• 한국임상약학회지
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• 제11권2호
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• pp.89-96
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• 2001

Ziprasidone is equally effective as haloperidol in treating schizophrenia with fewer side effects and drug interactions. Ziprasidone is an atypical antipsychotic agent and works by blocking serotonin and dopamine receptors in the central nervous system, specifically 5-HT2A and D2 receptors. Low anticholinergic side-effects and low EPS would recommend the drug for use in the elderly. Ziprasidone inhibits reuptake of norepinephrine and serotonin at neurojunction sites in vitro, indicating a potential efficacy for depression and negative symptoms which often follow after exacerbation of schizophrenia. Patients with recent acute myocardial infarction and uncompensated heart failure are contraindicated to the drug due to a possibility of QT prolongation. Although ziprasidone is metabolized by cytochrome P450 3A4, there is no significant drug interaction with the drugs that induce or inhibit the isoenzyme. Ziprasidone is safe with coadministration of lithium and there has been no significant drug interaction reported with oral birth control pills.

• 한국연소학회지
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• 제4권1호
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• pp.131-139
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• 1999

A Numerical Analysis of NOx production in Hydrogen-Air flame is performed using the quasi-laminar reaction modelling. As results, in low global strain rate region, $U_F/D_F\;{\leq}\;50,000$, the quasi-laminar reaction modelling reproduces the experimentally observed EINOx half power scaling that the ratio of EINOx and flame residence time, $L_f^3(D_F^2U_F)$, is proportional to the square root of global strain rate. Thus, it suggests that turbulence-chemistry interaction has a minor impact on the trend of NOx production in low global strain rate region. However, the quasi-laminar reaction modelling predicts the higher temperature and NOx than experimentally observed. This overprediction may be due to the lack of radiation and quasi-laminar reaction modelling.

• Wind and Structures
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• 제30권5호
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• pp.451-463
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• 2020

Two-dimensional numerical simulations are conducted at a low Reynolds number Re = 100 to investigate the near wake of three identical circular cylinders that are arranged in an equilateral triangular configuration. The incident angle of the three-cylinder configuration with respect to incoming flow is varied from θ = 0° to 60°, while the spacing between adjacent cylinders (L) covers a wide range of L/D = 1.25-7.0, where D is diameter of the cylinder. Typical flow structures in the near wake of the three-cylinder configuration are identified, including a single Karman vortex street, bistable flip-flopping near wake, anti-phase and/or in-phase vortex shedding, shear layer reattachment, and vortex impingement, depending on the configuration (L/D, θ). The behavior of Strouhal number (St) is discussed in detail, echoing the distinct structures of near wake. Furthermore, fluid forces on the individual cylinders are examined, which, though highly depending on (L/D, θ), exhibit a close correlation to the near wake behavior.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.67-74
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• 2008

The regional-scale transient groundwater-river interaction model is developed to gain a better understanding of the regional-scale relationships and interactions between groundwater and river system and quantify the residual river flow after groundwater abstraction from the aquifers with climate variability in the Waimea Plains, New Zealand. The effect of groundwater abstraction and climate variability on river flows is evaluated by calculating river flows at the downstream area for three different drought years (a 1 in 10 drought year, 1 in 20 drought year, and 1 in 24 drought year) and an average year with metered water abstraction data. The effect of future water demand (50 year projection) on river flows is also evaluated. A significant increase in the occurrence of zero flow, or very low flow of 100 L/sec at the downstream area is predicted due to large groundwater abstraction increase with climate variability. Modeling results shows the necessity of establishing dynamic cutback scenarios of water usage to users over the period of drought conditions considering different climate variability from current allocation limit to reduce the occurrence of low flow conditions at the downstream area.

• 대한전자공학회논문지
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• 제15권3호
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• pp.24-29
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• 1978

사이크로트론파와 전자속파의 결합에 의한 신형모드의 동작이 관찰되었다. 전파형성 과정을 분석하는 데 전자동력학과 결합모드에 의한 방법이 적용되었으며 유도된 이론적 이득식에서 신형초고주파 증폭기가 설계 제작 되었으며 실험결과잡음이 없이 고전력을 얻을 수 있는 증폭기임이 보여진다.

• Asian-Australasian Journal of Animal Sciences
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• 제12권6호
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• pp.846-849
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• 1999

Angus postweaning daily gain (PWDG) were analyzed to investigate heterogeneous variance by sex. A set of data (16,239 records) was divided into six sub-data sets according to level of environment. REML estimation was conducted by a multitrait model, where PWDG in each sex was treated as a separate trait. Estimates showed diversity among environmental levels, where the heritability for heifers was high in good environment but low in poor environment. The bull's estimates varied among environmental levels. The largest heterogeneity of phenotypic variance between sexes was estimated in a data set of the poor environment level. The genetic correlations between the heifer's PWDG and the bull's PWDG were high in the good environment and low in the poor environment (-0.17). The results suggest existence of genotype by sex interaction in the poor environment.

• 대한기계학회논문집B
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• 제22권3호
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• pp.360-372
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• 1998

This study deals with the interaction between buoyancy-induced convection and externally imposed excitation in the form of harmonic rocking and the effect of the interaction upon heat transfer in low-Pr liquids. A wide array of system responses are discussed using the spectral collocation numerical technique. The superposition of buoyancy and Coriolis forces leads to complex fluid flow and heat transfer. The transition to chaotic convection is accelerated, and heat transfer rates are reduced as the enclosure is excited at the fundamental frequency of oscillation associated with the pure buoyancy-driven case. Average heat transfer rates are correlated for Pr=0.02 and 0.03. The heat transfer is affected more in the Pr=0.03 liquid than the case of Pr=0.02.

• Bulletin of the Korean Chemical Society
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• 제30권1호
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• pp.145-148
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• 2009

Nucleotides are the building blocks of nucleic acids and essential for many cellular functions. In this study, ultrasonic absorption spectra of $\beta$-cyclodextrin ($\beta$-CD) and adenosine 5'-monophosphate (AMP) in aqueous solution were measured over the broad frequency range 0.1-40 MHz with emphasis on the low-frequency range below 1 MHz. Here we show that the interaction of $\beta$-CD and AMP complies with a typical spectrum of a single relaxation process. We determined reliable rate (kb) and equilibrium (K) constants and a standard volume change ($\Delta$V) of the reaction. They are $k_b=2.3{\times}{{10^{-6}}_s}^{-1},\;K=89M^{-1},\;and\;{\Delta}V=13.8(10^{-6}m^3mol^{-1})$, respectively.

• Earthquakes and Structures
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• 제3권3_4호
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• pp.495-506
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• 2012

An elasto-dynamic model for pile-soil-pile interaction together with a simple plate model is used in this study to assess the effect of flexible foundation slabs on the dynamic response of pile groups. To this end, different pile configurations with various slab thicknessesare considered in two soil media with low and high elastic moduli. The analyses include dynamic impedances and seismic responses of pile-group foundations. The presented results indicate that the stiffness and damping of pile foundations increase with thickness of the foundation slab; however, the results approach those for rigid slab as the slab thickness approaches twice the pile diameter for the cases considered in this study. The results also reveal that pile foundations with flexible slabs may amplify the earthquake motions by as much as 10 percent in the low to intermediate frequency ranges.

• Genomics & Informatics
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• 제16권4호
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• pp.37.1-37.3
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• 2018

Gene-gene interaction is a key factor for explaining missing heritability. Many methods have been proposed to identify gene-gene interactions. Multifactor dimensionality reduction (MDR) is a well-known method for the detection of gene-gene interactions by reduction from genotypes of single-nucleotide polymorphism combinations to a binary variable with a value of high risk or low risk. This method has been widely expanded to own a specific objective. Among those expansions, fuzzy-MDR uses the fuzzy set theory for the membership of high risk or low risk and increases the detection rates of gene-gene interactions. Fuzzy-MDR is expanded by a maximum likelihood estimator as a new membership function in empirical fuzzy MDR (EFMDR). However, EFMDR is relatively slow, because it is implemented by R script language. Therefore, in this study, we implemented EFMDR using RCPP ($c^{{+}{+}}$ package) for faster executions. Our implementation for faster EFMDR, called EMMDR-Fast, is about 800 times faster than EFMDR written by R script only.