total receptor populations were of the $M_1-subtype$ and the remaining 32% of the $M_2-subtype$. Ki values for the $M_1-$ and $M_2-subtypes$ were 2.42 nM and 629.3 nM, respectively. Ki values for $H_1-blockers$ that inhibited $[^3H]QNB$ binding varied with a wide range ($0.02-2.5\;{\mu}M$). The Pseudo-Hill coefficients for inhibition of $[^3H]QNB$ binding by most of $H_1-blockers$ examined except for oxomemazine inhibition of $[^3H]QNB$ binding were close to one. The inhibition curve for oxomemazine in competition with $[^3H]QNB$ was shallow(nH = 0.74) indicating the presence of two receptor populations with different affinities for this drug. The proportion of high and low affinity was 33:67. The Ki values for oxomemazine were $0.045{\pm}0.016\;{\mu}M$ for high affinity and $1.145{\pm}0.232\;{\mu}M$ for low affinity sites. These data indicate that muscarinic receptor blocking potency of $H_1-blockers$ varies widely between different drugs and that most of $H_1-blockers$ examined are nonselective antagonist for the muscarinic receptor subtypes, whereas oxomemazine might be capable of distinguishing between subclasses of muscarinic receptor.

• Journal of the Korea Concrete Institute
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• v.29 no.4
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• pp.353-360
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• 2017

The objective of this study is theoretical and empirical evaluation of the flexural performance of concrete filled pretensioned spun high strength concrete pile with ring type composite shear connectors (CFP pile). The specimens are comprised of standard CFP pile, PHC pile+composite shear connector+filed concrete (CFP-N-N), standard CFP pile with $1^{st}$ reinforcements (H13-8ea), and standard CFP pile with $1^{st}$ and $2^{nd}$ reinforcements(H19-8ea). Flexural performance evaluation results showed that the ductility is improved with increased steel ratio, which leads to the increased maximum load by 46.4% (with $1^{st}$ reinforcement) and 103.9% (with $1^{st}$ and $2^{nd}$ reinforcements) compared to standard CFP ( CFP-N-N). Comparing with the predicted ultimate limit state values of the CFP pile design method and the experimental results, the design method presented in this study is reasonable since safety factor of 1.23 and 1.40 times for each reinforcement step are secured.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.385-395
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• 2017

Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations, such are those containing phenylephrine and lerimazoline, may affect the overall contractile activity, and thus their therapeutic utility. This study aimed to examine the interaction between lerimazoline and phenylephrine in isolated rat aortic rings, and also to assess the substrate of the obtained lerimazoline-induced attenuation of phenylephrine contraction. Namely, while lower concentrations of lerimazoline ($10^{-6}M$ and especially $10^{-7}M$) expectedly tended to potentiate the phenylephrine-induced contractions, lerimazoline in higher concentrations ($10^{-4}M$ and above) unexpectedly and profoundly depleted the phenylephrine concentration-response curve. Suppression of NO with NO synthase (NOS) inhibitor $N^w$-nitro-L-arginine methyl ester (L-NAME; $10^{-4}M$) or NO scavanger $OHB_{12}$ ($10^{-3}M$), as well as non-specific inhibition of $K^+$-channels with tetraethylammonium (TEA; $10^{-3}M$), have reversed lerimazoline-induced relaxation of phenylephrine contractions, while cyclooxygenase inhibitor indomethacin ($10^{-5}M$) did not affect the interaction between two vasoconstrictors. At the receptor level, non-selective 5-HT receptor antagonist methiothepin reversed the attenuating effect of lerimazoline on phenylephrine contraction when applied at $3{\times}10^{-7}$ and $10^{-6}M$, but not at the highest concentration ($10^{-4}M$). Neither the 5-$HT_{1D}$-receptor selective antagonist BRL 15572 ($10^{-6}M$) nor 5-$HT_7$ receptor selective antagonist SB 269970 ($10^{-6}M$) affected the lerimazoline-induced attenuation of phenylephrine activity. The mechanism of lerimazoline-induced suppression of phenylephrine contractions may involve potentiation of activity of NO and $K^+$-channels and activation of some methiothepin-sensitive receptors, possibly of the 5-$HT_{2B}$ subtype.

• Journal of the Korean Chemical Society
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• v.42 no.2
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• pp.190-196
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• 1998

A new sampling and size exclusion chromatography (SEC) method for the analysis of underivatized cellulose are established. In this method, cellulose materials are first dissolved in N-methylmorpholine N-oxide (NMMO) and diluted by adding dimethyl sulfoxide (DMSO) to make the sample solutions of about 0.1% in 50/50 NMMO/DMSO (w/w). Sample solutions are analyzed using a glucose-treated divinylbenzene (DVB) SEC column and DMSO containing 0.05M LiBr and 2.5 blank as the eluant. The flow rate was constant at 1 mL/min and the whole SEC system including the column was heated at $80^{\circ}C$ to reduce the viscosity of DMSO. Addition of 0.05 M LiBr eliminated SEC baseline drifting, and addition of 2.5 blank seems to reduce the interaction between the sample and the column packing. SEC molecular weights were determined using a calibration curve constructed from a series of narrow pullulan standards, and they were used to measure the degree of degradation during two different pulp-to-sponge processings.

• 한국생물공학회:학술대회논문집
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• 2001.11a
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• pp.231-234
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• 2001

We performed a basic experiment for rapid. on-line, real-time measurement of HBsAg by using a BIACORE biosensor, a chip-based sensor utilizing surface plasmon resonance technology to quantify the recognition and interaction of biomolecules. We immobilized an a -HBsAg antibody on a CM5 chip surface which was activated by N-hydroxysuccinimide for amine coupling with HBsAg, and measured the mass increase from the coupling. This study showed the potential of this biosensor-based method as a rapid, multi-sample, on-line assay. Once properly validated, it can serve as a more powerful method for HBsAg quantification.