• Journal of Clinical Nutrition
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• 제10권2호
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• pp.38-44
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• 2018

Purpose: Parenteral nutrition (PN) is known to provide therapeutic beneficial improvements in malnourished patients for whom enteral nutrition is not feasible. The objective of this study was to investigate the current clinical characteristics and utilization of PN in Korea. Methods: We analyzed the Health Insurance Review Agency National Inpatients Sample database from 2014 to 2016, which included 13% of all hospitalized patients in Korea. Adult patients aged 20 years or older and receiving premixed multi-chamber bag containing PN were included for this study. Patient characteristics, admission type, primary diagnosis, and hospital demographics were evaluated. SAS version 9.4 was used for data analysis. Results: From 2014 to 2016, 149,504 patients received premixed PN, with 226,281 PN prescriptions being written. The mean patient age was 65.0 years, and 81,876 patients (54.8%) were male. Premixed 3-chamber bag and 2-chamber bag PN solutions were utilized in 131,808 (88.2%) and 32,033 (21.4%) patients, respectively. The number of patients hospitalized through the emergency department were 70,693 (47.3%), whereas 43,125 patients (28.8%) were administered PN in intensive care units. In the adult PN patients, the highest primary diagnosis was malignant neoplasm of the stomach (8,911, 6.0%), followed by organism unspecified pneumonia (7,008, 4.7%), and gastroenteritis and colitis of unspecified origin (6,381, 4.3%). Overall, 34% of adult PN patients were diagnosed with malignancies, the most common being neoplasm of the stomach (17.7%), neoplasm of bronchus/lung (11.2%), neoplasm of colon (11.1%), and neoplasm of liver/intrahepatic bile ducts (10.0%). PN solutions were most frequently administered in the metropolitan area (55.0%) and in hospitals with more than 1,000 beds (23.6%). Conclusion: PN was commonly administered in older patients, with primary diagnosis of malignancy in a significant number of cases. This study is the first large-scale description of PN-prescribing patterns in real-world clinical practice in South Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9865-9869
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• 2014

Background: Transthoracic fine needle aspiration (FNA) is one of several methods for establishing tissue diagnosis of lung lesions. Other tissue or cell sources for diagnosis include sputum, endobronchial biopsy, washing and brushing, endobronchial FNA, transthoracic core needle biopsy, biopsy from thoracoscopy or thoracotomy. The purpose of this study was to compare the sensitivity and specificity of FNA and other diagnostic tests in diagnosing lung lesions. Materials and Methods: The population included all patients undergoing FNA for lung lesions at Meir Medical Center from 2006 through 2010. Information regarding additional tissue tests was derived from the electronic archives of the Department of Pathology, patient records and files from the Department of Oncology. Sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values were calculated for each test. Results: FNA was carried out in 245 patients. Malignant tumors were diagnosed in 190 cases (78%). They included adenocarcinoma (43%), squamous cell carcinoma (15%), non-small cell carcinoma, not otherwise specified (19%), neurondocrine tumors (7%), metastases (9%) and lymphoma (3%). The specificity of FNA for lung neoplasms was 100%; sensitivity and diagnostic accuracy were 87%. Conclusions: FNA is the most sensitive procedure for establishing tissue diagnoses of lung cancer. Combination with core needle biopsy increases the sensitivity. Factors related to the lesion (nature, degenerative changes, location) and to performance of all stages of test affect the ability to establish a diagnosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4215-4221
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• 2013

Purposes: Lung cancer is prevalent worldwide and improvements in timely and effective diagnosis are need. Pentraxin-3 as a novel serum marker for lung cancer (LC) has not been validated in large cohort studies. The aim of the study was to assess its clinical value in diagnosis and prognosis. Methods: We analyzed serum PTX-3 levels in a total of 1,605 patients with LC, benign lung diseases and healthy controls, as well as 493 non-lung cancer patients including 12 different types of cancers. Preoperative and postoperative data were further assessed in patients undergoing LC resection. The diagnostic performance of PTX-3 for LC and early-stage LC was assessed using receiver operating characteristics (ROC) by comparing with serum carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA 21-1). Results: Levels of PTX-3 in serum were significantly higher in patients with LC than all controls. ROC curves showed the optimum diagnostic cutoff was 8.03ng/mL (AUC 0.823, [95%CI 0.789-0.856], sensitivity 72.8%, and specificity 77.3% in the test cohort; 0.802, [95%CI 0.762-0.843], sensitivity 69.7%, and specificity 76.4% in the validate cohort). Similar diagnostic performance of PTX-3 was observed for early-stage LC. PTX-3 decreased following surgical resection of LC and increased with tumor recurrence. Significantly elevated PTX-3 levels were also seen in patients with non-lung cancers. Conclusions: The present data revealed that PTX-3 was significantly increased in both tissue and serum samples in LC patients. PTX-3 is a valuable biomarker for LC and improved identification of patients with LC and early-stage LC from those with non-malignant lung diseases.

• 대한영상의학회지
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• 제84권1호
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• pp.311-317
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• 2023

컴퓨터단층촬영 유도 경피적 바늘 생검은 폐 이상 진단에 중요한 역할을 하며, 안전하고 효과적이지만 기흉, 출혈, 객혈, 공기 색전증 및 종양 파종과 같은 합병증의 위험이 있다고 알려져 있다. 그러나 시술 후 발생한 기종에 대한 증례 보고는 드물다. 저자들은 원발성 폐암의 경피적 바늘 생검 직후 발생한 기종 2예를 보고하고자 한다. 시술 후 단기 추적검사 컴퓨터단층 촬영에서 바늘 경로를 따라 새로 생긴 결절의 경우 혈종으로 찬 기종을 의심해야 한다.

• Journal of Chest Surgery
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• 제25권9호
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• pp.900-904
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• 1992

Pulmonary blastoma is a very rare, primary, malignant neoplasm of the lung. The tumor typically is large, well-defined mass and arises in the periphery of the lung. Histologically, it resembles fetal lung tissue evoking the concept that these tumors are drived from the primitive pluripotential pulmonary blastema, but controversy also exit about the nature of this tumor. Clinical evaluation is inconsistant and unreliable as to the diagnostic determination of the tumor type and degree of malignancy. Therefore, diagnosis is usually based on histologic findings. The prognosis after adequate resection appears to be better than for other malignant tumors of the lungs. We experienced a case of pulmonary blastoma occurring in 56-year-old female. She was hospitalized for evaluation of an abnormal shadow in the left lower lung field which found incidentally on chest roentgenogram. We approached the lesion though left posterolateral thoracotomy and performed the left lower lobectomy. The microscopic findings of resected specimen revealed characteristic appearance of pulmonary blastoma. The postoperative course was uneventful without complication.

• Journal of Chest Surgery
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• 제57권4호
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• pp.408-412
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• 2024

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

• Journal of Chest Surgery
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• 제36권7호
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• pp.535-538
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• 2003

자발성기흉이 원발성 폐암에 동반되어 나타나는 경우는 드물며, 특히, 원발성 폐암의 초발 소견으로 나타나는 경우는 더욱 드문 것으로 보고되고 있다. 우리나라에서도 폐암 환자의 증가 추세와 더불어 폐암에 동반된 자발성 기흉에 대한 논문이 드물게 발표되고 있다. 그러나, 이러한 경우의 폐암은 진행된 경우가 많아 페종양을 절제하게 되는 경우는 드물고 고식적 치료 즉 자발성 기흉의 페쇄성흉관삽관술, 항암요법, 방사선요법이 주가 되는 경우가 많다. 삼성서울병원 흉부외과에서는 최근 단순한 자연 기흉의 진단하에 기포절제술과 늑막유착술을 시행한 후 검체의 조직학적 검사상 원발성 폐암으로 진단되어 즉시 근치적 절제술 및 방사선요법을 시행하였으나 6개월 내 국소 재발된 1예를 경험하였기에 환자의 추적관찰 후 상태와 더불어 보고하는 바이다.

• Journal of Chest Surgery
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• 제31권8호
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• pp.820-822
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• 1998

원발성 악성 폐 임파종은 매우 드문 질환으로, 전체 악성 임파종의 0.34%에 불과하다. 인제 대학교 부산 백병원 흉부외과학 교실에서 경험한 증례는 76세된 남자환자로 흉부전산화 단층촬영상 임파절 종대를 동반 하지 않은 단일 종괴를 발견하고 개흉술을 통한 폐엽절제술후 병리조직학적으로 악성 임파종으로 확진되었 으며 항암화학요법을 시행하였기에 문헌 고찰과 함께 보고하고자 한다.

• Journal of Chest Surgery
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• 제30권1호
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• pp.112-115
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• 1997

악성림프종과 병발한 폐의 편평세포암종을 1례 치험하였다. 환자는 19세 남자로 비 흡연자였다. 수술은 우 전폐절제술을 시행하였고 조직소견상 전이의 증거는 없었다. 조직의 확진은 면역조직화자염색을 통해 이루어졌다. 환자는 술후 3개월째 흉벽으로 림프종의 재발이 있었으며 술후 5개월째 호흡부전으로 사망하였다.

• Journal of Chest Surgery
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• 제32권10호
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• pp.954-957
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• 1999

Primary malignant lymphomas of the lung are rare neoplasms representing 3.6% of all extranodal lymphomas and less than 1% of pulmonary malignancies, with its distinct clinicopathological features. A 60-year-old symptomatic man, who was a former non-smoker, had a cough and sputum. Chest roentgenogram and computed tomographic scan showed the presence of a posterior mass in the basal segment of the right lung. Transthoracic needle aspiration cytology was inadequate for the diagnosis of cancer. A subsequent right thoracotomy was carried out, which showed a primary pulmonary lymphoma of the bronchus-associated lymphoid tissue.