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Lung Cancer Detection by Screening - Presenting Circulating miRNAs as a Promising Next Generation Biomarker Breakthrough

  • Ramshankar, Vijayalakshmi;Krishnamurthy, Arvind
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2167-2172
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    • 2013
  • Lung cancer remains a major cause of morbidity and mortality worldwide, accounting for more deaths than any other cause. All the clinical practice guidelines recommended against routine screening for lung cancer have cited lack of robust evidence, at least until a few years back. However, the potential to screen lung cancers has received renewed interest due to superior performance of low dose CT (LD-CT) in detecting early stage cancers. The incremental costs and risks involved due to the invasive procedures in the screened population due to a high false positivity rate questions the use of LD-CT scan as a reliable community based screening tool. There is therefore an urgent need to find a less invasive and a more reliable biomarker that is crucial to increase the probability of early lung cancer detection. This can truly make a difference in lung cancer survival and at the same time be more cost and resource utilization effective. Sampling blood serum being minimally invasive, low risk and providing an easy to obtain biofluid, needs to be explored for potential biomarkers. This review discusses the use of circulatory miRNAs that have been able to discriminate lung cancer patients from disease free controls. Several studies conducted recently suggest that circulating miRNAs may have promising future applications for screening and early detection of lung cancer.

Lab Color Space based Rice Yield Prediction using Low Altitude UAV Field Image

  • Reza, Md Nasim;Na, Inseop;Baek, Sunwook;Lee, In;Lee, Kyeonghwan
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2017.04a
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    • pp.42-42
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    • 2017
  • Prediction of rice yield during a growing season would be very helpful to magnify rice yield as it also allows better farm practices to maximize yield with greater profit and lesser costs. UAV imagery based automatic detection of rice can be a relevant solution for early prediction of yield. So, we propose an image processing technique to predict rice yield using low altitude UAV images. We proposed $L^*a^*b^*$ color space based image segmentation algorithm. All images were captured using UAV mounted RGB camera. The proposed algorithm was developed to find out rice grain area from the image background. We took RGB image and applied filter to remove noise and converted RGB image to $L^*a^*b^*$ color space. All color information contain in both $a^*$ and $b^*$ layers and by using k-mean clustering classification of these colors were executed. Variation between two colors can be measured and labelling of pixels was completed by cluster index. Image was finally segmented using color. The proposed method showed that rice grain could be segmented and we can recognize rice grains from the UAV images. We can analyze grain areas and by estimating area and volume we could predict rice yield.

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A Comparative Research on the Reconstruction and Remodeling of Low-rise, Dilapidated Apartment Buildings (노후저층 공동주택의 재건축과 리모델링 사업의 비교 연구)

  • 이효진;김동훈;김진호;임남기
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2002.05a
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    • pp.75-80
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    • 2002
  • The purpose of this study is to conduct researches on the aspects of reconstruction and remodeling of low-rise, dilapidated apartment buildings in the provinces, using comparative methodologies, consequently coming up with the findings in the following. 1) Unlike the rebuilding projects in which the movement process tends to be made in a bulk (in a simultaneous manner), it turns out that when it comes to remodeling, it would be advisable to attempt moving the inhabitants as a group either by the size of their residence or by the building. 2) Given the peculiarities of the construction management mechanism, remodeling projects might seem disadvantageous on the part of the management on account of inadequate accumulation of information and experience. Hence, based on the impeccable assessment of the current status of the subject buildings from the phase of planning, its imperative to closely look into and take into consideration a variety of direct and/or indirect factors in advance of the implementation. 3) A series of comparative researches from the perspective of economical efficiency that remodeling projects appear profitable considering the overall costs including financial expenses, varied taxes, and so on that will be eventually brought forth during the reconstruction period, and all the more so when allowing for the consequential effects which they ought to have upon the natural and human resources, environmental and ecological condition, business potentials, etc. Amelioration to be desired on the basis of the findings above.

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A Study on the Effects of Advance and Discount Sales of Seasonal Products by Subscription on Logistics Costs (계절상품의 사전 예약판매가 물류비용에 미치는 영향에 관한 연구)

  • Kim, Byeongchan
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.11 no.3
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    • pp.219-230
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    • 2015
  • It is difficult to make plans about the production schedule and volume of seasonal products due to the huge uncertainty in the prediction of their demands, which is why the amounts of carryover seasonal products increase after the peak season. Traditional models fail to meet the important requirements of production and stock plans related to the enhanced efficiency of logistics system due to the reduced value of carryover products by the disposal based on large discounts and deterioration, which poses considerable difficulties with actual problem solving. This study examined the stages of product storage from the specialized factory warehouses during a low season through the stores and the warehouses of local distribution centers during a high season to stock disposal and carryover product warehouses after a high season. The study developed a model for logistics rationalization plans to minimize carryover products by advance selling new products by subscription during a low season in anticipation of high season demands, increasing the accuracy of demands prediction, and making stable production plans, as well as demonstrated its excellence through numerical analysis.

The Effect of Bumper Mismatch on Vehicle Repair Cost (차량 간 범퍼높이 차이가 수리비에 미치는 영향)

  • Choi, Dong-Won;Park, In-Song;Hong, Seung-Jun
    • Transactions of the Korean Society of Automotive Engineers
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    • v.18 no.1
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    • pp.99-104
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    • 2010
  • It is a frequent occurrence in urban traffic - a low-speed collision in which one vehicle hits the back of another. The vehicles often sustain expensive damage. Bumpers can reduce this damage, but only line up so the initial contact in an impact is bumper to bumper. Then the bumpers on the colliding vehicles have to absorb the crash energy, keeping damage away from expensive sheet metal, lights, and other components. In real world accidents, Bumper mismatches in crashes are increasing, and the resulting repair costs from low-speed collisions are escalating. In this study, we investigated the bumper rail height and analyzed their effects on repair cost. Futhermore, Our 16kph front-into-rear crash tests demonstrates bumper mismatch problem.

Design and Implementation of the Slope-Crack Prediction System by Using Wireless Sensor Networks (무선 센서 네트워크를 이용한 상시 사면 균열 예측시스템의 설계 및 구현)

  • Lim, Hwa-Jung;Tscha, Yeong-Hwan
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.1
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    • pp.186-192
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    • 2009
  • With the proliferation of ubiquitous computing we have witnessed the wide application of many wireless sensor networks into various areas because of easy installations and low-cost merits. The commercially available equipments for monitoring and predicting cracks in the mountain regions are still burden for us in terms of the installation complexity and the cost. Alternatively we in this paper design and implement a pilot slop-crack monitoring and prediction system which is based on low-cost commercial sensor networks. The proposed system is easy to install on cliffs, slopes, rocks, and banks and may minimize the destruction of the original geographical forms. Expected is that its installation and maintenance costs may reduce to the half of those of existing systems.

Optimal Mixture Contents of Accelerated Flowable Backfill Materials Using Surplus Soil for Underground Power Utilities (굴착잔토를 재활용한 지중전력구조물 급결성 유동화 뒷채움재의 최적배합비)

  • Cheon, Seon-Ho;Jeong, Sang-Seom;Lee, Dae-Soo;Cho, Hwa-Kyung
    • Proceedings of the Korean Geotechical Society Conference
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    • 2005.10a
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    • pp.395-404
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    • 2005
  • This study is to evaluate the physical and mechanical characteristics of flowable backfill and search for the optimal mixture contents of it used for constructing underground power utilities. flowable backfill is known as soil-cement slurry, void fill, and controlled low-strength material(CLSM). The benefits of CLSM include reduced equipment costs, faster construction, re-excavation in the future, and the ability to place material in confined spaces such as narrow parts nearly impossible for compaction or perimeter of underground power cables. The flowable slurry mixture made with 9 types of soil and 6 types of accelerated mixtures in the laboratory were evaluated for bleeding, flowability, heat resistance, and unconfined compressive strength to meet the aim values of this study.

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A study on the characteristics of $TiO_2$ electrode in dye-sensitized solar cells using electrospray method (정전분무법을 이용한 염료감응형 태양전지의 $TiO_2$ 박막 특성에 관한 연구)

  • Jang, Jin-Ju;Hong, Ji-Tae;Lee, Dong-Gil;Lee, Kyoung-Jun;Son, Min-Gu;Kim, Jin-Kyung;Kim, Hee-Je
    • Proceedings of the KIEE Conference
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    • 2009.07a
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    • pp.1423_1424
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    • 2009
  • Dye sensitized solar cells(DSC) have been very economical and easy method to convert solar energy to electricity. DSC can reach low costs in future outdoor power applications. However, to commercialize the DSC, there are still many shortages to overcome such as a low efficiency in a large size DSC. In this study, DSCs were fabricated by an electrospray coating method for the $TiO_2$ thin film. They were compared with DSCs prepared by conventional coating methods. We conducted an experiment to obtain the optimized parameters of voltage, flow rate, incident angle and distance in the electrospray method. After we manufactured $TiO_2$ film using that way, we could analyze the characteristics of DSC through SEM, UV curve, EIS.

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Design and Fabrication of Low-Voltage Twisting-Type Thermal Actuators for Micromirrors (마이크로 거울의 구동을 위한 저전압 비틀림형 열구동기의 설계 및 제작)

  • Kim, Dong-Hyun;Park, Yong-Chul;Park, Seung-Ho;Kwon, Oh-Myoung;Choi, Young-Ki;Lee, Joon-Sik
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.33 no.10
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    • pp.803-810
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    • 2009
  • Micromirrors have a wide range of applications such as optical switches, laser scanners, and digital projection displays. Due to their low performances and high costs, however, practical applications of micromirrors are quite limited. At present micromirrors demand not only a better design but also a simple fabrication process. In this study a twisting-type micromirror that can be driven by two thermal bimorph actuators bending in opposite directions is designed from electro-thermo-mechanical theories and fabricated through a simple MEMS process. Each actuator consists of $SiO_2$ and gold thin-film layers. Simplified analytical model has been built to optimize the performance of micromirror. Due to unexpected resistance increase of metal film and alignment mismatch during fabrication process, experimental rotation angles of micromirrors are about $11^{\circ}$ at applied voltages less than 0.6V. From numerical simulation and analytical studies, however, the next design can provide rotation angles over $20^{\circ}$ at the same applied voltage.

A Study on Flame Monitoring System Development for Combustion Management of Boilers (보일러 연소관리를 위한 화염감시 시스템 개발에 관한 연구)

  • Baek, Woon-Bo;Shin, Jin-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.27 no.11
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    • pp.1587-1594
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    • 2003
  • Increased energy costs have placed demands for improved combustion efficiency, high equipment availability, low maintenance and safe operation. Furthermore low NO$_x\$ modification, installed due to strict environmental legislation, requires very careful combustion management. The flame monitoring system has been developed specially to satisfy these requirements. We aimed at gaining the relationship between the burner flame image and emissions such as NO$_x$ and unburned carbon in furnace by utilizing the image processing method. For the first step of development, its possibility test was undertaken with bench furnace. The test proceeded to the second step with pilot furnace and the system was observed to be effective for evaluating the combustion conditions. By using this technology, it is possible to perform continuous monitoring of the combustion conditions and instant detection of individual changes for each burner to prevent future loss of ignition. This may contribute to the saving of burner adjusting times for the changes of loads and fuels and to the reduction of the slagging as well.