• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2987-2991
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• 2015

Background: The prognostic role of thyroid transcription factor-1 (TTF-1) expression in lung cancer has been assessed but with inconsistent results. The present study aimed to evaluate the prognostic value of TTF1 expression in advanced non-squamous non-small cell lung cancer (NSCLC). Materials and Methods: In this retrospective study, patients with stage IIIB-IV non-squamous NSCLC were enrolled. Progression free survival (PFS) and overall survival (OS) were assessed according to TTF1 expression status, age categories (${\leq}60$ vs >60 years), gender, performance status (PS) (0-2 vs 3-4), type of 1st line chemotherapy (pemetrexed containing vs others) and EGFR status. Results: A total of 120 patients were included. In univariate analysis, PFS was improved in patients with PS 0-2 (7.0 vs 2.0 months, p=0.002) and those who received pemetrexed-containing chemotherapy (9.2 vs 5.8 months, p=0.004). OS was improved in female patients (23.0 vs 8.7 months, p<0.0001), PS 0-2 (14.4 vs 2.0 months, p<0.0001), those with pemetrexed-containing chemotherapy (17.0 vs 11.0 months, p=0.019), TTF1-positive (12.8 vs 5.8 months, p=0.011) and EGFR- mutant patients (23.0 vs 11.7 months, p=0.006). In multivariate analysis, male gender (HR=2.34, p=0.025) and non-pemetrexed containing therapy (HR=2.24, p=0.022) were independent predictors of worse PFS. Wild EGFR status (HR=2.49, p=0.015) and male gender (HR=2.78, p=0.008) were predictors of worse OS. Conclusions: Pemetrexed-containing therapy significantly improved PFS while OS was improved in EGFR mutant patients. Female patients had better PFS and OS. TTF1 expression was not a prognostic marker in advanced non-squamous NSCLC.

• 보건교육건강증진학회지
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• 제22권4호
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• pp.17-40
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• 2005

Objective: The purpose of the this study was to test the effect of the alcohol preventive educational program for elementary school students through developing the web-based learning instruments. It will prevent the serious alcohol problem for adolescents and be the opening-learning according to learner's needs beyond the traditional classroom learning which has limitation of space and time. Method: This research designed based on web-based instructional system design by In-sung Jong(1997). This study was performed on the elementary school students who are the six grade in M city. The number of experimental group was 72 and control group's number was 72, totaled 144. Data were collected from September, 30th, 2004 to November, 5th, 2004, totaled 37days. The pretest and the posttest for web-based alcohol preventive education program were tested about knowledge and attitudes toward drinking. After the performance, the posttest was also tested the effect of this program under items by the interest of web-based learning, satisfaction, adequateness of material and so on. The data analysis was done using SPSS/Win 11.0 program. Result: The results of this study are as follows: 1) Compared with control group, experimental group which was educated the web-based alcohol preventive educational program for elementary school students was improved the knowledge on drinking, thin there was no significant difference. However, it showed significant difference between two groups after education. It was, therefore, partially supported. 2) Compared with control group, the experimental group which was educated the web-based alcohol preventive educational program for elementary school students showed significant difference in attitudes toward drinking. After education, it showed no significant difference attitudes. toward drinking between experimental group and control group. It was, therefore, partially supported. 3) The degree of learning motivation was an average.595 of 1 after learning applied to by the web-based alcohol preventive educational program for elementary school students. Then, it is relatively more higher than the result of existing studies. So, it showed that the motivation was done well. 4) Correlation among study variables It showed that there was the significantly positive correlation between knowledge and attitudes toward drinking of pretest experimental group. Also, there was the significantly positive correlation between attitudes toward drinking and learning motivation of pretest and posttest experimental group. Conclusion: I found that the web-based educational program helps the elarning process for the health education in the school field which the instructional materials lack. As a result, the web-based education motivates the learner's pleasure and promotes the learners interest. Also, it is possible for students to learn according to their own learning pace, repeated learning and active learning participation in the necessary parts. Therefore, I think the web-based educational program is worth as a intervention to get positive influence for the health education.

• 천문학회보
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• 제39권2호
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• pp.102-102
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• 2014

The NISS (Near-infrared Imaging Spectrometer for Star formation history) onboard NEXTSat-1 is the near-infrared instrument onboard NEXTSat-1 which is being developed by KASI. The main scientific targets are nearby galaxies, galaxy clusters, star-forming regions and low background regions in order to study the cosmic star formation history in local and distant universe. After the Preliminary Design Review, we have fixed major specifications of the NISS. The off-axis optical design with 15cm apertureis optimized to obtain a wide field of view ($2deg.{\times}2deg.$), while minimizing the sensitivity loss. The opto-mechanical structure of the NISS was designed to be safe enough to endure in the launching condition as well as the space environment. The tolerance analysis was performed to cover the wide wavelength range from 0.95 to $3.8{\mu}m$ and to reduce the degradation of optical performance due to thermal variation at the target temperature, 200K. The $1k{\times}1k$ infrared sensor is operated in the dewar at 80K stage. We confirmed that the NISS can be cooled down to below 200K in the nominal orbit through a radiative cooling. Here, we report the preliminary design of the NISS.

• 대한전자공학회논문지TC
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• 제48권1호
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• pp.16-24
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• 2011

해양에서의 음속은 수온, 염분, 압력에 의한 실험식으로 계산되며 해양에서의 평균 염분은 약 34 psu (practical salinity unit)로 수성이나 수평 거리에 따른 변화가 대부분 수 psu 이하이기 때문에 음속에 크게 영향을 마치지 못한다. 그러나 최근 여름철에 중국 양쯔강 범람에 의해서 24 psu 정도의 저염수가 제주 서부 해역으로 유입되는 사례가 발생하고 있으며 이 저염수는 음속에 영향을 미친다. 본 논문에서는 이러한 환경 변화가 수중통신에 미치는 영향을 분석하였다. 즉, 저염수로 인한 음속구조의 변화를 계산하였고, 저염수층 내에서 송수선 수심과 전달거리를 바꿔가며 음파 전달 경로를 모의하여 통신 채널을 추정하였으며, BPSK(Binary phase shift key) 변조방식을 이용하여 비트 오류율을 계산하였다. 동일한 실험 조건하에 저염수가 없는 경우의 성능을 비교하여, 저염수가 통신 성능에 어떠한 영향을 미치는가에 대해 분석하였다. 저염수는 수심 약 20m까지의 표층부에서 음속의 기울기를 양의 기울기로 변화시켜 음과 채널을 형성하였고, 표층부에서 대부분의 송수신 신호의 비트 오류율을 감소시키는 경향을 확인하였다. 본 논문의 저염수에 의한 수중 통신 성능에 미치는 영향을 분석한 결과는 정확한 해양 통신 및 탐지 성능분석을 하기 위해서는 해양환경의 변화를 고려하는 것이 매우 중요하다는 것을 시사한다.

• 한국지반신소재학회논문집
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• 제16권1호
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• pp.1-8
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• 2017

댐 변위 모니터링은 댐의 안전성을 위협하는 영향을 파악하여 댐과 관련된 붕괴사고를 사전에 방지하고, 댐을 안전하게 운영하고 유지 관리하는데 중요한 항목으로 사용되고 있다. 하지만, 기존 변위계측 분석 결과 원인불명의 변위가 발생하여 정확한 댐 거동 해석을 저해하고 있다. 본 연구에서는 광파기(Total Station) 기반 댐의 변위계측의 신뢰성 개선을 위해 그 보정방법을 제안하였다. 현재까지의 광파기에 의한 변형 모니터링은 기준점(2~3개소)과 광파기가 설치된 기계점 위치를 초기에 측량하여 불변으로 간주하였고, 측량과정에서 중요한 변위 산정요소가 되는 기준 수평 수직각은 고려하지 않고 측량을 실시하였다. 본 연구에서는 실제 댐 변위 계측시 기준점 측량을 통해 광파기의 위치 변화 및 기준 수평 수직각의 변화를 관측하였다. 그 결과 오차발생의 가장 큰 원인은 광파기 위치 변화와 댐 변위량 계산에 중요한 항목인 기준 수평 및 수직각임이 밝혀졌다. 또한, 이를 보정한 결과 최대 변위 20mm에서 약 ${\pm}5mm$로 감소하였다.

• 의료법학
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• 제15권1호
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• pp.263-302
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• 2014

The court handed down meaningful rulings related to medical sectors in 2013. This paper presents the ruling that the care workers could be the performance assistants of the care-giving service although the duties of care worker are not included in the liability stipulated in the medical contract signed with the hospital for reason of clear distinction of duties between care workers and nurses within the hospital in connection with the contract which was entered into between the hospital and patients. In relation to negligence and causal relationship, the court recognized medical negligence associated with the failure to detect the brain tumor due to the negligent interpretation of MRI findings while rejecting the causal relationship with consequential cerebral hemorrhage. The court also recognized negligence based on the observation on the grounds of inadequate medical records in a case involving the hypoxic brain damage caused during the cosmetic surgery. In terms of the scope of compensation for damages, this paper presents the ruling that the compensation should be estimated based on causal relationship only in case the breach of the 'obligation of explanation' is recognized, however rejecting the reparation for de factor property damages in the form of compensation, and the ruling that the lawsuit could be instituted in case that the damages exceeded the agreed scope despite the agreement that the hospital would not be held responsible for any aftereffects of surgery from the standpoint of lawsuit, along with the ruling that recognized the daily net income by reflecting the unique circumstances faced by individual students of Korean National Police University and artists of Western painting. Many rulings were handed down with respect to medical certificate, prescription, etc., in 2013. This paper introduced the ruling which mentioned the scope of medical certificate, the ruling that related to whether the diagnosis over the phone at the issuance of prescription could constitute the direct diagnosis of patient, along with the ruling that required the medical certificate to be generated in the name of doctor who diagnosed the patients, and the ruling which proclaimed that it would constitute the breach of Medical Act if the prescription was issued to the patients who were not diagnosed. Moreover, this paper also introduced the ruling that related to whether the National Health Insurance Service could make claim to the hospitals for the reimbursement of the health insurance money paid to pharmacies based on the prescription in the event that the hospitals provided prescription of drugs to outpatients in violation of the laws and regulations.

• 한국지하수토양환경학회지:지하수토양환경
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• 제8권2호
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• pp.55-61
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• 2003

본 연구의 목적은 반응벽체 매질로서 제올라이트의 표면특성을 계면활성제로 변화시켜 제조한 SMZ로 충진된 컬럼 시험을 수행함으로써 질산성 질소의 제거특성을 조사하는 것이다. SMZ컬럼 실험에서 얻어진 파과곡선의 해석결과를 이용하여 일차원 이류확산모델을 통해 예측되는 반응벽체의 질산성 질소(N $O_3$$^{-}$-N)제거효과와 실제 소규모 반응벽체 설계의 기본 인자 도출을 통한 설계방법론을 제시하였다 SMZ충진 컬럼 내 질산성 질소의 파과에 대한 예측이 선형 평형 흡착 이동모델을 이용하여 수행될 수 있음을 알 수 있었다. 유량을 변화시키면서 수행한 파과실험을 통해 얻은 파과시간과 반감기( $t_{\frac{1}{2}}$)는 유량의 크기에 반비례함을 알 수 있었다. 질산성 질소농도가 50mg/L인 지하수를 10 $m^3$/day의 처리용량으로 음용수 수질기준인 10mg/L로 감소시키고자 할 경우, 300 ton의 SMZ를 사용하여 약 6년 간 (5.8년)매질의 교체 없이 SMZ 반응벽체를 사용할 수 있을 것으로 예측되었으며, 초기 건설비용과 조사비용 등을 제외하고는 6년에 한 번씩 교체를 위한 매질비용으로 약 1억 6천 5백만 원과 주기적으로 간단한 유지관리와 모니터링 비용이 소요될 것으로 예측되었다.

• 한국약용작물학회지
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• 제26권5호
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• pp.391-400
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• 2018

Background: Atractylodes radix is a well-known medicinal crop having many physiological effects. This study was conducted to select useful Atractylodes japonica ${\times}$ Atractylodes macrocephala (AJM) cultivars by comparing anti-oxidative and anti-inflammatory efficacies. Methods and Results: Seven extracts from AJM cultivars were used to treat lipopolysacchride (LPS)-treated BV2 cells, and the effects on cell viability and inhibition on reactive oxygen species (ROS) and nitric oxide (NO) production were analyzed. In vitro scavenging activities of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxynitrite ($NOO^-$) radicals were also investigated. Contents of total phenol, atractylenolide I, and atractylenolide III in the AJM extracts were measured using high performance liquid chromatography (HPLC) or spectrophotometry. The experiments show that none of the seven extracts was cytotoxic above 89.2% at $20-250{\mu}g/m{\ell}$. Extracts of Gowon, Dawon, Sangchul, and Huchul inhibited ROS generation in a dose-dependent manner, and Sangchul extract showed the highest inhibition on ROS production. All the AJM extracts showed effective inhibitory activity after on NO release in the LPS-treated BV2 cells, and Sangchul extract showed the highest activity. Sangchul extract had the most potent scavenging activities for $NOO^-$ and had some DPPH radical scavenging effect. Sangchul extract also had the highest content at total phenol and atractylenolide I content. Atractylenolide III was not detected in the AJM extracts. Conclusions: The results suggested that Sangchul was the most useful anti-oxidative and anti-inflammatory resource among the AJM cultivars.

• 한국자기학회지
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• 제20권1호
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• pp.18-23
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• 2010

본 연구에서는 벡터 네트워크 분석기(vector network analyzer; VNA)와 코플라나 전송선(coplanar waveguide; CPW)을 이용한 강자성 공명 측정 방법을 개발하기 위해 두께가 각각 10, 20, 40 nm인 $Ni_{81}Fe_{19}$(Permalloy; Py) 합금 박막을 증착하여 측정하였다. 유리기판 위에 패터닝 작업을 거쳐 CPW를 형성하고 제작된 CPW 위에 Py 박막을 직접 올려놓아 시료의 반사/투과계수인 S-파라미터를 측정하였다. 외부자기장을 0 Oe에서 490 Oe까지 변화 시키며 측정해본 결과 Py 박막의 공명주파수는 2.5 GHz에서 7 GHz 범위 내에서 나타났으며 외부자기장의 세기가 커짐에 따라 공명주파수도 증가함을 확인하였다. S-파라미터를 분석하여 나온 공명주파수와 반치폭을 이용하여 포화자화량과 길버트 감쇠 상수를 구한 결과 Py 박막 40 nm에서 길버트 감쇠 상수 값 0.0124($\pm$0.0008)를 구했고 이는 선행 연구되었던 일반적인 강자성 공명 측정값과 일치함을 볼 수 있었다. 또한 두께별 의존도를 조사해본 결과 두께가 작아질수록 S-파라미터의 세기가 작아지는 것을 확인 할 수 있었으며, 강자성공명 분석 결과에서 Py 박막의 두께가 10 nm에서 40 nm까지 증가할 때 유효 포화 자화가 7.205($\pm$0.013) kOe에서 7.840($\pm$0.014) kOe로 증가하는 것을 확인 할 수 있었다.

• 한국식품과학회지
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• 제28권6호
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• pp.1126-1134
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• 1996

삼투처리로 전처리한 당근의 건조특성을 알기 위해 건조와 재수화 공정을 행하여 물리적인 특성을 조사하고, 수분이동 메카니즘을 규명하기 위해 확산 방정식과 건조 모델을 적용하여 알아보고자 하였다. 열풍 건조시 건조특성은 고온과 낮은 상대습도의 조건에서 건조효율이 우수하였으며, 갈변도나 specific volume 등도 높은 값을 보였으며 전반적 색차 또한 큰 값을 보였여 갈변정도와 유사한 경향을 보였다. 재수화 특성도 고온과 낮은 상대습도에서 건조한 것이 대체적으로 복원률과 재수화성이 높게 나타나 건조 특성이 재수화시에도 유사한 경향으로 나타남을 알 수 있었다. 수분의 이동을 나타내는 확산계수는 고온과 낮은 상대습도에서 높은 확산계수를 가졌으며, 온도의 영향이 상대습도보다 크게 나타나 상대습도를 낮추는 것 보다 건조온도를 높이는 것이 더 효과적인 운용방법임을 알 수 있었다. 건조과정을 기존의 건조모델로 표현하고자 적합성 여부를 조사해 본 결과 건조조건에 관계없이 quadratic model이 가장 높은 적합도를 보여 이 모델로서 건조시 수분함량의 감소를 시간의 함수로 나타낼 수 있었다. 건조시간과 풍속을 변화시키면서 실험을 행한 결과 시간에 따른 carotene 함량과 수분함량은 polynomial 형태로 모델화 할 수 있었고 풍속이 강할수록 평형수분함량 도달 시간은 빨라졌으나 1.2 m/s 이상의 풍속에서는 그 차이가 크지 않았으며, carotene 함량도 유사한 경향이었다. 재수화 특성값도 빠른 풍속에서 건조한 당근일수록 우수한 것으로 나타났으며, carotene 함량이나 전반적인 색차도 건조 후의 특성이 그대로 유지되었다. 기존모델과의 적합도를 살펴보면 풍속에 관계없이 quadratic mode이 가장 높은 적합도를 보여 건조시 수분의 이동을 예측할 수 있을 것으로 생각된다.