• BMB Reports
• /
• v.44 no.3
• /
• pp.158-164
• /
• 2011

Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed.

• Journal of the Korean Mathematical Society
• /
• v.50 no.6
• /
• pp.1199-1211
• /
• 2013

We introduce a new class of graphs, called quasi $m$-Cayley graphs, having good symmetry properties, in the sense that they admit a group of automorphisms G that fixes a vertex of the graph and acts semiregularly on the other vertices. We determine when these graphs are strongly regular, and this leads us to define a new algebro-combinatorial structure, called quasi-partial difference family, or QPDF for short. We give several infinite families and sporadic examples of QPDFs. We also study several properties of QPDFs and determine, under several conditions, the form of the parameters of QPDFs when the group G is cyclic.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.2
• /
• pp.891-894
• /
• 2013

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.

• Journal of the Korean Mathematical Society
• /
• v.57 no.1
• /
• pp.171-194
• /
• 2020

For a nonautonomous dynamics defined by a sequence of bounded linear operators on a Banach space, we give a characterization of the existence of an exponential dichotomy with respect to a sequence of norms in terms of the invertibility of a certain linear operator between general admissible spaces. This notion of an exponential dichotomy contains as very special cases the notions of uniform, nonuniform and tempered exponential dichotomies. As applications, we detail the consequences of our results for the class of tempered exponential dichotomies, which are ubiquitous in the context of ergodic theory, and we show that the notion of an exponential dichotomy under sufficiently small parameterized perturbations persists and that their stable and unstable spaces are as regular as the perturbation.

• ALGAE
• /
• v.23 no.3
• /
• pp.201-207
• /
• 2008

Based on samplings during 2006-2007 on the intertidal zone of Playa Tampico, Eréndira and Punta Baja, Baja California, Ulva pertusa Kjellman (Ulvales, Chlorophyta) was recorded for the first time for the Pacific coast of Mexico. An alga native to Asia, U. pertusa has just recently been recorded in the southern coast of California (USA). The identification of U. pertusa was based on the observation of the morphology and reproductive characters of the collected specimens. Furthermore, the species identity was confirmed by molecular comparison between nuclearencoded ITS2 sequences of the Mexican samples and those of other Ulva species in GenBnak data. Habitat and distribution of U. pertusa along the Pacific coast of North America are also described. Considering our new report of its occurrence in Mexico, we conclude that U. pertusa is expanding its geographical distribution by trans-ocean introductions.

• Archives of Plastic Surgery
• /
• v.40 no.3
• /
• pp.244-246
• /
• 2013

Lipomas are benign mesenchymal tumors that develop in areas of abundant adipose tissue. Due to the fatty composition of the breast, difficulties in diagnosis, treatment, and reconstruction are often encountered. We report a case of a 55-year-old female with a giant tumor of the right breast that comprised most of its mass, causing breast asymmetry. A thorough preoperative evaluation, followed by an uneventful difficult surgical resection and reconstruction, resulted in diagnosis of a benign lipoma. The case prompted this report because of its challenging size, location, diagnosis, and reconstructive solution.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.5 no.8
• /
• pp.1457-1471
• /
• 2011

A method to detect Trojan horses in messaging and Bluetooth in mobile phones by means of monitoring the events produced by the infections is presented in this paper. The structure of the detection approach is split into two modules: the first is the Monitoring module which controls connection requests and sent/received files, and the second is the Graphical User module which shows messages and, under suspicious situations, reports the user about a possible malware. Prototypes have been implemented on different mobile operating systems to test its feasibility on real cellphone malware. Experimental results are shown to be promising since this approach effectively detects various known malware.

• The Bulletin of The Korean Astronomical Society
• /
• v.36 no.2
• /
• pp.68.2-68.2
• /
• 2011

We present the detailed image decomposition of Hubble Space Telescope archival images for 235 nearby (z < 0.35) unobscured type 1 AGNs. It allows us to perform robust measurements of host galaxy properties and AGN luminosity contribution. We examine how the host properties correlate with AGN properties. Broad line type 1 and radio-loud AGNs are hosted preferentially by early type galaxies. Narrow line type 1 AGNs show a low fraction of tidal interaction, that might suggest the secular evolution may play an important role for triggering AGN activity, while the fraction of merging hosts is rather higher in luminous AGNs. We compare the nucleus luminosity and bulge luminosity and find that either our sample might have a smaller zero point in the M(BH)-L(bulge) relation (i.e. less massive black hole at a given bulge luminosity) relation compared to the normal galaxies or Eddington ratio of our sample could be systematically overestimated.

• Steel and Composite Structures
• /
• v.35 no.4
• /
• pp.527-544
• /
• 2020

This research presents the design and numerical assessment of composite steel-concrete frame structures with welded dissipative fuses. The assessment has been carried out based on linear response spectrum, nonlinear static pushover and time history procedures. The analytical expressions which define the envelope of the nonlinear response of the dissipative fuses are first presented and calibrated against experimental results available in literature. The assessment is then carried out according to a design methodology proposed herein. Outcomes of the numerical assessment indicate that the use of welded dissipative fuses successfully limited damage within the replaceable parts. Furthermore, although structures with dissipative fuses present lower strength and, generally, lower displacement capacity, their displacement ductility and global dissipative performance are generally higher than conventional structures, especially when the structure with dissipative fuses presents a dissipative configuration adjusted to the bending moment distribution diagram calculated for the applied seismic action.

• The korean journal of orthodontics
• /
• v.45 no.6
• /
• pp.333-340
• /
• 2015

Condylar hyperplasia (CH) is a rare disorder characterized by excessive bone growth that almost always presents unilaterally, resulting in facial asymmetry. Classification of the different types of CH can differ depending on the authors. Correct diagnosis is critical in determining the proper treatments and timing. This paper is a review of the recent literature on the epidemiology, etiology, diagnosis, classification, and surgical treatments of CH.